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European Radiology

July 11, 2026

Deep learning-based malignancy probability estimation of pulmonary nodules in PET/CT imaging

Lars Leijten
Erik H. J. G. Aarntzen
Roel L. J. Verhoeven
Adrienne H. Brouwers
Bram Geurts
Johannes A. van der Heide
Klaas Pieter Koopmans
Walter Noordzij
Gilles N. Stormezand
Erik H. F. M. van der Heijden
Colin Jacobs
July 11, 2026

Summary
Insight Report
Poll

Objective: To develop and evaluate a deep learning model (AITO-PETCT-MP) for estimating malignancy probability in indeterminate pulmonary nodules using [18F]FDG

...more

3 min

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Clinical Rheumatology

July 11, 2026

No association between alcohol consumption and hip osteoarthritis: a diverse national analysis of 87,585 adults from the “All of Us” research program

Shlok V. Patel
Shujaa T. Khan
Smit Brahmbhatt
Matthew E. Deren
Nicolas S. Piuzzi
July 11, 2026

Quiz
Clinical Scorecard

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Clinical Rheumatology

July 11, 2026

How do general practitioners diagnose and refer potential rheumatic musculoskeletal complaints? A scoping review

Georgy Gomon
Teresa Otón
Loreto Carmona
Saskia le Cessie
Rachel Knevel
July 11, 2026

Summary
Quiz
Poll
Clinical Scorecard

Objective: To summarize current knowledge on diagnostic trajectories in primary care for rheumatic musculoskeletal disorders (RMDs), identify knowledge gaps rel

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3 min

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Pediatric Cardiology

July 11, 2026

Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Recent Omicron COVID-19 Subtypes is Rare but Involves Severe Cardiovascular Features

Rabia S. Khan
Gary S. Beasley
July 11, 2026

Summary
Quiz
Clinical Scorecard

Objective: To evaluate the patterns of cardiovascular involvement in patients with MIS-C associated with the SARS-CoV-2 Omicron variant and compare findings bet

...more

4 min

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Bmc Gastroenterology

July 11, 2026

EUS-guided hepaticogastrostomy versus EUS-guided hepaticogastrostomy with antegrade stent placement in patients with unresectable malignant distal biliary obstruction: a meta-analysis of individual patient data

Mahmoud Shaaban Abdelgalil
Ahmad Abdelrazek
Mahmoud Samir Mohamed
Amro Hassan
Manar Alaa Mabrouk
Mohamed Nasser
Eyad Khalil Alhmeid
Abdullah Nizar
Abid Wazir
Noha Ali
Adam Hraybi
Ryad iqbal
Sadia Paracha
Shray Amin
July 11, 2026

Summary
Takeaways
Insight Report
Poll

Objective: To systematically compare the efficacy and safety of EUS-HGS alone versus EUS-HGAS in patients with unresectable malignant distal biliary obstruction

...more

Malignant biliary obstruction (MBO) is primarily caused by pancreatic cancer and poses significant diagnostic and therapeutic challenges.
Endoscopic ultrasound-guided biliary drainage (EUS-BD) is an alternative to ERCP when traditional methods fail due to anatomical difficulties.
Hepaticogastrostomy with antegrade stenting (HGAS) combines two drainage routes, potentially improving outcomes compared to EUS-guided hepaticogastrostomy (HGS) alone.
The study aims to compare the efficacy and safety of EUS-HGS versus EUS-HGAS in patients with unresectable malignant distal biliary obstruction.
Primary outcomes include time to recurrent biliary obstruction (RBO) and need for reintervention, with secondary outcomes assessing technical and clinical success.

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Conexiant

July 10, 2026

FDA Expands Bladder Cancer Regimen

Kathryn Wighton
July 10, 2026
2 min

Summary
Quiz
Clinical Scorecard

Objective: To approve new treatment options for adults with muscle-invasive bladder cancer who are candidates for cystectomy. Approach: Study Design: The KEYNOT

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2 min

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Conexiant

July 10, 2026

FDA Approves Subcutaneous Isatuximab-irfc

Kathryn Wighton
July 10, 2026
2 min

Summary
Takeaways
Quiz
Clinical Scorecard

Objective: To report the FDA approval of subcutaneous isatuximab-irfc for multiple myeloma. Approach: Indications: Approved for use in combination with pomalido

...more

2 min

The FDA approved subcutaneous isatuximab-irfc for three indications in adult patients with multiple myeloma.
Isatuximab-irfc is approved with pomalidomide and dexamethasone for patients with prior therapy including lenalidomide.
The drug is also approved with carfilzomib and dexamethasone for relapsed or refractory multiple myeloma.
For newly diagnosed multiple myeloma patients not eligible for stem cell transplantation, it is approved with bortezomib, lenalidomide, and dexamethasone.
The recommended dose is 1,400 mg subcutaneously, with warnings for hypersensitivity, neutropenia, and other risks.

...more

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Conexiant

July 10, 2026

Can Mecobalamin Prevent Pain Syndrome After Foot and Ankle Surgery?

Andrea Surnit
July 10, 2026
3 min

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To evaluate whether mecobalamin can prevent complex regional pain syndrome type 1 (CRPS-1) following foot and ankle surgery. Approach: Study Design:

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2 min

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UCI Health

July 10, 2026

New leadership expands Huntington’s Disease Center of Excellence at UCI Health

July 10, 2026
1 min

Summary
Insight Report
Quiz

Objective: To advance care and community engagement for Huntington's disease under the leadership of Nicolas Phielipp, MD. Approach: Leadership: Nicolas Phielip

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1 min

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Conexiant

July 10, 2026

Can GDMT Be Safely Stopped After AF Ablation?

Andrea Surnit
July 10, 2026
3 min

Summary
Insight Report
Quiz

Objective: To evaluate the safety of discontinuing guideline-directed medical therapy (GDMT) in patients with atrial fibrillation after catheter ablation and re

...more

2 min

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Conexiant

July 10, 2026

10 CMS and FDA Actions Affecting Care in 2026

Conexiant News Staff
July 10, 2026
7 min

Summary
Takeaways
Insight Report
Quiz

Objective: To highlight federal actions by CMS and FDA that may impact physician practice in 2026. Approach: 2026 Medicare Physician Fee Schedule Final Rule: Fi

...more

2 min

The 2026 Medicare Physician Fee Schedule final rule establishes separate conversion factors for qualifying and nonqualifying alternative payment model participants.
The 2026 Medicare Advantage and Part D final rule implements changes to prescription drug coverage and eliminates cost-sharing for certain adult vaccines.
CMS finalized a 2.6% update to payment rates for hospital outpatient services and ambulatory surgical centers meeting quality reporting requirements.
The FDA approved Foundayo, an oral GLP-1 therapy, for weight management in adults with obesity or overweight and related comorbid conditions.
The FDA cleared Dexcom’s Stelo Glucose Biosensor System for over-the-counter use by children aged 2 years and older who do not use insulin.

...more

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Conexiant

July 10, 2026

Cross-Linked HA Did Not Outperform Saline

Andrea Surnit
July 10, 2026
4 min

Summary
Quiz
Clinical Scorecard

Objective: To compare the efficacy of Hyruan ONE, hylan G-F 20, and saline in reducing pain and improving function in patients with symptomatic knee osteoarthri

...more

2 min

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Sentara

July 10, 2026

Sentara Brings 1st Minimally Invasive Treatment for Aortic Regurgitation to Virginia

July 10, 2026
4 min

Summary
Insight Report
Poll

Objective: To introduce the JenaValve Trilogy Transcatheter Heart Valve System as a minimally invasive treatment option for patients with aortic regurgitation.

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1 min

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The Pathologist

July 10, 2026

Protecting Newborns from Congenital Syphilis

July 10, 2026
6 min

Summary
Takeaways
Quiz
Clinical Scorecard

Objective: To discuss the rising rates of congenital syphilis in the US and the need for improved testing strategies to protect mothers and infants. Approach: C

...more

2 min

Congenital syphilis cases in the US reached nearly 4,000 in 2024, highlighting a significant public health crisis.
Most congenital syphilis cases are preventable, often due to missed testing and gaps in prenatal care.
40% of mothers of congenital syphilis cases did not receive any prenatal care, missing critical screening opportunities.
Updated guidelines recommend testing all pregnant women for syphilis early in pregnancy and again during the third trimester.
Improving awareness, access to care, and establishing universal screening for pregnant women are essential strategies.

...more

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The Pathologist

July 10, 2026

Lyme Antibodies May Improve Test Timing

July 10, 2026
3 min

Summary
Quiz
Clinical Scorecard

Objective: To identify immune antibodies that appear earlier than current laboratory markers of Lyme disease and assess their potential in diagnosing acute and

...more

2 min

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The Ophthalmologist

July 10, 2026

A Strategic Shift in Vision Healthcare

Dylan Joseph
July 10, 2026
5 min

Summary
Takeaways
Quiz
Poll
Clinical Scorecard

Objective: To address the myopia epidemic and evaluate the limitations of conventional vision correction methods compared to surgical options, emphasizing the n

...more

An estimated 5 billion people will have myopia by 2050, with up to 60% of urban learners currently affected.
Conventional vision correction methods, like spectacles and contact lenses, create a financial burden with no clinical endpoint.
Surgical vision correction, such as LASIK, can save patients up to ZAR 295,000 over 20 years compared to conventional methods.
Longitudinal data shows that daily contact lens wear carries a higher risk of microbial keratitis compared to LASIK.
Surgical correction stabilizes refractive error and mitigates long-term risks associated with progressive myopia.

...more

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The Ophthalmologist

July 10, 2026

View from the Neighborhood

Patrice Hicks
July 10, 2026
3 min

Summary
Insight Report
Quiz

Objective: To investigate the association between neighborhood disadvantage and visual difficulty and blindness. Approach: Study Design: Cross-sectional study a

...more

1 min

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The Medicine Maker

July 10, 2026

Biopharma Vital Signs – Part 4: The New Partnership Playbook

July 10, 2026
15 min

Summary
Takeaways
Insight Report
Quiz

Objective: To explore the changing partnership models within the biopharma ecosystem. Approach: Gavin Murdoch, SVP of Commercial Strategy, Abzena: Discusses the

...more

3 min

Partnerships in biopharma are evolving to address increasing complexity, requiring specialized expertise across various development stages.
Big pharma is increasingly partnering with Chinese companies, reflecting improved standards in Chinese R&D and significant deal values.
Smaller biotech firms are central to early development, allowing larger companies to engage later through licensing and strategic support.
Partnership models are shifting from traditional customer-supplier relationships to more integrated, collaborative approaches.
Companies are prioritizing organizational fit and cultural alignment in partner selection to enhance long-term collaboration success.

...more

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