MDSpire Home

November 14, 2026

Substantial Reduction in Pneumococcal Haemolytic Uraemic Syndrome After Vaccine Replacement

Helena Hildenwall
Valya Georgieva
Joachim Luthander
Susanne Westphal Ladfors
Lisa Sartz
Milan Chromek
November 14, 2026

Objective: Assess pHUS incidence in Sweden after PCV15 replaced PCV10 in 2023, adding serotypes 3 and 19A to vaccine coverage. Approach: Surveillance: Researche

...more

MDSpire News

November 13, 2026

Can visual feedback improve gait symmetry after THA?

Andrea Surnit
November 13, 2026
4 min

Objective: To compare visual feedback–based rehabilitation plus conventional physiotherapy with conventional physiotherapy alone for gait and clinical outcomes

...more

MDSpire News

November 13, 2026

Can brepocitinib improve remission in skin condition?

Andrea Surnit
November 13, 2026
4 min

Get quick, clinically relevant Q&A that turns long-form articles into clear answers for faster learning and discovery.

Take the Quiz

MDSpire News

November 13, 2026

FDA approves durvalumab for bladder cancer

Teraya Smith
November 13, 2026
2 min

Objective: The article examines the objective, findings, and clinical context described in FDA approves durvalumab for bladder cancer. Approach: Approval: The F

...more

2 min

MDSpire News

November 13, 2026

Food noise may accompany loss of eating control

Andrea Surnit
November 13, 2026
5 min

Get a concise, at-a-glance scorecard that distills clinical guidelines into key recommendations, patient insights, and treatment considerations.

View Scorecard

The Pathologist

November 13, 2026

AI Won’t Replace the Pathologist – But…

Jessica Allerton
November 13, 2026
10 min

Digital pathology and clinical AI remain incompletely implemented, with many departments using AI mainly for slide quality control and limited commercial models.
AI can support preanalytic and postanalytic tasks, including slide checks, case assembly, report completion, coding, and structured data capture.
Case prioritization and image analysis can help direct attention and improve consistency, but every case still requires complete assessment by a pathologist.
AI’s most significant contribution so far has been quality control, while selected prostate cancer applications have received FDA authorization for prognostic use.
Laboratories should validate AI tools on local specimens and workflows, assess human-tool performance, and monitor tools and discrepancies after deployment.

...more

MDSpire News

November 13, 2026

Audiometry identifies genetic loci linked to hearing loss

Andrea Surnit
November 13, 2026
5 min

Objective: Compare genetic associations and heritability estimates from quantitative audiometric measurements with those from diagnostic codes for sensorineural

...more

MDSpire News

November 13, 2026

CAR T cells may improve walking in stiff person syndrome

Andrea Surnit
November 13, 2026
5 min

Get a concise, at-a-glance scorecard that distills clinical guidelines into key recommendations, patient insights, and treatment considerations.

View Scorecard

The Analytical Scientist

November 13, 2026

The Big Challenges: Part Two – AI and the Data Deluge

November 13, 2026
14 min

Get quick, clinically relevant Q&A that turns long-form articles into clear answers for faster learning and discovery.

Take the Quiz

The Medicine Maker

November 13, 2026

Video: Sitting Down With… Delara Motlagh

November 13, 2026
1 min

Objective: The video interview discusses Delara Motlagh’s career, leadership, manufacturing challenges, iPSCs, and the roles of CDMOs and technology providers i

...more

1 min

United States Department Of Health And Human Services

November 13, 2026

Kennedy Brings MAHA Agenda to North Dakota, Promoting Regenerative Agriculture and Better Tribal and Rural Healthcare

Assistant Secretary for Public Affairs (ASPA)
November 13, 2026

Get quick, clinically relevant Q&A that turns long-form articles into clear answers for faster learning and discovery.

Take the Quiz

Jama Network Open

November 13, 2026

Updated Penicillin–Cephalosporin Cross-Reactivity Alerts and Cephalosporin Use in Patients With Penicillin Allergy

Cosby A. Stone
Scott D. Nelson
Laura Zahn
Allison B. McCoy
Megan Z. Wang
Ritu Banerjee
Milner Staub
Dara Mize
Elizabeth J. Phillips
Adam Wright
November 13, 2026

Among 26,903 patients with penicillin allergy labels, a revised risk-stratified alert was associated with increased cephalosporin use across inpatient, operating room, and outpatient settings.
Mean weekly cephalosporin use increased 17.8% for inpatient administrations, 35.4% in operating rooms, and 16.7% for outpatient orders.
After implementation, weekly fluoroquinolone use decreased 12.5% and clindamycin use decreased 34.5%, while carbapenem and metronidazole use did not change significantly.
The revised alerts reduced weekly penicillin-cephalosporin cross-reactivity alerts by 86%, and prescribers canceled 67.2% of orders after receiving the new in-line alert.
Review of 28 epinephrine administrations within 1 hour of cephalosporin exposure found no anaphylaxis; long-term outcomes and delayed allergy effects were not evaluated.

...more

Archives Of Toxicology

November 13, 2026

Correction: Updated overview of human biomonitoring for beauvericin and enniatins

Gisela H. Degen
Anamarija Romac
November 13, 2026

Objective: To correct errors in the published article. Approach: Author name: Corrects the first author’s name from “Gsela H. Degen” to “Gisela H. Degen.” Table

...more

1 min

Journal Of Medical Internet Research

November 13, 2026

Strengthening Privacy Protections for Reproductive Health Data in FemTech Apps

Jenny Castillo Cato
November 13, 2026

Get a structured, in-depth report that distills clinical articles into clear insights, data, and analysis for deeper learning.

Read Full Report

Jmir Dermatology

November 13, 2026

Nonsyndromic Clusters of Basal Cell Carcinomas: A Diagnostic and Treatment Challenge in a Case Report

Sarita Pattisam
Kelly Kimball
Austin Cusick
Angela Casey
November 13, 2026

Objective: To describe two patients with numerous, localized basal cell carcinomas (BCCs) without clinical features of an associated genetic syndrome, and discu

...more

Bmc Medicine

November 13, 2026

Looking Beyond Discrimination in Prehospital Scores to Improve Patient Outcomes

Philipp Kümpers
Alexandros Rovas
November 13, 2026

Objective: The article examines the objective, findings, and clinical context described in Looking Beyond Discrimination in Prehospital Scores to Improve Patien

...more

Jama Network Open

November 13, 2026

Workplace Violence Targeting Nurses: An Emergency Department Crisis

Marla C. Doehring
Megan M. Palmer
Benton R. Hunter
November 13, 2026

Objective: The article examines the objective, findings, and clinical context described in Workplace Violence Targeting Nurses: An Emergency Department Crisis.

...more

2 min

Critical Care

November 13, 2026

PRiVENT: Response to Cheng on Weaning Outcomes and Duration of Mechanical Ventilation

Franziska C. Trudzinski
Teresa Byczkowski
Benjamin Neetz
Janina Schubert-Haack
Manuel Feißt
Joachim Szecsenyi
Felix J. F. Herth
November 13, 2026

The primary endpoint classified patients who died before discharge as weaning failures, even if invasive ventilation had been discontinued temporarily.
PRiVENT enrolled patients at elevated risk for prolonged weaning and aimed to provide early access to specialized expertise.
Among ICU survivors, an exploratory analysis found higher odds of successful weaning with the intervention, but exclusion of deaths created potential selection bias.
Adjusted competing-risk analysis found no statistically significant association between the intervention and successful weaning (sHR, 1.12; 95% CI, 0.91-1.38; P = .30).
PRiVENT used a prospective, nonrandomized design to limit contamination across institutions, but this design retained limitations for causal inference.

...more