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Emergency Medicine Journal

  • August 1, 2026
Insights from Staff on the Implementation of Opt-Out Blood-Borne Virus Testing in Emergency Departments in England: A Qualitative Analysis
  • Siobhán Allison
  • Tom May
  • Jonathan Roberts
  • Rachel Hill-Tout
  • Stephen Hindle
  • Matthew Hickman
  • Lucy Yardley
  • Rachel Todd
  • Robyn Heath
  • Jeremy Horwood
  • August 1, 2026

Objective: To evaluate the implementation of opt-out blood-borne virus (BBV) testing in emergency departments (EDs) by investigating staff views and experiences

...more
4 min

Gut

  • August 1, 2026
Targeting the GSK3βhigh/NFATc1high Subtype to Overcome Therapy Resistance in Pancreatic Cancer via Induction of Homologous Recombination Repair Mechanisms
  • Muhammad Umair Latif
  • Xueang Liu
  • Aiko Bockelmann
  • Laura Huhnold
  • Geske Elisabeth Schmidt
  • Lukas Klein
  • Xueyuan Zhao
  • Lena-Christin Conradi
  • Karly Conrads
  • Anna Lena Weber
  • Sercan Mercan
  • Kristina Reutlinger
  • Atmika Paul
  • Zeynab Najafova
  • Steven A Johnsen
  • Zuriñe Bonilla Del Rio
  • Frederike Penz
  • Jovan Todorovic
  • Holger Bastians
  • Tim Beissbarth
  • Ulrich Sax
  • Ramy Ashry
  • Oliver H Krämer
  • Elisabeth Hessmann
  • Günter Schneider
  • Philipp Stroebel
  • Ivan Bogeski
  • Shiv K Singh
  • Volker Ellenrieder
  • August 1, 2026

Objective: To investigate the role of nuclear GSK3β-NFATc1 signaling in pancreatic ductal adenocarcinoma (PDAC) and its association with therapy resistance and

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4 min

Gut

  • August 1, 2026
Interaction between liver sinusoidal endothelial cells and hepatocytes through the IL-1α–IL1R1 pathway worsens ischaemia/reperfusion injury in older livers
  • Yasong Liu
  • Tingting Wang
  • Feng Zhang
  • Xuying Liu
  • Zhongying Hu
  • Jiebin Zhang
  • Haitian Chen
  • Jiaqi Xiao
  • Qiang You
  • Zhengqi Wu
  • Jia Yao
  • Yingcai Zhang
  • Shuhong Yi
  • Hua Li
  • Qi Zhang
  • Yang Yang
  • Rong Li
  • Jun Zheng
  • August 1, 2026

Objective: To elucidate the cellular contributors and mechanisms exacerbating ischaemia-reperfusion injury (IRI) in aged livers. Approach: Single-cell transcrip

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3 min

Gut

  • August 1, 2026
Genetic Analysis of Stool Frequency Reveals Involvement of Vitamin B1 Metabolism and Other Targetable Pathways in Gut Motility Regulation
  • Cristian Díaz-Muñoz
  • Isotta Bozzarelli
  • Esteban Alexander Lopera-Maya
  • Lazaros Belbasis
  • Valeria Lo Faro
  • Leticia Camargo Tavares
  • Francisco Heredia-Fernández
  • Biagio Di Lorenzo
  • Trishla Sinha
  • Cristina Esteban Blanco
  • Marie-Julie Favé
  • Philip Awadalla
  • Robin G Walters
  • Ferdinando Bonfiglio
  • Alexandra Zhernakova
  • Serena Sanna
  • Mauro D’Amato
  • August 1, 2026

Objective: To investigate the genetic determinants of stool frequency as a proxy for gut motility and identify associated pathways. Approach: Study Design: A mu

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3 min

Gut

  • August 1, 2026
Exploring the Links Between Demographic, Clinical, and Dietary Influences on Inflammatory Bowel Disease Flares: Insights from the PREdiCCt Prospective Cohort Study
  • Nathan Constantine-Cooke
  • Beatriz Gros
  • Nikolas Plevris
  • Linda J Williams
  • Gareth-Rhys Jones
  • Janet Kyle
  • Nicholas A Kennedy
  • Victor Velasco-Pardo
  • Alexander Rudge
  • Debbie Alexander
  • Carl A Anderson
  • Maiara Brusco de Freitas
  • Lisa M Derr
  • Lauranne AAP Derikx
  • Sian Gilchrist
  • Paul Henderson
  • Graham W Horgan
  • Peter Irving
  • Christopher A Lamb
  • Luke Jostins-Dean
  • James O Lindsay
  • Jonathan MacDonald
  • Craig Mowat
  • Charles Murray
  • Miles Parkes
  • Spyros I Siakavellas
  • Catalina A Vallejos
  • Daniel R Gaya
  • Jonathan M Rhodes
  • Alexandra M Johnstone
  • Christopher J Weir
  • Charlie W Lees
  • August 1, 2026

Objective: To determine the association between habitual diet and disease flare in inflammatory bowel disease (IBD). Approach: Study Design: A large, multicentr

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4 min

Gut

  • August 1, 2026
Targeting Sodium+/taurocholate Cotransporting Polypeptide for the Treatment of Liver Fibrosis
  • August 1, 2026

Objective: To explore the potential of sodium+/taurocholate cotransporting polypeptide (NTCP) as a therapeutic target for liver fibrosis. Approach: Study Design

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1 min

British Journal Of Ophthalmology

  • August 1, 2026
Assessment of the Incidence, Contributing Factors, and Outcomes of Retinopathy of Prematurity in Preterm Infants with Birth Weights Over 1500 g or Gestational Ages Beyond 32 Weeks in Turkey (TR-ROP 2) and Associated Legal Concerns: A Multicenter Study by the Turkish Neonatal Society
  • Ahmet Yagmur Bas
  • Esin Koc
  • Sezin Unal
  • Ibrahim Murat Hirfanoglu
  • August 1, 2026

Objective: To assess the prevalence and risk factors associated with the development of retinopathy of prematurity (ROP) in preterm infants with a birth weight

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4 min

Gut

  • August 1, 2026
Inhibition of Interleukin 10 Enhances Antitumor Immune Activity in Liver Metastases of Human Colorectal Cancer
  • August 1, 2026

Objective: To investigate the effects of interleukin 10 blockade on antitumor immune function in liver metastases of human colorectal cancer. Approach: Study De

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Gut

  • August 1, 2026
Gut Microbiota-Driven Secondary Bile Acid Synthesis Enhances Colorectal Cancer Risk Linked to Western Dietary Patterns
  • Annika Osswald
  • Esther Wortmann
  • David Wylensek
  • Stephanie Kuhls
  • Olivia I Coleman
  • Kenneth Peuker
  • Anne Strigli
  • Quinten R Ducarmon
  • Martin Larralde
  • Wei Liang
  • Nicole S Treichel
  • Fabian Schumacher
  • Colin Volet
  • Silke Matysik
  • Karin Kleigrewe
  • Michael Gigl
  • Sascha Rohn
  • Chun-Jun Guo
  • Burkhard Kleuser
  • Gerhard Liebisch
  • Angelika Schnieke
  • Jason M Ridlon
  • Rizlan Bernier-Latmani
  • Georg Zeller
  • Sebastian Zeissig
  • Dirk Haller
  • Krzysztof Flisikowski
  • Thomas Clavel
  • Soeren Ocvirk
  • August 1, 2026

Objective: To investigate the role of secondary bile acid production by gut bacteria in colorectal cancer (CRC) associated with Western dietary patterns. Approa

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5 min

Gut

  • August 1, 2026
Monitoring B cell Immune Responses Following Discontinuation of Treatment in Hepatitis B Infection
  • Sabela Lens
  • Alice R Burton
  • Jessica Davies
  • Maelle Locatelli
  • Mireia García-López
  • Anna Pocurull
  • Anna Jeffery-Smith
  • Nikolai Novikov
  • Simon P Fletcher
  • Xavier Forns
  • Sofía Pérez-del-Pulgar
  • Mala K Maini
  • August 1, 2026

Objective: To investigate the changes in B cell immune responses following the discontinuation of nucleos(t)ide analogue (NA) therapy in patients with chronic h

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MDSpire News

  • July 31, 2026
Postsurgical Ensartinib in ALK-Positive NSCLC
  • Kathryn Wighton
  • July 31, 2026
  • 5 min

Share your perspective with a quick, clinically relevant poll that captures real-world insights and clinician sentiment.

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MDSpire News

  • July 31, 2026
Psilocybin Therapy May Ease Severe PTSD
  • Andrea Surnit
  • July 31, 2026
  • 3 min
  1. Psilocybin-assisted therapy may be safe and show early clinical efficacy in military veterans with severe PTSD.
  2. Twelve veterans completed an 11-week intervention, including preparatory psychotherapy and two psilocybin dosing sessions.
  3. Seventy-five percent of participants achieved a treatment response, and 83% experienced clinically meaningful symptom improvement.
  4. No serious adverse events were reported, with mild to moderate transient effects like headache and anxiety observed.
  5. The study's small sample size and open-label design limit generalizability, necessitating larger randomized controlled trials.
...more

MDSpire News

  • July 31, 2026
Secukinumab Trial Targets Relapsed Polymyalgia Rheumatica
  • Kathryn Wighton
  • July 31, 2026
  • 5 min
  1. In the REPLENISH trial, 41% of patients receiving secukinumab achieved sustained remission at 52 weeks compared to 20% receiving placebo.
  2. The trial enrolled 381 patients aged 50 or older with relapsed polymyalgia rheumatica across 148 sites in 28 countries.
  3. Complete sustained remission occurred in 28% of the secukinumab 300 mg group, 25% in the 150 mg group, and 5% in the placebo group.
  4. Patients receiving secukinumab had lower annual cumulative glucocorticoid exposure, with doses 20% to 23% lower than the placebo group.
  5. Serious adverse events occurred in 14-16% of patients in the secukinumab groups, with fungal infections reported more frequently than in the placebo group.
...more

Baptist Health South Florida

  • July 31, 2026
Lung Cancer Care in 2026: Earlier Detection, Earlier Intervention, More Individualized Treatment
  • July 31, 2026
  • 6 min
  1. Lung cancer care is evolving with earlier detection through low-dose CT screening and advancements in targeted therapies and immunotherapy.
  2. Comprehensive biomarker testing at diagnosis is crucial for identifying actionable alterations and ensuring effective treatment options.
  3. Low-dose CT screening improves early detection, leading to higher survival rates, yet remains underutilized among eligible patients.
  4. Health-system interventions have successfully increased low-dose CT screening uptake among high-risk populations at Baptist Health.
  5. A multidisciplinary approach in lung cancer care enhances treatment planning and outcomes by integrating various specialist insights.
...more

The Medicine Maker

  • July 31, 2026
2026 Innovation Awards: Nominate Now
  • July 31, 2026
  • 2 min
  1. Nominations for the Innovation Awards are open until September 27, 2026.
  2. The awards recognize technologies advancing pharmaceutical development and manufacturing.
  3. Eligible technologies must have commercially launched between December 31, 2025, and September 27, 2026.
  4. Winners will be announced in December 2026, with only selected nominees contacted.
  5. Last year's Grand Winner was DOMINA from IMA Active, a modular platform for tablet manufacturing.
...more

MDSpire News

  • July 31, 2026
Can SGLT2 Inhibitors Affect Dementia?
  • Kathryn Wighton
  • July 31, 2026
  • 3 min

Objective: To investigate the association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and the likelihood of incident all-cause dementia in older p

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The Analytical Scientist

  • July 31, 2026
2026 Innovation Awards: Nominate Now
  • July 31, 2026
  • 2 min
  1. Nominations for the 2026 Innovation Awards are open until September 27, 2026.
  2. The awards recognize significant advancements in analytical science technologies and tools.
  3. Eligible innovations must have launched commercially between September 22, 2025, and September 27, 2026.
  4. Nominations can be submitted by both users and vendors, requiring proof of release.
  5. Winners will be announced in December 2026, with only selected nominees receiving acknowledgment.
...more

The Ophthalmologist

  • July 31, 2026
Partnership Targets Intraocular Biologics
  • July 31, 2026
  • 3 min
  1. BioMed X and Boehringer Ingelheim have launched a new research team focused on next-generation eye therapies at Boehringer's Ridgefield headquarters.
  2. The new team, Team NIB, aims to develop a human organotypic in vitro platform for intraocular biologics.
  3. Dr. Deniz Ugurlu Cimen will lead the team, specializing in stem cell-based disease modeling and advanced 3D human model systems.
  4. The initiative seeks to create predictive models for drug discovery in eye health, addressing vision-threatening diseases.
  5. The collaboration combines Boehringer's biologics expertise with BioMed X's innovation model to enhance drug discovery approaches.
...more