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European Radiology

  • August 22, 2026
Dynamic contrast-enhanced MRI for early evaluation of therapeutic response in pancreatic ductal adenocarcinoma
  • Martin D. Holland
  • Ezinwanne E. Onuoha
  • Darryl Outlaw
  • Mehmet Akce
  • Midhun Malla
  • Salila Hashmi
  • Sushanth Reddy
  • J. Bart Rose
  • Desiree E. Morgan
  • Grant R. Williams
  • Moh’d Khushman
  • Dana B. Cardin
  • Katherine Frederick-Dyer
  • Xiaoyu Jiang
  • Zarine K. Shah
  • Bassel El-Rayes
  • Junzhong Xu
  • Harrison Kim
  • August 22, 2026
  1. Pancreatic ductal adenocarcinoma (PDAC) has a low five-year survival rate of approximately 10% due to late diagnosis and limited treatment options.
  2. Dynamic contrast-enhanced MRI (DCE-MRI) may provide early evaluation of PDAC response to chemotherapy by quantifying tissue perfusion.
  3. A portable perfusion phantom (P4) was developed to correct inter- and intra-scanner variability in DCE-MRI measurements.
  4. In a preliminary study, P4-corrected DCE-MRI measurements differentiated responders from non-responders better than RECIST.
  5. The study aimed to validate the clinical utility of quantitative DCE-MRI for predicting early treatment response in PDAC at two institutions.
...more

World Journal Of Urology

  • August 22, 2026
Clinical Features, Treatment Approaches, and Survival Rates in Ductal Adenocarcinoma of the Prostate: A Retrospective Multicenter Study
  • A. Handke
  • P. Paffenholz
  • K. Schlack
  • K. E. Seifert
  • J. Linxweiler
  • J. Mink
  • F. Flockerzi
  • T. Nestler
  • M. Wenzel
  • C. Siech
  • C. Darr
  • V. Grünwald
  • F. Roghmann
  • K. H. Tully
  • August 22, 2026
  1. Prostatic ductal adenocarcinoma (PDA) is an aggressive subtype of prostate cancer with poorer prognosis compared to acinar adenocarcinoma.
  2. PDA is often diagnosed at advanced stages, correlating with higher ISUP grades, extraprostatic extension, and positive surgical margins.
  3. Lower serum PSA concentrations in PDA may contribute to underdiagnosis, despite its aggressive nature and high disease-specific mortality.
  4. The study enrolled 82 patients with histologically confirmed PDA from seven urological centers in Germany, focusing on oncologic outcomes.
  5. Overall survival for metastatic PDA is 72% at 5 years, with median survival reaching 77 months, highlighting its serious nature.
...more

Clinical Rheumatology

  • August 22, 2026
Correction: Electroacupuncture Slows the Advancement of Juvenile Collagen-Induced Arthritis Through Modulation of the NLRP3/NF-κB Signaling Pathway and Its Effects on Pyroptosis and Autophagy
  • Fater A. Khadour
  • Younes A. Khadour
  • Tao Xu
  • August 22, 2026

Objective: To correct specific figures in the original article regarding the effects of electroacupuncture on juvenile collagen-induced arthritis. Approach: Fig

...more
1 min

Bmc Cancer

  • August 22, 2026
Retraction Notice: Improved Antitumor Activity in Colon Cancer Utilizing EGF-Modified PLGA Nanoparticles Loaded with 5-Fluorouracil and Perfluorocarbon
  • Pingping Wu
  • Qing Zhou
  • Huayun Zhu
  • Yan Zhuang
  • Jun Bao
  • August 22, 2026
  1. The article titled 'Improved Antitumor Activity in Colon Cancer Utilizing EGF-Modified PLGA Nanoparticles Loaded with 5-Fluorouracil and Perfluorocarbon' has been retracted.
  2. The retraction was prompted by post-publication concerns regarding the integrity of the article's images.
  3. Similarities were noted between the fourth and sixth panels in the second row of Fig. 5A.
  4. The authors did not respond to the concerns raised by the Editors regarding the article.
  5. Due to the lack of response, the Editors lost confidence in the article's data and conclusions.
...more

Drugs - Real World Outcomes

  • August 22, 2026
Evaluation of Pain Management Efficacy Using Injectable Etoricoxib: Findings from the RAPID Study
  • Shiva Shankar Jha
  • Anoop Dhamangaonkar
  • Rajkumar Iyengar
  • Gautam Chakraverty
  • Kotini Saskar Rao
  • Abhijeet Mukherji
  • Sameer Muchhala
  • Vidhya Natarajan
  • August 22, 2026
  1. The RAPID study evaluated the efficacy of intramuscular etoricoxib 90 mg for acute pain management across 68 sites in India.
  2. Patients receiving intramuscular etoricoxib experienced significant pain reduction within 60 minutes, lasting up to 24 hours.
  3. Intramuscular etoricoxib was generally well tolerated, with few reported side effects, indicating its potential for acute pain management.
  4. The study aimed to assess pain intensity changes using the Numeric Pain Rating Scale and evaluate tolerability through adverse events.
  5. Etoricoxib's injectable formulation addresses the need for effective pain relief when oral medications are impractical or contraindicated.
...more

Lumendi

  • August 21, 2026
Ascending Colon HGD ESD Procedure with DiLumen C1 and IgE Grasper
  • August 21, 2026

Objective: To demonstrate the use of Lumendi’s DiLumen™ C1 overtube and IgE Grasper in enhancing the ESD procedure in the right colon. Approach: Procedure Demon

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MDSpire News

  • August 21, 2026
Study uncovers factors potentially associated with lower LUTS risk
  • Andrea Surnit
  • August 21, 2026
  • 4 min

Objective: To analyze factors associated with lower urinary tract symptoms (LUTS) in men, focusing on sexual behavior and other health-related factors. Approach

...more
1 min

MDSpire News

  • August 21, 2026
Sex-based differences in hip replacement outcomes
  • Andrea Surnit
  • August 21, 2026
  • 4 min

Objective: To investigate the influence of biological sex on postoperative outcomes following primary total hip arthroplasty (THA). Approach: Study Design: A re

...more

MDSpire News

  • August 21, 2026
Rheumatoid arthritis tied to birth outcomes
  • Kathryn Wighton
  • August 21, 2026
  • 4 min

Objective: To evaluate pregnancy outcomes in patients with rheumatoid arthritis (RA) compared to the general population. Approach: Study Design: A prospective m

...more
2 min

MDSpire News

  • August 21, 2026
Does kinematic alignment better restore gait in CPAK type 1 TKA?
  • Andrea Surnit
  • August 21, 2026
  • 5 min

Objective: To compare the effects of kinematic alignment (KA) and mechanical alignment (MA) on knee kinematics and patient-reported outcomes one year after tota

...more
2 min

MDSpire News

  • August 21, 2026
Prucalopride may enhance cognitive performance in remitted depression
  • Andrea Surnit
  • August 21, 2026
  • 4 min

Objective: To investigate the effects of prucalopride on cognitive performance in patients with remitted recurrent depression. Approach: Study Design: A randomi

...more
2 min

MDSpire News

  • August 21, 2026
IDSA updates guidance for antimicrobial-resistant gram-negative infections
  • Meg Barbor
  • August 21, 2026
  • 5 min

Objective: To provide updated guidance on treating antimicrobial-resistant gram-negative infections, incorporating newer therapies and evolving evidence. Approa

...more
2 min

The Pathologist

  • August 21, 2026
Why Healthcare Is Drowning in Data
  • Jessica Allerton
  • August 21, 2026
  • 5 min
  1. Healthcare systems generate vast amounts of diagnostic data, but clinicians struggle to access the right information at the point of care.
  2. Innovation often outpaces the systems needed to support it, creating a gap between potential and actual clinical practice.
  3. Fragmented diagnostic information across multiple systems complicates decision-making for clinicians, making it time-consuming.
  4. Collaboration among laboratories, clinicians, and IT teams is essential to embed actionable insights into clinical workflows.
  5. Pathologists and laboratory professionals are crucial for interpreting diagnostic information and shaping systems for data-driven care.
...more

The Pathologist

  • August 21, 2026
Can Portal Hypertension Testing Go Non-invasive?
  • August 21, 2026
  • 3 min

Objective: To evaluate non-invasive tests for identifying portal hypertension and determining the need for further testing. Approach: Review of Non-invasive Met

...more

The Ophthalmologist

  • August 21, 2026
Myopia Management with DIMS
  • Hakan Kaymak
  • Aldo Vagge
  • Stephanie Kearney
  • Cristina Álvarez Peregrina
  • Andrzej Grzybowski
  • August 21, 2026
  • 5 min
  1. Correction and control of myopia are distinct clinical acts, with axial length being central to modern myopia management.
  2. Second-generation spectacle lenses, like DIMS and H.A.L.T., aim for deliberate retinal signal design rather than just stronger optics.
  3. DIMS TED/MiYOSMART iQ shows retinal-topographic redistribution, while H.A.L.T. MAX focuses on dose-response optimization.
  4. Early clinical data indicate that MiYOSMART iQ significantly reduces axial elongation compared to single-vision spectacles.
  5. Key issues for second-generation lenses include durability, adaptation, visual performance, and the need for robust peer-reviewed data.
...more

The Ophthalmologist

  • August 21, 2026
Georgia Eye Partners Welcomes Glaucoma Specialist Dr. Cynthia Guerin
  • August 21, 2026
  • 2 min

Objective: To announce the addition of Dr. Cynthia M. Guerin to Georgia Eye Partners as a glaucoma specialist. Approach: Professional Background: Dr. Guerin is

...more

The Medicine Maker

  • August 21, 2026
What Pharma Can Learn From Military Intelligence
  • August 21, 2026
  • 6 min
  1. Tony Page transitioned from military intelligence to pharma, emphasizing the importance of structured intelligence approaches in product development.
  2. Page highlights that intelligence processes must be proactive and organized to support organizational strategy and decision-making.
  3. He stresses the need for companies to monitor their environment and anticipate potential obstacles during product development and launch.
  4. Page notes that many pharma companies fail to integrate intelligence effectively into planning, leading to reactive rather than proactive strategies.
  5. He warns that AI must be purpose-built for specific problems in pharma, rather than treated as a general productivity tool.
...more

Frontiers In Endocrinology

  • August 21, 2026
Transforming AI Insights into Practical Decision Support for Endocrine Disease Management
  • Tianqiang Wu
  • Wenpin Cai
  • Zhixiang Li
  • August 21, 2026

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