MDSpire - MDSpire Home
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

The Analytical Scientist

  • September 30, 2026
AI Reconstructs Molecular Structures From Simulated TERS Images
  • September 30, 2026
  • 3 min

Objective: To develop a deep learning model that reconstructs molecular geometries and identifies chemical elements from simulated tip-enhanced Raman spectrosco

...more

The Analytical Scientist

  • September 30, 2026
Machine Learning Alone Won’t Take Vibrational Spectroscopy Into the Clinic
  • September 30, 2026
  • 3 min

Objective: To examine the barriers to clinical adoption of machine learning-enabled vibrational spectroscopy, focusing on the complete analytical pipeline. Appr

...more

The Analytical Scientist

  • September 30, 2026
Vibe Coding Moves Beyond the Proteomics Prototype
  • James Strachan
  • September 30, 2026
  • 14 min
  1. Proteomics relies on software for data processing, with interdisciplinary teams developing tools for peptide identification and visualization.
  2. Mike MacCoss's lab has contributed to several widely used proteomics software tools, utilizing his expertise in mass spectrometry.
  3. Generative AI has enabled rapid exploratory software development, allowing researchers to test ideas quickly, though validation remains essential.
  4. MacCoss developed Osprey, an open-source peptide-centric DIA proteomics search tool, using vibe coding without typing code by hand.
  5. Osprey's main function is detection and scoring, allowing visual inspection of identifications in Skyline, enhancing data analysis.
...more

The Medicine Maker

  • September 30, 2026
FDA Approves First Gene Therapy for Sanfilippo Syndrome Type A
  • September 30, 2026
  • 3 min

Objective: To announce the FDA approval of Fayuvi, the first gene therapy for Sanfilippo syndrome type A. Approach: Treatment Description: Fayuvi (rebisufligene

...more

MDSpire News

  • September 29, 2026
First MCT8 deficiency therapy approved
  • Kathryn Wighton
  • September 29, 2026
  • 3 min

Objective: To announce the FDA approval of tiratricol for treating peripheral thyrotoxicosis in patients with MCT8 deficiency. Approach: FDA Approval: The FDA a

...more

MDSpire News

  • September 29, 2026
New dopamine agonist enters Parkinson disease care
  • Kathryn Wighton
  • September 29, 2026
  • 2 min
  1. The FDA approved tavapadon (Juvmo) for treating adults with Parkinson disease, as announced by AbbVie.
  2. The approval was based on the phase 3 TEMPO clinical trial program evaluating tavapadon in early Parkinson disease.
  3. In TEMPO-1, tavapadon improved daily living activities at week 26 compared to placebo, with significant score reductions.
  4. TEMPO-3 showed that tavapadon increased daily 'on' time without troublesome dyskinesia compared to placebo.
  5. Common mild to moderate adverse events included nausea, dizziness, and headache, with specific events varying by treatment.
...more

MDSpire News

  • September 29, 2026
Dietary fat type may matter after prostate cancer
  • Andrea Surnit
  • September 29, 2026
  • 4 min
  1. Replacing saturated or animal fats with monounsaturated or plant-based sources was linked to greater all-cause mortality in nonmetastatic prostate cancer patients.
  2. The study analyzed 4,884 patients diagnosed with nonmetastatic prostate cancer from 1986 to 2019, with a median follow-up of 12.8 years.
  3. Patients in the highest quintile of saturated fat intake had 24% higher all-cause mortality compared to those in the lowest quintile.
  4. Higher monounsaturated fat intake was associated with lower mortality, primarily due to reduced cardiovascular mortality.
  5. The study found no significant association between dietary fat intake and prostate cancer-specific mortality.
...more

MDSpire News

  • September 29, 2026
Spherical-equivalent contacts may shift binocular function
  • Andrea Surnit
  • September 29, 2026
  • 3 min

Objective: To assess changes in binocular vision measures when switching from spectacles to spherical-equivalent soft contact lenses in patients with low myopic

...more
2 min

MDSpire News

  • September 29, 2026
Aqueous cytology may diagnose iris metastasis without biopsy
  • Andrea Surnit
  • September 29, 2026
  • 3 min

Objective: To evaluate the effectiveness of aqueous humor cytology in diagnosing iris metastasis from lung adenocarcinoma based on a single patient case without

...more

MDSpire News

  • September 29, 2026
Wildfire pollution may pose cardiopulmonary risk
  • Andrea Surnit
  • September 29, 2026
  • 3 min
  1. Long-term exposure to wildfire-specific PM2.5 is linked to higher cardiopulmonary hospitalization risk compared to nonwildfire PM2.5.
  2. The study analyzed 57.3 million cardiovascular and 32.7 million pulmonary hospitalizations across 20 US states from 2006 to 2019.
  3. Each 1-µg/m³ increase in wildfire-specific PM2.5 was associated with increased hospitalization risk for various cardiopulmonary conditions.
  4. Subgroup analyses indicated higher hospitalization risks among racial and ethnic minorities and patients with obesity or diabetes.
  5. The study faced limitations including potential exposure measurement errors and lack of unique patient identifiers.
...more

Keck Medicine of USC

  • September 29, 2026
Meet Joni K. Doherty, MD
  • September 29, 2026
  • 4 min
  1. Joni K. Doherty, MD, is an otolaryngologist at Keck Medicine of USC with subspecialty certification in neurotology.
  2. She has advanced training in skull base surgery and focuses on hearing and balance related to the brain and nervous system.
  3. Doherty aims to see breakthroughs in gene therapy for restoring hearing and hopes for advancements in restoring auditory neurons.
  4. Her approach to patient care is characterized by attentiveness, compassion, and a calm bedside manner.
  5. Doherty values kindness and encourages medical students to choose specialties they love for a fulfilling career.
...more

Keck Medicine of USC

  • September 29, 2026
Voice Restoration: Expanding Treatment Options
  • September 29, 2026
  • 6 min

Objective: To explore innovative treatment options for patients with structural disorders of the vocal folds. Approach: Multidisciplinary Care: The USC Voice Ce

...more

Keck Medicine of USC

  • September 29, 2026
Thyroid Cancer: What Are the Latest Advances in Treatment?
  • September 29, 2026
  • 6 min

Objective: To discuss advancements in the treatment of thyroid cancer, emphasizing personalized care and minimizing long-term side effects. Approach: Personaliz

...more

Baptist Health South Florida

  • September 29, 2026
Prostate Cancer Care: Advances in Risk Stratification, Imaging and Treatment
  • September 29, 2026
  • 5 min
  1. Advances in imaging and biopsy techniques enable more precise identification of clinically significant prostate cancer.
  2. PSA testing remains crucial for early diagnosis, but results must be interpreted considering age, prostate size, and clinical history.
  3. Multiparametric MRI enhances diagnosis and guides targeted biopsies, improving the accuracy of prostate cancer detection.
  4. PSMA imaging significantly aids in localizing prostate cancer and assessing recurrence after treatment.
  5. Artificial intelligence is emerging as a tool to enhance MRI interpretation and integrate various data for better risk stratification.
...more

MDSpire News

  • September 29, 2026
Top 10 evidence-based essentials in pulmonology
  • MDSpire News Staff
  • September 29, 2026
  • 5 min

Objective: To summarize key evidence-based guidelines and findings in pulmonology related to various respiratory conditions. Approach: Global Initiative for Ast

...more
2 min

MDSpire News

  • September 29, 2026
Top 10 evidence-based essentials in radiology
  • MDSpire News Staff
  • September 29, 2026
  • 3 min

Objective: To provide a summary of essential evidence-based resources in radiology for imaging selection, safety, screening, diagnosis, treatment, and reporting

...more
2 min

The Analytical Scientist

  • September 29, 2026
Raman Laser Reduction Weakens Graphene Oxide Under Cyclic Loading
  • September 29, 2026
  • 3 min
  1. Laser reduction of graphene oxide decreases its fatigue resistance despite lowering defect levels as measured by Raman spectroscopy.
  2. The study indicates that the chemical identity and history of defects significantly affect graphene oxide's response to mechanical loading.
  3. Raman laser irradiation modifies graphene oxide chemically, preferentially removing epoxide groups while not repairing vacancy-type defects.
  4. Cyclic loading tests revealed that laser-reduced graphene oxide had shorter fatigue lifetimes compared to oxidized samples with similar defect ratios.
  5. The findings suggest that Raman defect ratios alone are insufficient for predicting the fatigue reliability of chemically modified graphene oxide.
...more

The Analytical Scientist

  • September 29, 2026
Tiny Heart Samples, Detailed Protein Data
  • September 29, 2026
  • 3 min

Objective: To develop a simplified extraction method for analyzing phospholamban using reduced cardiac tissue. Approach: Extraction Method: A one-pot method usi

...more