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The Medicine Maker

May 14, 2026

Breaking the “Black Box” in Bioprocessing

May 14, 2026
10 min

Summary
Insight Report
Quiz

Objective: To discuss the importance of analytics in biopharma and the specific challenges faced in bioprocessing, particularly regarding the integration of new

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Frontiers In Oncology

May 14, 2026

Cancer patients’ insights and experience of palliative and supportive care in the UAE: a qualitative study

Khalifa Mohammad AlOlama
Salem Omar Alameri
Yasin Wissi
Waleed Mezher Alabdli
Hamad Hisham AlHammadi
Ahmed Gabr AlDhaheri
Mariam Ali AlNaqbi
Mahmoud Ahmed Elshafey
Nour Abushousha
Abdullah Humaid O. Al-Shamsi
Sarah Humaid O. Al-Shamsi
Mohammed Humaid O. Al-Shamsi
Ahmad Tariq Kalantar
Albesher Y.Alfoteih
Abdulrahman Mahmoud Basioni
Wessam Alkrad
Siddig Ibrahim Abdelwahab
Amal Al Balushi
Faryal Iqbal
Neil Arun Nijhawan
Humaid O. Al-Shamsi
May 14, 2026

Summary
Takeaways
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Poll
Clinical Scorecard

Objective: Consider emphasizing the significance of the study in the context of the UAE's healthcare landscape. Key Findings: Organize findings under the identi

The study highlights a general lack of awareness about palliative care among cancer patients in the UAE, often developing only after service engagement.
Participants faced challenges such as communication difficulties, language barriers, and limited access to care outside hospital settings.
Cultural beliefs and family dynamics significantly influenced decision-making regarding palliative care among patients and caregivers.
Insurance coverage was identified as a key factor facilitating access to palliative care services in the UAE.
The study emphasizes the need for improved public awareness and integration of palliative care within cancer services in the UAE.

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Frontiers In Medicine

May 14, 2026

Effectiveness of AI-enhanced virtual patients for psychiatric interview training in health professions education: a meta-analysis

Senay Kilincel
Furkan Bulut
Pelin Goksel
Mirac Baris Usta
Tuba Mutluer
Oguzhan Kilincel
May 14, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To systematically review and meta-analyze the impact of AI-enhanced virtual patients on psychiatric interview performance, knowledge acquisition, and

AI-enhanced virtual patient simulations improve psychiatric interview training in health professions education.
The systematic review included 10 studies with approximately 450 participants across various health professions.
Pooled analyses indicated significant improvements in interview performance, knowledge acquisition, and learner confidence.
Subgroup analysis showed positive educational outcomes for both student and clinician populations.
Further large-scale randomized controlled trials are needed to confirm the long-term impact of AI-supported training.

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Frontiers In Medicine

May 14, 2026

Impact of frailty on post-procedural adverse outcomes in older adults aged ≥75 years undergoing percutaneous coronary intervention: a systematic review of observational studies

Peng Tian
Liping Wang
Tianjiao He
Qiurong Zhang
Yingying Cai
May 14, 2026

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Clinical Scorecard

Objective: To evaluate the impact of frailty on major clinical outcomes, both short- and long-term, in patients aged ≥75 years undergoing percutaneous coronary

Frailty significantly increases the risk of in-hospital and all-cause mortality in patients aged ≥75 years undergoing PCI.
Frail patients aged ≥75 years have a higher incidence of complications, including bleeding and stroke, following PCI.
The systematic review included 18 cohort studies with over 2 million patients, highlighting the prevalence of frailty in elderly PCI patients.
The GRADE evidence quality for outcomes related to frailty and PCI was rated low, indicating uncertainty in the findings.
Findings support the need for perioperative risk stratification and individualized management in elderly patients undergoing PCI.

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Frontiers In Medicine

May 14, 2026

Fulminant cerebral edema in the setting of acute dengue fever after mechanical thrombectomy in a patient with massive stroke and severe hypoalbuminemia: a case report

Haiwen Huang
Ying Li
Yonglin Li
Zhihua Liu
Jiajing Hu
May 14, 2026

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Takeaways
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Objective: To present a unique case of malignant cerebral edema following mechanical thrombectomy in a patient with acute dengue fever and significant hypoalbum

A 61-year-old man with significant hypoalbuminemia experienced rapid cerebral edema following mechanical thrombectomy for a large vessel occlusion stroke.
Acute dengue fever and bacterial pneumonia were identified post-thrombectomy, contributing to systemic inflammatory response and worsening neurological status.
Cerebral edema escalated rapidly, with midline shift increasing from 4 mm to 11 mm, indicating malignant edema and risk of brain herniation.
The case highlights the interplay of systemic inflammatory stressors and blood-brain barrier susceptibility in post-reperfusion cerebral edema.
The patient's family declined further intervention, leading to discharge against medical advice and subsequent death during follow-up.

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Frontiers In Pediatrics

May 14, 2026

Experiences of children with obesity and their parents of participating in a physical activity on prescription intervention: a qualitative study

Elvira Lange
Katarina Lauruschkus
Stefan Lundqvist
Karin Melin
Susanne Bernhardsson
May 14, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To explore children's and parents’ experiences of the Physical Activity on Prescription (PAP) intervention, focusing on overall experiences, perceive

The study investigates children's and parents' experiences with the Physical Activity on Prescription (PAP) program for obesity management.
Participants reported that PAP is a supportive, person-centered intervention that integrates healthcare with everyday life and organized sports.
Key themes identified include motivation through monitoring, the importance of family engagement, and the need for tailored activities.
Barriers to participation in PAP included financial and practical challenges, which could limit engagement in physical activities.
Overall, individually adapted and family-inclusive PAP is deemed feasible and acceptable in Swedish pediatric obesity care.

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Frontiers In Pediatrics

May 14, 2026

Skin residual bilirubin volume: a physiologically informed framework for transcutaneous bilirubin interpretation in neonates

H. O. Amadi
May 14, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: Emphasize the significance of TcB–TSB discordance. Key Findings: Include implications of the RVP phenomenon. Interpretation: Mention potential clinic

Transcutaneous bilirubinometry (TcB) is a non-invasive method for managing neonatal jaundice in resource-limited settings.
Skin residual bilirubin volume (SRBV) explains the discordance between transcutaneous bilirubin levels (TBL) and total serum bilirubin (TSB).
TcB measurements can exceed TSB, particularly during phototherapy, due to persistent cutaneous bilirubin.
The study observed a reproducible 'Recovery Value Flip' phenomenon, indicating dynamic changes in bilirubin levels during treatment.
Incorporating SRBV into TcB interpretation enhances monitoring safety and reliability in neonatal care without laboratory access.

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Frontiers In Medicine

May 14, 2026

Oliceridine effectively attenuates fentanyl-induced cough during general anesthesia induction

Ru-Yi Xing
Wen-Yi Gong
Chen-Guang Li
Ilyar Mamtili
Shuang-Xiong Zhu
Wen-Jun Zhou
Bing-Xing Li
Jie Cao
Xiao-Fang Yue
Kun Fan
May 14, 2026

Summary
Takeaways
Quiz
Poll

Objective: To assess the prophylactic efficacy of oliceridine against fentanyl-induced cough (FIC) and characterize its peri-induction safety profile, highlight

Oliceridine significantly reduces the incidence of fentanyl-induced cough (FIC) during anesthesia induction compared to normal saline.
In the study, 0% of patients receiving oliceridine experienced FIC, while 58.33% in the saline group did (p < 0.001).
Cough severity in the saline group varied, with 17.86% classified as mild, 20.24% as moderate, and 20.24% as severe.
Vital signs remained stable with no significant changes between groups, indicating oliceridine's safety profile.
Oliceridine's use as a prophylactic agent during anesthesia induction offers a safe approach without increasing adverse risks.

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Frontiers In Psychiatry

May 14, 2026

Cortical high-threshold and low-activation characteristics in adolescent depression: a cross-age differential analysis

Jialin Gai
Duanwei Wang
Fengya Zhen
Tao Kong
Xiuqing Niu
Xianwei Che
Shengqiao Wang
Zhe Liu
Cuixia An
Xu Lin
May 14, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To elucidate the neural mechanisms underlying adolescent depression by examining the relationship between resting motor threshold (RMT), cortical act

Adolescent depression shows distinct neurophysiological features, particularly in resting motor threshold (RMT) and cortical activation.
The study involved 85 treatment-naive patients divided into three age groups: adolescents, young adults, and middle-aged individuals.
Adolescents had a significantly higher RMT and lower prefrontal oxyhemoglobin activation compared to other age groups.
A strong negative correlation exists between RMT and cortical activation, while a strong positive correlation is found between RMT and depression severity.
High RMT and low cortical activation in adolescents serve as neurobiological markers for depression severity, guiding tailored neuromodulation strategies.

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Frontiers In Pediatrics

May 14, 2026

Acquired external auditory canal stenosis: clinical characteristics, surgical strategies and prognostic analysis

CaiYun Meng
Ruosha Lai
WeiJing Wu
Shu Yang
May 14, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To explore the clinical characteristics, optimal surgical approaches, and prognostic factors of traumatic external auditory canal stenosis (EACS) spe

Acquired external auditory canal stenosis (EACS) is a significant cause of conductive hearing loss in both children and adults.
In children, EACS is primarily caused by prior ear surgeries, with a postoperative recurrence rate of 57%.
The temporoparietal fascial flap is the most commonly used graft in pediatric EACS surgeries, with 86% of patients receiving drug-eluting stents.
Adults with EACS exhibit a lower recurrence rate of 25% and diverse etiologies, including trauma and inflammation.
The study highlights the need for tailored surgical approaches and long-term follow-up to improve outcomes in pediatric EACS.

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Frontiers In Oncology

May 14, 2026

Chronic psychosocial stress: a role in breast cancer etiology?

Roar Fosse
Cathrine Behr
May 14, 2026

Summary
Insight Report
Quiz

Objective: To review epidemiological and preclinical studies on the role of chronic psychosocial stress in breast cancer development and metastasis, highlightin

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Obesity Surgery

May 14, 2026

Laparoscopic Transcystic Common Bile Duct Exploration for the Treatment of Choledocholithiasis Following Roux-en-Y Gastric Bypass

Eric D. Moyer
McKell Quattrone
Andrew J. Rothka
Elizabeth Sodomin
Eric M. Pauli
Joshua S. Winder
May 14, 2026

Summary
Quiz
Clinical Scorecard

Objective: To report institutional experience with laparoscopic transcystic common bile duct exploration (LTCBDE) for the treatment of choledocholithiasis in pa

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Frontiers In Cardiovascular Medicine

May 14, 2026

Atorvastatin and almonertinib-induced myopathy in a polypharmacy context: a case report

Jifang Zhou
Lixia Yu
Huimin Xu
May 14, 2026

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To report a case of myopathy potentially induced by the concurrent use of atorvastatin and almonertinib in an elderly patient, highlighting its signi

Statin-induced myopathy is a common adverse effect, especially when combined with CYP3A4 inhibitors like almonertinib.
An 89-year-old male patient developed myopathy after starting atorvastatin while on almonertinib, evidenced by elevated CK levels.
Discontinuation of atorvastatin and almonertinib led to normalization of the patient's CK levels.
Almonertinib is a moderately sensitive substrate of CYP3A4, increasing the risk of statin-related myopathy.
Alternative cholesterol-lowering medications like PCSK9 inhibitors should be considered for patients on almonertinib.

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Frontiers In Medicine

May 14, 2026

Stem cell-derived extracellular vesicles as immunomodulatory agents: targeting pathological crosstalk in systemic lupus erythematosus and multiple sclerosis

Lifei Yao
Qiong Li
Wei Peng
Aimeng Sun
Shaofen Li
Mengting Zou
Xianyun Xu
May 14, 2026

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To examine the immunomodulatory effects and mechanisms of stem cell-derived extracellular vesicles (SC-EVs) in systemic lupus erythematosus (SLE) and

Systemic lupus erythematosus (SLE) and multiple sclerosis (MS) share overlapping immunopathological features despite being distinct autoimmune diseases.
Stem cell-derived extracellular vesicles (SC-EVs) can modulate immune responses and deliver bioactive cargo, enhancing intercellular communication.
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have shown potential in preclinical studies to alleviate immune dysregulation in SLE and neuroinflammation in MS.
The review identifies the miR-146a-5p/miR-21-5p/hypoxia-inducible factor-1α (HIF-1α) axis as a key regulatory mechanism shared by both diseases.
Leveraging MSC-EVs as cell-free therapeutic agents may provide a novel approach to address the shared immune dysfunction in SLE and MS.

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Frontiers In Immunology

May 14, 2026

Antibody targeting of the TNF–TNFR2 axis to overcome tumor immune resistance

Xiaozhen Kang
Xiangmin Tong
Shibing Wang
May 14, 2026

Summary
Takeaways
Quiz
Poll

Objective: To explore the role of TNFR2 in tumor-enhancing inflammation and immune evasion, and to evaluate specific therapeutic strategies targeting the TNF-TN

TNFR2 primarily regulates tumor-enhancing inflammation and immunosuppression, contributing to immune evasion in the tumor microenvironment.
Targeting the TNF–TNFR2 pathway offers novel therapeutic strategies, including monoclonal antibodies and bispecific antibodies, to combat immune resistance.
TNFR1 induces cytotoxic signaling, while TNFR2 promotes survival and proliferation, highlighting the need for receptor-selective therapeutic approaches.
Challenges for clinical implementation of TNFR2-targeted therapies include on-target toxicity and the need for patient stratification.
Future strategies may involve biomarker-guided therapy and localized targeting to enhance the efficacy of TNFR2-focused treatments.

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Frontiers In Immunology

May 14, 2026

Infection-driven proliferative phase impairment in chronic wounds: a mechanistic framework for precision regenerative therapy

Qingmei Yang
Chuyu Liu
Qi Wang
Jing An
Yulan Cai
May 14, 2026

Summary
Takeaways
Quiz

Objective: To propose a mechanistic framework, termed Infection-Driven Proliferative Phase Impairment (IDPPI), explaining how microbial communities impair the p

Chronic wounds fail to heal due to infection-driven impairment of the proliferative phase, disrupting cellular expansion and tissue repair.
Wound-associated microbial communities establish pathogenic ecosystems that compromise host regenerative programs through virulence factors and biofilm persistence.
The proposed IDPPI framework reorders causality, emphasizing infection-driven blockade of proliferative repair as a primary failure mode in chronic wounds.
Targeted therapeutic strategies should focus on suppressing microbial virulence, restoring immune homeostasis, and promoting regeneration using advanced materials.
Advancements in multi-omics, biomimetic models, and real-time technologies can enable dynamic assessment and adaptive interventions in chronic wound management.

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Frontiers In Immunology

May 14, 2026

Redox-metabolic circuits as a central regulator of T cell-based immunotherapy

Sarah McPhedran
Tian Zhao
Julian J. Lum
May 14, 2026

Summary
Takeaways
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Quiz
Poll
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Objective: Emphasize the significance of interconnected roles in cancer immunotherapy. Key Findings: Include context on therapeutic implications of findings. In

T cell immunotherapies face challenges in solid tumors due to nutrient-poor and oxidative tumor microenvironments.
Reactive oxygen species (ROS) are crucial for T cell activation and function, but excessive ROS can lead to T cell exhaustion.
Methionine metabolism and the GCN2 pathway are interconnected regulators that influence T cell redox state and metabolic responses.
Therapeutic manipulation of methionine availability and ROS can produce variable outcomes in cancer immunotherapy.
Emerging strategies, including integrated omics and CRISPR screening, aim to enhance T cell therapies by modulating metabolic pathways.

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Frontiers In Psychiatry

May 14, 2026

Recognizing anxiety and depression in cancer patients based on speech and facial expressions

Na Xu
Tao Wu
Li Sun
Ping Xin
Xu Tan
Na Luo
Yi Liu
May 14, 2026

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Quiz
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Objective: To develop a multimodal fusion approach for the simultaneous and precise evaluation of anxiety and depression in cancer patients, addressing the sign

The study develops a multimodal fusion approach to assess anxiety and depression in cancer patients using speech and facial cues.
A speech-video dataset of cancer patients was utilized, achieving an F1 value of 0.85 for depression and 0.74 for anxiety recognition.
Current psychological assessments for cancer patients often rely on subjective methods, leading to underdiagnosis of anxiety and depression.
The multimodal framework leverages unstructured data to provide objective screening, addressing limitations of traditional assessment methods.
The findings support the use of digital biomarkers for noninvasive psychological status screening in cancer patients, enhancing routine care.

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