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October 23, 2026

FDA raises TMB threshold for pembrolizumab

Mouj Hijazi
October 23, 2026
3 min

Objective: The article examines the objective, findings, and clinical context described in FDA raises TMB threshold for pembrolizumab. Approach: Regulatory deci

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MDSpire News

October 23, 2026

H2-blocker tachyphylaxis may limit LPR therapy

Andrea Surnit
October 23, 2026
4 min

Objective: Review evidence on H2-receptor antagonists for laryngopharyngeal reflux (LPR), including tolerance with continuous use and their role in current mana

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2 min

MDSpire News

October 23, 2026

FDA clears at-home risankizumab induction

Teraya Smith
October 23, 2026
2 min

Objective: The article examines the objective, findings, and clinical context described in FDA clears at-home risankizumab induction. Approach: Approval: The FD

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2 min

MDSpire News

October 23, 2026

Caffeine may be tied to lower cortical surface area

Andrea Surnit
October 23, 2026
5 min

Objective: To examine associations between adolescents’ caffeine consumption, sleep duration, cortical structure, and later mental health problems. Approach: Pa

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2 min

MDSpire News

October 23, 2026

Fulminant GBS may mimic brain death

Andrea Surnit
October 23, 2026
6 min

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MDSpire News

October 23, 2026

Lupus nephritis may remit despite HIV

Andrea Surnit
October 23, 2026
4 min

Objective: To describe renal and HIV outcomes during immunosuppressive treatment for biopsy-confirmed lupus nephritis in a patient with HIV. Approach: Case: Res

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2 min

MDSpire News

October 23, 2026

IOL exchange may ease postcataract dizziness

Andrea Surnit
October 23, 2026
4 min

Objective: To assess whether restoring habitual myopia could relieve persistent dizziness and visual discomfort after cataract surgery in a patient with strong

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2 min

The Pathologist

October 23, 2026

The Search for a Sepsis Signal

Helen Bristow
October 23, 2026
10 min

Objective: The article discusses limitations of current sepsis diagnosis, the potential role of emerging biomarkers in risk stratification, and challenges in tr

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The Pathologist

October 23, 2026

Could Wearables Redefine Diagnostics?

October 23, 2026
2 min

Objective: Review developments in wearable diagnostic systems and assess their potential applications and barriers to clinical use. Approach: Scope: The review

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2 min

The Medicine Maker

October 23, 2026

Live Roundtable: What Is the Biggest Bottleneck Holding Back Cell and Gene Therapy?

October 23, 2026
1 min

Objective: Present expert perspectives on the main barriers to making cell and gene therapies widely accessible and where the industry should focus its efforts.

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1 min

Critical Care

October 23, 2026

Response to “Left Ventricular Longitudinal Function and Hyperkinetic Profile: A New Echocardiographic Area for Exploration?”

Oscar Cavefors
Jonatan Oras
October 23, 2026

In exploratory post hoc analyses, 90-day mortality was 27% with LVEF >70% and 23% with LVEF 50%–70%, with no significant adjusted difference.
Patients with LVEF >70% had greater absolute GLS magnitude and modestly higher MAPSE than those with LVEF 50%–70%; S′ did not differ significantly.
No distinct MAPSE, GLS, or S′ threshold corresponding to a hyperdynamic LVEF profile was identified.
High-value GLS, MAPSE, and S′ groups were not associated with 90-day mortality in unadjusted or adjusted analyses.
The exploratory findings suggest hyperdynamic LVEF may not reflect a comparably hyperdynamic longitudinal systolic profile and warrant cautious interpretation.

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Jama Network Open

October 23, 2026

Neighborhood Disadvantage and Disparities in Atrial Fibrillation Detection

Kamala P. Tamirisa
Larry R. Jackson
October 23, 2026

Objective: To assess whether neighborhood disadvantage is associated with differences in atrial fibrillation (AF) diagnosis and treatment. Approach: Population

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United States Department Of Health And Human Services

October 23, 2026

ACL Selects 70 Phase 1 Winners in Challenge to Make Community Gardens More Accessible

Administration for Community Living (ACL)
October 23, 2026

On October 23, 2026, ACL named 70 Phase 1 winners in the nationwide Cultivating Connected Communities Prize Challenge.
Teams from 37 states and Tribal communities proposed ways to improve community garden access for people with disabilities and older adults.
A multidisciplinary expert panel selected winners based on accessibility strategies, sustainability, and community partnerships.
Each Phase 1 winner will receive $4,000 and may advance to Phase 2 to implement plans and monitor outcomes.
Phase 2 proposals are due by May 2027, and teams may receive an additional prize of up to $8,000 based on implementation results.

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Jmir Medical Informatics

October 23, 2026

Travel Distance Between Patients and Providers for Medicare Outpatient Oncology Telehealth and Office Visits, 2021–2023: A Cross-Sectional Claims Study

Lingbo Liu
Tracy Onega
Erika L Moen
Anna N A Tosteson
Rebecca E Smith
Qianfei Wang
Lauren Cowan
Fahui Wang
October 23, 2026

Get a concise, at-a-glance scorecard that distills clinical guidelines into key recommendations, patient insights, and treatment considerations.

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Jama Network Open

October 23, 2026

Profile and Financial Impact of Measures Dropped From Medicare Advantage Star Ratings

Derek T. Lake
Yasin Civelek
Amelia M. Bond
Dhruv Khullar
October 23, 2026

The analysis included 425 Medicare Advantage contracts covering 29.0 million enrollees and evaluated 13 components of 11 measures removed from 2026 Star Ratings.
Only 5 of the 13 removed measures were topped out, while none of the 30 retained measures met the study’s topping-out definition.
Removed measures had higher average scores than retained measures, but their removal lowered composite scores in the simulation.
After measure removal, ratings decreased for 35.1% of contracts, remained unchanged for 62.6%, and increased for 2.4%.
The modeled annual 2026 quality bonus payment pool fell by $2.09 billion, or 13.9%, as 33 contracts lost eligibility and 6 gained it.

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National Institutes Of Health

October 23, 2026

Precision T-cell treatment slows resistant cancers in early clinical trial results

October 23, 2026

Objective: Assess the safety, optimal dose, and preliminary antitumor activity of invikafusp alfa (invika) in patients with advanced cancers, many resistant to

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2 min

Journal Of Medical Internet Research

October 23, 2026

The AI Scientist’s Evolving Role: From Robotic Systems to Research Organizations

Cliff Dominy
October 23, 2026

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United States Department Of Health And Human Services

October 23, 2026

CMS and States Unveil $275 Million Program to Attract and Retain Nursing Home Nurses

Centers for Medicare and Medicaid Services (CMS)
October 23, 2026

Objective: The article examines the objective, findings, and clinical context described in CMS and States Unveil $275 Million Program to Attract and Retain Nurs

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