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MDSpire is an innovative platform aiming to create a smarter, faster, and more connected medical community.

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June 27, 2026

Early-Phase Data Support Novel Contrast Agent

Julia Cipriano, MS, CMPP
June 27, 2026
3 min

Summary
Insight Report
Poll

Objective: To evaluate the safety and efficacy of the novel perflutren-based ultrasound-enhancing agent MVT-100 compared to Definity in healthy volunteers. Appr

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June 27, 2026

PAHR: Prognostic Marker in Severe Aortic Stenosis?

Julia Cipriano, MS, CMPP
June 27, 2026
3 min

Summary
Quiz
Clinical Scorecard

Objective: To evaluate the association of pressure-adjusted heart rate (PAHR) with survival in patients with severe aortic stenosis (AS). Approach: Study Design

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June 27, 2026

GLP-1 Drugs Tied to Smell, Taste Changes

Andrea Surnit
June 27, 2026
5 min

Summary
Insight Report
Quiz

Objective: To evaluate whether glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is associated with incident smell and taste disturbances in patients with

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June 27, 2026

Upfront Cost Guidance Limited in US Guidelines

Andrea Surnit
June 27, 2026
6 min

Summary
Quiz
Clinical Scorecard

Objective: To evaluate the incorporation of economic and resource use-related guidance in US clinical practice guidelines. Approach: Study Design: Cross-section

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June 27, 2026

GLP-1 RAs May Ease Psoriasis, PsA Data Limited

Andrea Surnit
June 27, 2026
4 min

Summary
Insight Report
Quiz

Objective: To evaluate the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on psoriasis and psoriatic arthritis (PsA). Approach: Review Methodo

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June 27, 2026

AI Model Trails Expert Skin Lesion Readers

Andrea Surnit
June 27, 2026
6 min

Summary
Insight Report
Poll
Clinical Scorecard

Objective: To compare the diagnostic accuracy of artificial intelligence (AI) systems with that of physicians in diagnosing skin lesions. Approach: Study Design

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June 27, 2026

Case Report Describes Possible Betahistine–Suicidality Link

Andrea Surnit
June 27, 2026
4 min

Summary
Insight Report
Quiz

Objective: To describe a possible association between betahistine exposure and depressive symptoms with suicidal ideation. Approach: Case Report: A 33-year-old

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June 27, 2026

Echo AI: From Innovation to Adoption

Julia Cipriano, MS, CMPP
June 27, 2026
5 min

Summary
Quiz
Clinical Scorecard

Objective: To explore the incorporation of artificial intelligence (AI) into echocardiography and the challenges of broader adoption. Approach: Building Better

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June 27, 2026

Mavacamten Treatment Associated With Improved Diastolic Function, Remodeling Markers

Kathryn Wighton
June 27, 2026
3 min

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To assess the effects of mavacamten on diastolic function and cardiac remodeling in patients with symptomatic obstructive hypertrophic cardiomyopathy

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June 27, 2026

Synthetic Echo Motion May Aid ECG Risk Modeling

Kerri Miller
June 27, 2026
3 min

Summary
Insight Report
Quiz
Clinical Scorecard
Topic Commentary

Objective: To develop a model that integrates synthetic echocardiographic motion into ECG analysis for classifying diastolic dysfunction risk phenotypes and str

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Archives Of Toxicology

June 27, 2026

Correction: The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals

C. J. Henderson
A. W. McLaren
A. K. MacLeod
D. Lin
A. R. Cameron
L. R. Chatham
J. Moggs
F. Inesta‑Vaquera
John P. Thomson
Richard R. Meehan
P. Chakravarty
M. Schwarz
C. Roland Wolf
June 27, 2026

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To correct the oversight regarding the reuse of an image in the original article. Approach: Image Correction: Clarification regarding the reuse of an

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Archives Of Toxicology

June 27, 2026

Structure–activity relationship of synthetic cathinones: integrated in silico, in vitro, and in vivo studies of α-PiHP analogues

Martalu D. Pazos
Guillermo García-Díez
David Pubill
Xavier Berzosa
Roger Estrada-Tejedor
Jorge Camarasa
Elena Escubedo
Raúl López-Arnau
Núria Nadal-Gratacós
June 27, 2026

Summary
Insight Report
Poll
Clinical Scorecard
Topic Commentary

Objective: To comprehensively investigate α-PiHP and five of its analogues, namely MDPiHP, 3-Me-α-PiHP, 4-Me-α-PiHP, 3-F-α-PiHP, and 4-F-α-PiHP, to elucidate th

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Archives Of Toxicology

June 27, 2026

Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling

Eszter Borsos
Blandine Descamps
Nick Hetzschold
Elisabeth Varga
Doris Marko
Georg Aichinger
June 27, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To develop a physiologically based kinetic (PBK) model predicting tissue concentrations of alternariol (AOH) and alternariol monomethyl ether (AME) i

Alternariol (AOH) and alternariol monomethyl ether (AME) are emerging mycotoxins found in various food commodities.
The European Food Safety Authority has indicated that chronic dietary exposure to AOH and AME may exceed toxicological concern thresholds.
AOH and AME exhibit genotoxicity, oxidative stress induction, and potential endocrine-disrupting effects in vitro.
Physiologically based kinetic (PBK) modeling was developed to predict human tissue concentrations of AOH and AME after oral intake.
The study aims to provide a quantitative understanding of AOH and AME bioactivity as a preliminary step towards risk assessment.

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Critical Care

June 27, 2026

Neutrophil EMR3 dynamics in critically ill patients with sepsis: an ICU experience

Yilei Ma
Peihao Yu
Xiaofen Wang
Ruofei Chen
Wei Ni
Huixing Liu
Xinru Fang
Feng Zhao
Qianwen Hu
Sai Qiao
Suwen Yang
Hong Jin
Jingjuan Song
Dongdong Zhao
Lei Fang
Jun Zhang
Jiancang Zhou
June 27, 2026

Summary
Insight Report
Poll

Objective: To examine neutrophil EMR3 for early sepsis identification and longitudinal host-response dynamics in critically ill patients. Approach: Study Design

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Archives Of Toxicology

June 27, 2026

Deficient arsenic methylation and global proteomic reprogramming in human keratinocytes during arsenic-induced skin carcinogenesis

Alexandra N. Nail
Mayukh Banerjee
Manting Xu
Caitlin H. Reynolds
Miroslav Stýblo
Peter H. Cable
Daniel W. Wilkey
Michael L. Merchant
Ana P. Ferragut Cardoso
Shelia D. Thomas
J. Christopher States
June 27, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard
Topic Commentary

Objective: To investigate the proteomic changes and arsenic methylation status in human keratinocytes during arsenic-induced skin cancer development. Approach:

Chronic exposure to inorganic arsenic affects approximately 220 million people and is linked to non-melanoma skin cancer development.
HaCaT cells exposed to inorganic arsenite for 28 weeks transform into an aggressive cSCC-like phenotype and can form tumors in immunocompromised mice.
Comprehensive longitudinal proteomic profiling is necessary to understand the protein expression changes during iAsIII-induced malignant transformation.
Arsenic methylation status may influence the molecular mechanisms driving keratinocyte malignant transformation, as HaCaT cells do not methylate iAsIII.
The study aims to assess arsenic metabolism across various human keratinocyte lines to identify key metabolites and molecular targets in arsenic-induced cSCC.

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European Radiology

June 27, 2026

Feasibility of lung imaging at 0.55T for assessment of interstitial lung disease in patients with pulmonary sarcoidosis

Maurice Pradella
Hanns-Christian Breit
Jens Bremerich
Constantinos Anastasopoulos
Michael Bach
Oliver Bieri
Katrin E. Hostettler
Grzegorz Bauman
June 27, 2026

Takeaways
Insight Report
Poll
Topic Commentary

The study evaluates 0.55T MRI for assessing interstitial lung disease in pulmonary sarcoidosis patients, addressing limitations of traditional imaging methods.
Fifteen patients with pulmonary sarcoidosis underwent chest CT and 0.55T MRI scans, with a reference cohort of thirty healthy volunteers for normative values.
MRI scans utilized a 0.55-T whole-body scanner and employed advanced bSSFP techniques for high-resolution morphological and functional lung imaging.
Image evaluation involved three radiologists assessing CT and MRI scans for various pulmonary findings, with interrater and inter-modality agreement quantified.
The study aims to establish the feasibility of using low-field MRI in clinical settings for comprehensive lung assessment in sarcoidosis patients.

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European Radiology

June 27, 2026

Does adding a high-resolution 3D sequence improve the accuracy of erosion detection in pediatric sacroiliac joint MRI?

Nele Herregods
Robert G. W. Lambert
Stephanie Wichuk
Eva Schiettecatte
Thomas Renson
Joke Dehoorne
Lennart B. O. Jans
Jacob L. Jaremko
June 27, 2026

Summary
Insight Report
Poll

Objective: To evaluate the value of adding a volumetric interpolated breath-hold examination (VIBE) sequence to pediatric sacroiliac joint MRI for detecting ero

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Archives Of Toxicology

June 27, 2026

Chemical components of tattoo inks and their potential role in carcinogenesis and their side effects

Luiza Czaczkowska
Ewa Jabłońska
Julia Bury
Natalia Szurant
Wioletta Ratajczak-Wrona
June 27, 2026

Summary
Insight Report
Poll

Objective: To investigate the chemical constituents of tattoo ink and their potential links to cancer development and other adverse effects. Approach: Research

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