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Choose specialties Cardiology Dermatology Endocrinology Family Medicine Gastroenterology Hematology Internal Medicine Neurology ObGyn Oncology Ophthalmology Optometry Pediatrics Rheumatology Pulmonary Psychiatry Pathology Surgery Orthopedic Medicine Radiology Otolaryngology Infectious Disease

Nature Medicine

May 31, 2026

MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial

Martin Wermke
Sebastian Ochsenreither
Dirk Jaeger
Heiko Becker
Annalen Bleckmann
Farastuk Bozorgmehr
Manik Chatterjee
Stefanie Groepper
Mathias Haenel
Judith S. Hecker
Max-Felix Häring
Daniel Heudobler
Norbert Hilf
Martin Hofmann
Meike Hutt
Andrea Mayer-Mokler
Sarah Missel
Manuel Ruh
Heiko Schuster
Olga Veremchuk
Moritz Kleemiss
Stefan Knop
Simon Laban
Martin Sebastian
Silvia Spoerl
Cedrik Michael Britten
Carsten Reinhardt
May 31, 2026

Summary
Takeaways
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Objective: To evaluate the safety, tolerability, pharmacokinetics, and initial antitumor activity of IMA401 as monotherapy and in combination with pembrolizumab

IMA401 is a TCR-based bispecific T cell engager targeting MAGE-A4 and MAGE-A8 in patients with recurrent or refractory solid tumors.
The study evaluates IMA401's safety, tolerability, pharmacokinetics, and initial antitumor activity as monotherapy and with pembrolizumab.
MAGE-A4/8 target peptide shows high presentation levels on tumor cells and is nearly absent in normal tissues, providing a favorable therapeutic window.
IMA401 combines a high-affinity TCR-based domain with a low-affinity T-cell-recruiting domain for enhanced T cell activation and tumor targeting.
The primary objective of the IMA401-101 study is to determine the maximum tolerated dose and/or recommended phase 2 dose of IMA401.

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Digital Health

May 30, 2026

The effectiveness of mobile health interventions on bowel symptoms, self-care ability, and quality of life in colorectal cancer patients after anus-preserving operation: A systematic review and meta-analysis

Yaolan Wang
Yujie Li
Chun Zhang
Caili Li
Lan Li
Mingjun Huang
May 30, 2026

Summary
Takeaways
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Clinical Scorecard

Objective: To systematically review the characteristics of mHealth interventions for CRC patients after sphincter-preserving surgery and conduct a meta-analysis

Colorectal cancer is the third most common malignancy and the second leading cause of cancer-related mortality globally.
Sphincter-preserving surgery often leads to long-term bowel dysfunction in 48% to 82.6% of patients, impacting their quality of life.
Current management of bowel dysfunction relies on self-care behaviors, but traditional support methods often fail to improve outcomes.
Mobile health (mHealth) interventions have shown potential benefits for quality of life and self-efficacy in colorectal cancer survivors.
This study aims to systematically review mHealth interventions and conduct a meta-analysis on their effects on bowel symptoms and self-care ability.

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Digital Health

May 30, 2026

Characteristics of behavior change techniques in theory-based self-management education and support interventions for adults with type 2 diabetes using digital technology: A scoping review

EunSeok Cha
Meihua Ji
Colleen Dawkins
Xiaoyan Qi
Hyesun Jang
Melissa Spezia Faulkner
May 30, 2026

Summary
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Objective: To establish a comprehensive knowledge base for developing theory-driven, person-centered digital diabetes self-management education and support (DSM

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Jama Network Open

May 30, 2026

Immigration Ban and the US Health Care Workforce

Tarun Ramesh
Michael Liu
Hao Yu
May 30, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To evaluate trends in physician and registered nurse immigration from 19 banned countries and characterize US communities most affected by the immigr

The US federal government enacted a complete immigration ban on 19 countries on December 2, 2025, affecting all immigration pathways.
Annual physician inflow from banned countries rose from 350 in 2010 to 459 in 2023, comprising 2.5% of total physician inflow.
In 2023, 2.15% of all US physicians and 1.41% of all US nurses were from the banned countries, totaling nearly 24,000 physicians and 56,000 nurses.
Counties with at least one physician from banned countries were more likely to be designated as primary care Health Professional Shortage Areas.
The study highlights that the immigration ban could exacerbate healthcare workforce shortages in underserved communities.

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Digital Health

May 30, 2026

Sex-specific effects of digital home-based neuromodulation combined with mindfulness-based meditation on knee osteoarthritis symptoms

Chiyoung Lee
Juyoung Park
Chen X. Chen
Xiaoxiao Sun
C. Kent Kwoh
Shen Liu
Hongyu Miao
Hyochol Ahn
May 30, 2026

Takeaways
Insight Report
Quiz
Poll

Transcranial direct current stimulation (tDCS) is a non-invasive technique that modulates cortical excitability and may alleviate pain in knee osteoarthritis (KOA).
Mindfulness-based meditation (MBM) has been shown to effectively manage chronic pain and may enhance pain-related brain function in individuals with KOA.
Combining tDCS with MBM could activate complementary mechanisms in pain processing, potentially improving knee-specific clinical pain and symptoms.
Sex differences significantly influence individual responses to tDCS and mindfulness interventions, necessitating a sex-stratified design in research.
A digitally delivered, home-based model of tDCS and MBM is feasible, safe, and associated with high adherence rates among individuals with KOA.

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Bone Marrow Transplantation

May 30, 2026

Early high-resolution immune profiles are associated with survival, relapse and graft-versus-host-disease after allogeneic hematopoietic cell transplantation

Patrick Terrence Brooks
Lia Minculescu
Hans Jakob Hartling
Rebecca Svanberg Teglgaard
Jose Antonio Salado-Jimena
Lone Smidstrup Friis
Brian Kornblit
Ida Schjødt
Søren Lykke Petersen
Niels Smedegaard Andersen
Jens Lundgren
Susanne Dam Nielsen
Lars Klingen Gjærde
Hanne Vibeke Marquart
Henrik Sengeløv
Sisse Rye Ostrowski
May 30, 2026

Summary
Takeaways
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Quiz
Poll

Objective: To evaluate the associations between immune cell composition and function at day +28 post-allogeneic hematopoietic cell transplantation (allo-HCT) an

The study evaluated immune profiles in 77 adult allo-HCT recipients at day +28 post-transplantation to assess associations with clinical outcomes.
Increased immune cell counts and elevated cytokine-release responses were linked to improved survival and lower relapse incidence in allo-HCT patients.
Higher CD4 T cell PD-1 expression and HLA-DR on CD8 T cells correlated with poorer overall survival among allo-HCT recipients.
The research emphasizes the significance of early innate immune reconstitution for monitoring allo-HCT patients and potential therapeutic targets.
High-resolution immunophenotyping combined with functional assays was utilized to investigate immune cell composition and activation status.

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Digital Health

May 30, 2026

Analysis of the quality and reliability of benign paroxysmal positional vertigo-related short videos on TikTok and Bilibili: A cross-sectional study

Chunping Zheng
Lijuan Tang
Chunbo Wu
Luan Huang
Runjun Luo
May 30, 2026

Summary
Takeaways
Insight Report
Quiz
Poll

Objective: To analyze the distribution, quality, reliability, and accuracy of BPPV-related video content on TikTok and Bilibili, and to investigate the relation

Benign Paroxysmal Positional Vertigo (BPPV) is a common vestibular disorder affecting 20-30% of patients with vertigo.
BPPV is caused by otoconia displacement in the inner ear, leading to episodes of vertigo triggered by head movements.
The study evaluates the quality and reliability of BPPV-related videos on TikTok and Bilibili, focusing on misinformation risks.
Short-video platforms often lack peer review, resulting in variable information quality and potential health risks.
This research aims to analyze video content and viewer interaction metrics to improve digital health communication strategies.

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Npj Digital Medicine

May 30, 2026

Sensor wide association studies in digital medicine

Nico Steckhan
Felix Broghammer
Dylan Powell
May 30, 2026

Summary
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: Revise to include direct attribution. Key Findings: Add direct sourcing for each finding. Interpretation: Remove editorial interpretation. Limitation

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Npj Digital Medicine

May 30, 2026

Droplet microfluidics with image texture quantification for detection of rare antibiotic-resistant subpopulations from bloodstream infections

Sagar N. Agnihotri
Nikos Fatsis-Kavalopoulos
Emma Vikdahl
Jonas Windhager
Agustin A. Corbat
Dan I. Andersson
Maria Tenje
May 30, 2026

Summary
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Objective: To develop a rapid and accurate method for detecting heteroresistance (HR) in bacterial populations from bloodstream infections using droplet microfl

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May 29, 2026

FDA Expands Afrezza to Pediatric Diabetes

Kathryn Wighton
May 29, 2026
3 min

Summary
Takeaways
Quiz
Clinical Scorecard
Top Thought Leaders

Objective: To inform about the FDA's approval of Afrezza for children and adolescents with diabetes. Key Findings: Afrezza offers a needle-free mealtime insulin

The FDA has approved Afrezza for children aged 6 and older with type 1 or type 2 diabetes.
Afrezza is an inhaled mealtime insulin that is administered using a portable inhaler.
The approval was supported by data from the INHALE-1 trial and over 20 years of inhaled insulin studies.
Afrezza offers a needle-free option for mealtime insulin, addressing challenges faced by pediatric patients.
Afrezza is not suitable for patients with chronic lung diseases and requires lung function assessments.

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May 29, 2026

Anterior Lumbar Interbody Fusion (ALIF): A Collaborative Approach to Spine Surgery

May 29, 2026

Summary
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Quiz

Objective: To demonstrate the collaborative approach between a vascular surgeon and a neurosurgeon in performing anterior lumbar interbody fusion (ALIF). Key Fi

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May 29, 2026

FDA Expands Guselkumab Label in PsA

Kathryn Wighton
May 29, 2026
2 min

Summary
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Quiz
Clinical Scorecard

Objective: To inform about the FDA's approval of guselkumab for inhibiting structural joint damage in adults with active psoriatic arthritis. Key Findings: Guse

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May 29, 2026

Can Uric Acid Distinguish Lipedema From Overweight?

Andrea Surnit
May 29, 2026
3 min

Summary
Takeaways
Insight Report
Quiz
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Objective: To investigate whether uric acid levels can differentiate between lipedema, lymphedema, and overweight. Key Findings: Median uric acid levels were 5.

Uric acid levels may help differentiate lipedema, lymphedema, and overweight, but significance was lost after adjusting for confounding factors.
In a study, median uric acid levels were 5.1 mg/dL in lipedema, 5.4 mg/dL in lymphedema, and 4.6 mg/dL in overweight controls.
The uric acid-to-cystatin c clearance ratio improved discrimination between disease groups, with area under the curve values of 0.72 and 0.76.
Neither uric acid nor the ratio remained significantly associated with disease status after adjusting for age, BMI, and other factors.
The study faced limitations, including the lack of universally accepted diagnostic criteria for lipedema and potential confounding dietary factors.

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May 29, 2026

Caries May May Signal Oral Antibiotic Resistance

Andrea Surnit
May 29, 2026
3 min

Summary
Takeaways
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Quiz
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Clinical Scorecard

Objective: To analyze the differences in antibiotic resistance and biofilm-forming capacity of supragingival bacteria in patients with active dental caries comp

Patients with active dental caries exhibit species-specific differences in antibiotic resistance compared to those with good oral health.
In a study of 319 bacterial isolates, significant differences in susceptibility to ampicillin were found in Veillonella parvula between caries and healthy patients.
Biofilm formation varied, with 79% of isolates from caries patients classified as moderate biofilm producers, while 82% from healthy patients were non-biofilm producers.
Resistant isolates were identified across multiple taxa, including Streptococcus oralis and Fusobacterium nucleatum, with beta-lactamase activity confirmed in some.
The study's findings indicate that associations between caries and antibiotic resistance are species-specific and not universally applicable across all taxa.

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May 29, 2026

RA Prescribing Patterns Shift Over 15 Years

Kathryn Wighton
May 29, 2026
5 min

Summary
Quiz
Clinical Scorecard

Objective: To analyze changes in medication prescribing patterns and disease activity in rheumatoid arthritis (RA) patients managed under a treat-to-target stra

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May 29, 2026

AI Shows Promise for Intraoperative Lung Adenocarcinoma Assessment

Andrea Surnit
May 29, 2026
6 min

Takeaways
Insight Report
Quiz
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SuRImage, an AI model, was evaluated in a multicenter study using smartphone photos of lung specimens for intraoperative assessment.
The model demonstrated moderate-to-good discrimination in diagnostic tasks and outperformed frozen section analysis in predefined comparisons.
SuRImage achieved high sensitivity and specificity, with 97% sensitivity and 92% specificity for binary identification of invasive lung adenocarcinoma.
The study included 1,727 patients and 2,910 surgical resection images, focusing on clinical stage IA lung adenocarcinoma.
SuRImage's performance varied across subgroups, particularly showing lower discrimination for grade 1 invasive adenocarcinoma.

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The Pathologist

May 29, 2026

Why We Made a Mobile Digital Pathology Lab

Helen Bristow
May 29, 2026
8 min

Summary
Insight Report
Quiz
Top Thought Leaders

Objective: To address the challenges in diagnosing rare cancers by improving access to expertise and data through a mobile digital pathology lab, particularly i

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May 29, 2026

FDA Monthly Preview: Key June Decisions to Watch

Kathryn Wighton
May 29, 2026
3 min

Summary
Insight Report
Quiz

Objective: Revise to include the significance of the FDA decisions. Key Findings: Revise to include specific trial details and safety profiles. Interpretation:

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