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March 20, 2026

Obesity Care Lags Behind Advances in Treatment

Kerri Miller
March 20, 2026
3 min

Eighty-eight percent of individuals with obesity face stigma affecting their care experience. A new perspective by Miras et al. in Obesity Science & Practice id

...more

88% of individuals with obesity face stigma affecting care.
Dependence on BMI hinders effective obesity diagnosis.
9 major challenges in current obesity care identified.
Individualized treatment targets recommended.
Economic impacts of obesity on productivity noted.
Advanced treatment options are underused.
Stigma persists in healthcare settings.
Need for obesity to be treated as a chronic disease emphasized.

March 20, 2026

A Case for Reframing ‘Skin of Color’

Kerri Miller
March 20, 2026
2 min

Rashmi Sarkar, MD, and Hitaishi Mehta, MD, discuss the limitations of the Fitzpatrick scale in addressing diverse skin types, particularly for darker skin tones

...more

Fitzpatrick scale limitations for darker skin types.
Evolution of the term 'skin of color' (SOC).
SOC's role in advancing healthcare equity.
Proposed distinction of SOC into four components.
Acknowledgment of underused assessment tools for SOC.
Need for clarity in clinical contexts when using SOC.
Tension between specificity and visibility in dermatology.

March 20, 2026

Open Dressings Show Early Contamination

Meg Barbor
March 20, 2026
2 min

A study published in the International Wound Journal revealed that open-but-unused wound dressings can become contaminated with microbes soon after opening, eve

...more

Open-but-unused wound dressings showed microbial contamination shortly after opening.
65% of samples tested positive for microbial growth.
Higher contamination rates observed in hospitals than primary care settings.
Coagulase-negative staphylococci were the most common contaminants.
Scissors used for cutting dressings were contaminated in 75% of cases.
Silver-containing dressings had slightly lower contamination rates.
Study highlights need for improved handling protocols to prevent contamination.

The ASCO Post

March 20, 2026

Hypofractionated Locoregional RT in Early Breast Cancer

Matthew Stenger
March 20, 2026
3 min

A French phase III trial, UNICANCER HypoG-01, has revealed that hypofractionated locoregional radiotherapy (RT) at 40 Gy over 3 weeks is noninferior to the stan

...more

Study compared hypofractionated RT (40 Gy, 3 weeks) vs standard RT (50 Gy, 5 weeks).
Noninferiority for lymphedema risk was established.
1,221 women participated post-tumor resection.
Median follow-up was 4.8 years.
Similar incidence of arm lymphedema in both groups.
Most common adverse events were pain (69%) and fatigue (65%).
The research was funded by the French National Cancer Institute.

The ASCO Post

March 20, 2026

MajesTEC-3: ‘Unprecedented’ Benefit in Previously Treated Multiple Myeloma

Caroline Helwick
March 20, 2026
10 min

In the MajesTEC-3 trial, a combination of teclistamab and daratumumab demonstrated significant efficacy for previously treated multiple myeloma patients, achiev

...more

Teclistamab combined with daratumumab shows 83% risk reduction in progression.
587 patients evaluated with a primary focus on progression-free survival.
Overall survival significantly better with the combination therapy.
Infection rates initially high; guidelines for management have been implemented.
Teclistamab shows promise as the new standard for treatment of relapsed multiple myeloma.

The ASCO Post

March 20, 2026

Early Findings From First Human Study of In Vivo CAR T in Myeloma

Caroline Helwick
March 20, 2026
8 min

Encouraging results from the first-in-human trial of in vivo CAR T-cell therapy KLN-1010 for multiple myeloma reflect promising safety and effectiveness, as rep

...more

KLN-1010 is an in vivo CAR T-cell therapy showing promising results for multiple myeloma.
100% of participants achieved early MRD negativity by month one.
Safety profile shows manageable adverse effects, with no high-grade CRS or ICANS.
Therapy eliminates the need for lymphodepletion and apheresis.
Data indicates improved patient outcomes and simplified logistics for treatment.

March 20, 2026

FDA Clears Setmelanotide for Hypothalamic Obesity

Kerri Miller
March 20, 2026
4 min

The FDA has approved setmelanotide (IMCIVREE) as the first treatment for acquired hypothalamic obesity, a condition caused by damage to the hypothalamus affecti

...more

Setmelanotide is FDA-approved for acquired hypothalamic obesity.
Shows a placebo-adjusted BMI reduction of 18.4%.
Approved for adults and children aged 4 and older.
Common side effects include nausea and skin hyperpigmentation.
Serious warnings include acute adrenal insufficiency.
Available immediately in the US.
Rhythm Pharmaceuticals offers a patient support program.

March 20, 2026

Healthy Lifestyle Lowers Cardiometabolic Risk in Hypertension

Julie Greenbaum
March 20, 2026
5 min

A study from Harvard analyzed data from 25,820 patients, revealing that higher adherence to a healthy lifestyle post-hypertension diagnosis significantly reduce

...more

Study revealed lifestyle adherence cuts cardiovascular and diabetes risks.
High lifestyle scores associated with 51% and 79% lower risks respectively.
Findings urge integrated lifestyle changes with medication.
Lifestyle score assessed via diet, exercise, smoking, etc.
Significant room for improvement in lifestyle adherence among health professionals.

March 20, 2026

Psilocybin Trial in Treatment-Resistant Depression Shows Mixed Results

Henry Thomas
March 20, 2026
3 min

A phase 2b randomized clinical trial assessed the efficacy of psilocybin-assisted psychotherapy on treatment-resistant depression (TRD) but found no significant

...more

Psilocybin-assisted psychotherapy trial failed to meet primary endpoint for TRD.
144 adults participated after stopping existing antidepressants.
Significant early reduction in depressive symptoms noted with high-dose psilocybin.
Functional unblinding may bias results through expectancy effects.
Suicidal ideation higher in psilocybin 25 mg group.
Adverse events common; some serious responses emerged.
Recommendations for improved trial designs suggested.

The Pathologist

March 20, 2026

From Molecules to Meaning

Sharjeel Chaudhry
March 20, 2026
4 min

Molecular pathology is evolving to play a crucial role in patient care by transitioning from traditional diagnostic methods to a focus on molecular behavior of

...more

Molecular pathology enhances disease understanding beyond morphology.
It impacts treatment decisions through biomarker identification.
HPV status can change cancer prognostic outlook.
ctDNA allows for non-invasive monitoring.
Bridging the communication gap between pathologists and patients is crucial.
Precision medicine is achievable in routine care through molecular pathology.
Molecular pathologists are integral to modern clinical practice.

The Pathologist

March 20, 2026

Hidden Gene Error Found in Fatty Liver

March 20, 2026
2 min

A study in Hepatology reveals a rare inherited variant in the MET gene responsible for steatotic liver disease (SLD) in certain patients, independent of typical

...more

MET gene variant linked to steatotic liver disease.
Study published in Hepatology by Mayo Clinic.
Disruption in MET signaling affects lipid metabolism.
1.1% of patients with SLD have rare MET variants.
First reported nonmalignant MET-driven steatotic liver disease.
Functional assays confirm variant's impact on liver metabolism.
Further studies needed for diagnostic implications.

The Ophthalmologist

March 20, 2026

The European Myopia Network

Andrzej Grzybowski
March 20, 2026
7 min

The European Myopia Network (EMN) addresses the rising prevalence of myopia across Europe through a collaborative effort involving over 27 experts from various

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EMN is a collaborative initiative to tackle myopia prevalence in Europe.
Prof. Andrzej Grzybowski leads the European Council of EMN.
The network includes 27 experts from various countries.
Educational resources and online meetings are provided for knowledge exchange.
Current research includes the link between education systems and myopia prevalence.
EMN promotes early detection and preventive strategies for myopia.
Membership is free and open to various professionals interested in myopia.

The Ophthalmologist

March 20, 2026

Expanding the Therapeutic Landscape in Wet Age-related Macular Degeneration

Hasenin Al-Khersan
March 20, 2026
6 min

Age-related macular degeneration (AMD) significantly impacts vision in individuals over 50. Early intervention is crucial for slowing disease progression and pr

...more

AMD is a leading cause of vision issues in those aged 50+.
Early intervention and education are key to slowing progression.
Anti-VEGF therapies have transformed wet AMD treatment but come with a high treatment burden.
New TKIs and sustained-release delivery methods show promise for improved outcomes.
Vorolanib uniquely blocks IL-6 and is in advanced trials.
Reducing treatment frequency may enhance patient adherence and outcomes.

Frontiers In Endocrinology

March 20, 2026

Alcohol consumption exacerbates high-fat diet-mediated disruptions in myelopoiesis and osteoclastogenesis in mouse models of metabolic dysfunction-associated liver diseases

Hami Hemati
Madison B. Blanton
Lauren Rutt
Nicholas Keiran
Rebecca Geron
Florence Lima
Rebecca L. McCullough
Ilhem Messaoudi
March 20, 2026

Objective: To characterize the bone marrow hematopoietic compartment and its link to osteoclastogenesis in mouse models of MASLD and MetALD, focusing on specifi

...more

High-fat diet (HFD) depletes hematopoietic stem cells, while HFD plus ethanol (HFD+EtOH) preserves them and skews hematopoiesis toward myeloid progenitors.
HFD+EtOH significantly increases committed osteoclast precursors compared to HFD alone, enhancing osteoclastogenesis and associated bone activity.
Mice on HFD+EtOH exhibit elevated osteoclast activity, increased epiphyseal area, and prolonged growth plate activity, affecting bone structure.
The study highlights the interplay between metabolic dysfunction-related liver diseases and hematopoietic health, emphasizing the need for integrated treatment approaches.
Findings suggest that alcohol exacerbates the effects of a high-fat diet on immune and skeletal health, warranting further research into these interactions.

Frontiers In Surgery

March 20, 2026

Comparison of the mixed approach and medial approach in laparoscopic right hemicolectomy for right colon cancer: a retrospective study

Mao-Xing Liu
Fei Tan
Shun-Yu Deng
Kechen Guo
Jia-Di Xing
Pin Gao
Kai Xu
Xiang-Qian Su
March 20, 2026

Objective: To determine the 3-year disease-free survival (DFS) and overall survival (OS) outcomes of the mixed approach vs. the medial approach in laparoscopic

...more

European Radiology (Springer)

March 20, 2026

Between automation and alienation: rethinking AI’s role in radiologist well-being

Elif Can
Jawed Nawabi
March 20, 2026

Objective: To assess the impact of AI on radiologist well-being, particularly regarding burnout, workload, and other systemic factors. Key Findings: AI's impact

...more

Radiology experiences the highest AI exposure, with 80% of FDA-cleared AI devices targeting this specialty by late 2025.
AI's impact on radiologist well-being is complex, influenced by implementation design, governance, and the sociotechnical environment.
Properly implemented AI can reduce burnout by lowering workload, but may increase cognitive burden if it shifts tasks to supervision.
AI can amplify burnout by exacerbating systemic stressors, leading to increased productivity targets and cognitive overload.
Economic incentives and workforce shortages shape AI deployment in radiology, risking operational burdens without clinician involvement.

Infection (Springer)

March 20, 2026

No symptoms, no problem? an analysis of asymptomatic and symptomatic sexually transmitted infections and the impact on clinical outcomes in a student-run free clinic

Gabriel Alexander Lee
Yuehe Wang
Isabella Gluzman
Gunnar Meyer
Hayley Dunlop
Frances Trezza
Nisha Makkar
Bella Donnelly
Nathan Helsabeck
Courtney DuBois Shihabuddin
March 20, 2026

Objective: To describe the frequency of STIs in patients at a student-run free clinic and compare infection rates between asymptomatic and symptomatic patients,

...more

STIs disproportionately affect adolescents and underserved populations, with 1 in 5 people in the U.S. having an STI at any time.
Asymptomatic infections, particularly chlamydia and gonorrhea, can lead to severe health complications if untreated.
Student-run free clinics (SRFCs) provide essential STI testing and care to uninsured and underinsured patients.
This study evaluates STI testing patterns and outcomes in a SRFC, focusing on differences between asymptomatic and symptomatic patients.
Findings aim to inform screening protocols and resource allocation to reduce STI disparities in vulnerable communities.

Frontiers In Endocrinology

March 20, 2026

Heat stress-mediated oxidative damage in male germ cells: potential protective effects of L-citrulline

Yan Qin
Hongmei Wu
Linfeng Mo
Huihuang Shen
Yanqing Tan
Weijun Li
Yonghua He
Wei Peng
March 20, 2026

Objective: Emphasize the systematic nature of the analysis. Key Findings: Include more specific details from the source. Interpretation: Elaborate on clinical i

...more

Heat stress significantly impairs male reproductive function by disrupting spermatogenesis and inducing oxidative stress in germ cells.
Oxidative stress leads to excessive reactive oxygen species accumulation, causing damage to lipids, proteins, and DNA in male reproductive cells.
L-citrulline shows potential as a protective agent against heat stress-induced reproductive damage by modulating the arginine-nitric oxide pathway.
L-citrulline preserves mitochondrial function and reduces apoptotic signaling, thereby mitigating oxidative injury in male germ cells.
The review emphasizes the need for translational research on L-citrulline to improve fertility outcomes in men exposed to heat stress.

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