Mohamed Abdelmonem and Marion Carrillo preview 2 interactive round tables at the ASCP Annual Meeting in November in Montréal.
One round table will discuss how ASCP can make global membership more valuable, accessible, and relevant to international members.
Speakers cite finances, education access, language, technology, professional recognition, local regulations, and health care system differences as participation barriers.
The mentorship discussion will address cultural responsiveness, language, professional expectations, career pathways, and differences in laboratory medicine across countries.
The sessions will use discussion, real-world examples, audience polling, and open dialogue to identify challenges and develop practical solutions.
Objective: To identify blood metabolites associated with future cardiac disease progression in people with chronic Chagas disease. Approach: Study samples: Rese
Chagas disease can remain asymptomatic for decades, but 20% to 30% of chronically infected people develop clinically significant cardiac disease.
Researchers analyzed stored serum samples from 72 patients with chronic Chagas disease in Bolivia using liquid chromatography–mass spectrometry.
Among patients initially without cardiac involvement, 15 developed more advanced disease during follow-up, while 48 remained stable.
Eight metabolites were associated with future progression, and 10 of 45 candidate biomarker panels achieved at least 60% sensitivity and 90% specificity.
The biomarkers require validation in larger, geographically diverse studies, standardized testing methods, and evidence of clinical utility before routine use.
Researchers coated a three-dimensional nanotubular copper current collector with an approximately 10-nm layer of Ti₃C₂Tₓ MXene for anode-free lithium-metal batteries.
The MXene coating interacted with electrolyte hexafluorophosphate anions and promoted uniform lithium nucleation and a lithium fluoride-rich solid-electrolyte interphase.
X-ray photoelectron spectroscopy, time-of-flight secondary ion mass spectrometry, and transmission electron microscopy characterized the interface and showed lithium fluoride nanoparticles along the M
In lean-electrolyte coin cells with NCM811 cathodes, modified collectors retained 78.1 mAh/g at cycle 125, compared with 44.9 mAh/g for unmodified copper.
At cycle 125, Coulombic efficiency was 99.06% with the modified collector and 95.01% with unmodified copper; larger-format testing remains necessary to assess commercial performance.
Objective: Assess whether atmospheric pressure solids analysis probe mass spectrometry (ASAP-MS) can rapidly screen surfaces for illicit drug residues, compared
Researchers collected 420 surface swabs over 3 weeks from bathrooms, tables, and a bar in an anonymous pub in southern England.
Confirmatory LC-MS detected cocaine in 250 swabs and ketamine in 70; 64 swabs contained both substances.
Direct, untargeted ASAP-MS rapidly screened swabs but mainly detected samples with relatively high cocaine levels and missed many residues found by LC-MS.
Methanol extraction with targeted ASAP-MS increased sensitivity, but the method still missed 59.51% of cocaine-positive and 88.57% of ketamine-positive samples identified by LC-MS.
ASAP-MS produced 15 false-positive results, including apparent ketamine signals linked to procaine, and the researchers said further optimization is needed before routine on-site screening.
Objective: To estimate how often adults with likely long COVID improve or achieve complete symptom resolution over time. Approach: Study design: Prospective obs
In the RECOVER-Adult cohort, 50% of adults with likely long COVID at 12 months had sustained improvement by 36 months.
Complete symptom resolution was estimated in 15% of participants by 24 months and 27% by 36 months.
By 36 months, sustained improvement ranged from 60% among participants with smell or taste disturbances to 19% among those with multisystem symptoms.
Improvement probabilities were higher among participants infected during the Omicron period than among those infected before Omicron, and were similar by sex.
The observational study could not establish causality, and its primary outcome reflected improvement below the likely long COVID threshold rather than complete recovery.
Objective: To assess whether adding fusion to decompression improves 12-month outcomes for patients with degenerative lumbar spondylolisthesis and whether patie
This cohort study included 2,252 patients with degenerative lumbar spondylolisthesis treated with decompression alone or decompression with fusion.
At 12 months, the study found no clear differences between procedures in disability, pain, quality of life, treatment satisfaction, or subsequent spine surgery.
Prespecified patient characteristics, including age, sex, smoking status, BMI, back pain intensity, and ASA grade, did not clearly modify comparative treatment effects.
Decompression alone was associated with fewer perioperative complications, operations about 85 minutes shorter, and hospital stays 1.9 days shorter than fusion.
An exploratory post hoc analysis found worse disability outcomes with fusion among men with BMI of at least 30 kg/m², a finding requiring further investigation.
Objective: To assess whether rosacea is associated with subsequent irritable bowel syndrome (IBS), and whether IBS is associated with subsequent rosacea. Approa
In a Korean population-based cohort, patients with rosacea had a 30% higher adjusted hazard of subsequently developing IBS than matched controls.
Patients with IBS had a 61% higher adjusted hazard of subsequently developing rosacea, although the absolute incidence of rosacea remained low.
The study included 712,331 adults and used matched cohorts and Cox models adjusted for sociodemographic factors and comorbidities.
Bidirectional associations persisted in sensitivity analyses adjusting for isotretinoin, doxycycline, and minocycline exposure, but estimates were attenuated.
The observational study could not establish causality, and administrative diagnoses, missing lifestyle and microbiome data, and health care use may have affected estimates.
Objective: The article examines the objective, findings, and clinical context described in FDA tentatively approves generic lenacapavir. Approach: Regulatory st
The FDA tentatively approved Dr. Reddy’s generic lenacapavir injection for HIV pre-exposure prophylaxis in adults and adolescents weighing at least 35 kg.
Tentative approval does not permit US marketing while applicable patent protections remain in effect, but may accelerate regulatory reviews in 120 participating low- and middle-income countries.
Under the partnership agreement, the injectable formulation is priced at $40 per person annually, and the required initial oral loading course costs up to $17.
In PURPOSE 1 and PURPOSE 2, twice-yearly lenacapavir reduced HIV incidence by 96% versus estimated background incidence and by 89% versus daily oral PrEP.
The efficacy findings concern Gilead’s original formulation, not a separate trial of the generic; lenacapavir labeling warns of resistance with undiagnosed HIV and requires testing before initiation a
Objective: The article examines the objective, findings, and clinical context described in Can Immunopeptidomics Redefine Cancer Immunotherapy Development?. App
Immunopeptidomics uses liquid chromatography-tandem mass spectrometry to profile antigenic peptides displayed by major histocompatibility complex molecules.
In pancreatic ductal adenocarcinoma, immunopeptidomics can help identify tumor-specific and T-cell targets, including spliced, modified, and cryptic peptides.
Immunopeptidomics workflows combine immunoaffinity purification, high-resolution mass spectrometry, and bioinformatics to characterize diverse HLA-bound peptides.
Data-dependent acquisition provides high-confidence fragmentation spectra, whereas data-independent acquisition supports broad coverage and reproducibility across replicates.
Electron-activated dissociation can resolve peptide isomers and labile modifications, while targeted methods such as multiple reaction monitoring can validate and quantify selected antigens.
Objective: The article examines the objective, findings, and clinical context described in BMS Details Patient Death in Zola-Cel Multiple Sclerosis Trial. Appro
A patient with highly active relapsing multiple sclerosis died 44 days after receiving zola-cel in a Phase I trial.
The patient developed delayed motor symptoms that BMS did not classify as ICANS; symptoms persisted despite corticosteroids and intravenous immunoglobulin.
After high-dose cyclophosphamide, the patient developed septic pneumonia and died the following day; BMS reported no other deaths among 190 patients treated in autoimmune-disease studies.
In Breakfree-2, cytokine release syndrome occurred in 28 of 66 participants, and five developed ICANS, including one grade 4 event that resolved within four days.
Among seven evaluable participants with highly active relapsing MS and at least 26 weeks of follow-up, six had no relapses, disability progression, or new MRI activity.
Objective: Present a case of severe, PCR-confirmed leptospirosis in a homeless man and discuss the disease’s urban epidemiology in relation to climate condition
Leptospirosis is usually acquired through soil or water contaminated by infected-animal urine, with rodents serving as the principal reservoir.
Approximately 5% to 10% of infections progress to severe multisystem disease, including jaundice and acute kidney injury, with reported mortality of 5% to 15%.
New York City locally acquired cases rose from about 3 annually during 2001–2020 to 15 in each of 2021 and 2022, and 24 in 2023.
Heavy precipitation, flooding, inadequate drainage, and warmer, wetter conditions may increase urban exposure by spreading Leptospira and prolonging its environmental survival.
Housing instability, neighborhood disinvestment, inadequate sanitation, and rodent burden contribute to disproportionate leptospirosis risk among socioeconomically disadvantaged people.
Objective: To review the clinical relevance of ESR1 mutations and the role of digital PCR in high-sensitivity ctDNA analysis for metastatic breast cancer. Appro
Objective: The article examines the objective, findings, and clinical context described in FDA approves HPV immunotherapy for RRP. Approach: Approval: The FDA g
The FDA granted accelerated approval to Voceryq to reduce surgical papilloma excisions in adults with recurrent respiratory papillomatosis.
Voceryq is the first plasmid DNA-based immunotherapy approved in the United States and targets HPV types 6 and 11.
Approval was supported by an open-label, single-arm phase 1/2 study of 32 adults, without a concurrent control group.
Among 26 patients who had required at least 3 surgeries before treatment, 7 had no excisions during the following 12 months.
The FDA label recommends 4 intramuscular doses 3 weeks apart after surgical removal of visible papillomas, administered by a trained health care professional.
Objective: Compare corneal structure and endothelial characteristics in young adults with more than 10 years of childhood daily disposable hydrogel contact lens
In a cross-sectional study, 42 young adults who had worn daily disposable omafilconA hydrogel lenses since childhood were compared with age-matched nonwearers.
After an average of 11 years of lens wear, corneal epithelial and stromal thickness did not differ significantly between groups across the measured regions.
Endothelial cell density and hexagonality were comparable between groups, but cell-size variation was significantly greater in the superior and superonasal regions among lens wearers.
Researchers reported no ocular adverse events among contact lens wearers during the preceding 10 years.
The cross-sectional design, small sample, limited measurement area, and use of one lens type and replacement schedule limit the study’s generalizability.
In the RESTORE-RA trial, structured tapering of biologic or targeted synthetic DMARDs was noninferior to standard dosing for maintaining low disease activity at 24 weeks.
Low disease activity was maintained by 88.2% of patients assigned to tapering and 89.6% assigned to continued treatment in the per-protocol analysis.
Some secondary disease activity measures favored continued treatment, although patient-reported disease activity and quality-of-life measures did not differ significantly.
Among 23 tapering-group patients who lost low disease activity by week 12, 17 regained it by week 24 after treatment reescalation.
Exploratory analyses found lower low-disease-activity maintenance with tapered JAK inhibitors than with continued JAK inhibitors, but were not powered to establish drug-class noninferiority.