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Archives Of Orthopaedic And Trauma Surgery

August 30, 2026

Evaluation of Four Proximal Screws in Locking Plate Fixation for Proximal Humerus Fractures: A Clinical and Radiological Study of 105 Cases

Christian Michelitsch
Philipp Florian Stillhard
Christoph Zindel
Christoph Sommer
Yves Pascal Acklin
August 30, 2026

Proximal humerus fractures are common in the elderly, often requiring surgical stabilization due to high complication rates.
This study evaluated the adequacy of fixation using four screws positioned cranially in the humeral head for fracture treatment.
A retrospective cohort study was conducted on patients with AO/OTA type 11-A: C proximal humerus fractures treated between 2007 and 2010.
Patients were divided into two groups based on screw configuration: four-screw fixation and multi-screw fixation.
Postoperative care included physiotherapy and radiographic assessments to confirm fracture healing and implant positioning.

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Clinical Research In Cardiology

August 30, 2026

Insights from the PVI-SHAM-AF Trial: Implications of Catheter Ablation on Symptoms in Atrial Fibrillation Patients

Ulrich Laufs
Michael Böhm
Felix Mahfoud
Rolf Wachter
August 30, 2026

Objective: To clarify findings from the PVI-SHAM-AF trial regarding the impact of catheter ablation on symptoms and quality of life in patients with atrial fibr

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Journal Of Gastroenterology

August 30, 2026

Assessment of the Safety and Efficacy of Upadacitinib in Treating Crohn’s Disease Among East Asian Patients: A Post Hoc Evaluation of Phase 3 Randomized Trials

Minhu Chen
Xiang Gao
Kenji Watanabe
Toshimitsu Fujii
Jae Hee Cheon
Shu-Chen Wei
Yuh-Ying Yeh
Yasuko Ishikawa
Patrick M. Hecht
Andrew Garrison
Irina Fish
Fernando Aponte
Silvio Danese
Hiroshi Nakase
August 30, 2026

Objective: To evaluate the efficacy and safety of upadacitinib in East Asian patients with moderately to severely active Crohn's disease (CD) based on phase 3 c

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Archives Of Orthopaedic And Trauma Surgery

August 29, 2026

Nighttime Intramedullary Nailing for Femoral Fractures Shows Comparable Outcomes: Analysis from a 13-Year Level I Trauma Center Study

Artsiom Abialevich
Vadim Benkovich
Vladislav Osinsky
Yosef Adiniaev
Ilan Tzaytlin
Yotam Heinemann
Asaf Acker
August 29, 2026

The study analyzed 288 adult femoral fracture procedures treated with intramedullary fixation between January 2010 and January 2023.
Nighttime procedures involved younger patients and higher rates of high-energy trauma compared to daytime procedures.
Demographic factors such as BMI, diabetes, and prior medical history showed no significant differences between daytime and nighttime cohorts.
The primary outcome measured was any postoperative complication, with secondary endpoints including radiographic abnormalities and specific complications.
Statistical analyses included multivariable logistic regression to assess the relationship between nighttime surgery and postoperative complications.

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Jama Network Open

August 29, 2026

Mortality Risks Associated with Elective Atrial Fibrillation Ablation Procedures in Japan

Koichi Inoue
Koshiro Kanaoka
Yasunori Ueda
Haruhiko Abe
Kuniyasu Ikeoka
Tsuyoshi Mishima
Tatsuhisa Ozaki
Takuya Ohashi
Satoshi Osaki
Yoko Sumita
Yoshitaka Iwanaga
Yasushi Matsumura
Yasushi Sakata
August 29, 2026

Elective atrial fibrillation ablation is a widely used procedure aimed at improving quality of life through symptom relief.
Mortality estimates for AF ablation vary significantly, ranging from 0.05% in high-quality centers to 0.46% in broader administrative data.
The Japanese Registry of All Cardiac and Vascular Disease provides a reliable dataset for assessing periprocedural mortality in AF ablation.
The study focuses on elective AF ablation, excluding emergency cases to ensure accurate assessment of procedural safety.
Outcomes measured include in-hospital mortality, 30-day readmission rates, and major complications related to the procedure.

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Drugs - Real World Outcomes

August 29, 2026

Efficacy and Safety of Reinitiating PD-1 Inhibitors Following Previous Immunotherapy in Older Adults (≥ 60 Years) with Advanced Non-Small-Cell Lung Cancer: A Retrospective Analysis from a Single Center

Xiao-Yue Jiang
Xin Li
Hui Huang
Min Pan
Qiu-Qiu Chen
Chun-Qiao Chen
August 29, 2026

In older patients with advanced non-small-cell lung cancer, PD-1 inhibitor rechallenge yielded a 21.4% objective response rate.
The median overall survival for older patients reinitiating PD-1 inhibitors was 11.3 months.
Safety profiles in older patients aligned with known PD-1 inhibitor toxicities, necessitating close monitoring for pneumonitis and hepatic enzyme elevations.
Exploratory analyses indicated improved overall survival associated with better ECOG performance status and reduced metastatic burden.
Older adults with NSCLC often present unique clinical characteristics, highlighting the need for tailored treatment approaches.

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Digital Health

August 29, 2026

The Impact of AI-Generated Health Misinformation in Somalia: An Urgent Global Challenge in the Digital Age

Samar Yusuf Omar
Maryama Ahmed Ali
Abdirahman Mohamed Adan
Ilyas Abdullahi khalif
August 29, 2026

AI-driven misinformation is rapidly increasing and poses significant risks to fragile health systems, particularly in Somalia.
Somalia's digital landscape is evolving quickly, but low digital literacy and weak governance exacerbate vulnerabilities to health misinformation.
AI-generated misinformation can automate and amplify misleading health messages, complicating public health decision-making.
Limited digital governance and media regulation in Somalia allow AI-generated misinformation to exploit existing inequities.
Urgent attention from international researchers and policymakers is needed to address the challenges of health misinformation in Somalia.

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Obesity Surgery

August 29, 2026

Overcoming Administrative Hurdles: Exploring Challenges in the Evaluation Process for Metabolic and Bariatric Surgery in the U.S.

Rylee Barber
Stephen Moorhead
Kalina Siehl
Ronit Pathak
Mary K Bryant
August 29, 2026

Objective: To examine appointment accessibility and program requirements among patients pursuing metabolic and bariatric surgery (MBS) in North Carolina and Sou

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Acr Open Rheumatology

August 29, 2026

Decreased Levels of CXCR3+CCR6+ CD4+ T Cells and IL-17+ RORγt+ CD4+ T Cells During Secukinumab Therapy Correlate with Responsiveness to Subsequent Biologic Treatments in Axial Spondyloarthritis Patients

Addison Pacheco
Patricia Remalante-Rayco
Nigil Haroon
Denis Poddubnyy
Robert D. Inman
August 29, 2026

Approximately 40% of axial spondyloarthritis patients fail to respond to biologic treatments, including TNFis and IL17is.
Increased type 1 interferon-regulated gene expression is observed in secukinumab nonresponders compared to responders.
The study analyzed patients who did not respond to secukinumab after failing TNFi to assess subsequent biologic treatment outcomes.
Peripheral blood mononuclear cells were isolated and analyzed to evaluate immunologic changes during biologic treatment.
Most patients ultimately respond to a third biologic treatment, regardless of the class of the biologic.

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Journal Of Neuro-Oncology

August 29, 2026

Outcomes and hematologic side effects following whole-brain radiotherapy, photon craniospinal irradiation, and proton craniospinal irradiation in patients with solid-tumor leptomeningeal disease: a systematic analysis

Mishaal Munir
Kavita Sehrawat
Hanan Hassan
Matthew Hall
Minesh P. Mehta
Jonathan. T. Yang
Rupesh Kotecha
August 29, 2026

Leptomeningeal disease (LMD) is a complication of advanced solid tumors, notably breast cancer and non-small cell lung cancer.
Management of LMD is complex and may involve systemic agents, intrathecal therapy, and various forms of radiotherapy.
Proton craniospinal irradiation (CSI) may reduce radiation exposure to normal tissues compared to conventional photon CSI.
Early studies suggest proton CSI may improve CNS progression-free survival and overall survival without increasing serious adverse events.
A systematic review is needed to synthesize outcomes of different radiotherapy modalities for solid-tumor LMD due to existing evidence heterogeneity.

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Nature Medicine

August 29, 2026

Evaluating the Efficacy of Combined Antithrombotic Treatment with Strong Antiplatelet Agents in Patients with Atrial Fibrillation and Acute Coronary Syndrome: A Randomized Controlled Study

Konstantinos D. Rizas
Konstantinos Mourouzis
Dominik Rath
Christoph B. Olivier
Laura Elisa Villegas Sierra
Theofanis Korovesis
Amin Polzin
Amani Al Tawil
Reza Wakili
Lukas von Stuelpnagel
Katharina Mayer
Marion Janisch
Tanja Ulrich
Sarah Lang
Sebastian K. G. Maier
Florian Brattinger
Lorenz Bott-Flügel
Harilaos Bogossian
Konstantinos Iliodromitis
Luisa Freyer
Julius Steffen
Konstantin Stark
Elodie Eiffener
Lauren E. Sams
Tobias Petzold
Axel Linke
Felix M. Heidrich
Samuel Sossala
Saif Zako
Nikolaos Dagkonakis
Andreas Schäfer
Frank Edelmann
David M. Leistner
Mariya Maslarska
Fabian Knebel
Georg Nickenig
Blerim Luani
Tienush Rassaf
Hüseyin Ince
Ibrahim Akin
Micha T. Maeder
Meinrad Gawaz
Hans-Josef Feistritzer
Norbert Frey
Stefan Kääb
Riza Sahin
Matthias Pauschinger
Thomas Stiermaier
Ingo Eitel
Marc Kollum
Jan Sebastian Wolter
Michael Schreinlechner
Axel Bauer
Christoph Stellbrink
Ulf Landmesser
Paulus Kirchhof
Dirk Sibbing
Holger Thiele
Adnan Kastrati
Ulrich Mansmann
Steffen Massberg
August 29, 2026

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Digital Health

August 29, 2026

A Mobile Health Intervention Utilizing Behavioral Economics to Enhance Medication Adherence in Hypertensive Patients: Results from a Three-Arm Randomized Controlled Trial

Jan Strebel
Anjali Raja Beharelle
Michael Mayr
Valeriya Nemtsova
Joachim Zahnd
Gregoire Wuerzner
Georg Ehret
Michael Stiefel
Emrush Rexhaj
Théo Meister
Annina S. Vischer
Thilo Burkard
August 29, 2026

Hypertension is a leading risk factor for cardiovascular disease, with non-adherence rates to medication ranging from 50% to 80% among patients.
Medication non-adherence contributes to approximately 125,000 deaths annually in the U.S. and significant healthcare costs of USD 100–300 billion.
The BEHAVE-HTN study evaluated a mobile health application designed to improve medication adherence among hypertensive patients in Switzerland.
Participants were randomly assigned to three groups: mApp with financial incentives, mApp without incentives, and standard-of-care.
The mApp includes features like medication reminders, rewards for adherence, and gamification to support habit formation and BP control.

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Dermatology And Therapy

August 29, 2026

Evaluation of Adjuvant Nivolumab in Patients with Resected Stage III–IV Melanoma: Two-Year Findings from the AdjuMel Study

Stéphane Dalle
Philippe Saiag
Céleste Lebbé
Jean-Jacques Grob
Brigitte Dréno
Sophie Dalac
Bernard Asselain
François Skowron
Sophie Darras
Nicolas Jovenin
Gaëlle Quereux
Amir Khammari
Capucine Rieuf
Florence Brellier
Laurent Mortier
August 29, 2026

Nivolumab is an approved adjuvant treatment for patients with completely resected stage III–IV melanoma, addressing rising mortality rates in Europe.
The AdjuMel study evaluates real-world use, effectiveness, and safety of adjuvant nivolumab in patients with resected stage III–IV melanoma in France.
At 2 years, relapse-free survival for patients in the study reached 52.8%, with lower recurrence rates in stage IIIA compared to IIIB–D.
Tumor ulceration was linked to a higher risk of recurrence or death, while age also influenced outcomes, with younger patients faring better.
The safety profile of adjuvant nivolumab remained consistent with previous reports, showing no adverse effects on health-related quality of life.

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Acr Open Rheumatology

August 29, 2026

The Role of Humanoid Assistants in Addressing the Rheumatology Workforce Shortage: A Look Ahead

Adam Kilian
Laura Upton
Joshua Samec
Shivang Chaudhary
Adam Friedman
Eva Waineo
Terry Moore
August 29, 2026

The rheumatology workforce shortage is projected to exceed 100% by 2030, with significant implications for patient care access.
Humanoid colleagues are defined as physically embodied robots capable of performing clinical tasks and engaging with patients.
Humanoid systems could be trained through rheumatology fellowship programs, allowing for supervised clinical interactions.
Accountability for AI interactions would remain with human clinicians, ensuring patient safety and educational oversight.
Training humanoid trainees alongside fellows may enhance educational outcomes for both faculty and students.

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Acta Neuropathologica

August 29, 2026

Elevated concentrations of cell-free hemoglobin and iron found in cerebral thrombi of stroke patients prior to the Omicron variant: new contributors to the prothrombotic effects of SARS-CoV-2

María Payá
Cristian Alcahut-Rodríguez
Rosa A. Barbella-Aponte
Francisco Hernández-Fernández
Juan D. Molina-Nuevo
Gemma Barroso-García
Beatriz Castro-Robles
Susana López-López
Lourdes Arias-Salazar
Óscar Ayo-Martín
Jorge García-García
Blanca Yélamos-Sanz
Natalia García-Flores
Alba G. Arandilla
Rafael Moreno-Luna
Alicia Aliena-Valero
Isabel Vielba-Gómez
José I. Tembl
Juan B. Salom
Gemma Serrano-Heras
Tomás Segura
August 29, 2026

SARS-CoV-2 has led to over 777 million infections and 7 million deaths globally since its emergence in December 2019.
COVID-19 increases the risk of cerebrovascular disease, with ischemic stroke occurring in approximately 1.5% of infected individuals pre-Omicron.
COVID-19-related strokes are often cryptogenic, associated with poorer outcomes and higher NIHSS scores compared to non-COVID-19 strokes.
The study investigates cerebral thrombi from COVID-19 patients to identify molecular drivers of the prothrombotic state linked to SARS-CoV-2.
Elevated levels of cell-free hemoglobin and iron were found in cerebral thrombi, suggesting new contributors to the prothrombotic effects of SARS-CoV-2.

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Pharmacoepidemiology And Drug Safety

August 29, 2026

Association of Heart Failure Hospitalization Risk with Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors Compared to Erythropoiesis-Stimulating Agents: A Nationwide Claims Analysis

Yuki Kunitsu
Keiko Ikuta
Daiki Hira
Shunsaku Nakagawa
Tomohiro Terada
August 29, 2026

HIF-PHIs are oral therapies for renal anemia that stabilize HIF pathways and stimulate erythropoietin production.
Daprodustat, a HIF-PHI, is associated with an increased risk of heart failure hospitalization compared to ESAs in non-dialysis CKD patients.
The study utilized a nationwide Japanese claims database to assess heart failure hospitalization risk associated with HIF-PHIs.
Patients with heart failure were included if they initiated HIF-PHIs or ESAs while receiving ongoing diuretic therapy.
The primary outcome measured was hospitalization for heart failure, with secondary outcomes including emergency hospitalization and intravenous diuretic administration.

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Obesity Surgery

August 29, 2026

Initial Mental Health Conditions and Subsequent Psychiatric Results Following Metabolic-Bariatric Surgery: A Retrospective Cohort Analysis

Patricia M. Ortega
Luke Boyle
Dana Mahdi
Zahra Al-Essah
Ali Abdul Hussein
Mina Abdul Hussein
Aslesha Deshraju
Elena Brachimi
Prasidha Rai
Elsie Ampomah
Neha Hussain
Faizan Kiani
Mary Obigbesan
Lucy Tweedlie
Samantha Scholtz
Sanjay Purkayastha
Christos Tsironis
Sherif Hakky
Ravi Aggarwal
Ahmed R. Ahmed
Tricia Tan
Julia Kenkre
Kleopatra Alexiadou
Saira Hameed
Harvinder Chahal
Jonathan Cousins
Chioma Izzi-Engbeaya
August 29, 2026

Metabolic-bariatric surgery (MBS) is the most effective treatment for severe obesity, leading to significant weight loss and reduced morbidity.
Up to 50% of individuals seeking MBS have co-existing mental health conditions, which may impact postoperative recovery and quality of life.
While depressive and anxiety symptoms often improve in the first year after MBS, long-term follow-up may reveal increased risks of self-harm and suicide.
The study evaluated psychiatric and metabolic outcomes in adults undergoing MBS, focusing on the impact of pre-existing mental health conditions.
Data were collected from a high-volume tertiary MBS unit, with a follow-up period of two years to assess outcomes related to mental health and weight loss.

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Journal Of Neuro-Oncology

August 29, 2026

Assessment of Radiological Changes in Primary Central Nervous System Lymphoma Following Corticosteroid Treatment and Its Prognostic Implications for Overall Survival: A Multicenter Analysis

Florian Scheichel
D. Pinggera
T. Rossmann
B. Popadic
S. Aspalter
V. Schön
A. Woehrer
M. M. Dorostkar
C. Dorfer
C. F. Freyschlag
F. Marhold
August 29, 2026

Primary central nervous system lymphoma (PCNS-LBCL) accounts for approximately 3% of intracranial tumors.
Corticosteroid therapy (CST) can lead to significant tumor regression in PCNS-LBCL, but responses vary widely among patients.
The study involved a multicenter prospective analysis of patients scheduled for biopsy, with a focus on radiological changes post-CST.
Eighteen patients were included in the prospective study after excluding those without a second MRI or with other diagnoses.
Survival analysis aimed to determine if the radiological response to CST could predict overall survival in PCNS-LBCL patients.

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