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Conexiant

July 10, 2026

FDA Approves Subcutaneous Isatuximab-irfc

Kathryn Wighton
July 10, 2026
2 min

Summary
Takeaways
Quiz
Clinical Scorecard

Objective: To report the FDA approval of subcutaneous isatuximab-irfc for multiple myeloma. Approach: Indications: Approved for use in combination with pomalido

...more

2 min

The FDA approved subcutaneous isatuximab-irfc for three indications in adult patients with multiple myeloma.
Isatuximab-irfc is approved with pomalidomide and dexamethasone for patients with prior therapy including lenalidomide.
The drug is also approved with carfilzomib and dexamethasone for relapsed or refractory multiple myeloma.
For newly diagnosed multiple myeloma patients not eligible for stem cell transplantation, it is approved with bortezomib, lenalidomide, and dexamethasone.
The recommended dose is 1,400 mg subcutaneously, with warnings for hypersensitivity, neutropenia, and other risks.

...more

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Conexiant

July 10, 2026

10 CMS and FDA Actions Affecting Care in 2026

Conexiant News Staff
July 10, 2026
7 min

Summary
Takeaways
Insight Report
Quiz

Objective: To highlight federal actions by CMS and FDA that may impact physician practice in 2026. Approach: 2026 Medicare Physician Fee Schedule Final Rule: Fi

...more

2 min

The 2026 Medicare Physician Fee Schedule final rule establishes separate conversion factors for qualifying and nonqualifying alternative payment model participants.
The 2026 Medicare Advantage and Part D final rule implements changes to prescription drug coverage and eliminates cost-sharing for certain adult vaccines.
CMS finalized a 2.6% update to payment rates for hospital outpatient services and ambulatory surgical centers meeting quality reporting requirements.
The FDA approved Foundayo, an oral GLP-1 therapy, for weight management in adults with obesity or overweight and related comorbid conditions.
The FDA cleared Dexcom’s Stelo Glucose Biosensor System for over-the-counter use by children aged 2 years and older who do not use insulin.

...more

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Conexiant

July 10, 2026

Cross-Linked HA Did Not Outperform Saline

Andrea Surnit
July 10, 2026
4 min

Summary
Quiz
Clinical Scorecard

Objective: To compare the efficacy of Hyruan ONE, hylan G-F 20, and saline in reducing pain and improving function in patients with symptomatic knee osteoarthri

...more

2 min

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Sentara

July 10, 2026

Sentara Brings 1st Minimally Invasive Treatment for Aortic Regurgitation to Virginia

July 10, 2026
4 min

Summary
Insight Report
Poll

Objective: To introduce the JenaValve Trilogy Transcatheter Heart Valve System as a minimally invasive treatment option for patients with aortic regurgitation.

...more

1 min

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The Pathologist

July 10, 2026

Protecting Newborns from Congenital Syphilis

July 10, 2026
6 min

Summary
Takeaways
Quiz
Clinical Scorecard

Objective: To discuss the rising rates of congenital syphilis in the US and the need for improved testing strategies to protect mothers and infants. Approach: C

...more

2 min

Congenital syphilis cases in the US reached nearly 4,000 in 2024, highlighting a significant public health crisis.
Most congenital syphilis cases are preventable, often due to missed testing and gaps in prenatal care.
40% of mothers of congenital syphilis cases did not receive any prenatal care, missing critical screening opportunities.
Updated guidelines recommend testing all pregnant women for syphilis early in pregnancy and again during the third trimester.
Improving awareness, access to care, and establishing universal screening for pregnant women are essential strategies.

...more

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The Pathologist

July 10, 2026

Lyme Antibodies May Improve Test Timing

July 10, 2026
3 min

Summary
Quiz
Clinical Scorecard

Objective: To identify immune antibodies that appear earlier than current laboratory markers of Lyme disease and assess their potential in diagnosing acute and

...more

2 min

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The Ophthalmologist

July 10, 2026

A Strategic Shift in Vision Healthcare

Dylan Joseph
July 10, 2026
5 min

Summary
Takeaways
Quiz
Poll
Clinical Scorecard

Objective: To address the myopia epidemic and evaluate the limitations of conventional vision correction methods compared to surgical options, emphasizing the n

...more

An estimated 5 billion people will have myopia by 2050, with up to 60% of urban learners currently affected.
Conventional vision correction methods, like spectacles and contact lenses, create a financial burden with no clinical endpoint.
Surgical vision correction, such as LASIK, can save patients up to ZAR 295,000 over 20 years compared to conventional methods.
Longitudinal data shows that daily contact lens wear carries a higher risk of microbial keratitis compared to LASIK.
Surgical correction stabilizes refractive error and mitigates long-term risks associated with progressive myopia.

...more

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The Ophthalmologist

July 10, 2026

View from the Neighborhood

Patrice Hicks
July 10, 2026
3 min

Summary
Insight Report
Quiz

Objective: To investigate the association between neighborhood disadvantage and visual difficulty and blindness. Approach: Study Design: Cross-sectional study a

...more

1 min

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The Medicine Maker

July 10, 2026

Biopharma Vital Signs – Part 4: The New Partnership Playbook

July 10, 2026
15 min

Summary
Takeaways
Insight Report
Quiz

Objective: To explore the changing partnership models within the biopharma ecosystem. Approach: Gavin Murdoch, SVP of Commercial Strategy, Abzena: Discusses the

...more

3 min

Partnerships in biopharma are evolving to address increasing complexity, requiring specialized expertise across various development stages.
Big pharma is increasingly partnering with Chinese companies, reflecting improved standards in Chinese R&D and significant deal values.
Smaller biotech firms are central to early development, allowing larger companies to engage later through licensing and strategic support.
Partnership models are shifting from traditional customer-supplier relationships to more integrated, collaborative approaches.
Companies are prioritizing organizational fit and cultural alignment in partner selection to enhance long-term collaboration success.

...more

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Frontiers In Reproductive Health

July 10, 2026

Prevalence of bacteriospermia and its association with semen parameters among men attending a fertility clinic in Kumasi, Ghana

Evans Anokye Kumi
Victor Boachie Owusu
Ebenezer Kojo Addae
Peter Nyarko Coffie
Eric Darko
Rex Kwadwo Mawuli Djokoto
Kweku Bedu-Addo
John Asiedu Larbi
July 10, 2026

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To determine the prevalence of bacteriospermia and examine its association with semen parameters among males attending a fertility clinic in Kumasi,

...more

3 min

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Frontiers In Immunology

July 10, 2026

Targeting macrophage metabolism: mechanisms, cellular crosstalk and implications in obesity-associated metabolic diseases

Chensi Yao
Wei Zheng
Yamei Jin
Jiahao Sheng
Mengjiao Kang
Jijuan Zhong
Min Li
Liyun Duan
Xiao Yuan
July 10, 2026

Summary
Takeaways
Insight Report
Quiz
Poll

Objective: To summarize the functional phenotypes and metabolic characteristics of macrophages in the context of obesity-related metabolic diseases. Approach: R

...more

3 min

Obesity is a chronic metabolic disorder linked to systemic inflammation and is a significant risk factor for various metabolic diseases.
Macrophages play a crucial role in maintaining tissue homeostasis and are involved in the progression of obesity-related metabolic disorders.
The concept of immunometabolism describes the interplay between immune cell activation and systemic metabolic homeostasis during obesity.
Macrophages exhibit phenotypic plasticity, polarizing into M1 or M2 subsets based on local environmental cues, influencing their functions.
Understanding macrophage metabolism and interactions with metabolic tissues may lead to novel therapeutic strategies for obesity-related disorders.

...more

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Frontiers In Medicine

July 10, 2026

Education and training models for point-of-care ultrasound in perioperative medicine: a narrative review

Zhonghang Xu
Huiqiao Lian
Xuli Ren
July 10, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To synthesize educational theory and propose an integrated training model for perioperative point-of-care ultrasound (POCUS). Approach: Search Strate

...more

3 min

Point-of-care ultrasound (POCUS) is essential in perioperative medicine for real-time assessment of various clinical conditions.
POCUS education in anesthesiology is inconsistent, with barriers including faculty expertise, training time, and equipment access.
Simulation-based education is proposed as an effective method for teaching POCUS before high-stakes clinical examinations.
An integrated training model for POCUS includes six simulation-based education approaches, emphasizing cognitive preparation and team-based decision-making.
Key research priorities include validating competency thresholds and studying the impact of simulation training on clinical performance and patient outcomes.

...more

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Frontiers In Medicine

July 10, 2026

Case Report: Recurrent intrahepatic cholestasis: two rare cases with their novel variants of ATB8B1 and atypical clinical findings

Jiaxun Li
Qi Wei
Sicong Liu
Luyu Lv
Huarong Ding
Liping Guo
Diefei Hu
Qiuyue Ning
July 10, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To describe two unusual cases of siblings affected by recurrent intrahepatic cholestasis type 1 (RIC1) and to present genetic evidence of novel ATP8B

...more

3 min

Recurrent intrahepatic cholestasis type 1 (RIC1) is an autosomal recessive disorder caused by variants in ATP8B1.
The study presents two siblings with atypical clinical presentations of RIC1, deviating from classical patient profiles.
Two novel compound heterozygous variants of ATP8B1 were identified, impacting protein expression and contributing to cholestasis.
Case 1 involved a 35-year-old man with severe jaundice and ineffective treatment, leading to his eventual death from sepsis.
Case 2, the sister, experienced recurrent cholestasis attacks with digestive symptoms, highlighting variability in clinical presentation.

...more

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Frontiers In Medicine

July 10, 2026

Serum and urinary golgi membrane protein 1 (GOLM1/GP73/G73) for chronic kidney disease staging

Jiaqi Xu
Jiawen Lin
Chao Ma
Jianishaya Yeerlan
Shuping Li
Wenjian Zhu
Zhihua Zheng
Mingcheng Huang
July 10, 2026

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To evaluate whether serum and urinary Golgi membrane protein 1 (GOLM1/GP73) could serve as biomarkers for chronic kidney disease (CKD). Approach: Stu

...more

3 min

The study evaluated serum and urinary Golgi membrane protein 1 (GOLM1/GP73) as potential biomarkers for chronic kidney disease (CKD).
Serum G73 levels increased with CKD severity, while urinary G73 and the urine G73-to-creatinine ratio decreased significantly.
Adding serum G73 to clinical models improved the discrimination of advanced CKD, with an AUC increase from 0.81 to 0.85.
Serum G73 showed modest ability to distinguish acute kidney injury from chronic kidney disease, with AUC values ranging from 0.59 to 0.75.
The findings suggest that serum and urinary G73 could serve as non-invasive biomarkers to enhance CKD staging and clinical decision-making.

...more

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Frontiers In Endocrinology

July 10, 2026

Hemodynamic effects of finerenone on blood pressure and heart rate in hospitalized patients with type 2 diabetes: a real-world study

Song Wen
Dandan Yun
Yanju He
Xiucai Li
Lijiao Chen
Chaoxun Wang
Yulan Zhu
Dongxiang Xu
Dan Liu
Jiyu Li
Ligang Zhou
July 10, 2026

Summary
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To evaluate the real-world acute effects of finerenone on blood pressure (BP) and heart rate (HR) in hospitalized patients with type 2 diabetes (T2D)

...more

3 min

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Frontiers In Endocrinology

July 10, 2026

Serum anti-Müllerian hormone response to pyrroloquinoline quinone supplementation in healthy women: no overall change and exploratory subgroup findings

Saori Tsuji
Tsuyoshi Takiuchi
Mika Handa
Naoki Miura
Hisae Aoyagi
Yuki Uematsu
Miwako Shidomi
Kazutake Fukada
Chiaki Ogura
Tadashi Kimura
Michiko Kodama
July 10, 2026

Summary
Takeaways
Insight Report
Poll

Objective: To evaluate the effects of oral PQQ supplementation on ovarian reserve and related clinical and biochemical outcomes in healthy women. Approach: Stud

...more

3 min

Pyrroloquinoline quinone (PQQ) supplementation did not significantly change serum anti-Müllerian hormone (AMH) levels in healthy women.
Younger participants with lower baseline AMH showed a non-significant increase in AMH after PQQ supplementation.
Older participants with lower baseline AMH experienced a significant decrease in AMH levels following PQQ supplementation.
The study involved 50 healthy women aged 25–42 years, with blood samples collected before and after 90 days of PQQ supplementation.
Exploratory subgroup analyses indicated inconsistent findings, highlighting the need for larger, placebo-controlled trials.

...more

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Frontiers In Psychiatry

July 10, 2026

Latent profile analysis and associated factors of alexithymia among patients with chronic obstructive pulmonary disease

Liang Ji
Jing Xu
Xiao Huang
Shuxiang Chen
Pengmei Lin
Ziyue Chen
Qilin Shen
Fei Wang
July 10, 2026

Summary
Insight Report
Poll

Objective: To explore the latent profiles of alexithymia among patients with COPD and to analyze their associated factors. Approach: Study Design: Cross-section

...more

3 min

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Journal Of Neuro-Oncology

July 10, 2026

Leptomeningeal disease (LMD) after resection of brain metastases: results of the multicenter SUBAROMA study

Laura Mühlhausen
Martin Kocher
Hanah Hadice Karadachi
Ulrich Sure
Yahya Ahmadipour
Levin Häni
Danial Nasiri
Tommaso Araceli
Martin Proescholdt
Nils Ole Schmidt
Andrea Cattaneo
Vera Nickl
Florian Scheichel
Franz Marhold
Stefan J. Grau
Christina A. Hamisch
Franz L. Ricklefs
Yahya Zghaibeh
Roland H. Goldbrunner
Stephanie T. Jünger
July 10, 2026

Summary
Quiz
Clinical Scorecard

Objective: To identify risk factors for postoperative leptomeningeal disease (LMD) development in patients with brain metastases (BM) who underwent surgical tre

...more

4 min

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