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Choose specialties Cardiology Dermatology Endocrinology Family Medicine Gastroenterology Hematology Internal Medicine Neurology ObGyn Oncology Ophthalmology Optometry Pediatrics Rheumatology Pulmonary Psychiatry Pathology Surgery Orthopedic Medicine Radiology Otolaryngology Infectious Disease

May 18, 2026

Non-Invasive Testing for Coronary Artery Disease

May 18, 2026

Summary
Takeaways
Insight Report
Quiz
Poll

Objective: To discuss the role of non-invasive testing in the diagnosis and management of coronary artery disease. Key Findings: Non-invasive testing improves e

Non-invasive testing plays a crucial role in diagnosing coronary artery disease.
Evidence-based strategies enhance the effectiveness of non-invasive diagnostic methods.
Imaging modalities are essential for early detection and risk stratification.
Appropriate use of these tests improves clinical decision-making.
Dr. Uprety emphasizes the importance of tailored diagnostic approaches in patient care.

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May 18, 2026

FDA Clears Golimumab Biosimilars

Kathryn Wighton
May 18, 2026
2 min

Summary
Quiz
Clinical Scorecard

Objective: To report on the FDA's approval of Immgolis and Immgolis Intri as interchangeable biosimilars to Simponi and Simponi Aria for rheumatoid arthritis an

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May 18, 2026

Whole-Body MRI: Evidence Gap Widens

Kerri Miller
May 18, 2026
3 min

Summary
Insight Report
Poll
Clinical Scorecard
Top Thought Leaders

Objective: To evaluate the clinical benefits and risks associated with whole-body MRI screening in the general population, emphasizing the lack of supporting ev

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May 18, 2026

FDA Approves Baxdrostat for Resistant Hypertension

Kathryn Wighton
May 18, 2026
2 min

Summary
Insight Report
Quiz

Objective: To evaluate the efficacy of baxdrostat in treating resistant hypertension in adults with uncontrolled blood pressure despite existing antihypertensiv

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May 18, 2026

Could Digital Twins Forecast Forensic Risk?

Kathryn Wighton
May 18, 2026
4 min

Summary
Quiz
Clinical Scorecard

Objective: To explore the potential applications and implications of digital twins in forensic mental health risk management and their broader impact on patient

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May 18, 2026

Top 10 States with the Lowest Costs for Running a Medical Practice

Conexiant News Staff
May 18, 2026
3 min

Summary
Insight Report
Quiz

Objective: To identify states with the lowest costs for operating a medical practice based on various economic indices. Key Findings: Arkansas has the lowest pr

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May 18, 2026

Recent COVID-19 Shot Linked to Less Spread

Kerri Miller
May 18, 2026
3 min

Summary
Quiz
Poll

Objective: To assess the association between recent COVID-19 vaccination and the risk of SARS-CoV-2 transmission in household settings, specifically focusing on

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The Pathologist

May 18, 2026

The AACR 2026 Roundup: Why Quantitative Precision Matters

Marwan Alsarraj
May 18, 2026
6 min

Summary
Quiz
Top Thought Leaders

Objective: To highlight specific advancements in liquid biopsy technologies, including ctDNA measurement techniques and their implications for precision oncolog

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The Pathologist

May 18, 2026

Blood Test Predicts Immunotherapy Response

May 18, 2026
3 min

Summary
Takeaways
Quiz

Objective: To develop a machine-learning approach for predicting immunotherapy response in melanoma using blood-derived DNA. Key Findings: Identified nine conse

A machine-learning approach using blood-derived DNA can predict immunotherapy response in melanoma.
The study identified nine conserved tumor microenvironment ecotypes linked to biology, survival, and immunotherapy response.
The cfDNA-based method outperformed traditional biomarkers like tumor mutational burden and PD-L1 expression.
High levels of inflammatory ecotypes SE7 and SE8 correlated with better treatment outcomes, while SE4 indicated resistance.
This noninvasive blood test may enable longitudinal monitoring of tumor microenvironment changes during therapy.

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The Analytical Scientist

May 18, 2026

A Singular Approach to Combatting Infectious Disease

Anis Larbi
LaToya Montgomery
May 18, 2026
5 min

Summary
Quiz
Top Thought Leaders

Objective: To explore the role of single-cell analysis in enhancing vaccine development and understanding immune responses to emerging pathogens. Key Findings:

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The Medicine Maker

May 18, 2026

This Week’s CGT News: Novo’s Parkinson’s Pivot

May 18, 2026
7 min

Summary
Quiz

Objective: To summarize recent advancements in gene therapy and cell therapy, particularly focusing on Parkinson's disease and other conditions. Key Findings: C

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The Ophthalmologist

May 18, 2026

Theialife Appoints New CEO

May 18, 2026
2 min

Summary
Takeaways
Quiz

Objective: To announce the appointment of Thomas Ruggia as CEO and the advancement of ND10 into phase 3 development. Key Findings: Ruggia has over 25 years of e

Theialife appointed Thomas Ruggia as CEO to advance its oral therapy for pediatric myopia into phase 3 development.
Ruggia has over 25 years of experience in ophthalmology and previously led global commercialization at Samsara Vision.
The company is preparing to initiate phase 3 trials of ND10, a first-in-class oral therapy targeting myopia progression in children.
ND10 is supported by over two decades of data from Denmark, showing encouraging efficacy and safety in over 1,200 treated children.
Theialife is also developing a broader ophthalmology pipeline, including treatments for dry eye disease and wet AMD.

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The Medicine Maker

May 18, 2026

Scaling Genomics for Precision Medicine

Robert Balog
May 18, 2026
5 min

Summary
Quiz
Poll
Top Thought Leaders

Objective: To highlight the advancements in microarray technology that facilitate the urgent integration of genomic insights into clinical practice for precisio

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The Ophthalmologist

May 18, 2026

Smarter Drug Management, Stronger Practices

Kurt Defenbaugh
May 18, 2026
7 min

Summary
Quiz
Top Thought Leaders

Objective: To highlight the importance of effective drug management strategies for independent ophthalmology practices amidst a trend of consolidation in the in

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Discover top thought leaders in a clinical topic, with data-driven rankings and expert profiles highlighting their influence and contributions.

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Frontiers In Oncology

May 18, 2026

Solid-variant primary pulmonary adenoid cystic carcinoma with pleural metastasis and malignant pleural effusion: a rare case report

Suyi Guo
Yang Zhai
Hongbian Gao
Caixia Ding
May 18, 2026

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To highlight diagnostic challenges and provide clinical evidence for treatment in a rare case of solid-variant primary pulmonary adenoid cystic carci

Primary pulmonary adenoid cystic carcinoma (PACC) is a rare lung malignancy, constituting 0.04%–0.2% of primary lung neoplasms.
The solid variant of PACC is characterized by aggressive behavior and poses significant diagnostic challenges due to its immunophenotypic overlap with squamous cell carcinoma.
A 65-year-old man was diagnosed with solid-variant PACC after initial misinterpretation as squamous cell carcinoma, highlighting diagnostic pitfalls.
The patient presented with pleural metastasis and malignant pleural effusion, classified as stage IV disease, receiving a combination of immunotherapy and chemotherapy.
This case provides preliminary evidence for the feasibility of chemoimmunotherapy in advanced PACC, emphasizing the need for accurate diagnostic approaches.

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Get a concise, at-a-glance scorecard that distills clinical guidelines into key recommendations, patient insights, and treatment considerations.

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Frontiers In Oncology

May 18, 2026

Association between the composite CRP–TyG index and incident malignancy risk in hospitalized patients with diabetes: a retrospective cohort study with nonlinear effect analysis

Xinyuan Cui
Mengru Yuan
Yanting Mao
Bojin Xu
Haiping Zhou
Shan Huang
Wenfang Peng
May 18, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To evaluate the association between the CRP–TyG composite index and the risk of incident malignancy in hospitalized patients with diabetes, emphasizi

The CRP–TyG composite index is a significant marker for assessing cancer risk in hospitalized patients with diabetes.
A total of 5,500 diabetic inpatients were analyzed, revealing 344 incident malignancies during the study period.
Malignancy risk increased progressively across CRP–TyG quartiles, with the highest quartile showing a 92% increased risk.
A nonlinear association was identified, with a notable inflection point at a CRP–TyG z-score of 0.62.
The composite index outperformed CRP or TyG alone in predicting gastrointestinal cancer risk among diabetic patients.

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Frontiers In Cardiovascular Medicine

May 18, 2026

Interruption of the right middle and lower lobe pulmonary arteries combined with arterial aneurysm formation at the origin of the right subclavian artery branch: a case report

Chengshi Hou
Guocheng Zhao
May 18, 2026

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To report a rare case of interrupted pulmonary arteries in an adult and discuss its diagnosis and management, emphasizing the rarity of such cases. K

A 64-year-old female presented with interrupted pulmonary arteries in the right middle and lower lobes and a right subclavian artery aneurysm.
CT pulmonary angiography confirmed congenital interruption of the right middle and lower lobe pulmonary arteries with collateral circulation and pulmonary hypertension.
The patient's symptoms included chest tightness and shortness of breath, with elevated D-dimer levels prompting further imaging evaluation.
Treatment focused on managing pulmonary hypertension and conservative monitoring of the right subclavian artery aneurysm due to the patient's stable condition.
Regular follow-up assessments showed stable blood pressure, lipid levels, and no progression of pulmonary arterial hypertension or aneurysm enlargement.

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Get a concise, at-a-glance scorecard that distills clinical guidelines into key recommendations, patient insights, and treatment considerations.

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Frontiers In Immunology

May 18, 2026

Clinical applications and challenges of CD40/CD40L signaling regulation in autoimmune diseases

Yangyang Man
Xiaoni Chen
Yi Liu
Biao Zhang
Jiahua Hu
Xianliang Hou
May 18, 2026

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To explore the CD40/CD40L signaling pathway's role in autoimmune disorders, specifically rheumatoid arthritis, systemic lupus erythematosus, and Sjög

The CD40/CD40L axis is crucial for linking innate and adaptive immunity, influencing autoimmune inflammation.
Dysregulated CD40/CD40L signaling is implicated in autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus.
Therapeutic targeting of CD40/CD40L must consider cell-specific signaling to enhance safety and efficacy.
Both membrane-bound and soluble forms of CD40L can activate CD40, affecting immune responses and inflammation.
Safety challenges, including thromboembolic events, have emerged in early trials of CD40/CD40L-targeted therapies.

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Get a concise, at-a-glance scorecard that distills clinical guidelines into key recommendations, patient insights, and treatment considerations.

Get quick, clinically relevant Q&A that turns long-form articles into clear answers for faster learning and discovery.

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