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MDSpire is an innovative platform aiming to create a smarter, faster, and more connected medical community.

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March 6, 2026

Side Effects: Medicine's Blind Spot

Kerri Miller
March 6, 2026
6 min

A recent announcement from 53 medical schools revealed that graduates had only received 1.2 hours of nutrition education annually. Starting in the fall of 2026,

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53 medical schools revealed average nutrition education of 1.2 hours/year.
New mandate starts fall 2026 requiring a minimum of 40 hours.
Most U.S. medical schools lack clinical nutrition courses.
HHS to support nutrition education with a $5 million initiative.
Training gaps in nutrition need addressing for better patient advice.

March 6, 2026

Cardiac Arrest Patterns After Holidays

Kathryn Wighton
March 6, 2026
3 min

A nationwide study in South Korea found that out-of-hospital cardiac arrest rates increased by 9% on the first working day post-holidays compared to other weekd

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9% increase in cardiac arrest on first working day after holidays.
203,471 cases analyzed from 2013-
Median age of patients was 71 years, with 64% being male.
Higher rates in those over 65 and with cardiac causes.
No increase after single-day holidays; more significant after longer breaks.
Behavioral changes post-holiday may influence arrest rates.
Study limitations include observational design and missing data.
Future research should focus on factors affecting postholiday incidences.

March 6, 2026

RA-ILD: Tracking Function and CT

Kathryn Wighton
March 6, 2026
4 min

A prospective cohort study of patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) revealed that pulmonary function and imaging meas

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105 RA-ILD patients were studied over 24 months.
8% mortality rate recorded, largely unrelated to pulmonary decline.
Majority exhibited mild RA-ILD with 80% having pulmonary fibrosis.
FVC remained stable at 76% across the study.
12% improved, 69% stable, and 19% worsened at 24 months in imaging assessments.
Challenges conventional views on ILD mortality patterns.
Study's limitations include sample size and follow-up issues due to COVID-19.

March 6, 2026

Digital Tool Cuts Antibiotic Prescribing

Jess Allerton
March 6, 2026
2 min

A pragmatic trial in Rwanda demonstrated that a digital clinical decision support algorithm known as ePOCT+ can significantly reduce inappropriate antibiotic pr

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ePOCT+ algorithm effectively reduced antibiotic prescriptions in Rwanda.
Antibiotic use decreased from 71% to 25% in pediatric consultations.
The study included nearly 60,000 consultations in 32 health centers.
Structured assessments and point-of-care tests were part of the algorithm.
Recovery outcomes were similar in both intervention and control groups.
Non-randomized design limited causal conclusions.
Digital tools may enhance antibiotic stewardship in low-resource settings.

March 6, 2026

Weighted Vest in Obesity Trial

Kerri Miller
March 6, 2026
3 min

A secondary analysis of the 12-month INVEST in Bone Health trial revealed that greater upright time in older adults with obesity impacted hip bone mineral densi

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Greater upright time linked to hip bone density changes.
Participants were older adults with obesity or overweight.
Three study groups: weight loss only, resistance training, weighted vest.
Upright time influenced hip density in weight-loss-only group.
30-min increase corresponded to decreased bone density.
Highlighted need for mechanical loading in bone health.
Further studies needed on upright time and vest use.

March 6, 2026

Framework Targets Hospital-Onset UTIs

Kathryn Wighton
March 6, 2026
6 min

Hospital-onset urinary tract infections (HOUTIs) pose significant risks to inpatient care, necessitating unified prevention strategies for both catheter-associa

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New recommendations for preventing HOUTIs have been established.
Developed by a panel of 17 multidisciplinary experts.
Focus on both CAUTI and non-CAUTI infections.
Emphasis on standardized surveillance definitions.
Importance of electronic health records for tracking infections.
Recommendations for minimizing catheter use.
Training for all personnel involved in urinary management.
Recognition of gaps in current research on non-CAUTI infections.

The Pathologist

March 6, 2026

Are AI Models Cheating in Biomarker Predictions?

March 6, 2026
3 min

A multi-cohort analysis involving 8,221 cancer patients assessed the efficacy of deep learning models in predicting cancer biomarkers from histology images. The

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AI can predict tumor biomarkers, but often confounded by unrelated factors.
Study included 8,221 patients with various cancers.
High accuracy noted, but depends on tumor grade and mutation burden.
Simple models matched AI performance sometimes.
Bias-aware strategies recommended for AI deployment.
Confirmatory molecular testing remains crucial for treatment decisions.

The Pathologist

March 6, 2026

The Medical Illustrator

Helen Bristow
March 6, 2026
11 min

James Perkins, a prominent medical illustrator, transitioned from a potential career in vertebrate paleontology to medical illustration after realizing his pass

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James Perkins began his career path in vertebrate paleontology.
Transitioned to medical illustration through a master's program.
Worked on significant publications like Robbins and Netter's series.
Emphasizes science communication through art.
Balances academia with professional work.

The Ophthalmologist

March 6, 2026

Commercial Launch of OS 4 Up

March 6, 2026
2 min

Oertli Instrumente AG has launched the OS 4 Up™, a new surgical platform designed for cataract and vitreoretinal surgery. This innovative system enhances surgic

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OS 4 Up™ launched for cataract and vitreoretinal surgery.
Introduces phaco modulation for real-time energy adjustment.
Offers dynamic infusion to stabilize intraocular pressure.
Developed with user requirements in mind.
Focus on creating a joyful environment for operating teams.
Combines physics and fluidics for enhanced precision.
Allows for controlled surgery under calm chamber conditions.

The Ophthalmologist

March 6, 2026

Debunking Myths in Eye-Brain Health

March 6, 2026
6 min

Ivania Patry and Ping Zhao from Bulbitech emphasize the emerging role of AI in ophthalmology, particularly through eye-tracking technology. They clarify misconc

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AI analyzes statistical patterns, not directly diagnosing.
Video-oculography quantifies metrics like saccadic latency.
Clinical validation is crucial for AI tool adoption.
Workflow integration and data ownership are challenges.
Human interpretation is essential alongside AI assistance.
AI enhances precision but requires careful implementation.
Future integration requires large longitudinal data studies.

The Medicine Maker

March 6, 2026

The Strategic Role of CRA AI Agents in Clinical Research

Andrew Mackinnon
March 6, 2026
9 min

The complexity and inefficiencies of clinical trials are leading to significant delays in the approval of new therapies, with trial cycle times increasing while

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Clinical trials face increasing delays due to operational inefficiencies.
AI is primarily targeting early drug discovery phases.
CRAs are overwhelmed with manual tasks and data management.
'White space' consumes a significant amount of drug development time.
Agentic AI can automate trial processes and improve efficiency.
The partnership between AI and CRAs is vital for faster drug approvals.
Current R&D spending per approved drug is around $6 billion.
Effective use of AI could lead to a monumental wave of new medicines.

March 6, 2026

A two-sample Mendelian randomization study of the causal relationship between respiratory diseases, gastric cancer risk, and Helicobacter pylori infection

Kim, Youjin
Lee, Seunghyun
Lee, Jongin
Park, Min Young
Min, Jeehee
Ma, Xiaoxue
Sumikawa, Maiko Hajime
Yoon, Jin-Ha
Lee, Wanhyung
March 6, 2026

Objective: To evaluate the causal relationships between genetic liability to specific respiratory diseases (asthma, COPD, IPF, and LDEA) and gastric cancer outc

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March 6, 2026

Does the management of anastomotic leakage after rectal cancer resection affect long-term oncological survival? A retrospective propensity score-adjusted cohort study

Ammann, Y.
Marti, L.
Warschkow, R.
Bischofberger, S.
Reißfelder, C.
Schmied, B.
Brunner, W.
Tarantino, I.
March 6, 2026

Objective: To determine the influence of anastomotic leakage (AL) and its subclasses on long-term oncological outcomes, specifically cancer-specific survival, o

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Anastomotic leakage (AL) significantly affects morbidity, mortality, and functional outcomes in rectal cancer surgery.
The ISREC classification categorizes AL into grades A, B, and C, influencing management strategies and therapeutic interventions.
Patients with AL were divided into leak and no-leak groups, with further stratification based on the ISREC classification.
The study aimed to assess the impact of AL and its subclasses on long-term oncological outcomes after rectal cancer resection.
Statistical analyses were conducted to evaluate risk factors for AL and its subclasses, alongside survival outcomes.

March 6, 2026

St Mark’s protocol for standardised examination under anaesthesia for rectovaginal fistulae

Okocha, M.
Rowe, A.
Elgendy, K.
Thomas, G.
Tozer, P.
Vaizey, C.
March 6, 2026

Objective: To document the St Mark’s protocol for examination under anaesthesia (EUA) in suspected rectovaginal fistulae. Key Findings: The five-stage protocol

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Rectovaginal fistulae (RVFs) significantly impair patients' quality of life, stemming from various causes like obstetric trauma and Crohn's disease.
Diagnosis of RVFs can be challenging, often requiring examination under anesthesia (EUA) for definitive evaluation and planning.
The St Mark’s protocol for EUA includes five stages: inspection, endoanal ultrasonography, probing, insufflation, and dye testing.
Intraoperative endoanal ultrasonography enhances the assessment of sphincter integrity and fistula tract definition during EUA.
The structured protocol aids in documenting findings and informs surgical decisions, especially in ambiguous cases or post-repair evaluations.

March 6, 2026

MYELOstudy: lymph node stage of aggressiveness in medullary thyroid cancer—a retrospective multi-center study analysis

Objective: To assess the correlation between clinicopathological features of medullary thyroid carcinoma (MTC) and the presence and stage of cervical nodal meta

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March 6, 2026

Vancouver B3 periprosthetic fractures of the femur: options for treatment

Fink, Bernd
Hoyka, Marius
March 6, 2026

Objective: To analyze various therapeutic options for Vancouver B3 periprosthetic femoral fractures in light of current knowledge and their implications for cli

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March 6, 2026

Tissue tracking under long-horizon occlusions with contrastive learning

Inglezou, Myrto
Kegkeroglou, Nikolaos
Delimpasis, Leonidas
Chatzakos, Panagiotis
Porichis, Antonios
March 6, 2026

Objective: To develop a robust methodology for tracking soft-tissue regions during surgery, particularly addressing long-horizon occlusions, which are critical

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The proposed methodology enhances tissue tracking during surgery by integrating dense optical flow estimation with camera localization.
A self-supervised template matching method using contrastive learning is developed to improve tissue re-identification under occlusions.
The approach effectively mitigates localization drift without scene mapping, ensuring continuous tracking over long durations.
Validation of the method is conducted on the public SurgT benchmark and a synthetic dataset designed for long-horizon occlusions.
Existing tracking methods struggle with long-horizon occlusions, highlighting the significance of the proposed solution in surgical environments.

March 6, 2026

Pediatric shoulder instability: epidemiology, etiology, diagnosis and treatment

Paksoy, Alp
Moroder, Philipp
Akgün, Doruk
March 6, 2026

Objective: To provide an overview of shoulder instability in the pediatric population, including its epidemiology, causes, diagnosis, and management strategies.

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Shoulder instability is increasingly common in children and adolescents due to higher participation in competitive sports.
Pediatric shoulder dislocations are rare in children under 10, with significant risk increasing in those aged 14-18.
Diagnosis of shoulder instability relies on thorough history and physical examination, including specific provocative tests.
Imaging techniques like MRI and CT are crucial for assessing shoulder injuries, balancing benefits against radiation risks.
Conservative treatment is traditionally preferred for primary dislocations, but early surgical intervention may reduce recurrence.

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