MDSpire - MDSpire Home
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

The Medicine Maker

  • November 11, 2026
FDA Updates Potency Rules for Cell and Gene Therapies
  • November 11, 2026
  • 3 min

Objective: The article examines the objective, findings, and clinical context described in FDA Updates Potency Rules for Cell and Gene Therapies. Approach: Life

...more
2 min

The Analytical Scientist

  • November 11, 2026
Musings from The Power List: Guinevere Lageveen-Kammeijer
  • November 11, 2026
  • 8 min
  1. Guinevere Lageveen-Kammeijer studies glycosylation and its changes in diseases such as cancer, using CE-MS-based glyco(proteo)omics.
  2. Her group aims to reveal previously hidden molecular details and extend glycomic analysis toward individual cells.
  3. She expects single-cell glycomics to reveal cellular heterogeneity and sees separation science, including CE-MS, as important for resolving molecular complexity.
  4. She emphasizes that greater sensitivity and more data do not automatically produce better science; measurements and computational patterns require validation and biological interpretation.
  5. A CE experiment using prostate-specific antigen as a model glycoprotein revealed CE's ability to separate glycoforms with differently linked sialic acids and redirected her PhD toward prostate cancer
...more

The Analytical Scientist

  • November 11, 2026
Tracking Honey’s Seasonal Chemical Fingerprints
  • November 11, 2026
  • 3 min

Objective: Identify seasonal chemical patterns in Scottish honey using phenolic-focused, untargeted ion mobility liquid chromatography–mass spectrometry. Approa

...more
2 min

The Pathologist

  • November 11, 2026
Testing Times for Immunohistochemistry
  • April Schrank-Hacker
  • November 11, 2026
  • 7 min
  1. Rising cancer incidence, expanding biomarker menus, and staffing shortages are increasing IHC workload and straining pathology laboratories.
  2. David Newell identifies order intake, instrument loading, and unloading as key IHC workflow failure points.
  3. Batch-based ordering, batching habits, and inconsistent instrument use can delay starts and create avoidable instrument idle time.
  4. Newell reports that extending daily IHC staining-area coverage from 8 to 9.5 hours and changing workflows increased capacity from 120 to 180 slides per day without new equipment.
  5. The article recommends end-to-end workflow review and cross-functional collaboration to identify bottlenecks and plan for future laboratory needs.
...more

The Pathologist

  • November 11, 2026
Why Accurate Pathology AI Is Not Enough
  • November 11, 2026
  • 2 min

Objective: To explain why high diagnostic accuracy alone does not establish the clinical value of AI in digital pathology and to propose a framework for evaluat

...more

The Medicine Maker

  • November 11, 2026
Lonza to Acquire Five US CDMO Sites from Merck KGaA
  • November 11, 2026
  • 3 min

Objective: The article examines the objective, findings, and clinical context described in Lonza to Acquire Five US CDMO Sites from Merck KGaA. Approach: Transa

...more
2 min

The Medicine Maker

  • November 11, 2026
FDA Investigates Malignancy Risk Linked to Zolgensma Gene Therapy
  • November 11, 2026
  • 3 min

Objective: The article examines the objective, findings, and clinical context described in FDA Investigates Malignancy Risk Linked to Zolgensma Gene Therapy. Ap

...more
2 min

The Medicine Maker

  • November 11, 2026
Gene Editing Shows Promise for Alpha-1 Antitrypsin Deficiency
  • November 11, 2026
  • 3 min

Objective: Assess liver gene correction and safety after LNP-delivered base editing in a patient with alpha-1 antitrypsin deficiency (AATD). Approach: Study and

...more
2 min

Intensive Care Medicine

  • November 11, 2026
Rapid Molecular Testing for VAP: Remaining Challenges and Priorities for Future Research
  • Louis Kreitmann
  • Thiago Lisboa
  • Massimo Girardis
  • November 11, 2026

Get quick, clinically relevant Q&A that turns long-form articles into clear answers for faster learning and discovery.

Take the Quiz

Critical Care

  • November 11, 2026
In septic shock–associated atrial fibrillation, cardioversion and stroke volume index—not heart rate alone—indicate successful rate control
  • Martin Balik
  • Michel Slama
  • Bruno Levy
  • Michael Fries
  • Michael Joannidis
  • Demosthenes Makris
  • Sebastian Rehberg
  • Fabio Guarracino
  • November 11, 2026

Get quick, clinically relevant Q&A that turns long-form articles into clear answers for faster learning and discovery.

Take the Quiz

Critical Care

  • November 11, 2026
Timing of Phoenix Sepsis Score Risk Stratification Relative to Hydrocortisone Treatment in Sepsis
  • Wenzhen Zhuo
  • Mengyan Sun
  • Meiting Li
  • Xiaoyang Gong
  • November 11, 2026
  1. PSS risk strata were based on the most severe organ dysfunction measurements during the first 12 hours after PICU admission.
  2. Hydrocortisone began at median 4.7 hours in high-risk and 4.1 hours in low-risk patients, so some classification measurements may have followed treatment initiation.
  3. The authors’ letter notes that treatment-related changes in organ dysfunction could affect PSS classification, but whether reclassification occurred or influenced estimates is uncertain.
  4. The propensity model included 12-hour PRISM III scores and refractory shock, covariates that may include posttreatment information and may not be suitable baseline confounders.
  5. The letter proposes analyses using shared pretreatment eligibility for an admission-time decision or pretreatment scores among eligible, untreated children at 12 hours.
...more

MDSpire News

  • November 10, 2026
Cash aid may narrow neonatal mortality gaps
  • Andrea Surnit
  • November 10, 2026
  • 3 min

Objective: To assess changes in early and overall neonatal mortality in Flint, Michigan, after the January 2024 launch of the Rx Kids cash-transfer program. App

...more
2 min

MDSpire News

  • November 10, 2026
Motugivatrep may be well tolerated at 1 year
  • Andrea Surnit
  • November 10, 2026
  • 4 min

Objective: Assess the 52-week safety and clinical outcomes of motugivatrep 0.3% ophthalmic suspension, used alone or with existing dry eye therapies, in adults

...more
2 min

MDSpire News

  • November 10, 2026
New oral option for TGCT when surgery poses risks
  • Teraya Smith
  • November 10, 2026
  • 2 min

Objective: The article reports the FDA approval of pimicotinib for adults with symptomatic TGCT when surgery may worsen functional limitations or cause severe m

...more

The Analytical Scientist

  • November 10, 2026
Making Moves
  • James Strachan
  • Henry Thomas
  • November 10, 2026
  • 17 min

Get quick, clinically relevant Q&A that turns long-form articles into clear answers for faster learning and discovery.

Take the Quiz

The Pathologist

  • November 10, 2026
Reexamining the George Floyd Autopsy
  • Gang He
  • November 10, 2026
  • 8 min
  1. The medical examiner classified Floyd’s death as a homicide caused by cardiopulmonary arrest complicating law enforcement subdual, restraint, and neck compression.
  2. The autopsy found no life-threatening injuries or distinctive traumatic evidence of airway or neck damage, but those absences do not exclude functional breathing impairment.
  3. Floyd’s hospital-admission blood contained fentanyl at 11 ng/mL and methamphetamine at 19 ng/mL, alongside substantial cardiovascular disease.
  4. Toxicology and cardiac findings were plausible contributors to cardiopulmonary arrest, but they do not establish that drugs and disease fully explain the death.
  5. Floyd’s ability to speak indicates that his airway was not completely obstructed while he spoke, but does not establish adequate breathing or oxygenation.
...more

The Pathologist

  • November 10, 2026
Sequencing Improves Lung Infection Diagnosis
  • November 10, 2026
  • 2 min

Objective: To assess the diagnostic performance of metagenomic and targeted next-generation sequencing (NGS) of bronchoalveolar lavage fluid in patients with su

...more
2 min

The Medicine Maker

  • November 10, 2026
Analytical Champions: Sarah O’Keeffe
  • November 10, 2026
  • 16 min

Get quick, clinically relevant Q&A that turns long-form articles into clear answers for faster learning and discovery.

Take the Quiz