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Frontiers In Cardiovascular Medicine

  • September 9, 2026
Evaluation of Various eGFR Formulas in Predicting 1-Year Major Adverse Cardiovascular Events Following Percutaneous Coronary Intervention in Acute Coronary Syndrome Patients
  • Yicheng Wang
  • Fangming Liu
  • Ruoxi Qi
  • Xiaohan Wang
  • Jiajie Mei
  • Zhenzhu Liu
  • Lijiao Zhang
  • Wenli Xie
  • Ming Yu
  • Xiaodong Zhang
  • Hongyan Wang
  • Zhaohong Geng
  • September 9, 2026
  1. The study evaluated the predictive performance of creatinine-based versus cystatin C–based eGFR equations for 1-year MACE in PCI patients.
  2. A cohort of 560 patients undergoing PCI for acute coronary syndrome was analyzed, with 72 experiencing MACE during the follow-up.
  3. Cystatin C–based equations identified more patients with impaired renal function compared to creatinine-based formulas.
  4. Logistic regression showed the greatest discriminative ability for predicting 1-year MACE, while machine learning models had modest performance.
  5. Creatinine-based eGFR was more strongly associated with 1-year MACE than cystatin C–based eGFR, but neither showed clinical superiority.
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Frontiers In Surgery

  • September 9, 2026
Establishing Optimal Anterior Hairline Shape and Hair Density Ratio Through Morphometric Evaluation in Chinese Women
  • Yiyi Zhang
  • Dadong Tang
  • Lanzhi Zhang
  • Jingping Wu
  • Fengrui Cheng
  • Hongbin Cheng
  • September 9, 2026
  1. The study aimed to determine the ideal anterior hairline shape and hair density ratio in Chinese women for improved surgical planning.
  2. Ninety participants rated five hairline configurations, with round, triangular, and M-shaped contours receiving significantly higher aesthetic scores.
  3. The preferred hair-bearing proportion was identified as a height ratio of 0.505 and a width ratio of 0.373.
  4. Participants evaluated hairline contours based on overall impression, naturalness, attractiveness, youthfulness, and agreeableness.
  5. The findings provide quantitative evidence for tailoring hair transplantation and aesthetic interventions to the preferences of Chinese women.
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Frontiers In Cardiovascular Medicine

  • September 9, 2026
Innovative Device for Ventricular Septal Reconstruction Following Post-Myocardial Infarction Rupture: Findings from Preclinical and Initial Human Trials
  • Changjing Huang
  • Nan Cai
  • Youqian Li
  • Yao Yao
  • Zexun Zhu
  • Weike Wu
  • Kaibing Ren
  • Siwei Wu
  • Jingfeng Liu
  • Jingyuan Hou
  • Haifeng Hong
  • Hanlin Li
  • Zhihui Hu
  • Zhixiong Zhong
  • Wei Zhong
  • September 9, 2026
  1. Post-myocardial infarction ventricular septal rupture (PIVSR) has a poor prognosis, with survival rates of 6% at 1 month and below 3% at 1 year with pharmacological therapy.
  2. The Ventricular Septal Reconstruction Device (VSRD) was developed specifically for PIVSR and features a unique design to adapt to the pathological characteristics of the condition.
  3. In preclinical trials, the VSRD was successfully implanted in 10 out of 11 animals, with no structural malfunction or delivery-system failure reported.
  4. In the first-in-human study, all four patients had successful implantation of the VSRD, with residual shunts remaining ≤2 mm during follow-up.
  5. The study concluded that the VSRD showed procedural feasibility and acceptable short-term safety, but larger studies are needed to assess long-term outcomes.
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Frontiers In Surgery

  • September 9, 2026
Preoperative Ratio of High-Sensitivity C-Reactive Protein to Albumin as a Predictor of Arteriovenous Fistula Failure in Hemodialysis Patients: A Retrospective Cohort Analysis with Landmark Assessment
  • Shanshan Huo
  • Peng Shu
  • Zhuping Wen
  • Xiaodi Ma
  • Shuang Wang
  • Fang Xu
  • September 9, 2026
  1. The study analyzed 279 patients undergoing first-time arteriovenous fistula (AVF) creation to evaluate the high-sensitivity C-reactive protein-to-albumin ratio (HRR).
  2. AVF failure occurred in 50.5% of patients during a median follow-up of 50 months, with HRR showing a significant association with increased failure risk.
  3. Multivariable analysis indicated that each unit increase in HRR was linked to a 65% higher risk of AVF failure, independent of vessel diameter.
  4. The model demonstrated moderate discrimination at 24 months (AUC = 0.608) and indicated positive net clinical benefit from incorporating HRR in risk assessment.
  5. The findings suggest that preoperative HRR may help identify high-risk patients for AVF failure, although external validation of the results is necessary.
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European Radiology

  • September 9, 2026
Cardiac Structure in Pediatric Patients at Ages 2 and 10 Following Repair of Congenital Diaphragmatic Hernia: A Comparative MRI Study of ECMO and Non-ECMO Cases
  • Schanas Jawhar
  • Greta Thater
  • Stefan Appelhaus
  • Michael Boettcher
  • Julia Elrod
  • Frank G. Zoellner
  • Florian Kipfmueller
  • Marcia Matos-Karaorman
  • Stefan O. Schoenberg
  • Meike Weis
  • September 9, 2026
  1. Congenital diaphragmatic hernia (CDH) affects 1 in 2000–5000 live births and can lead to pulmonary hypoplasia and pulmonary arterial hypertension (PAH).
  2. The study compared cardiac morphology and function in 57 children with CDH, categorized into ECMO and non-ECMO groups, using MRI at ages 2 and 10.
  3. Cardiac parameters assessed included the pulmonary artery to aorta ratio (PA/Ao), right-to-left ventricular ratio (RV/LV), and eccentricity index (EI).
  4. The ECMO group had a higher prevalence of right-sided hernias and differences in patch use compared to the non-ECMO group.
  5. Statistical analyses included independent-samples t-tests and binary logistic regression to evaluate associations between ECMO treatment and cardiac morphology.
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Frontiers In Oncology

  • September 9, 2026
Case Study: Thoracic Spinal Metastasis Observed Without Clear Intrahepatic Recurrence Following Conversion Therapy and Hepatectomy in Hepatocellular Carcinoma
  • Jiahui Chen
  • Yanhua Huang
  • Difan Zhou
  • September 9, 2026
  1. A 61-year-old man with hepatitis B-related HCC underwent conversion therapy and hepatectomy, showing no intrahepatic recurrence initially.
  2. Despite negative liver imaging, rising alpha-fetoprotein and des-gamma-carboxy prothrombin levels indicated potential extrahepatic disease progression.
  3. PET/CT later revealed a destructive T2 vertebral lesion, leading to multilevel thoracic spinal metastases and subsequent neurological deterioration.
  4. The case highlights the importance of systemic restaging when tumor markers rise, even with negative liver imaging results.
  5. Prompt evaluation of spinal lesions is critical to prevent irreversible neurological injury following detection of metastases.
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Frontiers In Surgery

  • September 9, 2026
Uncommon Case of Intramuscular Venous Malformation in the Subscapularis Muscle Mimicking Traumatic Brachial Plexopathy
  • Jin Hang Loh
  • Zhun Shen Tan
  • Elaine Zi Fan Soh
  • Chia Hua Lim
  • Muhammad Shafiq Azhar
  • Jamari Sapuan
  • Shalimar Abdullah
  • September 9, 2026
  1. A 27-year-old man developed progressive weakness and numbness in the right upper limb after an occupational fall, initially suspected as traumatic brachial plexopathy.
  2. MRI revealed an intramuscular venous malformation in the right subscapularis muscle, compressing the brachial plexus cords.
  3. Due to surgical risks, fluoroscopy-guided percutaneous bleomycin sclerotherapy was performed instead of open resection.
  4. Following treatment, the patient experienced significant neurological recovery and improved motor strength by Month 7.
  5. This case highlights the diagnostic challenges and treatment options for venous malformations mimicking brachial plexus injuries.
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Frontiers In Medicine

  • September 9, 2026
Editorial: The Interconnection of Lifestyle Choices and Chronic Illnesses: Strategies, Insights, and Public Health Issues
  • Sofia Mendes Sieczkowska
  • Leonardo Vidal Andreato
  • Guilherme Torres Vilarino
  • Luís Fernando Deresz
  • Danilo Reis Coimbra
  • September 9, 2026
  1. Non-communicable diseases (NCDs) account for approximately three-quarters of global mortality and significantly contribute to the health burden.
  2. Bernell and Howard propose a functional definition of chronic conditions based on recurrence and persistence rather than fixed temporal thresholds.
  3. Modifiable lifestyle factors, such as physical inactivity and unhealthy dietary patterns, are linked to the progression of chronic diseases.
  4. Barriers to effective public health interventions include structural obstacles and inadequate knowledge-attitude-practice (KAP) scores among patients.
  5. The Research Topic highlights the need for targeted prevention strategies and the integration of behavioral science into clinical practice.
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Frontiers In Oncology

  • September 9, 2026
Creation and assessment of claims-based algorithms for detecting interstitial lung disease in Japanese cancer patients utilizing real-world data in standard clinical settings
  • Yu-Jing Huang
  • Toshihiro Takeda
  • Yoshie Shimai
  • Taizo Murata
  • Kento Sugimoto
  • Yoshito Takeda
  • Haruhiko Hirata
  • Makoto Yamamoto
  • Midori Yoneda
  • Seigo Minami
  • Masahiro Higashi
  • Alan James Michael Brnabic
  • Zbigniew Kadziola
  • Tsutomu Kawaguchi
  • Yucherng Chen
  • Yasushi Matsumura
  • September 9, 2026
  1. A claims-based algorithm was developed to identify interstitial lung disease (ILD) in Japanese cancer patients using machine-learning modeling.
  2. The study analyzed data from 13,601 patients, with 415 classified as ILD cases through natural language processing of CT reports.
  3. The LASSO reduced model achieved a sensitivity of 33.5% and specificity of 99.3%, indicating its performance in identifying true-positive ILD cases.
  4. External validation of the algorithm showed a sensitivity of 19.8% and specificity of 99.4%, demonstrating its applicability in different datasets.
  5. The algorithm may assist in case confirmation for retrospective studies evaluating ILD risk associated with various cancer treatments.
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Frontiers In Oncology

  • September 9, 2026
Radiomic Heterogeneity of ASL Perfusion Correlates with Early Mortality in IDH-Wildtype Glioblastoma, Independent of Tumor Volume: Insights from Time-Varying Effects Using Tumor-Aware DTI-ALPS
  • Rafail C. Christodoulou
  • Georgios Vamvouras
  • Platon S. Papageorgiou
  • Evros Vassiliou
  • Elena E. Solomou
  • Sokratis G. Papageorgiou
  • Michalis F. Georgiou
  • September 9, 2026
  1. ASL perfusion heterogeneity is associated with early mortality in IDH-wildtype glioblastoma, independent of tumor volume and clinical variables.
  2. The study analyzed 322 patients with IDH-wildtype WHO grade 4 glioblastoma using volume-adjusted Cox proportional hazards models.
  3. Mortality within 365 days correlated with greater ASL heterogeneity, with hazard ratios indicating significant associations after adjustments.
  4. DTI-ALPS did not enhance classifier performance or show independent prognostic value in relation to survival outcomes.
  5. Findings suggest the necessity for volume-adjusted testing in radiomics research, as tumor volume significantly influenced overall survival results.
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Frontiers In Cardiovascular Medicine

  • September 9, 2026
Delivery Reveals Brugada Syndrome in a 32-Year-Old Primigravida: A Case Study
  • Peng Liu
  • Ruilong Gao
  • Yaliu Yang
  • Zhengqin Zhai
  • Yifeng Zhou
  • September 9, 2026
  1. A 32-year-old primigravida experienced ventricular fibrillation shortly after an uncomplicated vaginal birth.
  2. The patient's ECG revealed a spontaneous type 1 Brugada syndrome pattern following resuscitation.
  3. No structural heart disease was found, and genetic testing did not identify pathogenic variants associated with Brugada syndrome.
  4. Multiple factors, including epidural ropivacaine, postpartum autonomic instability, and electrolyte imbalance, likely unmasked latent Brugada syndrome.
  5. An implantable cardioverter-defibrillator was placed for secondary prevention, and no arrhythmic episodes were recorded during 18 months of follow-up.
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Frontiers In Medicine

  • September 9, 2026
Management of Chlorine-Induced Acute Respiratory Distress Syndrome with Noninvasive Ventilation and Prone Positioning: A Case Study
  • Yu E. Xue
  • Jianyue Zhang
  • Zanfeng Cao
  • Zuopeng Zhang
  • September 9, 2026
  1. Chlorine exposure from disinfectants can lead to acute respiratory distress syndrome (ARDS), primarily affecting the respiratory system.
  2. A 76-year-old man developed moderate ARDS after inhaling chlorine gas from a trichloroisocyanuric acid disinfectant in a swimming pool.
  3. The patient was treated with noninvasive mechanical ventilation, awake prone positioning, and glucocorticoids, resulting in complete recovery.
  4. Chest imaging revealed bilateral pulmonary infiltrates consistent with acute toxic inhalation lung injury and ARDS.
  5. Chlorine poisoning lacks a specific antidote, necessitating treatment focused on symptom control and monitoring until stability is achieved.
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Frontiers In Immunology

  • September 9, 2026
Development of a New Mouse Model for Lupus Mesenteric Vasculitis and Investigation of Its Aggravation Mechanisms
  • Maki Fujishiro
  • Kunihiro Hayakawa
  • Yuko Kataoka
  • Marina Shinoura
  • Hiroyuki Tomita
  • Yuna Saito
  • Takuya Nishi
  • Keigo Ikeda
  • Kenji Takamori
  • Iwao Sekigawa
  • Shinji Morimoto
  • September 9, 2026
  1. The study developed a new mouse model for lupus mesenteric vasculitis (LMV) using BWF1 mice treated with the TLR7/8 agonist R848.
  2. R848 treatment resulted in intestinal vasculitis, elevated serum autoantibody levels, and accelerated systemic lupus erythematosus (SLE) pathology.
  3. The model revealed microbiota alterations and increased fecal propionic acid concentrations associated with LMV.
  4. Broad-spectrum antibiotics tended to suppress LMV pathology during the early induction phase in the mouse model.
  5. The findings suggest a potential role for intestinal propionate in maintaining homeostasis in LMV, warranting further investigation.
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Frontiers In Medicine

  • September 9, 2026
Bladder Contraction Linked to Diffuse Nephrogenic Adenoma: A Case Study
  • Ning Xu
  • Qi Zhang
  • Xiangcheng Qin
  • September 9, 2026
  1. A 52-year-old man presented with irritative lower urinary tract symptoms and was diagnosed with diffuse nephrogenic adenoma after multiple evaluations.
  2. Cystoscopy revealed numerous papillary tumor-like lesions and bladder-wall thickening, leading to decreased bladder capacity.
  3. Histopathological evaluations showed suppurative inflammation and granulation-tissue proliferation, confirming the diagnosis of nephrogenic adenoma.
  4. The patient underwent radical cystectomy and orthotopic ileal neobladder substitution due to severe bladder contracture and quality-of-life impairment.
  5. Post-surgery, the patient reported improved voiding intervals and resolution of pain, with normal renal function and no evidence of hydronephrosis.
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Frontiers In Oncology

  • September 9, 2026
The Impact of Treatment on Host Dynamics: A Framework for Understanding the Development of Second Primary Cancers
  • Rosiane Batista Mastelari
  • Tiago Veiras Collares
  • September 9, 2026
  1. Second primary cancers (SPCs) arise from diverse origins, influenced by genetic predisposition, environmental factors, and treatment exposure.
  2. The therapy-conditioned host framework describes how treatment alters the biological state of patients, impacting subsequent cancer risk.
  3. SPCs develop through various pathways, including inherited susceptibility, environmental exposures, and pre-existing somatic mosaicism.
  4. Treatment exposure can lead to mutagenesis and clonal changes in normal tissues, which may differ biologically from pre-treatment conditions.
  5. The proposed model emphasizes the importance of understanding the biological state generated by treatment rather than focusing solely on treatment history.
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Frontiers In Neurology

  • September 9, 2026
Efficacy Comparison of Virtual Reality, Robotics, and Brain-Computer Interface Techniques for Upper Limb Rehabilitation Post-Stroke: A Systematic Review and Network Meta-Analysis
  • Ruichun Pang
  • Zhiyin Hu
  • Chongyang Luo
  • Zhongxu Liu
  • Shuna Zhang
  • September 9, 2026
  1. This systematic review compared the effectiveness of virtual reality, robotics, and brain-computer interfaces for upper limb rehabilitation post-stroke.
  2. The analysis included 25 RCTs with 1,145 stroke survivors, assessing interventions against conventional physical therapy.
  3. Robotics-based interventions showed stronger evidence for improving upper-limb motor function compared to virtual reality and brain-computer interfaces.
  4. ROT-CPT ranked first for the Modified Barthel Index, while VR-CPT ranked first for the Wolf Motor Function Test in secondary outcomes.
  5. BCI-based interventions were represented by only one study, limiting the ability to draw reliable conclusions about their effectiveness.
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Frontiers In Surgery

  • September 9, 2026
Evaluating the Diagnostic Effectiveness, Safety, and Clinical Relevance of Stereotactic Biopsy for Brainstem Lesions: A Systematic Review and Meta-Analysis of Recent Evidence
  • Hanqiang Du
  • Jiajia Wang
  • Qicheng Liu
  • Gaoquan Luo
  • September 9, 2026
  1. Stereotactic biopsy for brainstem lesions has a high diagnostic yield of 93.5%, based on a systematic review of 76 reports.
  2. Overall complications from stereotactic biopsy were reported at 10.5%, with permanent neurological morbidity at 0.83% and procedure-related mortality at 0.30%.
  3. The study included 71 full-text articles and 5 abstract reports, with 55 independent studies contributing to quantitative synthesis.
  4. Diagnostic yield was inversely associated with study size, with a yield of 93.7% when excluding studies with fewer than 20 participants.
  5. Differences in population, technique, and outcome definitions necessitate cautious interpretation of results rather than universal recommendations.
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Frontiers In Immunology

  • September 9, 2026
The Role of the SPA17-AXL Pathway in Melanoma Progression and the Antitumor Potential of SPA17-Targeted Vaccination
  • Lan Zhang
  • Mengshu You
  • Bin Yan
  • Jian Zhang
  • Yi Yao
  • Qingyan Zhang
  • Zuozhong Xie
  • Shixiang Wang
  • Qian Gao
  • September 9, 2026
  1. SPA17 is overexpressed in melanoma and correlates with poor prognosis, increased metastatic burden, and resistance to immunotherapy.
  2. Knockdown of SPA17 in melanoma cells inhibits migration and reduces tumor growth in vivo without affecting cell proliferation.
  3. SPA17 depletion enhances CD8+ T-cell infiltration and cytotoxic activity against melanoma cells, indicating its role in immune evasion.
  4. AXL is a critical downstream effector of SPA17, with its overexpression rescuing migration defects and restoring lymphocyte-mediated killing.
  5. Therapeutic vaccination targeting SPA17 significantly restrains melanoma progression and increases tumor-infiltrating CD8+ T cells.
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