Objective: To assess whether baseline frailty modified semaglutide’s cardiovascular effects and other outcomes in adults with established cardiovascular disease
Objective: To compare hemostatic efficacy and safety of cold-stored platelets with conventional room-temperature platelets in patients undergoing complex cardia
In the phase 3 CHIPS trial, cold-stored platelets maintained noninferior hemostatic efficacy compared with room-temperature platelets in cardiac surgery patients.
Cold-stored platelets met the prespecified noninferiority criterion at every evaluated storage duration through 21 days, with posterior probabilities exceeding 99.9%.
Chest tube output at 24 hours did not differ significantly between groups, and longer cold-storage duration did not appear to affect output.
Reexploration for bleeding occurred in 4.2% of cold-stored platelet recipients and 1.8% of room-temperature platelet recipients, while cold-stored recipients received more blood products.
Exploratory safety analyses found no statistically significant between-group differences in thrombotic events, other reported adverse events, or 28-day mortality.
Objective: To assess whether daily peanut consumption affects brain insulin responsiveness and related metabolic measures in older adults. Approach: Design and
In a randomized crossover trial of 31 adults aged 60 to 75 years, participants consumed 60 g of unsalted, skin-roasted peanuts daily for 16 weeks and completed a 16-week control period.
Peanut consumption was associated with a lower insulin-induced cerebral blood flow response in one right-hemisphere cluster spanning parts of memory-related brain regions.
The regional blood flow changes were not significantly associated with previously reported improvements in verbal recognition memory.
Peanut consumption did not significantly affect global brain insulin responsiveness, liver fat, glucose homeostasis, cholesterol, or high-sensitivity C-reactive protein.
The small study used cerebral blood flow as an indirect measure of insulin-related neuronal activity and lacked an energy- and macronutrient-matched control.
Objective: To summarize the FDA approval of satralizumab-mwge for thyroid eye disease, the supporting phase 3 trial results, and relevant dosing and safety info
The FDA approved satralizumab-mwge (Enspryng) for adults with thyroid eye disease, making it the first approved at-home subcutaneous treatment for the condition.
Patients or trained caregivers can administer satralizumab-mwge, with injections at weeks 0, 2, and 4 followed by maintenance dosing every 4 weeks.
In SatraGO-2, proptosis response at week 24 occurred in 52.9% of satralizumab-treated patients and 23.4% of placebo recipients; the trial met its primary end point.
SatraGO-1 did not meet its primary end point; proptosis response occurred in 49.0% of satralizumab-treated patients and 31.2% of placebo recipients.
Prescribing information calls for screening for hepatitis B and tuberculosis and monitoring for infection, elevated liver enzymes, and reduced neutrophil counts.
Objective: To develop and evaluate a method for predicting liquid chromatography retention times across different experimental systems. Approach: Two-step predi
The 2-step method predicts compound elution order first, then converts that order into retention times for a specific laboratory method.
Its graph neural network uses molecular structure, column information, and mobile-phase pH to predict retention order.
A polynomial calibration uses confidently identified compounds as anchors; the researchers found that as few as 15 anchors could be sufficient.
Across 171 reversed-phase chromatography datasets, the condition-aware model had a retention-order error rate of 4.89%, versus 5.61% without condition information.
The method supported compound annotations in human fecal samples but is limited to reversed-phase chromatography and depends on accurate metadata and anchor identifications.
Objective: The video interview covers Nucleome Therapeutics’ use of Micro Capture-C to reconstruct DNA’s three-dimensional architecture and identify causal dise
Objective: The article examines the objective, findings, and clinical context described in What Can Skin Reveal About Dementia?. Approach: Clinical context: Tod
Overlapping symptoms and mixed pathologies can make clinical presentation alone insufficient to distinguish Alzheimer’s disease from dementia with Lewy bodies and other dementias.
Skin biopsy testing detects cutaneous phosphorylated alpha-synuclein, a protein associated with synucleinopathies, including Lewy body disease.
In the Syn-D study, cutaneous phosphorylated alpha-synuclein was detected in participants with mild cognitive impairment associated with suspected dementia with Lewy bodies.
A 6-month study of patients with dementia with Lewy bodies estimated an approximately 52% annualized increase in cutaneous phosphorylated alpha-synuclein from baseline.
Some Syn-D participants had both cutaneous phosphorylated alpha-synuclein and abnormal phosphorylated tau 217 findings, suggesting coexisting Lewy body and Alzheimer disease pathologies.
Objective: Review how the biology of cell-free fetal DNA (cffDNA) may limit noninvasive prenatal testing (NIPT) and identify research directions that could impr
Noninvasive prenatal testing screens for fetal genetic abnormalities from maternal blood from about 10 weeks’ gestation, but positive results require invasive confirmation.
The review identifies low fetal fraction, difficulty distinguishing fetal from maternal DNA, and differences between placental and fetal genotypes as key limitations.
Most circulating cell-free fetal DNA is about 143 base pairs long, but circular, ultrashort, and much longer fragments have also been identified.
The mechanisms by which cell-free fetal DNA enters and circulates in maternal blood remain unresolved, and direct evidence for release in apoptotic extracellular vesicles is lacking.
The authors call for research on DNA origin and particle association, which could inform fetal DNA enrichment methods and support more reliable diagnostic applications.
Objective: The article examines the objective, findings, and clinical context described in Musings from The Power List: Adrián de la Fuente Ballesteros. Approac
Adrián de la Fuente Ballesteros develops and validates greener, more sustainable analytical methods to detect contaminants and bioactive compounds in food and environmental samples.
He says analytical methods must be economically affordable while addressing emerging contaminants and keeping pace with new technologies.
He argues that affordable methods, open-source tools, citizen science, and open knowledge are important to making analytical science more inclusive.
He identifies delayed method validation, reference materials, and regulation, along with funding and research-to-practice transfer, as challenges for analytical science.
International collaborations, teaching, and science communication have shaped his career and his perspective on unequal access to research resources.
Objective: The article examines the objective, findings, and clinical context described in Enhancing Primary Care Through the WHO Basic Package of Rehabilitatio
Primary care is a key setting for rehabilitation, but services are often poorly integrated, particularly in low- and middle-income countries.
The WHO developed the Basic Package of Interventions for Rehabilitation to expand access where rehabilitation specialists are scarce or unavailable.
The toolkit is designed for primary care personnel without rehabilitation training and includes an intervention list, clinical resource, and implementation guide.
The Basic Package prioritizes interventions intended to be safe, evidence-based, and easy to learn, with a decision-tree format supporting clinical decisions.
The article describes a participatory, three-phase process used to develop the intervention list and clinical resource.
Objective: To characterize outcomes after spine SBRT in adults aged 70 years or older and identify predictors of local failure and vertebral compression fractur
This retrospective study evaluated SBRT outcomes in 161 patients aged 70 years or older with 208 spinal metastases treated at one center from 2002 to 2024.
SBRT was delivered alone or with decompression and stabilization, with treatment selection individualized according to neurologic findings, epidural disease, spinal stability, and other clinical facto
The study assessed local failure, vertebral compression fracture, pain response, and radiation toxicity using clinical follow-up and imaging.
Local failure required radiographic progression at the treated level, assessed by a neurosurgeon or neuroradiologist and confirmed on subsequent imaging.
Vertebral compression fracture included a new fracture or progression of a pre-existing fracture at any treated level after SBRT, regardless of attribution.
Objective: To map published research on climate-related effects in general surgery, identify knowledge gaps, and establish research priorities. Approach: Search
Healthcare accounts for approximately 8.5% of US greenhouse gas emissions, and operating rooms are especially energy- and resource-intensive.
This scoping review mapped peer-reviewed research on climate change and general surgery, including surgical oncology, acute care, trauma, and burn surgery.
The review followed PRISMA-ScR guidance and searched four databases on August 29, 2025, without search filters or limiters.
Of 6,678 citations identified, 28 articles met the review’s inclusion criteria after screening and duplicate removal.
Because study objectives and outcomes were heterogeneous, the authors synthesized the included literature thematically rather than quantitatively.
Objective: Report a correction to Dr S. O. Onal’s affiliation in a published Original Investigation. Approach: Correction: The affiliation was incorrect in “Cli
An affiliation for Dr S. O. Onal was incorrect in the Original Investigation “Clinical Digital Health Engagement and Psychological Distress Among Adults.”.
The Original Investigation was published on July 16, 2026.
The article has since been corrected.
The correction concerns Dr S. O. Onal’s affiliation.
The context does not specify the incorrect or corrected affiliation.
Objective: To describe a large community-based digital program delivering GLP-1 receptor agonist (GLP-1RA) treatment to women and assess treatment outcomes over
The digital-first program prescribed and dispatched GLP-1 receptor agonist therapy to 8,127 adult women recruited from a community population.
The remote care model included monthly questionnaires, weekly live-video check-ins, supervised weight and medication verification, and clinician-led dose titration.
Participants were aged 18 to 79 years, had a mean baseline weight of 104.2 kg and BMI of 38.2, and 95.5% had obesity.
At 6 months, 7,297 participants (89.8%) provided weight measurements and 6,466 (79.6%) completed repeat biochemical assessment.
The study examined treatment response by age, starting weight, socioeconomic position, and ethnicity in a large real-world cohort of women.
Objective: The episode highlights practical nutrition, physical fitness, and affordable cooking for first responders and families. Approach: Episode content: Se
Objective: To compare the efficacy and safety of surgical gastrojejunostomy (S-GJ), endoscopic stenting (ES), and EUS-guided gastroenterostomy (EUS-GE) for pall
Malignant gastric outlet obstruction causes nausea, vomiting, poor oral intake, malnutrition, and reduced quality of life in patients with advanced malignancies.
Palliative options include surgical gastrojejunostomy, endoscopic stenting, and EUS-guided gastroenterostomy, each with trade-offs in durability, morbidity, and recovery.
The Bayesian network meta-analysis compared clinical success and reintervention, with adverse events, 30-day mortality, oral intake timing, hospital stay, and survival as secondary outcomes.
The analysis included 15 studies—7 randomized trials and 8 cohort studies—with 827 patients and evidence spanning all three treatment comparisons.
The primary network combined randomized and eligible comparative cohort evidence, with randomized-trial-only sensitivity analyses and study-design subgroup analyses assessing robustness.
Objective: To commemorate Professor Paolo Pederzoli’s contributions to pancreatic surgery, research, education, and patient care. Approach: Multidisciplinary ca
Paolo Pederzoli helped establish a multidisciplinary approach to pancreatic disease in Verona during the 1990s.
From 2002 to 2011, he led Italy’s first hospital unit devoted exclusively to pancreatic diseases and helped establish the Verona pancreatic school.
His research addressed pancreatic fistulas, acute necrotizing pancreatitis, pancreatic cancer surgery, lymphadenectomy, and genomic research.
As president of the Italian Foundation for Research in Pancreatology, he secured funding for research projects and young investigators.
Colleagues remembered Pederzoli as a teacher who guided trainees while fostering responsibility, and as a physician who stayed closely engaged with patients.
The pilot trial tested whether adding amygdala neurofeedback to residential dialectical behavior therapy reduced affective instability in borderline personality disorder.
Participants were recruited after 6 weeks of a 12-week residential dialectical behavior therapy program and had Borderline Symptom List–23 scores of at least 1.5.
Participants assigned to neurofeedback completed three sessions, each comprising two training runs.
The study included a treatment-as-usual control arm and assessments at baseline, immediately after treatment, and 3 months; self-report follow-up also occurred at 6 months.
Daily-life negative affect instability measured by ecological momentary assessment was the primary endpoint, while self-report and neural outcomes were secondary endpoints.