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MDSpire is an innovative platform aiming to create a smarter, faster, and more connected medical community.

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Choose specialties Cardiology Dermatology Endocrinology Family Medicine Gastroenterology Hematology Internal Medicine Neurology ObGyn Oncology Ophthalmology Optometry Pediatrics Rheumatology Pulmonary Psychiatry Pathology Surgery Orthopedic Medicine Radiology Otolaryngology Infectious Disease

Npj Digital Medicine

May 30, 2026

Sensor wide association studies in digital medicine

Nico Steckhan
Felix Broghammer
Dylan Powell
May 30, 2026

Summary
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: Revise to include direct attribution. Key Findings: Add direct sourcing for each finding. Interpretation: Remove editorial interpretation. Limitation

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Npj Digital Medicine

May 30, 2026

Droplet microfluidics with image texture quantification for detection of rare antibiotic-resistant subpopulations from bloodstream infections

Sagar N. Agnihotri
Nikos Fatsis-Kavalopoulos
Emma Vikdahl
Jonas Windhager
Agustin A. Corbat
Dan I. Andersson
Maria Tenje
May 30, 2026

Summary
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To develop a rapid and accurate method for detecting heteroresistance (HR) in bacterial populations from bloodstream infections using droplet microfl

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May 29, 2026

FDA Expands Afrezza to Pediatric Diabetes

Kathryn Wighton
May 29, 2026
3 min

Summary
Takeaways
Quiz
Clinical Scorecard

Objective: To inform about the FDA's approval of Afrezza for children and adolescents with diabetes. Key Findings: Afrezza offers a needle-free mealtime insulin

The FDA has approved Afrezza for children aged 6 and older with type 1 or type 2 diabetes.
Afrezza is an inhaled mealtime insulin that is administered using a portable inhaler.
The approval was supported by data from the INHALE-1 trial and over 20 years of inhaled insulin studies.
Afrezza offers a needle-free option for mealtime insulin, addressing challenges faced by pediatric patients.
Afrezza is not suitable for patients with chronic lung diseases and requires lung function assessments.

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May 29, 2026

Anterior Lumbar Interbody Fusion (ALIF): A Collaborative Approach to Spine Surgery

May 29, 2026

Summary
Insight Report
Quiz

Objective: To demonstrate the collaborative approach between a vascular surgeon and a neurosurgeon in performing anterior lumbar interbody fusion (ALIF). Key Fi

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May 29, 2026

FDA Expands Guselkumab Label in PsA

Kathryn Wighton
May 29, 2026
2 min

Summary
Insight Report
Quiz
Clinical Scorecard
Top Thought Leaders

Objective: To inform about the FDA's approval of guselkumab for inhibiting structural joint damage in adults with active psoriatic arthritis. Key Findings: Guse

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May 29, 2026

Can Uric Acid Distinguish Lipedema From Overweight?

Andrea Surnit
May 29, 2026
3 min

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To investigate whether uric acid levels can differentiate between lipedema, lymphedema, and overweight. Key Findings: Median uric acid levels were 5.

Uric acid levels may help differentiate lipedema, lymphedema, and overweight, but significance was lost after adjusting for confounding factors.
In a study, median uric acid levels were 5.1 mg/dL in lipedema, 5.4 mg/dL in lymphedema, and 4.6 mg/dL in overweight controls.
The uric acid-to-cystatin c clearance ratio improved discrimination between disease groups, with area under the curve values of 0.72 and 0.76.
Neither uric acid nor the ratio remained significantly associated with disease status after adjusting for age, BMI, and other factors.
The study faced limitations, including the lack of universally accepted diagnostic criteria for lipedema and potential confounding dietary factors.

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May 29, 2026

Caries May May Signal Oral Antibiotic Resistance

Andrea Surnit
May 29, 2026
3 min

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard
Top Thought Leaders

Objective: To analyze the differences in antibiotic resistance and biofilm-forming capacity of supragingival bacteria in patients with active dental caries comp

Patients with active dental caries exhibit species-specific differences in antibiotic resistance compared to those with good oral health.
In a study of 319 bacterial isolates, significant differences in susceptibility to ampicillin were found in Veillonella parvula between caries and healthy patients.
Biofilm formation varied, with 79% of isolates from caries patients classified as moderate biofilm producers, while 82% from healthy patients were non-biofilm producers.
Resistant isolates were identified across multiple taxa, including Streptococcus oralis and Fusobacterium nucleatum, with beta-lactamase activity confirmed in some.
The study's findings indicate that associations between caries and antibiotic resistance are species-specific and not universally applicable across all taxa.

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Discover top thought leaders in a clinical topic, with data-driven rankings and expert profiles highlighting their influence and contributions.

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May 29, 2026

RA Prescribing Patterns Shift Over 15 Years

Kathryn Wighton
May 29, 2026
5 min

Summary
Quiz
Clinical Scorecard
Top Thought Leaders

Objective: To analyze changes in medication prescribing patterns and disease activity in rheumatoid arthritis (RA) patients managed under a treat-to-target stra

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May 29, 2026

AI Shows Promise for Intraoperative Lung Adenocarcinoma Assessment

Andrea Surnit
May 29, 2026
6 min

Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

SuRImage, an AI model, was evaluated in a multicenter study using smartphone photos of lung specimens for intraoperative assessment.
The model demonstrated moderate-to-good discrimination in diagnostic tasks and outperformed frozen section analysis in predefined comparisons.
SuRImage achieved high sensitivity and specificity, with 97% sensitivity and 92% specificity for binary identification of invasive lung adenocarcinoma.
The study included 1,727 patients and 2,910 surgical resection images, focusing on clinical stage IA lung adenocarcinoma.
SuRImage's performance varied across subgroups, particularly showing lower discrimination for grade 1 invasive adenocarcinoma.

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The Pathologist

May 29, 2026

Why We Made a Mobile Digital Pathology Lab

Helen Bristow
May 29, 2026
8 min

Summary
Insight Report
Quiz

Objective: To address the challenges in diagnosing rare cancers by improving access to expertise and data through a mobile digital pathology lab, particularly i

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May 29, 2026

FDA Monthly Preview: Key June Decisions to Watch

Kathryn Wighton
May 29, 2026
3 min

Summary
Insight Report
Quiz
Top Thought Leaders

Objective: Revise to include the significance of the FDA decisions. Key Findings: Revise to include specific trial details and safety profiles. Interpretation:

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The Medicine Maker

May 29, 2026

Reimagining Risk and Resilience

Stephanie Harden
Tracy Hibbs
May 29, 2026
7 min

Summary
Quiz
Clinical Scorecard

Objective: Revise to ensure direct connection to the source material. Key Findings: Include direct attribution for each finding. Interpretation: Remove unsuppor

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The Pathologist

May 29, 2026

Could One Test Replace Multiple Leukemia Assays?

May 29, 2026
3 min

Takeaways
Insight Report
Poll

A new long-read sequencing approach may improve detection of fusion oncogenes in pediatric B-cell acute lymphoblastic leukemia (B-ALL).
The study evaluated a tool called FUSILLI, which analyzes long-read RNA sequencing data for identifying gene fusions in B-ALL.
FUSILLI demonstrated the highest sensitivity for detecting clinically relevant fusions in high-depth sequencing samples.
The study found that approximately 10 million reads per sample may be needed for optimal fusion detection performance.
Long-read whole-transcriptome sequencing could support comprehensive molecular profiling of pediatric B-ALL, reducing the need for multiple assays.

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The Ophthalmologist

May 29, 2026

Magnesium & DR Risk

May 29, 2026
3 min

Summary
Insight Report
Poll

Objective: To investigate the association between serum magnesium levels and diabetic retinopathy (DR) in patients with type 2 diabetes. Key Findings: Low serum

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May 29, 2026

Retinal Imaging AI May Flag Brain Health Risk

Kerri Miller
May 29, 2026
3 min

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To explore the potential of AI-driven analysis of retinal images in assessing brain health and its implications for dementia and stroke risk stratifi

AI-driven analysis of retinal images may support earlier risk stratification for dementia and stroke, but evidence for improved clinical outcomes is insufficient.
Nearly half of dementia cases may be preventable or delayed through risk factor modification, and up to 80% of strokes can be prevented with timely detection.
The retina's shared characteristics with the central nervous system make it a potential site for assessing brain health through AI-driven 'oculomics'.
Most oculomics models are in early clinical evaluation and have been judged by technical performance metrics, which may not establish clinical usefulness.
The authors call for clearer definitions and regulatory standards for oculomics tools, emphasizing they should complement existing screening strategies.

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The Ophthalmologist

May 29, 2026

EYP-1901 for Retinal Exudative Diseases

Ashkan M. Abbey
May 29, 2026
6 min

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To evaluate the efficacy and safety of EYP-1901 in treating retinal exudative diseases such as wet age-related macular degeneration (AMD) and diabeti

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May 29, 2026

Not All Poststroke Cognitive Patterns Plateau

Kathryn Wighton
May 29, 2026
4 min

Summary
Quiz
Clinical Scorecard

Objective: To investigate the evolution of cognitive impairment following stroke over time and identify recovery trajectories across different cognitive domains

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May 29, 2026

Top 10 Evidence-Based Essentials in Internal Medicine

Conexiant News Staff
May 29, 2026
4 min

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To outline widely used evidence-based guidelines and clinical tools that inform internal medicine care. Key Findings: Annual updates from the America

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