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The Pathologist

June 9, 2026

Pathologist Perspectives on PD-L1 CPS Scoring in Challenging Cases.

June 9, 2026
1 min

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To provide expert insights into CPS scoring in challenging cases across different indication types. Key Findings: Indication-specific staining charac

Dr. Georgios Deftereos provides expert insights on CPS scoring in challenging pathology cases.
The presentation covers indication-specific staining characteristics affecting CPS evaluation.
Scoring demonstrations are included to enhance understanding of CPS evaluation.
Tips for accurate and efficient evaluation of CPS scoring will be shared.
An interactive Q&A session will allow for discussion and clarification of concepts.

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Frontiers In Immunology

May 6, 2026

Editorial: Overcoming resistance to immune checkpoint inhibitors: mechanisms and strategies in cancer therapy

Margherita Piccinelli
Elio Gregory Pizzutilo
Maria Gemelli
Dhifaf Sarhan
Stefano Cavalieri
May 6, 2026

Summary
Takeaways
Insight Report
Quiz
Poll

Objective: Emphasize the clinical implications of understanding resistance mechanisms. Key Findings: ICIs show variable outcomes, with 20-40% of patients achiev

Immune checkpoint inhibitors (ICIs) enhance antitumor immunity by blocking CTLA-4 and PD-1/PD-L1 pathways exploited by tumors.
Resistance to ICIs can be primary or acquired, with 20-40% of patients achieving durable responses, leaving many without benefit.
Tumor microenvironment (TME) significantly influences immune responses, categorized as 'hot' or 'cold' based on immune infiltration.
Defects in antigen presentation and T-cell exhaustion are key mechanisms of resistance to immunotherapy, prompting combination strategies.
Cancer cachexia may alter Fcγ receptor expression, impacting ICI pharmacokinetics and contributing to poorer treatment outcomes.

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Frontiers In Immunology

May 6, 2026

Editorial: Beyond therapeutic innovation in genitourinary cancers: the unmet need for biologically driven patient selection

Brigida Anna Maiorano
Linda Cerbone
Carlo Messina
Pasquale Rescigno
Giandomenico Roviello
May 6, 2026

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To explore the role of specific biomarkers and biological determinants, including tissue-based and circulating biomarkers, in guiding clinical decisi

The therapeutic landscape of genitourinary cancers has transformed with new treatments, yet patient selection remains a challenge.
Biomarkers play a crucial role in predicting treatment response, but current options are heterogeneous and insufficient.
Tumor biology and microenvironment complexity significantly influence therapeutic outcomes in genitourinary malignancies.
Metabolic reprogramming and regulatory molecules like microRNAs are key factors in tumor progression and treatment sensitivity.
Future advancements depend on integrative models that combine multi-omics data and dynamic tumor characterization for better patient outcomes.

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Get a concise, at-a-glance scorecard that distills clinical guidelines into key recommendations, patient insights, and treatment considerations.

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Share your perspective with a quick, clinically relevant poll that captures real-world insights and clinician sentiment.

Obesity Surgery

May 6, 2026

The Efficacy of Transversus Abdominis Plane Blocks in Roux-en-Y Gastric Bypass – a Systematic Review and Meta-Analysis of Randomised Control Trials

Caroline Drumm
Matthew G. Davey
Shane Moore
Taya Keating
Noel E. Donlon
May 6, 2026

Summary
Takeaways
Insight Report
Poll
Clinical Scorecard

Objective: To evaluate the effectiveness of TAP blocks in patients undergoing RYGB surgery, focusing on postoperative pain scores at recovery, 6, 12, and 24 hou

Roux-en-Y gastric bypass (RYGB) is an effective bariatric surgery for weight loss and metabolic condition management.
Post-operative pain management is crucial in RYGB to prevent complications like respiratory issues and delayed recovery.
Transversus abdominis plane (TAP) blocks are regional anaesthetic techniques that may reduce post-operative pain and opioid use.
This study aims to evaluate the effectiveness of TAP blocks in RYGB through a systematic review and meta-analysis of randomized controlled trials.
Primary outcomes include post-operative pain scores and opioid requirements, assessed at various recovery time points.

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Frontiers In Immunology

May 6, 2026

Editorial: Lipid influence on lung immune-structural cell crosstalk: implications for respiratory health

Benoit Allard
May 6, 2026

Summary
Takeaways
Insight Report
Poll
Clinical Scorecard

Objective: Consider adding a statement on the significance of understanding lipid roles in respiratory health. Key Findings: Add implications for each finding t

Lipids play a crucial role in lung immune-structural cell interactions, influencing respiratory health and disease outcomes.
Pulmonary surfactant lipids regulate innate immunity and are involved in pathogen sensing and inflammation modulation.
Viral pneumonia is characterized by selective remodeling of lipid mediator networks, challenging the notion of a uniform 'lipid storm'.
Pseudomonas aeruginosa employs lipid-centered strategies for immune evasion and tissue damage, highlighting the need for lipid-targeted therapies.
Lower levels of lipoxin A4 are linked to severe COVID-19 outcomes, emphasizing the importance of resolution programs in respiratory pathology.

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May 6, 2026

Treatment Intensity in the Frontline Setting for Transplant-Ineligible Patients With Multiple Myeloma

Mark Davis
May 6, 2026
18 min

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To evaluate the impact of treatment intensity on outcomes for transplant-ineligible patients with multiple myeloma (MM), emphasizing its significance

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May 6, 2026

Building Bridges: The Impact of Medical Science Liaison and Advanced Practice Provider Collaborations

Katherine Albert
Kristina Byers
Chelsey Boggs
May 6, 2026
11 min

Summary
Takeaways
Insight Report
Quiz
Poll

Objective: To explore the collaboration between medical science liaisons (MSLs) and advanced practice providers (APPs) in enhancing cancer care through educatio

Collaboration between medical science liaisons (MSLs) and advanced practice providers (APPs) enhances cancer care through education and research.
MSLs provide tailored education and support clinical trials, enabling APPs to make informed decisions and improve patient outcomes.
The MSL role, established in 1967, has evolved to include clinical trial support and medical education, distinct from commercial sales.
MSLs operate in a non-promotional capacity, delivering unbiased, evidence-based information while adhering to compliance standards.
Effective MSL-APP partnerships focus on clinical research, medical education, and insight gathering, bridging scientific innovation and clinical application.

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May 6, 2026

Colorectal Cancer Treatment During Pregnancy

Kathryn L. Green
Rachel Hatch
May 6, 2026
17 min

Summary
Insight Report
Poll
Clinical Scorecard

Objective: To discuss the complexities of diagnosing and treating colorectal cancer (CRC) in pregnant patients, emphasizing the importance of a multidisciplinar

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Share your perspective with a quick, clinically relevant poll that captures real-world insights and clinician sentiment.

May 6, 2026

Advances in Hodgkin Lymphoma Treatment: Clinical Considerations for Managing Toxicities in Nivolumab-AVD Therapy

Maria D. Guerrero
May 6, 2026
13 min

Summary
Quiz

Objective: To evaluate the efficacy and safety of Nivolumab-AVD compared to BV-AVD in treating advanced-stage classical Hodgkin lymphoma (cHL). Key Findings: Ni

Get quick, clinically relevant Q&A that turns long-form articles into clear answers for faster learning and discovery.

May 6, 2026

Retrospective Characterization of Specialized Palliative Care in Patients With Gliomas

Sisse Josephine Rudkjøbing
Katrine Rahbek Schønnemann
Jesper Rahr Lauritsen
Bo Halle
Rikke Hedegaard Dahlrot
May 6, 2026
13 min

Summary
Quiz

Objective: To evaluate the referral patterns and characteristics of patients with gliomas receiving specialized palliative care (SPC) and assess the interdiscip

Get quick, clinically relevant Q&A that turns long-form articles into clear answers for faster learning and discovery.

May 6, 2026

Distress Screening in a Cancer Survivorship Clinic: Impact on Psychosocial Referrals

Heather Sloan
Sarah J. Jennings
Kristi Adair
Anne Stein
May 6, 2026
24 min

Summary
Quiz
Clinical Scorecard

Objective: To evaluate the impact of distress screening on psychosocial referrals for head and neck cancer survivors. Key Findings: Rephrase findings for clarit

Get a concise, at-a-glance scorecard that distills clinical guidelines into key recommendations, patient insights, and treatment considerations.

Get quick, clinically relevant Q&A that turns long-form articles into clear answers for faster learning and discovery.

May 5, 2026

Smartwatch May Track AD Status in Children

Andrea Surnit
May 5, 2026
3 min

Summary
Takeaways

A recent study examined the correlation between smartwatch-measured nighttime scratching and disease severity in pediatric patients with atopic dermatitis. The

Study assessed smartwatch-measured scratching in pediatrics.
Involved 50 subjects aged 4-15 with atopic dermatitis.
Metrics included scratch count, duration, and burden.
Moderate correlation with clinical severity and improvement observed.
The scratch burden index had strong predictive abilities.
Study highlights limitations including small sample size and lack of causal inference.
Further validation needed before clinical application.

May 5, 2026

GLP-1 Agents May Reduce Psoriasis Severity

Andrea Surnit
May 5, 2026
4 min

Summary
Takeaways

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may help reduce the severity of psoriasis in patients with metabolic conditions, according to a review fro

GLP-1 RAs may reduce psoriasis severity in metabolic patients.
Significant PASI score reductions observed (40%-80%).
Semaglutide showed 52% PASI reduction in a trial with diabetic patients.
Evidence from studies is inconsistent, citing small sample sizes.
Potential adverse effects include gastrointestinal issues and rare skin conditions.
Not approved for psoriasis; use is off-label.
Can be coadministered with common psoriasis medications.

May 5, 2026

CGM Shows Potential for Diagnosing Diabetes in Pregnancy

Andrea Surnit
May 5, 2026
3 min

Summary
Takeaways

Continuous glucose monitoring (CGM) shows promise in identifying gestational diabetes by capturing clinically relevant glucose patterns. However, a review finds

CGM may help identify gestational diabetes earlier.
Current evidence doesn't support CGM replacing OGTT as the diagnostic standard.
Higher glucose variability linked to adverse neonatal outcomes.
Validity of CGM as a diagnostic tool requires further research.
Many studies lacked the power to detect significant clinical outcomes.

May 5, 2026

ADA Member Advantage endorses HP for technology solutions

Mary Beth Versaci
May 5, 2026
2 min

Summary
Takeaways

The ADA Member Advantage has partnered with HP Inc. to provide its members with exclusive access to advanced technology solutions aimed at modernizing dental pr

ADA Member Advantage endorses HP Inc. for technology solutions.
Members can purchase computers and printers online.
The goal is to modernize dental practices.
The endorsement emphasizes reliability and security.
Allen Reavis, D.D.S., supports the initiative.
HP's Jon Klipstein backs the commitment to healthcare efficiency.
Available offers require registration on the HP member store.
Learn more at ADA.org/hp.

May 5, 2026

Medical Oddities: Brain Health, Sunny-Side Up

Teraya Smith
May 5, 2026
5 min

Summary
Takeaways

A comprehensive analysis from Loma Linda University's Adventist Health Study-2 indicates a significant inverse relationship between egg consumption and Alzheime

Loma Linda University study analyzes egg consumption and Alzheimer's.
40,000 adults followed for 15 years.
Egg intake linked to significantly lower Alzheimer’s risk.
Nutrients like choline and DHA support brain health.
Strong observational study with confirmed diagnoses despite limitations.

May 5, 2026

Low Follow-Up After Behavioral ED Care

Kathryn Wighton
May 5, 2026
5 min

Summary
Takeaways

A retrospective cohort study published in JAMA Network Open revealed alarming follow-up rates for primary care after emergency department (ED) visits for mental

Only 14% of mental health ED visits had primary care follow-up.
11% of substance use ED visits were followed by condition-concordant care.
Racial disparities exist in follow-up rates among Medicaid beneficiaries.
Higher comorbidity burden correlated with more follow-up.
Integrated managed care was introduced in Washington to enhance care coordination.
Study limitations include potential underestimation due to claims data.
Further outreach and coordination are needed to improve access and adherence.

May 5, 2026

AI Platform Linked to Modest Anxiety Improvements

Kathryn Wighton
May 5, 2026
5 min

Summary
Takeaways

A recent study involving 995 university students in Israel assessed the impact of a conversational AI platform on psychological distress. The 12-week randomized

Conversational AI platform reduced anxiety and improved well-being vs. group therapy.
Study involved 995 university students with psychological distress.
AI used techniques from cognitive behavioral therapy.
Modest changes were noted; attrition was significant.
Group therapy had no significant improvements in anxiety scores.

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