From the Journals

Experts Prioritize 3 Drugs for Alzheimer's

A global expert consensus identifies three repurposed drugs, including the shingles vaccine, as top candidates for Alzheimer disease clinical trials

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  • 1

    Delphi consensus identified three high-priority candidates: Zostavax, sildenafil, and riluzole.

  • 2

    Zostavax has shown a 20% reduction in dementia diagnoses.

  • 3

    Sildenafil is linked to cognitive benefits in preclinical models.

  • 4

    Riluzole preserved brain glucose metabolism in a phase 2a trial.

  • 5

    Pragmatic trials recommended for further evaluation of these agents.

Original Source(s)

Experts Prioritize 3 Drugs for Alzheimer's

A global expert consensus identifies three repurposed drugs, including the shingles vaccine, as top candidates for Alzheimer disease clinical trials

  • by Kerri Miller

  • February 20, 2026

  • 5 min

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