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The Medicine Maker

  • August 11, 2026
Musings from The Power List: Ann Cleves
  • Ann Cleeves
  • August 11, 2026
  • 4 min
  1. Ann Cleves highlights advancements in macrocyclic peptide research, particularly through collaboration with Merck.
  2. Recent work published in JCIM demonstrates methods for conformational analysis of macrocyclic peptides using NMR data.
  3. Small molecules retain advantages in drug optimization, including oral dosing and computational modeling capabilities.
  4. Cleves challenges the belief that existing drugs can easily address unmet therapeutic needs, emphasizing the need for novel compounds.
  5. She argues that drug repurposing and AI models have limitations in addressing complex therapeutic challenges.
...more

Frontiers In Immunology

  • August 11, 2026
Editorial: Volume II of the Community Series on Interactions Among Ferroptosis, Immune Response, and Inflammatory Processes
  • Hao Wang
  • Matheus Silvério Mattos
  • Weijia Zhang
  • August 11, 2026
  1. Ferroptosis is a regulated cell death process linked to iron accumulation and lipid peroxidation, impacting various tissue injuries.
  2. The editorial discusses Volume II of a series exploring the interactions between ferroptosis, immune responses, and inflammation.
  3. Recent studies highlight immune dysfunction related to ferroptosis as a factor in serious conditions like cancer and sepsis.
  4. Ferroptosis is implicated in neurodegenerative diseases, with potential interventions targeting this process suggested for Alzheimer's and Parkinson's.
  5. Ferroptosis contributes to chronic inflammation in diseases like inflammatory bowel disease and arthritis, affecting macrophage signaling pathways.
...more

Frontiers In Oncology

  • August 11, 2026
Case Study of an Inflammatory Myofibroblastic Tumor Involving the Urachus
  • Jiafu Liu
  • Ran Wei
  • Xiaoxing Miao
  • Jinbo Han
  • Jie Wang
  • August 11, 2026
  1. Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm, with urachal involvement being particularly uncommon.
  2. A 62-year-old female presented with urinary frequency and dysuria, leading to the discovery of a urachal mass via imaging.
  3. Surgical intervention involved laparoscopic resection of the urachal mass and partial cystectomy, confirming IMT through histopathology.
  4. Histopathological analysis showed spindle-shaped cells and positivity for ALK and vimentin, with negative margins achieved.
  5. At 3-month follow-up, imaging revealed no signs of recurrence, and the patient reported resolution of urinary symptoms.
...more

Dermatology And Therapy

  • August 11, 2026
Correction: Addressing Gaps in Chronic Prurigo Management: Evidence-Based Diagnostic and Treatment Guidelines from a Delphi Consensus Panel
  • Pedro Mendes-Bastos
  • Inês Lobo
  • Gilberto Pires da Rosa
  • Rita Pimenta
  • Margarida Gonçalo
  • August 11, 2026
  1. The article corrects a statement regarding dupilumab reimbursement in Portugal, confirming it was reimbursed in January 2025.
  2. An error in the dosage for lebrikizumab was corrected from '125 mg every 4 weeks' to '250 mg every 2 weeks'.
  3. Tralokinumab's dosage was also corrected to '300 mg every 2 weeks' in the treatment section.
  4. The corrections were made to ensure accurate information regarding chronic prurigo management.
  5. The article has been officially amended to reflect these corrections.
...more

MDSpire News

  • August 10, 2026
HHS Proposes Mandatory GRAS Notices
  • Kathryn Wighton
  • August 10, 2026
  • 3 min

Objective: To improve food ingredient oversight and enhance transparency regarding substances added to the food supply. Approach: GRAS Notification Requirement:

...more

MDSpire News

  • August 10, 2026
FDA Approves Melanoma BRAF Companion Test
  • Kathryn Wighton
  • August 10, 2026
  • 1 min

Objective: To announce the FDA approval of PGDx elio tissue complete CDx as a companion diagnostic for advanced melanoma. Approach: Diagnostic Technology: PGDx

...more

Sentara

  • August 10, 2026
Sentara Virginia Beach General Hospital earns national recognition for heart, lung care
  • August 10, 2026
  • 3 min
  1. Sentara Virginia Beach General Hospital was named to Newsweek’s America’s Best Hospitals for Specialized Care 2026 for excellence in pulmonary and cardiac care.
  2. The ranking highlights 1,375 hospitals across seven specialties, reflecting strong performance in quality, safety, and patient experience.
  3. Sentara Virginia Beach General Hospital is one of only eight Virginia hospitals recognized in the report, emphasizing community hospital capabilities.
  4. The 2026 rankings incorporate enhanced methodology, including expanded safety indicators and specialty-specific certifications for quality assessment.
  5. This recognition assures local patients of access to nationally recognized heart and lung care expertise without needing to travel.
...more

Sentara

  • August 10, 2026
Sentara develops successful approach to preventing MRSA, cutting infections in half
  • August 10, 2026
  • 4 min
  1. Sentara developed an IT-enabled intervention to reduce MRSA infections across 12 hospitals, cutting cases nearly in half since its implementation.
  2. The new process includes a risk scoring system that alerts nurses to high-risk patients for targeted preventative measures.
  3. Sentara's MRSA cases decreased from 53 in 2022 to 29 in 2023, with a consistent trend of 28 cases in 2025.
  4. The initiative has saved approximately $2 million in healthcare costs over five years due to reduced MRSA infections.
  5. Other health systems have shown interest in Sentara's approach, seeking guidance on developing similar infection prevention tools.
...more

MDSpire News

  • August 10, 2026
New Screen May Expand Molecular Glue Discovery
  • Andrea Surnit
  • August 10, 2026
  • 4 min

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Phoenix Children's Medical Connection

  • August 10, 2026
Introducing Pediatric Palliative Care Earlier in Phase 1 Trials
  • August 10, 2026
  • 6 min

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MDSpire News

  • August 10, 2026
Fever of unknown origin: Experts define minimum workup needed
  • Meg Barbor
  • August 10, 2026
  • 5 min

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MDSpire News

  • August 10, 2026
Novel oral Shigella vaccine cuts illness in US trial
  • Doug Brunk
  • August 10, 2026
  • 6 min

Objective: To evaluate the efficacy and safety of a two-dose, live-attenuated oral vaccine candidate (WRSs2) against Shigella sonnei in healthy adults. Approach

...more

MDSpire News

  • August 10, 2026
Repurposed drugs offer no sustained benefit for long COVID fatigue
  • Alun Evans
  • August 10, 2026
  • 4 min

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MDSpire News

  • August 10, 2026
Sexual networks drive spread of drug-resistant Shigella sonnei
  • Henry Thomas
  • August 10, 2026
  • 5 min
  1. A genomic epidemiology study found that sexually transmissible Shigella sonnei spread more widely and intensely than other domestically acquired strains in England.
  2. Resistance to key antimicrobials was detected in 69.4% of isolates from presumptive men who have sex with men (pMSM), compared to lower rates in other groups.
  3. The mean geographic distance between pMSM isolates was significantly greater than that of non-pMSM isolates, indicating distinct transmission patterns.
  4. The study highlighted the need for tailored public health strategies, including vaccination and treatment guidelines, to address sexual transmission of shigellosis.
  5. Limitations of the study included potential misclassification of sexual transmission and disruptions in transmission patterns due to the COVID-19 pandemic.
...more

MDSpire News

  • August 10, 2026
Can Controlled Breathing Reduce Substance Craving?
  • Andrea Surnit
  • August 10, 2026
  • 3 min

Objective: To evaluate the effectiveness of controlled breathing interventions in reducing substance craving among patients with substance use disorders. Approa

...more

The Ophthalmologist

  • August 10, 2026
The RK Eye Reimagined
  • Arun Gulani and Aaishwariya Gulani
  • August 10, 2026
  • 13 min
  1. Radial Keratotomy (RK) significantly changed refractive surgery by providing alternatives to glasses for many patients.
  2. The post-RK eye is a complex biomechanical system that evolves over time, requiring integrated management rather than isolated treatments.
  3. Surgeons must adopt an architectural mindset to understand the RK eye's structural changes and their impact on vision.
  4. Successful RK management involves a comprehensive understanding of the ocular surface, cornea, lens, and their interrelationships.
  5. No two RK eyes are the same; individualized assessment is crucial for determining the dominant reconstructive problem.
...more

The Medicine Maker

  • August 10, 2026
This Week’s CGT News: In Vivo CAR T Draws Major Investment
  • August 10, 2026
  • 4 min

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The Medicine Maker

  • August 10, 2026
Building Commercial Readiness in Advanced Therapies
  • August 10, 2026
  • 6 min

Share your perspective with a quick, clinically relevant poll that captures real-world insights and clinician sentiment.

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