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February 6, 2026

Biomarkers Expand Precision in CRC

Julia Cipriano, MS, CMPP
February 6, 2026
5 min

Advancements in diagnostic, prognostic, and predictive biomarkers are transforming the management of colorectal cancer (CRC). Grounded in a narrative review by

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Established biomarkers like KRAS and MSI are critical in CRC management.
Emerging noninvasive tests include multitarget stool DNA and ctDNA assays.
Multi-omics integration aids in prognostic model development.
Predictive factors such as RAS mutations guide treatment selection.
Future challenges include validation trials and assay standardization.
Personalized CRC care can enhance patient outcomes through tailored interventions.

The Analytical Scientist

February 6, 2026

Waters at HPLC 2025

February 6, 2026
1 min

At the HPLC 2025 event, Waters introduced the Alliance iS, highlighting its innovative capabilities in chromatography technology. Attendees appreciated the even

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Waters introduced Alliance iS at HPLC
Event featured ice cream for attendees.
Focus on advancements in chromatography technology.
Aimed to engage professionals in analytical chemistry.
Showcased the future prospects in the field.

The Pathologist

February 6, 2026

When Other People’s Cells Become Our Own

February 6, 2026
3 min

Recent research published in Advanced Science explores microchimerism, where genetically distinct cells persist in the body, notably through pregnancy, twinning

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Microchimerism involves genetically distinct cells in the body.
It occurs during pregnancy and through medical procedures.
Detection methods are inadequate due to cell rarity.
Expert surveys identified key research questions.
PCR is a common detection method but has limitations.
Lack of standardized definitions complicates research.
The absence of reliable markers leads to inconsistent results.

The Analytical Scientist

February 6, 2026

Business-in-Brief: January 2026

February 6, 2026
3 min

Merck will acquire JSR Life Sciences' chromatography business to enhance the purification of monoclonal antibodies, with a deal expected to finalize by Q2 2026.

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Merck acquires JSR Lifesciences for protein chromatography.
Velaris strengthens automation by acquiring Markes International.
Shimadzu set to buy Tescan for $678 million.
Specac buys Amax Precision for enhanced OEM capabilities.
Thermo Fisher and NVIDIA collaborate to boost lab automation.

The Analytical Scientist

February 6, 2026

Alliance iS Demo: Smarter QC Workflows with Error Prevention

February 6, 2026
1 min

Andrea Gheduzzi, LC Market Development Manager at Waters Corporation, showcases the Alliance iS system, designed to revolutionize Quality Control (QC) lab opera

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Alliance iS transforms QC lab operations.
Guided sequences enhance user experience.
Automatic column recognition streamlines processes.
Enhanced autosampler design improves performance.
Built-in pre-run checks prevent costly errors.

The Pathologist

February 6, 2026

Meeting Growing Laboratory Demands With Digital Whole-Slide Imaging

February 6, 2026
1 min

Hamamatsu will showcase their innovative digital whole-slide imaging systems at ECP 2025 in Vienna, highlighting the advantages for laboratories engaged in both

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Hamamatsu will present at ECP 2025 in Vienna.
Focus on digital whole-slide imaging.
Systems include NanoZoomer and MoxiePlex.
Benefits for routine and research applications.
Improves imaging standards.
Helps manage increased lab workloads.
Reduces diagnostic turnaround times to hours.

The Analytical Scientist

February 6, 2026

Ronak Chawla on Innovation and the Future of the Analytical Lab

February 6, 2026
1 min

Ronak Chawla, Senior Director of Next-Generation LC Systems at Waters Corporation, highlights the capabilities of the Alliance iS in addressing contemporary lab

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Alliance iS reduces human error by up to 40%.
Features AI-powered anomaly detection.
Seamless workflows with intuitive design.
Offers end-to-end traceability.
Discussed by Ronak Chawla from Waters Corporation.

The Ophthalmologist

February 6, 2026

eyejourney: New AI Patient Platform Launched

February 6, 2026
2 min

Innoptix has introduced eyejourney, an innovative AI-driven patient education platform aimed at enhancing ophthalmic care. By addressing the issue that patients

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Innoptix launched eyejourney, an AI-powered patient education platform.
Designed to improve patient retention of consultation information.
Offers personalized videos created by surgeons using digital avatars.
Helps clinics manage patient anxiety and administrative burdens.
Provides multilingual support for diverse patient populations.

The Ophthalmologist

February 6, 2026

Searching for the Spectral Signature of Alzheimer’s

February 6, 2026
2 min

Recent research from the Istituto Italiano di Tecnologia in Rome highlights a significant advancement in Alzheimer's disease (AD) diagnosis through a novel tri-

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Tri-spectral imaging integrates with fundus cameras.
It captures data in blue, green, and red bands.
Study involved 38 patients with mild AD.
Initial results show increased blue reflectance in AD patients.
Machine learning model achieved AUC of 0.
Need for larger validation studies emphasized.

KFF Health News

February 6, 2026

Could Medicaid Data Deter Emergency Care?

Phil Galewitz
Amanda Seitz
February 6, 2026
8 min

The Trump administration's recent decision to grant ICE access to Medicaid data poses significant challenges for hospitals caring for immigrant patients. This m

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Trump administration allows ICE access to Medicaid data.
Concerns over patient confidentiality arise.
Emergency Medicaid covers urgent and pregnancy care for immigrants.
22 states have sued to block data-sharing agreements.
Patients may avoid treatment out of fear of deportation.
Judge's ruling limits ICE to information on unlawful residents.
Hospitals face ethical dilemmas regarding patient privacy.
Immigrants express fear of seeking medical assistance due to potential repercussions.

The Medicine Maker

February 6, 2026

The Role of AI in Rare Disease Drug Discovery

Dan Williams
February 6, 2026
11 min

Recent technological innovations, particularly in AI and gene therapy, are revolutionizing drug development for rare diseases. Despite significant challenges li

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Technological innovations are enhancing drug development processes.
AI aids in analyzing healthcare data, speeding up drug discovery.
Rare diseases pose special challenges due to their low patient populations.
Regulatory and economic factors affect rare disease drug development.
AI can distinguish symptoms of rare diseases from common ones.
Efficient data-sharing frameworks are essential for advancing treatment.
Early diagnosis can lead to better management and interventions.
Investing in AI for drug discovery is increasing markedly.

February 5, 2026

Surgical Sequencing in Esophageal Cancer

Margery Weinstein
February 5, 2026
3 min

A phase 3 clinical trial from Sichuan Cancer Hospital investigated treatment outcomes for locally advanced esophageal squamous cell carcinoma. Patients underwen

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The study compared neoadjuvant chemoradiotherapy and surgery with adjuvant therapy.
No significant overall survival difference was found.
Complete pathologic response greatly improved outcomes.
Similar adverse effect rates were observed between groups.
Tumor resection with negative margins was achieved in over 95% of patients.
Study limitations include single-center design and modest sample size.
Tailored treatment strategies are essential for optimal patient outcomes.

The Pathologist

February 5, 2026

Can We Keep Diagnostic Autonomy in an AI World?

February 5, 2026
9 min

Pathology training is undergoing significant changes due to AI integration, according to Amal Asar, Consultant Histopathologist at Northern Care Alliance. The t

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Pathology training is hands-on and faces new challenges with AI.
Increasing workload and consultant shortages affect education.
AI integration raises concerns about workforce de-skilling.
Proposed solutions include audits and regular assessments.
Future competencies must include AI and digital workflows.
Training should preserve diagnostic autonomy.
The balance between efficiency and professional judgement is crucial.
Ethical frameworks are essential for safe AI implementation.

February 5, 2026

Oral TYK2 Inhibition in Atopic Dermatitis

Kathryn Wighton
February 5, 2026
4 min

In a phase 2 randomized clinical trial, oral ICP-332 effectively reduced atopic dermatitis severity and pruritus in 75 adults over four weeks, demonstrating a f

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ICP-332 reduced atopic dermatitis severity in adults.
75 participants aged 18-75 were involved.
The trial showed 64% of ICP-332 patients achieved a 75% improvement.
Treatment duration was 4 weeks.
No serious adverse events were reported.
Adverse events mainly mild to moderate.
The study underscores the need for phase 3 trials.

The ASCO Post

February 5, 2026

Chemotherapy-Free Regimen Improves Outcomes in Newly Diagnosed Patients With Ph-Positive ALL

Wendy LaGrego
February 5, 2026
3 min

The phase III GIMEMA ALL2820 trial results reveal that a chemotherapy-free regimen, combining the TKI ponatinib and the bispecific T-cell engager blinatumomab,

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Combination of ponatinib and blinatumomab was tested in the trial.
Event-free survival was 87% for the experimental group.
This therapy resulted in a higher remission rate compared to traditional chemotherapy.
62% of control patients achieved MRD-negative status after crossover.
Serious adverse effects were manageable.
Findings could lead to a shift in treatment paradigms in Ph-positive ALL.

February 5, 2026

Smell Screening With a Mobile Test

Kathryn Wighton
February 5, 2026
3 min

A novel mobile application-based olfactory screening test shows promise for rapid olfactory dysfunction diagnosis. Conducted at a US tertiary medical center, th

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Novel mobile olfactory screening test developed.
Study with 484 participants showed diagnostic accuracy.
Test sensitivity: 74%, specificity: 86%.
Age and olfactory dysfunction related to test scores.
Rapid, scalable tool with cloud-based data storage.
Limitations include single-center design and test performance variability.
Lead author: Dr. Benjamin J. Bernard.

February 5, 2026

Vegan Diets and Infant Growth: Any Clues?

Kerri Miller
February 5, 2026
6 min

A nationwide retrospective cohort study led by Kerem Avital, MPH, examined growth patterns in infants from vegan, vegetarian, and omnivorous households using da

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Study analyzed growth in infants from various dietary households.
99% were from omnivorous households.
Early underweight risk was higher in vegan infants.
Stunting prevalence similar across all diets by 24 months.
Well-planned vegan diets can support healthy growth.
Nutritional counseling is vital for vegan families.
Data based on records from Family Child Centers.
Study had limitations regarding data collection and dietary assessments.

The Pathologist

February 5, 2026

From Classroom Curiosity to Global Movement

Jessica Allerton
February 5, 2026
1 min

Blessing Oyeleye, the Founder and Executive Director of the Pathology Awareness Foundation in Nigeria, emphasizes the importance of enhancing pathology educatio

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Blessing Oyeleye advocates for global pathology education.
Importance of a strong diagnostic workforce highlighted.
Recognized in The Pathologist Power List: Leading Voices
Founder and Executive Director of the Pathology Awareness Foundation, Nigeria.
Conversation with Deputy Editor Jessica Allerton underscores educational initiatives.

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