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MDSpire is an innovative platform aiming to create a smarter, faster, and more connected medical community.

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June 28, 2026

Blindness Linked to Higher Loneliness Scores

Andrea Surnit
June 28, 2026
4 min

Summary
Quiz
Clinical Scorecard

Objective: To evaluate the association between major eye diseases and loneliness scores in patients with diagnosed ocular conditions. Approach: Study Design: Cr

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June 28, 2026

Can AI Extract Echo Report Data as Accurately as Expert Annotation?

Kerri Miller
June 28, 2026
5 min

Summary
Insight Report
Poll
Topic Commentary

Objective: To evaluate the accuracy of a large language model (GPT-5 mini) in extracting structured cardiovascular data from free-text echocardiography reports.

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June 28, 2026

Elastography Distinguishes Cardiac Amyloidosis Types

Kathryn Wighton
June 28, 2026
3 min

Summary
Takeaways
Quiz
Clinical Scorecard

Objective: To evaluate whether myocardial stiffness measured with three-dimensional shear wave elastography can differentiate between light chain cardiac amyloi

A study of 72 patients assessed myocardial stiffness using three-dimensional shear wave elastography alongside other diagnostic methods.
The two primary forms of cardiac amyloidosis are light chain and transthyretin cardiac amyloidosis, differing in disease progression and treatment.
Shear wave velocity was higher in patients with transthyretin cardiac amyloidosis compared to those with light chain cardiac amyloidosis.
An algorithm combining patient age, N-terminal pro-B-type natriuretic peptide, and shear wave velocity achieved 100% sensitivity and specificity.
The study suggests that three-dimensional shear wave elastography may effectively distinguish between types of cardiac amyloidosis.

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June 28, 2026

Inside the Baseball Athlete's Heart

Kerri Miller
June 28, 2026
3 min

Summary
Insight Report
Quiz
Topic Commentary

Objective: To characterize sport-specific exercise-induced cardiac remodeling in elite baseball players using echocardiography. Approach: Study Design: A cross-

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June 27, 2026

Synthetic Echo Motion May Aid ECG Risk Modeling

Kerri Miller
June 27, 2026
3 min

Summary
Insight Report
Quiz
Clinical Scorecard
Topic Commentary

Objective: To develop a model that integrates synthetic echocardiographic motion into ECG analysis for classifying diastolic dysfunction risk phenotypes and str

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June 27, 2026

Early-Phase Data Support Novel Contrast Agent

Julia Cipriano, MS, CMPP
June 27, 2026
4 min

Summary
Insight Report
Poll
Topic Commentary

Objective: To evaluate the safety and efficacy of the novel perflutren-based ultrasound-enhancing agent MVT-100 compared to Definity in healthy volunteers. Appr

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June 27, 2026

PAHR: Prognostic Marker in Severe Aortic Stenosis?

Julia Cipriano, MS, CMPP
June 27, 2026
3 min

Summary
Quiz
Clinical Scorecard

Objective: To evaluate the association of pressure-adjusted heart rate (PAHR) with survival in patients with severe aortic stenosis (AS). Approach: Study Design

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June 27, 2026

GLP-1 Drugs Tied to Smell, Taste Changes

Andrea Surnit
June 27, 2026
5 min

Summary
Insight Report
Quiz

Objective: To evaluate whether glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is associated with incident smell and taste disturbances in patients with

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June 27, 2026

Upfront Cost Guidance Limited in US Guidelines

Andrea Surnit
June 27, 2026
6 min

Summary
Quiz
Clinical Scorecard

Objective: To evaluate the incorporation of economic and resource use-related guidance in US clinical practice guidelines. Approach: Study Design: Cross-section

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June 27, 2026

GLP-1 RAs May Ease Psoriasis, PsA Data Limited

Andrea Surnit
June 27, 2026
4 min

Summary
Insight Report
Quiz

Objective: To evaluate the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on psoriasis and psoriatic arthritis (PsA). Approach: Review Methodo

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June 27, 2026

AI Model Trails Expert Skin Lesion Readers

Andrea Surnit
June 27, 2026
6 min

Summary
Insight Report
Poll
Clinical Scorecard

Objective: To compare the diagnostic accuracy of artificial intelligence (AI) systems with that of physicians in diagnosing skin lesions. Approach: Study Design

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June 27, 2026

Case Report Describes Possible Betahistine–Suicidality Link

Andrea Surnit
June 27, 2026
4 min

Summary
Insight Report
Quiz

Objective: To describe a possible association between betahistine exposure and depressive symptoms with suicidal ideation. Approach: Case Report: A 33-year-old

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June 27, 2026

Echo AI: From Innovation to Adoption

Julia Cipriano, MS, CMPP
June 27, 2026
5 min

Summary
Quiz
Clinical Scorecard

Objective: To explore the incorporation of artificial intelligence (AI) into echocardiography and the challenges of broader adoption. Approach: Building Better

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June 27, 2026

Mavacamten Treatment Associated With Improved Diastolic Function, Remodeling Markers

Kathryn Wighton
June 27, 2026
3 min

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To assess the effects of mavacamten on diastolic function and cardiac remodeling in patients with symptomatic obstructive hypertrophic cardiomyopathy

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Archives Of Toxicology

June 27, 2026

Correction: The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals

C. J. Henderson
A. W. McLaren
A. K. MacLeod
D. Lin
A. R. Cameron
L. R. Chatham
J. Moggs
F. Inesta‑Vaquera
John P. Thomson
Richard R. Meehan
P. Chakravarty
M. Schwarz
C. Roland Wolf
June 27, 2026

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To correct the oversight regarding the reuse of an image in the original article. Approach: Image Correction: Clarification regarding the reuse of an

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Archives Of Toxicology

June 27, 2026

Structure–activity relationship of synthetic cathinones: integrated in silico, in vitro, and in vivo studies of α-PiHP analogues

Martalu D. Pazos
Guillermo García-Díez
David Pubill
Xavier Berzosa
Roger Estrada-Tejedor
Jorge Camarasa
Elena Escubedo
Raúl López-Arnau
Núria Nadal-Gratacós
June 27, 2026

Summary
Insight Report
Poll
Clinical Scorecard
Topic Commentary

Objective: To comprehensively investigate α-PiHP and five of its analogues, namely MDPiHP, 3-Me-α-PiHP, 4-Me-α-PiHP, 3-F-α-PiHP, and 4-F-α-PiHP, to elucidate th

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Archives Of Toxicology

June 27, 2026

Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling

Eszter Borsos
Blandine Descamps
Nick Hetzschold
Elisabeth Varga
Doris Marko
Georg Aichinger
June 27, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To develop a physiologically based kinetic (PBK) model predicting tissue concentrations of alternariol (AOH) and alternariol monomethyl ether (AME) i

Alternariol (AOH) and alternariol monomethyl ether (AME) are emerging mycotoxins found in various food commodities.
The European Food Safety Authority has indicated that chronic dietary exposure to AOH and AME may exceed toxicological concern thresholds.
AOH and AME exhibit genotoxicity, oxidative stress induction, and potential endocrine-disrupting effects in vitro.
Physiologically based kinetic (PBK) modeling was developed to predict human tissue concentrations of AOH and AME after oral intake.
The study aims to provide a quantitative understanding of AOH and AME bioactivity as a preliminary step towards risk assessment.

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Critical Care

June 27, 2026

Neutrophil EMR3 dynamics in critically ill patients with sepsis: an ICU experience

Yilei Ma
Peihao Yu
Xiaofen Wang
Ruofei Chen
Wei Ni
Huixing Liu
Xinru Fang
Feng Zhao
Qianwen Hu
Sai Qiao
Suwen Yang
Hong Jin
Jingjuan Song
Dongdong Zhao
Lei Fang
Jun Zhang
Jiancang Zhou
June 27, 2026

Summary
Insight Report
Poll

Objective: To examine neutrophil EMR3 for early sepsis identification and longitudinal host-response dynamics in critically ill patients. Approach: Study Design

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