Objective: To evaluate the noninferiority of rituximab compared to ocrelizumab in preventing new or enlarging T2-weighted MRI lesions in patients with newly dia
Objective: To evaluate the effectiveness of a rapid 4-gene mRNA test, qMIDSV3, as a triage tool for distinguishing oral squamous cell carcinoma from low-risk or
Objective: To evaluate the association between urinary biomarkers of environmental chemical exposure during pregnancy and gestational length and birth weight-fo
Objective: To evaluate the impact of robotic-assisted total knee arthroplasty (TKA) on revision rates compared to conventional TKA. Approach: Study Design: A Le
Robotic-assisted total knee arthroplasty did not show lower revision rates compared to conventional procedures in a national registry study.
Surgeons with high baseline revision rates experienced increased late revision hazards after adopting robotic-assisted total knee arthroplasty.
The study analyzed data from 85,075 total knee arthroplasties performed by 178 surgeons from 1999 to 2023.
Failure patterns and revision rates for infection, implant loosening, and instability remained unchanged after robotic adoption.
The study did not assess patient-reported outcomes or functional recovery, limiting the understanding of robotic-assisted total knee arthroplasty's benefits.
Objective: To explore the increasing trend of physicians running for office in the 2026 election cycle and its implications. Approach: Overview of Trends: A rec
A record number of physicians are running for office in the 2026 election cycle, prompting discussions about their evolving role in public life.
Physicians are viewed as trustworthy and equipped with skills relevant to governance, yet they remain underrepresented in US government compared to lawyers.
Motivations for physician-candidates include health care crises, economic issues, and a perceived ethical duty to advance community and public health.
The increasing visibility of physicians in politics raises concerns about the potential erosion of public trust in medicine and the perception of impartiality.
The current wave of physician-candidates is likely to continue, driven by dissatisfaction with traditional political figures and the centrality of health care in political debate.
Objective: To assess the efficacy of topical NSAIDs as adjunctive therapy for diabetic macular edema (DME). Approach: Study Design: Systematic review and meta-a
Topical NSAIDs may provide modest visual benefits as adjunctive therapy for diabetic macular edema (DME), according to a systematic review.
The review analyzed six studies involving 446 patients and 892 eyes, focusing on the effects of NSAIDs alongside anti-VEGF therapy.
Pooled analysis showed a statistically significant improvement in best-corrected visual acuity with NSAID therapy, but clinical relevance is uncertain.
Anatomical outcomes, including central macular thickness and macular volume, did not show statistically significant benefits from NSAID treatment.
The authors call for further exploration and larger studies to clarify the long-term efficacy and safety of topical NSAIDs in DME management.
Objective: To investigate intraocular pressure (IOP) changes during hemodialysis in patients with end-stage kidney disease (ESKD). Approach: Study Design: A pro
Objective: To outline Ocular Therapeutix's plans for submitting a New Drug Application for AXPAXLI in wet AMD. Approach: FDA Meeting: Ocular Therapeutix held a
Objective: To highlight the importance of communication, education, and support in genomic medicine, emphasizing the gap between achieving technical milestones
Progress in genomic medicine has been measured by technical achievements, but the journey for patients often begins after a diagnosis is made.
Families frequently face uncertainties and decisions after receiving a genetic diagnosis, highlighting the need for effective communication and support.
Laboratories focus on quality indicators like turnaround time and diagnostic yield, but these metrics do not assess patient understanding or follow-up.
As genomic medicine evolves, the challenge includes translating scientific advancements into meaningful care and informed decision-making for families.
Culturally sensitive education and accessible follow-up care are essential for effective genomic medicine, especially in regions with limited resources.
Objective: To update breast cancer reporting protocols in alignment with the latest WHO classifications and recommendations. Approach: Updates Overview: The Col
Objective: To clarify the structural origins of defect peaks in high-temperature carbon materials and enhance Raman sensitivity for gas detection. Approach: Car
Objective: To investigate how honeybee queens transfer pesticide residues into their eggs when colony-level defenses are overwhelmed. Approach: Study Design: Th
Objective: To report on recent advancements in cell and gene therapies, including the approval of Tregzi and other notable studies. Approach: FDA Approval of Tr
The FDA has approved Tregzi, the first regulatory T cell-based immunotherapy for blood cancer patients undergoing stem cell transplantation.
Tregzi aims to improve chronic graft-versus-host disease-free survival in adults receiving allogeneic stem cell transplants.
The approval of Tregzi is supported by the PRECISION-T trial, which showed significant survival benefits compared to standard transplants.
Epicrispr's EPI-321 therapy may increase lean muscle volume in patients with facioscapulohumeral muscular dystrophy, according to early trial results.
New CAR T-cell therapies are being developed to target specific mutations in rare blood cancers and glioblastoma, showing promising preclinical results.
Objective: To explore how cell and gene therapy (CGT) companies, payers, and healthcare systems are rethinking pricing and reimbursement models for advanced the
Objective: To illustrate a structured clinical approach for diagnosing and managing immune checkpoint inhibitor (ICI)-associated aseptic meningitis in lung canc
Objective: To synthesize evidence around the challenges in the clinical management of Adult Degenerative Scoliosis (ADS), focusing on diagnostic difficulties, p
Objective: To develop 'armored' anti-CD19 CAR-NK cells coexpressing GITR ligand (GITRL) to target malignant B cells and to counteract Treg-mediated suppression.
Objective: To synthesize current research on the mechanisms of action, clinical applications, and safety profiles of Janus kinase (JAK) inhibitors in the manage