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MDSpire News

  • August 12, 2026
FDA Clears Exoskeleton for Spinal Cord Injury
  • Kathryn Wighton
  • August 12, 2026
  • 2 min

Objective: To report on the FDA clearance of the Eve exoskeleton for eligible wheelchair users with spinal cord injury. Approach: Clinical Trial: The FDA cleara

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Kff Health News

  • August 12, 2026
Hospitals Say They Found a Tool To Help Reduce Childbirth Risks: Wristbands
  • Andrew Jones
  • August 12, 2026
  • 9 min

Objective: To address maternal mortality and complications after childbirth using silicone wristbands as a visual reminder of postpartum health risks, initiated

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MDSpire News

  • August 12, 2026
Can Treprostinil Change IPF Care?
  • Kathryn Wighton
  • August 12, 2026
  • 4 min
  1. The TETON-1 trial evaluated inhaled treprostinil in 598 patients with idiopathic pulmonary fibrosis over 52 weeks.
  2. Inhaled treprostinil resulted in a smaller decline in forced vital capacity compared to placebo.
  3. Clinical worsening occurred in 32% of patients receiving treprostinil versus 45% receiving placebo.
  4. Cough was reported in 55% of patients on treprostinil, compared to 33% on placebo.
  5. The study noted a high rate of discontinuation of study treatment, with 41% for treprostinil and 33% for placebo.
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MDSpire News

  • August 12, 2026
Product Labels Miss Hidden Chemicals
  • Teraya Smith
  • August 12, 2026
  • 2 min

Objective: To identify unlabeled potentially harmful chemicals in personal care and cleaning products marketed as 'natural,' 'non-toxic,' and 'fragrance-free.'

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2 min

The Analytical Scientist

  • August 12, 2026
A Life at the Interface: Sitting Down With Joel Harris
  • Henry Thomas
  • August 12, 2026
  • 12 min

Objective: To explore the career and research contributions of Joel M. Harris in the field of chemistry, particularly focusing on time-resolved spectroscopy and

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The Analytical Scientist

  • August 12, 2026
Mass Spec Roundup: Molecular Glues, Microbiomes, and Metabolomes
  • August 12, 2026
  • 6 min
  1. A multiplexed mass spectrometry screen identified DCAF11 as a molecular glue requiring glutathionylation for DDX18 degradation.
  2. The platform immobilizes E3 ligases on beads to enhance the discovery of molecular glues and their interactions with cellular proteins.
  3. In-source freezing improved IR-MALDESI spatial resolution and suppressed metabolic changes in fresh leaf tissue during mass spectrometry imaging.
  4. A five-way benchmark identified DIA- and Slice-PASEF as the best performers for gut metaproteomics, enhancing protein detection and functional coverage.
  5. DIA-based approaches generally recovered more proteins than DDA-PASEF, supporting better taxonomic and functional assignments in metaproteomics.
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The Ophthalmologist

  • August 12, 2026
NHS Contract Boosts Disability Eye Care
  • August 12, 2026
  • 3 min

Objective: To provide specialist eye care to children with disabilities attending special schools in London and the South East, as stated by SeeAbility. Approac

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The Ophthalmologist

  • August 12, 2026
A Sequential Approach to DME
  • August 12, 2026
  • 4 min

Objective: To evaluate a novel sequential treatment regimen for diabetic macular edema (DME) and compare its outcomes with standard anti-VEGF therapy. Approach:

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The Medicine Maker

  • August 12, 2026
Can Exosomes Unlock Nanomedicine’s Regenerative Medicine Potential?
  • August 12, 2026
  • 12 min
  1. NurExone Biologic is developing exosome-based therapeutics to enhance precision in delivering therapies to damaged tissues.
  2. ExoPTEN, NurExone's lead candidate, targets PTEN to support nerve repair in conditions like spinal cord and optic nerve injuries.
  3. Exosomes serve as natural delivery vehicles that respond to distress signals, facilitating therapeutic cargo transport to damaged areas.
  4. Manufacturing exosome-based therapies faces challenges in consistency due to variability in biological systems and production conditions.
  5. The acellular approach of using exosomes may allow for easier development of off-the-shelf products with broader applicability.
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Frontiers In Neurology

  • August 12, 2026
Editorial: Volume II on Neurological and Neuropsychiatric Conditions in Military Personnel and Veterans
  • Lisa C. Krishnamurthy
  • Venkatagiri Krishnamurthy
  • Mary Jo Pugh
  • William C. Walker
  • Chen Lin
  • August 12, 2026
  1. Neurological and neuropsychiatric disorders are common among military personnel and Veterans, influenced by unique military service challenges.
  2. Conditions like TBI, PTSD, and chronic pain often manifest as interconnected syndromes, complicating diagnosis and treatment.
  3. Long-term monitoring and rehabilitation strategies are essential for Veterans, as neurological risks evolve significantly over time.
  4. Recognition of symptoms is crucial for effective care, as many may be misattributed to other disorders, hindering appropriate intervention.
  5. The health burden extends beyond individuals to families, with psychological distress affecting caregivers differently based on their roles.
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Frontiers In Immunology

  • August 12, 2026
Analysis of Bibliometric Trends and Visual Insights on Macrophages in Traditional Chinese Medicine from 2003 to 2023
  • Ge Zhu
  • Mingjie Xu
  • Jingxing Li
  • Jiachun Xu
  • Zhen Zhou
  • August 12, 2026

Objective: To systematically analyze bibliometric trends in macrophage research within Traditional Chinese Medicine (TCM) from 2003 to 2023. Approach: Data Sour

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Frontiers In Digital Health

  • August 12, 2026
Enhancing Clinical Drug Development with AI: Strategies to Mitigate Data Bias, Bridge the Digital Divide, and Include Underrepresented Patient Groups
  • Dimitris Papanicolaou
  • Sotirios Perdikeas
  • Graham B. Jones
  • August 12, 2026
  1. AI methodologies can accelerate clinical trials by identifying patients likely to respond positively to specific medications.
  2. Datasets used for predictive analyses must be representative of diverse populations to leverage the advantages of AI in precision medicine.
  3. Biases in datasets, such as underrepresentation of certain racial and ethnic groups, limit the effectiveness of predictive models.
  4. Patient-generated data can be biased due to language disparities and unequal access to healthcare and digital resources.
  5. Enhancing dataset heterogeneity is essential to mitigate biases and improve the generalizability of AI-driven clinical trial outcomes.
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Intensive Care Medicine

  • August 12, 2026
Evolving Critical Care Approaches: Enhancing Resilience and Preparedness for Future Pandemics
  • Manuel Ruiz-Bailén
  • María del Carmen Ruiz-Iniesta
  • August 12, 2026
  1. The COVID-19 pandemic revealed critical care vulnerabilities, including uneven preparedness and challenges in mobilizing specialized personnel.
  2. ICU capacity definitions are inconsistent, and operational data often fail to distinguish between nominal and deployable resources.
  3. Workforce sustainability is a primary challenge, with critical care professionals facing burnout linked to excessive workloads and insufficient mental health support.
  4. Equity in pandemic responses requires fair distribution of resources and enhancement of ICU infrastructure in underserved areas.
  5. Innovations in critical care must be thoughtfully integrated to avoid worsening disparities, as organizational preparedness remains essential.
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Frontiers In Pediatrics

  • August 12, 2026
Correction: Factors Influencing Individual Hearing Loss Risk: A Systematic Review and Meta-Analysis of Birth Weight, Ototoxic Medications, and Surgical Background
  • Hanwen Luo
  • Jianghua He
  • Dapeng Chen
  • Xiaoming Xu
  • Jing Zhao
  • Xiaoyan Yang
  • Jing Shi
  • August 12, 2026

Objective: To identify factors influencing individual hearing loss risk in NICU neonates. Approach: Meta-Analysis: A systematic review and meta-analysis were co

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Frontiers In Surgery

  • August 12, 2026
Navigating Diagnostic Difficulties in Boerhaave Syndrome with Bilateral Pleural Involvement: The Complementary Functions of CT Imaging, Endoscopy, and Video-Assisted Thoracoscopic Surgery
  • Junxue Han
  • Ximing Mu
  • Chaojie Xue
  • Aofei Yang
  • Shujuan Bai
  • Dongde Li
  • August 12, 2026
  1. Boerhaave syndrome is a rare condition caused by esophageal perforation, often following severe vomiting, leading to serious complications.
  2. Diagnosis can be challenging, as imaging may not always localize the perforation, complicating timely treatment.
  3. A 36-year-old male patient presented with chest pain after vomiting, with CT revealing bilateral pleural effusions and pneumomediastinum.
  4. The patient underwent video-assisted thoracoscopic surgery, which included pleural debridement and drainage, leading to recovery.
  5. Effective diagnosis and management of Boerhaave syndrome require a multidisciplinary approach involving various specialists.
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Critical Care

  • August 12, 2026
Limitations in Balloon Dimensions Affect the Interpretation of REBOA Findings
  • Habib Frost
  • Anette Kristiansen
  • August 12, 2026
  1. The REBOARREST trial investigated REBOA in out-of-hospital cardiac arrest but has significant limitations affecting its findings.
  2. The 20 mm balloon used in the trial resulted in a 49–61% underinflation of the aortic lumen area for the median participant age of 68.
  3. Delayed treatment was noted, with a median time of 47 minutes from arrest to balloon inflation, which may impact outcomes.
  4. The REBOA Medical 20 mm balloon lacks CE mark certification under the EU Medical Device Regulation for cardiac arrest treatment.
  5. Exclusion of 21 patients post-randomization may bias the study results and affect the integrity of safety and performance assessments.
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Frontiers In Psychiatry

  • August 12, 2026
Case Study: Misdiagnosis Due to Overlapping Symptoms in a Patient with Major Depression Subsequently Found to Have Systemic Amyloidosis
  • Yuexi Liang
  • Wei Li
  • Lanying Liu
  • August 12, 2026
  1. Systemic amyloidosis can present with non-specific symptoms that overlap with major depression, leading to diagnostic delays.
  2. A 57-year-old male patient initially diagnosed with major depression was later found to have systemic amyloidosis with cardiac involvement.
  3. The patient's treatment for depression included duloxetine and olanzapine, but symptoms persisted and worsened, leading to further investigation.
  4. Cardiac involvement is the primary cause of morbidity and mortality in systemic amyloidosis, complicating its diagnosis.
  5. Increased interdisciplinary awareness and reduced cognitive bias are necessary to prevent misdiagnosis in patients with overlapping symptoms.
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Frontiers In Medicine

  • August 12, 2026
Correction: Cardiac Arrest Associated with Acquired Long QT Syndrome During Gynecological Laparoscopy: A Case Study
  • Wenwen Wang
  • Ruijing Wang
  • Guangwei Li
  • Yun Zhang
  • August 12, 2026

Objective: To correct the author affiliation in the previously published case report. Approach: Correction Details: The correction addresses the omission of aut

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