MDSpire - MDSpire Home
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

MDSpire News

  • August 3, 2026
FDA Approves Pluvicto for Hormone-Sensitive Prostate Cancer
  • Kathryn Wighton
  • August 3, 2026
  • 3 min
  1. The FDA approved Pluvicto for adults with PSMA-positive metastatic hormone-sensitive prostate cancer.
  2. The approval is based on the phase 3 PSMAddition trial, showing Pluvicto reduced disease progression risk by 28%.
  3. An updated analysis indicated a 33% reduction in disease progression or death risk with Pluvicto plus standard care.
  4. Grade 3 or higher adverse events occurred in 51% of patients receiving Pluvicto, compared to 43% with standard care.
  5. Pluvicto is an intravenous radioligand therapy that targets prostate cancer cells expressing PSMA using lutetium-177.
...more

MDSpire News

  • August 3, 2026
Can Peroxisome Preservation Slow Aging?
  • Andrea Surnit
  • August 3, 2026
  • 2 min

Objective: To investigate the effects of inhibiting the peroxisomal protein PRX-11 on aging and mitochondrial health in Caenorhabditis elegans. Approach: Experi

...more

MDSpire News

  • August 3, 2026
Enzyme Disruption Could Impair Retinal Homeostasis
  • Andrea Surnit
  • August 3, 2026
  • 3 min

Share your perspective with a quick, clinically relevant poll that captures real-world insights and clinician sentiment.

Take the Poll

Kff Health News

  • August 3, 2026
Earlier Lifeline for Rural Hospitals Faces Test Under ‘Big Beautiful’ Law
  • Sarah Jane Tribble
  • Tony Leys
  • August 3, 2026
  • 10 min
  1. Sturgis Hospital closed after three years of operating under a new emergency-focused model, leaving its community without critical healthcare.
  2. The Rural Emergency Hospital model, created by Congress, aims to support rural hospitals but has faced challenges, including declining patient numbers.
  3. Over 1,700 hospitals are eligible for the Rural Emergency Hospital model, but only more than 50 have signed on, raising concerns about its effectiveness.
  4. Federal funding reductions from the One Big Beautiful Bill Act are expected to significantly impact rural hospitals, which often have high Medicaid enrollment.
  5. The emergency hospital model provides a 5% boost in Medicare payments and additional funding, but many hospitals still struggle financially.
...more

The Pathologist

  • August 3, 2026
Why Rare Diseases Need Long Reads
  • Jessica Allerton
  • August 3, 2026
  • 6 min

Share your perspective with a quick, clinically relevant poll that captures real-world insights and clinician sentiment.

Take the Poll

The Pathologist

  • August 3, 2026
Cancer Detection: The e-Nose Knows
  • August 3, 2026
  • 3 min

Objective: To investigate the potential of electronic 'nose' (e-nose) technology for noninvasive cancer detection through the analysis of volatile organic compo

...more
1 min

The Analytical Scientist

  • August 3, 2026
Can Immunopeptidomics Redefine Cancer Immunotherapy Development?
  • Katherine Tran
  • August 3, 2026
  • 4 min
  1. Immunopeptidomics analyzes antigenic peptides presented by MHC molecules, enhancing the development of targeted cancer immunotherapies.
  2. This field aids in identifying novel T-cell targets and tumor-specific antigens, crucial for improving therapies for hard-to-treat cancers like PDAC.
  3. High-resolution mass spectrometry (HRMS) is essential for identifying peptides bound to MHC molecules, facilitating comprehensive immunopeptidome coverage.
  4. Innovations like tunable electron-activated dissociation (EAD) improve peptide fragmentation and differentiation of isomeric residues, impacting immune response.
  5. Combining analytical approaches enhances specificity and throughput in immunopeptidomics, driving the design of personalized cancer immunotherapies.
...more

The Ophthalmologist

  • August 3, 2026
The Need for Speed
  • Jeanne Hecht
  • David R.P. Almeida
  • August 3, 2026
  • 8 min
  1. Ford Motor Company's vertical integration at its River Rouge Plant enabled unprecedented car production without outside help.
  2. The retinal drug-development industry can learn from Ford's example to streamline clinical trials and overcome fragmentation.
  3. Good sites and efficient processes, rather than the number of sites, are crucial for speeding enrollment in retinal trials.
  4. Vertical integration can enhance trial efficiency by reducing barriers and improving collaboration among stakeholders.
  5. Sponsors should adopt flexible protocols and integrate technology to adapt to evolving trial designs in retinal research.
...more

The Ophthalmologist

  • August 3, 2026
Lessons from a Retina Pioneer
  • August 3, 2026
  • 10 min

Share your perspective with a quick, clinically relevant poll that captures real-world insights and clinician sentiment.

Take the Poll

The Medicine Maker

  • August 3, 2026
This Week’s CGT News: Gene-Editing Trial Death Raises Concerns
  • August 3, 2026
  • 5 min

Share your perspective with a quick, clinically relevant poll that captures real-world insights and clinician sentiment.

Take the Poll

Emergency Medicine Journal

  • August 1, 2026
Insights from Staff on the Implementation of Opt-Out Blood-Borne Virus Testing in Emergency Departments in England: A Qualitative Analysis
  • Siobhán Allison
  • Tom May
  • Jonathan Roberts
  • Rachel Hill-Tout
  • Stephen Hindle
  • Matthew Hickman
  • Lucy Yardley
  • Rachel Todd
  • Robyn Heath
  • Jeremy Horwood
  • August 1, 2026

Objective: To evaluate the implementation of opt-out blood-borne virus (BBV) testing in emergency departments (EDs) by investigating staff views and experiences

...more
4 min

Gut

  • August 1, 2026
Targeting the GSK3βhigh/NFATc1high Subtype to Overcome Therapy Resistance in Pancreatic Cancer via Induction of Homologous Recombination Repair Mechanisms
  • Muhammad Umair Latif
  • Xueang Liu
  • Aiko Bockelmann
  • Laura Huhnold
  • Geske Elisabeth Schmidt
  • Lukas Klein
  • Xueyuan Zhao
  • Lena-Christin Conradi
  • Karly Conrads
  • Anna Lena Weber
  • Sercan Mercan
  • Kristina Reutlinger
  • Atmika Paul
  • Zeynab Najafova
  • Steven A Johnsen
  • Zuriñe Bonilla Del Rio
  • Frederike Penz
  • Jovan Todorovic
  • Holger Bastians
  • Tim Beissbarth
  • Ulrich Sax
  • Ramy Ashry
  • Oliver H Krämer
  • Elisabeth Hessmann
  • Günter Schneider
  • Philipp Stroebel
  • Ivan Bogeski
  • Shiv K Singh
  • Volker Ellenrieder
  • August 1, 2026

Objective: To investigate the role of nuclear GSK3β-NFATc1 signaling in pancreatic ductal adenocarcinoma (PDAC) and its association with therapy resistance and

...more
4 min

Gut

  • August 1, 2026
Interaction between liver sinusoidal endothelial cells and hepatocytes through the IL-1α–IL1R1 pathway worsens ischaemia/reperfusion injury in older livers
  • Yasong Liu
  • Tingting Wang
  • Feng Zhang
  • Xuying Liu
  • Zhongying Hu
  • Jiebin Zhang
  • Haitian Chen
  • Jiaqi Xiao
  • Qiang You
  • Zhengqi Wu
  • Jia Yao
  • Yingcai Zhang
  • Shuhong Yi
  • Hua Li
  • Qi Zhang
  • Yang Yang
  • Rong Li
  • Jun Zheng
  • August 1, 2026

Objective: To elucidate the cellular contributors and mechanisms exacerbating ischaemia-reperfusion injury (IRI) in aged livers. Approach: Single-cell transcrip

...more
3 min

Gut

  • August 1, 2026
Genetic Analysis of Stool Frequency Reveals Involvement of Vitamin B1 Metabolism and Other Targetable Pathways in Gut Motility Regulation
  • Cristian Díaz-Muñoz
  • Isotta Bozzarelli
  • Esteban Alexander Lopera-Maya
  • Lazaros Belbasis
  • Valeria Lo Faro
  • Leticia Camargo Tavares
  • Francisco Heredia-Fernández
  • Biagio Di Lorenzo
  • Trishla Sinha
  • Cristina Esteban Blanco
  • Marie-Julie Favé
  • Philip Awadalla
  • Robin G Walters
  • Ferdinando Bonfiglio
  • Alexandra Zhernakova
  • Serena Sanna
  • Mauro D’Amato
  • August 1, 2026

Objective: To investigate the genetic determinants of stool frequency as a proxy for gut motility and identify associated pathways. Approach: Study Design: A mu

...more
3 min

Gut

  • August 1, 2026
Exploring the Links Between Demographic, Clinical, and Dietary Influences on Inflammatory Bowel Disease Flares: Insights from the PREdiCCt Prospective Cohort Study
  • Nathan Constantine-Cooke
  • Beatriz Gros
  • Nikolas Plevris
  • Linda J Williams
  • Gareth-Rhys Jones
  • Janet Kyle
  • Nicholas A Kennedy
  • Victor Velasco-Pardo
  • Alexander Rudge
  • Debbie Alexander
  • Carl A Anderson
  • Maiara Brusco de Freitas
  • Lisa M Derr
  • Lauranne AAP Derikx
  • Sian Gilchrist
  • Paul Henderson
  • Graham W Horgan
  • Peter Irving
  • Christopher A Lamb
  • Luke Jostins-Dean
  • James O Lindsay
  • Jonathan MacDonald
  • Craig Mowat
  • Charles Murray
  • Miles Parkes
  • Spyros I Siakavellas
  • Catalina A Vallejos
  • Daniel R Gaya
  • Jonathan M Rhodes
  • Alexandra M Johnstone
  • Christopher J Weir
  • Charlie W Lees
  • August 1, 2026

Objective: To determine the association between habitual diet and disease flare in inflammatory bowel disease (IBD). Approach: Study Design: A large, multicentr

...more
4 min

Gut

  • August 1, 2026
Targeting Sodium+/taurocholate Cotransporting Polypeptide for the Treatment of Liver Fibrosis
  • August 1, 2026

Objective: To explore the potential of sodium+/taurocholate cotransporting polypeptide (NTCP) as a therapeutic target for liver fibrosis. Approach: Study Design

...more
1 min

British Journal Of Ophthalmology

  • August 1, 2026
Assessment of the Incidence, Contributing Factors, and Outcomes of Retinopathy of Prematurity in Preterm Infants with Birth Weights Over 1500 g or Gestational Ages Beyond 32 Weeks in Turkey (TR-ROP 2) and Associated Legal Concerns: A Multicenter Study by the Turkish Neonatal Society
  • Ahmet Yagmur Bas
  • Esin Koc
  • Sezin Unal
  • Ibrahim Murat Hirfanoglu
  • August 1, 2026

Objective: To assess the prevalence and risk factors associated with the development of retinopathy of prematurity (ROP) in preterm infants with a birth weight

...more
4 min

Gut

  • August 1, 2026
Inhibition of Interleukin 10 Enhances Antitumor Immune Activity in Liver Metastases of Human Colorectal Cancer
  • August 1, 2026

Objective: To investigate the effects of interleukin 10 blockade on antitumor immune function in liver metastases of human colorectal cancer. Approach: Study De

...more