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MDSpire is an innovative platform aiming to create a smarter, faster, and more connected medical community.

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Choose specialties Cardiology Dental Dermatology Endocrinology Family Medicine Gastroenterology Hematology Internal Medicine Neurology ObGyn Oncology Ophthalmology Optometry Pediatrics Rheumatology Pulmonary Psychiatry Pathology Surgery Orthopedic Medicine Radiology Otolaryngology Infectious Disease

Baptist Health South Florida

March 3, 2026

Motion Preservation in the Lumbar Spine: Total Joint Replacement Restores Function in a 35-Year-Old Patient

March 3, 2026
4 min

Marilia Gioia, 35, suffered from debilitating back pain due to multiple car accidents, leading to severe limitations in her daily activities and ultimately her

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Marilia Gioia suffered severe chronic back pain affecting her life.
Multiple conservative treatments failed to improve her condition.
Dr. Frank Vrionis recommended a combination of disc replacement and facet arthroplasty.
The surgery helped preserve spinal motion.
Immediately post-surgery, Marilia felt restored sensation in her legs.
She has stopped taking pain medication and started physical therapy.
Motion preservation surgery may offer benefits over spinal fusion.

March 3, 2026

HPV Uptake Grows Over Time

Conexiant News Staff
March 3, 2026
3 min

A cluster randomized clinical trial published in JAMA Network Open examined a multicomponent strategy to enhance HPV vaccination rates in pediatric primary care

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The study aimed to boost HPV vaccination rates in pediatric patients.
A multicomponent intervention was tested over 36 months.
Initial vaccination rates showed no statistical significance.
Intervention group showed improved initiation rates to 82.0% at 36 months.
Clinician behaviors improved, including addressing parental hesitancy.
Implementation was disrupted by the COVID-19 pandemic.
A system-focused approach is critical for sustainable vaccination workflows.

March 3, 2026

Chronic Back Pain Tied to Auditory Hypersensitivity

Kerri Miller
March 3, 2026
5 min

A randomized controlled trial published in Annals of Neurology found that adults with chronic back pain (CBP) rated aversive sounds as more unpleasant than pain

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Adults with chronic back pain rate aversive sounds worse than controls.
Study involved 142 patients and 51 controls.
Pain reprocessing therapy effectively reduces auditory unpleasantness.
Neuroimaging showed greater responses in chronic pain patients.
Findings suggest sensory amplification can be treated.

March 3, 2026

Penicillins Lead in SSI Prevention

Conexiant News Staff
March 3, 2026
3 min

A meta-analysis by Motaghi et al. evaluated the effectiveness of various antibiotic regimens in preventing surgical site infections (SSIs) in elective colorecta

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Broad-spectrum penicillins and cephalosporin combinations were most effective against SSIs.
105 trials with 18,273 patients assessed antibiotic regimens.
74% reduction in SSI risk with broad-spectrum penicillins.
No significant differences in hospital stay lengths observed.
Metronidazole with broad-spectrum penicillin reduced adverse events.
Consistency in antibiotic selection is crucial for prophylaxis.
Findings may influence future clinical guidelines.

The Medicine Maker

March 3, 2026

Solving the Problem of Insolubility: Part III

March 3, 2026
6 min

Austin Px CEO Elizabeth Hickman and CSO Dave Miller discussed KinetiSol's innovative approach to drug delivery that leverages plastics recycling technology. Thi

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KinetiSol improves drug delivery by dissolving poorly soluble molecules.
Technology inspired by plastics recycling.
Recent studies show potential for parenteral and inhalation delivery.
KinetiSol won the Advancing Pharmacy Research Award.
Innovation is focusing on overcoming traditional drug development challenges.
Machine learning democratizes drug discovery, allowing smaller entities to contribute.
CDMOs are crucial for translating innovations into patient treatments.

March 3, 2026

Ivermectin vs Permethrin for Scabies

Kathryn Wighton
March 3, 2026
3 min

A multicenter, assessor-blinded trial showed that topical 5% permethrin cream outperformed oral ivermectin for treating classic scabies, achieving a clinical cu

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The trial demonstrated clinical superiority of permethrin over ivermectin.
1,092 participants were enrolled from 294 households.
Primary endpoint was clinical cure rate at day
Permethrin achieved an 88.5% cure rate compared to ivermectin's 71.8%.
Cutaneous adverse events were reported in 9.9% for ivermectin and 13.6% for permethrin.
The study was led by Franck Boralevi.
Important factors include compliance and treatment ease.

Fox Chase Cancer Center

March 3, 2026

Fox Chase Cancer Center Celebrates Innovation, Sustained Growth, and Upward Momentum

March 3, 2026
1 min

Fox Chase Cancer Center exemplifies progress in cancer care through innovation and collaboration. The faculty and staff are dedicated to overcoming the challeng

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Fox Chase Cancer Center is committed to innovating cancer care.
The 2025 Annual Report is titled 'Prevail'.
Key values include relentless curiosity and collaboration.
Achievements showcase sustained growth in cancer treatment.
The center supports hope and progress for patients and the community.

March 3, 2026

Antibiotic Guideline Gaps Raise SSI Risk

Conexiant News Staff
March 3, 2026
3 min

A nationwide analysis of over 119,000 noncardiac surgeries indicates persistent gaps in adherence to perioperative antibiotic prophylaxis guidelines from the In

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26.1% of cases nonadhered to antibiotic guidelines.
Most common deviation: antibiotic choice (13.3%).
SSIs occurred in 4.4% of cases.
Nonadherence to antibiotic choice increased SSI risk by 43%.
Cefazolin is the recommended antibiotic for many noncardiac surgeries.
Strategies proposed to improve adherence include benchmarks and decision support tools.

March 3, 2026

GLP-1 RAs in Chronic Migraine

Kathryn Wighton
March 3, 2026
3 min

A study presented at the American Academy of Neurology's 78th Annual Meeting found that adults with chronic migraine who initiated glucagon-like peptide-1 recep

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GLP-1 receptor agonists may reduce ED visits and hospitalizations for chronic migraine.
The study compared GLP-1 RAs to topiramate.
21,994 patients were analyzed.
24% of GLP-1 RA users visited the ED compared to 26% for topiramate.
GLP-1 RA initiation linked with lesser additional preventive medications.
Propensity score matching used for cohort balance.
Further trials are needed to confirm these findings.

March 3, 2026

Empowering Visiting Nurses in Audiology

Alun Evans
March 3, 2026
3 min

A cluster randomized controlled trial published in PLOS One examined the effectiveness of a structured hearing loss education program aimed at visiting nurses c

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Study improved hearing screening by visiting nurses for older adults.
Cluster randomized controlled trial conducted in Japan with 102 participants.
Intervention included a lecture and hands-on training.
Simple screening tools enhanced implementation rates.
Improvements in nurses' knowledge and confidence in hearing care were observed.
Findings suggest integration of hearing care training is beneficial in geriatric settings.

The Pathologist

March 3, 2026

Why Creativity Belongs in Pathology

March 3, 2026
3 min

Pathology blends creativity with science, focusing on observation to interpret various visual elements for accurate diagnoses. The #pathart movement highlights

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Pathology integrates observation and creativity.
#pathart movement highlights beauty in diagnostic materials.
Social media serves as a gallery for pathologists.
Engaging with pathology creatively aids education.
Collaboration across disciplines enhances the profession.
Upcoming Pathology Captures art gallery to showcase community artwork.
No artistic background is needed for participation.
Invites sharing of creations for wider visibility and communication.

The Pathologist

March 3, 2026

Toxicant Exposure Echoes for Generations

March 3, 2026
3 min

A comprehensive rat study spanning 20 generations has revealed the stable transmission of epigenetic changes linked to adult-onset diseases and abnormal births

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Study reveals lasting epigenetic changes from vinclozolin exposure.
Examined 20 generations of rats.
Increased DNA methylation regions across generations.
Observed adult-onset diseases in multiple organs.
Abnormal births reported in later generations.
Discusses implications for human reproductive health.
Led by Michael Skinner at Washington State University.
Future research needed to clarify mechanisms.

The Ophthalmologist

March 3, 2026

UK Authorization for Aflibercept

March 3, 2026
2 min

The UK's MHRA has approved aflibercept 8 mg (Eylea®) for treating visual impairment caused by retinal vein occlusion (RVO). This marks the third approval for th

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Aflibercept 8 mg approved for retinal vein occlusion (RVO) in the UK.
Suitable for treating visual impairment from RVO.
Approval based on QUASAR trial data.
8 mg group had fewer injections and similar visual outcomes as 2 mg.
Over 60% of patients in 8 mg achieved longer treatment intervals.
Safety profile consistent with previous studies.
Updated posology allows minimum 4-week treatment intervals.

The Ophthalmologist

March 3, 2026

Eyelid Surgery is Not Cosmetic Surgery

Dion Paridaens
March 3, 2026
5 min

Blepharoplasty, often perceived as merely cosmetic, is a critical surgical procedure impacting vision, ocular surface health, and facial functionality. Misunder

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Blepharoplasty is not just cosmetic; it has functional implications.
Eyelids play a vital role in ocular protection and tear film stability.
Oculoplastic surgeons combine cosmetic and ophthalmic expertise.
Complications from eyelid surgery can severely impact quality of life.
Experience in oculoplastic procedures is crucial to minimize risks.
Patients should be informed about functional trade-offs in surgery.
Eyelid surgery demands meticulous surgical judgement and understanding.

The Analytical Scientist

March 3, 2026

Mapping Molecular Discordance in the Brain

March 3, 2026
2 min

A groundbreaking single-cell proteomics study from the University of California, San Francisco and Stanford University has unveiled a detailed protein map of th

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Single-cell proteomics reveals protein-level brain development maps.
Study involved individual cell quantification from prenatal tissues.
Protein abundance differs significantly from mRNA levels.
Key transition observed from intermediate progenitors to excitatory neurons.
Findings link protein expression dynamics to neurodevelopmental vulnerabilities.
Results suggest future research directions integrating genetic data.
Possible implications for understanding early molecular dysregulation in neurodevelopmental disorders.

The Analytical Scientist

March 3, 2026

Bad Hair Day

March 3, 2026
2 min

A recent survey conducted by scientists at the Silent Spring Institute revealed that numerous hair extension products contain hazardous chemicals linked to canc

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Study by Silent Spring Institute analyzed 43 hair extension products.
Over 900 chemical signals detected including 169 compounds.
Hazardous chemicals found in both synthetic and natural extensions.
Organotins linked to skin irritation detected in 10% of products.
Chemicals associated with carcinogenicity and hormonal disruption.
Emphasizes health risks for Black women, urging proactive industry changes.

March 2, 2026

FDA Okays Weekly Option in Achondroplasia

Kathryn Wighton
March 2, 2026
2 min

The FDA has approved navepegritide (YUVIWEL) to enhance linear growth in pediatric patients aged 2 years and above with achondroplasia and open epiphyses, based

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Navepegritide approved by FDA for growth in achondroplasia.
Target age: 2 years and older.
Improves annualized growth velocity.
Rare Pediatric Disease Priority Review Voucher issued.
Potential complications include spinal issues and muscular problems.
Injection site reactions are common adverse effects.
Commercial launch expected by Q2 2026.

Baptist Health South Florida

March 2, 2026

Gautam Yagnik, M.D., Joins the NFL Physicians Society Board of Directors

March 2, 2026
1 min

Gautam Yagnik, M.D., an orthopedic surgeon at Baptist Health Orthopedic Care, has been appointed to the NFL Physicians Society Board of Directors, recognized fo

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Dr. Gautam Yagnik is an orthopedic surgeon.
He is a team physician for the Miami Dolphins.
Appointed to the NFL Physicians Society Board.
Recognized for expertise in sports medicine.
NFLPS focuses on player health and safety.
Founded in 1966, it enhances medical care for NFL players.
Supports team physicians and athletic trainers.

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