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MDSpire News

  • September 4, 2026
FDA approves first therapy for Alexander disease
  • Kathryn Wighton
  • September 4, 2026
  • 2 min

Objective: To announce the FDA approval of zilganersen (Zanvastro) for treating Alexander disease. Approach: FDA Approval: The FDA approved zilganersen injectio

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2 min

MDSpire News

  • September 4, 2026
Biomarker may flag early pregnancy risk
  • Andrea Surnit
  • September 4, 2026
  • 4 min

Objective: To investigate the association of low maternal serum isthmin-2 (ISM2) levels in the first trimester with the risk of preeclampsia (PE) and fetal grow

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2 min

Fox Chase Cancer Center

  • September 4, 2026
Adaptive Radiation Boost for Rectal Cancer (ARBOR)
  • September 4, 2026
  • 3 min

Objective: To determine the safety and efficacy of additional adaptive radiation therapy following standard chemoradiation treatment in patients with rectal can

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Fox Chase Cancer Center

  • September 4, 2026
Adaptive Radiation for Locally Advanced Unresectable Pancreatic Cancer
  • September 4, 2026
  • 4 min

Objective: To learn if Adaptive Radiation Therapy (ART) is safe and effective in treating patients with locally advanced pancreatic cancer. Approach: Study Desi

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The Pathologist

  • September 4, 2026
Can Technology Make Pathology More Human? Part 2
  • Helen Bristow
  • September 4, 2026
  • 9 min
  1. AI is expected to enhance the pathologist's work by improving efficiency and supporting decision-making without diminishing professional autonomy.
  2. Pathologists face increasing workloads due to workforce shortages and demand, making AI a potential solution to manage these challenges.
  3. The role of pathologists may expand beyond diagnosis to include treatment planning, particularly in the context of precision medicine and companion diagnostics.
  4. AI can automate routine tasks, allowing pathologists to focus on complex tests and contribute more directly to treatment decisions.
  5. Pathologists are encouraged to engage actively with emerging technologies to enhance their influence and adapt to the evolving landscape of healthcare.
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MDSpire News

  • September 4, 2026
Extended antiviral therapy may not improve long COVID
  • Andrea Surnit
  • September 4, 2026
  • 4 min

Objective: To evaluate the efficacy of nirmatrelvir–ritonavir treatment for up to 25 days in improving cognitive dysfunction, autonomic dysfunction, or exercise

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The Pathologist

  • September 4, 2026
Whole Blood Opens New Route to Biomarker Discovery
  • September 4, 2026
  • 2 min
  1. A new method for extracting extracellular vesicles (EVs) from whole blood could enhance diagnostic biomarker discovery.
  2. The optimized PROSPR workflow produces purified EVs suitable for protein and lipid analysis in under 20 minutes.
  3. Whole-blood EVs contain unique molecular information not captured by plasma EVs, including 251 distinct proteins.
  4. The study highlights the potential of using stored whole-blood specimens for revisiting existing cohorts in EV research.
  5. Further validation is necessary before the identified biomarkers can be considered for clinical use.
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The Ophthalmologist

  • September 4, 2026
Fanny Kaplan and the Attempted Assassination of Vladimir Lenin
  • Stephen G. Schwartz
  • Christopher T. Leffler
  • Peter M. Allen
  • Andrzej Grzybowski
  • September 4, 2026
  • 5 min
  1. On August 30, 1918, Vladimir Lenin was shot in an assassination attempt, with two bullets striking him and one hitting a bystander.
  2. Fanny Kaplan, arrested shortly after the shooting, confessed and was executed, although some historians question her role as the shooter.
  3. Kaplan, born Feyga Chaimovna Roitblat, was a revolutionary who suffered visual impairment, possibly due to a previous bomb explosion.
  4. Her ophthalmologic diagnosis remains unclear, with suggestions of hysterical blindness or injuries from the bomb blast affecting her vision.
  5. Despite her visual impairment, Kaplan's shooting accuracy was notable, hitting Lenin with two of three shots, a higher rate than modern police officers.
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The Ophthalmologist

  • September 4, 2026
Rethinking Ophthalmology Referrals
  • September 4, 2026
  • 3 min
  1. A Canadian study analyzed 634 ophthalmology referrals to assess quality using a 21-point checklist across five domains.
  2. The mean completeness score of referrals was 11.6 out of 21, with significant gaps in essential clinical information.
  3. Optometrists submitted the most complete referrals, while ophthalmologist referrals showed the greatest variability in detail.
  4. Overall referral completeness did not predict diagnostic agreement; clear identification of the referrer and provisional diagnosis was crucial.
  5. The study suggests focusing on pertinent clinical information and using standardized templates to improve referral quality.
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Compendium

  • September 4, 2026
Curve Dental Introduces Integrated Dental Membership Plan Management
  • News Staff
  • September 4, 2026
  • 3 min
  1. Curve Dental launched Curve Memberships to help practices manage in-house membership plans for patients without dental insurance.
  2. The system integrates membership information with patient records and existing workflows, automating enrollment and payment management.
  3. More than 20% of working-age US adults lack dental benefits, making in-house membership plans a viable alternative payment model.
  4. Curve Memberships aims to enhance patient retention and provide practices with recurring revenue outside traditional insurance reimbursement.
  5. The feature includes tools for identifying candidates, delivering invitations, posting payments, and tracking program performance.
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Inside Dentistry

  • September 4, 2026
Pearl Launches Second Opinion 3D for CBCT Imaging
  • News Staff
  • September 4, 2026
  • 3 min
  1. Pearl launched Second Opinion 3D, an AI technology for CBCT imaging, now available to dental practices in the U.S. and Canada.
  2. The platform integrates with the existing Second Opinion interface and allows for licensed radiologist report requests.
  3. Second Opinion 3D automatically identifies and color-codes anatomical structures in CBCT scans for enhanced visualization.
  4. The software includes features for insurance claim documentation and AI-powered pathology detection for various dental conditions.
  5. Pearl's technology has received regulatory clearance in 120 countries and aims to bridge dental and systemic health.
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MDSpire News

  • September 4, 2026
Inside the hip osteoarthritis microbiome
  • Kathryn Wighton
  • September 4, 2026
  • 3 min

Objective: To investigate differences in intra-articular microbial taxa and functions between patients with hip osteoarthritis and nonarthritic controls. Approa

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The Medicine Maker

  • September 4, 2026
Musings from The Power List: Peng Lu
  • September 4, 2026
  • 4 min

Objective: To discuss advancements in drug development, particularly in the context of bradykinin-mediated angioedema and the role of small molecules. Approach:

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Frontiers In Neurology

  • September 4, 2026
Effectiveness and Cortical Network Alterations of a Multimodal Sensory Feedback Robot for Upper-Limb Rehabilitation in Post-Stroke Patients: A Randomized Controlled Study
  • Li-Hui Zhao
  • Jun-Peng Zhang
  • Jia-Jia Wu
  • Yu Cao
  • Zhan-Yue Lu
  • Xu-Yun Hua
  • Xia Bi
  • Jian-Guang Xu
  • September 4, 2026
  1. This study examined the effects of multimodal sensory-feedback robot-assisted training on upper-limb recovery in post-stroke patients.
  2. Thirty-eight stroke patients were randomly assigned to either conventional rehabilitation or rehabilitation supplemented with robotic training.
  3. Post-intervention, the experimental group showed significant improvement in Fugl-Meyer Assessment scores compared to the control group.
  4. Functional near-infrared spectroscopy revealed increased fronto-motor connectivity in the experimental group after the intervention.
  5. The study suggests that multimodal sensory-feedback robotic training may enhance short-term upper-limb motor recovery post-stroke.
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Frontiers In Oncology

  • September 4, 2026
A novel nomogram utilizing tumor burden for assessing synchronous esophageal and gastric cancers: creation and external validation
  • Meng Xie
  • Jing Wang
  • Ziyu Jia
  • Ke Ji
  • Qi Wu
  • September 4, 2026
  1. A prognostic nomogram for synchronous esophageal and gastric cancers (SEGC) was developed using a Combined EG_Stage framework.
  2. The study included a development cohort of 46 patients and an external validation cohort of 88 patients from the SEER database.
  3. Key predictors in the nomogram were age, treatment modality, and Combined EG_Stage, with overall survival as the primary endpoint.
  4. The external validation showed a C-index of 0.681 and significant differences in median overall survival based on risk stratification.
  5. The model is considered hypothesis-generating due to modest discrimination and limited sample size, necessitating further multicenter validation.
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Frontiers In Immunology

  • September 4, 2026
Plasticity of Lineage and Immune Evasion in Primary SCLC and Transformation from LUAD to SCLC: Loss of Antigen Presentation and Shifts in Therapeutic Strategies
  • Hongying Xu
  • Benhua Li
  • Jun Yang
  • Xin Tang
  • September 4, 2026
  1. Lineage plasticity in SCLC contributes to immune resistance by impairing MHC-I antigen processing and presentation.
  2. Neuroendocrine differentiation is linked to reduced antigen presentation in primary SCLC and experimental models.
  3. Transformation from EGFR-mutant LUAD to SCLC may involve similar alterations in antigen presentation, though not yet confirmed.
  4. Current immunotherapy strategies have shown limited durable benefits in SCLC, particularly in transformed cases.
  5. Antigen presentation capacity is crucial for immune checkpoint blockade efficacy in SCLC, influencing treatment outcomes.
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Frontiers In Endocrinology

  • September 4, 2026
Enhancing Family Planning Strategies for Women of Advanced Reproductive Age: A Faster-Fewer-Finished Model
  • Sesh K. Sunkara
  • Christos Venetis
  • Thomas D’Hooghe
  • Francesca E. Duncan
  • Tamara Hunter
  • Susana Montenegro
  • Frank Broekmans
  • September 4, 2026

Get a structured, in-depth report that distills clinical articles into clear insights, data, and analysis for deeper learning.

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Acta Neuropathologica

  • September 4, 2026
Identification of ARPP21 as a Key Gene Associated with Amyotrophic Lateral Sclerosis Through Familial, Neuropathological, and Cellular Investigations in French Populations
  • Sibylle de Bertier
  • Maria-Del-Mar Amador
  • Claire Guissart
  • Tomoko Miki
  • Séverine Boillée
  • Christian S. Lobsiger
  • Delphine Bohl
  • Anne-Laure Fauret-Amsellem
  • Adrien Bohic
  • Anna-Gaelle Giguet-Valard
  • Rémi Bellance
  • Katell Beauvais
  • Vincent Meininger
  • Gaelle Bruneteau
  • François Salachas
  • Christophe Vial
  • William Camu
  • Florence Esselin
  • Elisa de la Cruz
  • Emilien Bernard
  • Danielle Seilhean
  • Stéphanie Millecamps
  • September 4, 2026
  1. Amyotrophic lateral sclerosis (ALS) is primarily sporadic, with familial cases accounting for about 10% of occurrences.
  2. Whole-exome sequencing revealed an ARPP21 variant associated with ALS in a large French pedigree with autosomal dominant transmission.
  3. The ARPP21 variant c.1586C>T, p.Pro529Leu was identified as a high-effect variant in a large study involving 17,919 ALS cases.
  4. The study involved genetic analysis of 1190 French ALS patients, focusing on those without pathogenic variants in known ALS genes.
  5. Neuropathological analyses were conducted on post-mortem tissues from ALS patients to investigate the impact of ARPP21 variants.
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