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MDSpire is an innovative platform aiming to create a smarter, faster, and more connected medical community.

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February 23, 2026

FDA Approves New Option in Obesity

Kathryn Wighton
February 23, 2026
3 min

The Allurion Gastric Balloon System, recently approved by the FDA, is a swallowable device aimed at assisting weight loss in adults aged 22 to 65 years with obe

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FDA approved the Allurion Gastric Balloon System.
Designed for adults 22-65 with obesity.
Administered in a 15-minute office visit.
Remains in stomach for about 4 months.
Can have up to 2 balloons in a 10-month period.
Alternative to surgery and glucagon-like peptide-1s.
Demonstrated safety and efficacy in real-world conditions.

February 23, 2026

DiLumen C1 Instructional Video

February 23, 2026

The DiLumen C1 Instructional Video offers a comprehensive guide on the preparation of the device for procedural use. It covers necessary steps that surgeons and

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- The DiLumen C1 is a medical device. - The instructional video provides step-by-step guidance. - Preparation is critical for effective procedures. - Aimed primarily at surgeons and technicians. - Enhances clinical workflow and efficiency. - Focuses on device functionality during medical use.

February 23, 2026

Telesurgery Matches Local Surgery in RCT

Doug Brunk
February 23, 2026
3 min

A multicenter randomized clinical trial conducted by Ye Wang, MD, and colleagues in China demonstrated that telesurgery for urologic procedures is as effective

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Telesurgery proved noninferior to local robotic surgery in urologic cases.
Trial involved 72 patients across five Chinese hospitals.
Surgical success rates: 100% for telesurgery, 94% for local surgery.
Median operative times were similar: 152 mins (telesurgery) vs 135 mins (local).
Monitoring showed stable system performance over distances up to 2800 km.
Limitations included small sample size and absence of prior randomized data.
The study was funded by multiple research grants.

February 23, 2026

Rapunzel Syndrome Masks Weight Loss

Kathryn Wighton
February 23, 2026
2 min

A 10-year-old girl experienced 8 months of progressive weight loss and intermittent abdominal pain, leading to a diagnosis of Rapunzel syndrome, a rare form of

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10-year-old girl with 8 months of weight loss and abdominal pain.
Initial ultrasound was inconclusive.
Magnetic resonance enterography diagnosed a trichobezoar.
Surgical intervention confirmed Rapunzel syndrome.
Composed of hair/vegetable fibers; risk of obstruction/perforation if untreated.
ADHD contributed to diagnosis delay.
Post-op recovery involved dietary supervision and behavioral therapy.
Follow-up showed weight improvement and symptom resolution.

February 23, 2026

Digital Resilience Training Reduces PTSD Risk

Henry Thomas
February 23, 2026
3 min

A study led by Jennifer Wild, DClinPsy, at the University of Oxford revealed that early-career paramedics who underwent an online cognitive resilience training

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Early-career paramedics benefited from cognitive resilience training.
iCT-R significantly reduced PTSD and MDD.
The study included 570 participants from 15 UK universities.
The training program lasted 6 weeks with follow-up practices.
Targeted cognitive risk factors were key to effectiveness.
Findings support the need for improved mental health interventions for first responders.
Future studies will assess long-term effects at 2 years.

The Medicine Maker

February 23, 2026

Building an Integrated Discovery Engine

February 23, 2026
5 min

Concept Life Sciences, led by newly appointed Chief Scientific Officer Adam Davenport, focuses on enhancing drug discovery through integrated decision-making an

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Adam Davenport appointed CSO in January
Focus on integrated drug discovery and early decision-making.
Spatial biology enhances target validation and reduces risk.
Emphasis on neuroscience amidst high unmet needs.
Advanced modalities include peptides and antibody-drug conjugates.
AI and machine learning facilitate data analysis.
Integrated approach improves capital efficiency and accelerates timelines.

February 23, 2026

Lifestyle Interventions vs Gestational Diabetes

Kathryn Wighton
February 23, 2026
4 min

A recent meta-analysis demonstrates that physical activity-based lifestyle interventions are the most effective in reducing gestational diabetes among pregnant

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Physical activity-based interventions ranked highest in reducing gestational diabetes.
The study analyzed 104 trials involving 35,993 pregnant women.
IPD analyses showed a 10% reduction in gestational diabetes risk.
Group delivery improves intervention effectiveness.
Educational inequalities impact intervention benefits.
Study limitations include incomplete IPD and trial diversity.
The research was supported by multiple health organizations.

The Medicine Maker

February 23, 2026

Cirena Launches High-Purity Long RNA to Accelerate CRISPR and Genome-Editing Research

February 23, 2026
2 min

Cirena, based in Boulder, Colorado, has officially launched its services after successfully providing high-quality long RNA to research teams in the US, Europe,

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Cirena launches long RNA services in Boulder, CO.
Focus on enhancing CRISPR and prime editing efficiency.
Allows for rapid, quality production of long RNA.
Aims to reduce delays in RNA delivery.
Supports various research domains including oncology and vaccine development.

February 23, 2026

Sleep Disruption and Osteoarthritis Risk

Kathryn Wighton
February 23, 2026
3 min

Research indicates that insufficient sleep, specifically less than 6 hours per night, significantly increases the risk of knee osteoarthritis (OA) by over 40%.

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Sleeping less than 6 hours increases knee OA risk by 41%.
Persistent insomnia also raises OA risk significantly.
Study involved 502,363 UK Biobank participants.
Night shift work correlated with higher OA risk.
Research indicates potential preventive lifestyle changes.
Results adjusted for various demographic and occupational factors.
Limitations include reliance on self-reported data and cohort diversity.

February 23, 2026

Hypertension: Biomarkers Clarify Heart Failure Risk

Kathryn Wighton
February 23, 2026
4 min

Hypertensive adults with both prediabetes and subclinical myocardial injury or stress face over a fivefold increased risk of incident heart failure compared to

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Hypertensive adults with prediabetes and myocardial injury have a 4.20-fold risk of heart failure.
Biomarkers: hs-cTnI ≥6 ng/L (men), ≥4 ng/L (women), NT-proBNP ≥125 pg/mL.
Study based on 8,234 participants.
Key findings: Prediabetes without myocardial injury shows no excess risk.
Observational study design limits causal conclusions.
Follow-up median: 3.2 years, resulting in 122 heart failure events.
Importance of biomarker monitoring emphasized.

The Pathologist

February 23, 2026

Dissecting Standards

Arianna Rubinetti
February 23, 2026
5 min

In anatomic pathology, the accuracy of gross examinations is crucial, directly affecting diagnoses, tumor staging, and patient management. The introduction of l

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Licensure ensures training and accountability for pathologists’ assistants.
Improper gross examination can lead to legal issues for pathologists.
Pathologists' assistants must complete a NAACLS-accredited master's program.
The projected decline in the pathology workforce necessitates licensed PAs.
Licensing aligns PAs with regulated healthcare professionals to enhance patient safety.

The Pathologist

February 23, 2026

Why Does Ovarian Cancer Spread So Fast?

February 23, 2026
2 min

Recent research published in Science Advances reveals a significant mechanism by which epithelial ovarian cancer (EOC) spreads aggressively within the abdomen.

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EOC cells in ascites exist mainly as compact spheroids.
These spheroids often include mesothelial cells.
Mesothelial cells aid in cancer tissue invasion.
Presence of malignant cells is linked to shorter progression-free survival.
Ascites is an active environment promoting metastasis.
Potential therapeutic target: disrupt cancer-mesothelial interactions.
Evaluate both malignant and nonmalignant cells for disease progression.

The Analytical Scientist

February 23, 2026

PFAS Bioaccumulation: The Biology of Forever

February 23, 2026
20 min

Carrie McDonough, an Associate Professor of Chemistry at Carnegie Mellon University, emphasizes the need for new risk assessment models for PFAS due to their un

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PFAS interact uniquely with proteins and phospholipids.
Traditional risk assessment models for persistent organic pollutants are inadequate for PFAS.
Research focuses on bioaccumulation and exposure from drinking water.
Unidentified organofluorine compounds pose analysis challenges.
Long-term exposure assessment is crucial for evaluating health impacts.
Advanced analytical techniques, especially high-resolution mass spectrometry, are necessary.
The transformation of PFAS precursors into persistent compounds complicates risk understanding.

The Ophthalmologist

February 23, 2026

Resveratrol and Diabetic Retinopathy

February 23, 2026
3 min

Recent advancements in diabetic retinopathy (DR) treatments focus on reactive therapy, notably anti-VEGF injections and laser photocoagulation. However, these m

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Diabetic retinopathy treatments are mainly reactive.
Resveratrol is identified as a potential multi-target modulator for early DR.
It influences mitochondrial health, inflammatory signaling, and neuroglial behavior.
Resveratrol has shown protective effects on retinal structure in preclinical studies.
Its anti-inflammatory properties involve suppression of multiple mediators.
Current evidence for resveratrol is preclinical and not yet suitable for clinical use.

The Ophthalmologist

February 23, 2026

Competence Over Time

Ann Sofia Skou Thomsen
Lars Konge
February 23, 2026
5 min

Ophthalmology training currently relies heavily on time as a measure of competence, leading to disparities in trainee proficiency. Traditional methods, despite

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Time-based training in ophthalmology is inadequate.
Competence should replace time as a measure of readiness.
CBME emphasizes demonstrated skills over years of training.
Objective assessments are crucial for progress.
Barriers to CBME include resistance to transparency.
Simulation training should be standard.
Early identification of skill gaps is essential.

ASCO AI in Oncology

February 23, 2026

AI-Driven Multiagent System for Guiding First-Line Immunotherapy for NSCLC

Lisa Astor
February 23, 2026
1 min

Objective: To improve predictive tools for guiding first-line immunotherapy decisions in patients with previously untreated non-small cell lung cancer (NSCLC),

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ASCO AI in Oncology

February 23, 2026

Surveys Reveal Increased Physician Productivity, Billing From AI Scribe Implementation

ASCO AI Staff
February 23, 2026
1 min

Objective: To evaluate the impact of AI ambient scribes on physician productivity, workflow satisfaction, and EMR challenges in oncology clinics. Key Findings:

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AI ambient scribes in oncology clinics enhance physician workflow satisfaction and reduce EMR-related challenges.
A study showed AI scribes increased mean clinic visits from 16.63 to 18.45 and total fees from $7,101.60 to $7,893.70 per day.
Physicians reported spending more time with patients and less time on documentation after AI scribe implementation.
Survey results indicated improved satisfaction with EMR documentation and fewer challenges post-AI scribe use.
Despite increased productivity, there were no significant changes in fees per visit or documentation quality.

The ASCO Post

February 20, 2026

Epcoritamab Plus R² in Follicular Lymphoma: A Potential New Treatment Standard

Caroline Helwick
February 20, 2026
9 min

A phase III trial (EPCORE FL-1) demonstrated that the bispecific antibody epcoritamab-bysp combined with rituximab-lenalidomide (R2) significantly reduced disea

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Epcoritamab-R2 reduced disease progression risk by 80% compared to R2 alone.
The study involved 488 relapsed follicular lymphoma patients.
Epcoritamab enhances progression-free survival and overall response rates.
Outpatient treatment administration is possible, increasing patient access.
Safety profiles showed manageable side effects, mainly neutropenia.
Results suggest a shift in standard-of-care treatment for follicular lymphoma.

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