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MDSpire News

  • October 19, 2026
FDA approves dostarlimab for advanced rectal cancer
  • Mouj Hijazi
  • October 19, 2026
  • 3 min

Objective: The article examines the objective, findings, and clinical context described in FDA approves dostarlimab for advanced rectal cancer. Approach: Approv

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2 min

MDSpire News

  • October 19, 2026
Catheter stop orders may be losing ground
  • Andrea Surnit
  • October 19, 2026
  • 4 min

Objective: The article examines the objective, findings, and clinical context described in Catheter stop orders may be losing ground. Approach: Design: Repeated

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1 min

The Medicine Maker

  • October 19, 2026
Three Targets, One CAR T Therapy
  • October 19, 2026
  • 4 min

Objective: Evaluate the safety, feasibility, and early clinical activity of a CAR T-cell therapy targeting CD19, CD20, and CD22 in patients with relapsed or ref

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2 min

The Medicine Maker

  • October 19, 2026
Hiring for What Comes Next
  • Teresa Reti
  • October 19, 2026
  • 7 min

Objective: The article examines the objective, findings, and clinical context described in Hiring for What Comes Next. Approach: Milestone-focused hiring: Board

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3 min

The Pathologist

  • October 19, 2026
New Tick-Borne Virus Identified in China
  • October 19, 2026
  • 3 min

Objective: To identify and characterize a previously unknown tick-borne virus in patients with fever and tick exposure in China. Approach: Patient testing: Rese

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2 min

The Pathologist

  • October 19, 2026
Introducing The Pathologist Hall of Fame
  • Helen Bristow
  • October 19, 2026
  • 4 min

Objective: Introduce a permanent Hall of Fame recognizing individuals whose influence on pathology has endured. Approach: Eligibility: The Hall of Fame recogniz

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2 min

The Analytical Scientist

  • October 19, 2026
Musings from The Power List: Christopher Rüger
  • October 19, 2026
  • 13 min

Objective: The article examines the objective, findings, and clinical context described in Musings from The Power List: Christopher Rüger. Approach: Research fo

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3 min

The Analytical Scientist

  • October 19, 2026
44,000 Protein Forms Mapped in Plasma
  • October 19, 2026
  • 3 min

Objective: To map the diversity of protein forms (proteoforms) in human plasma and examine how proteoform diversity relates to measurements from affinity-based

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2 min

The Medicine Maker

  • October 19, 2026
SRSF1 Gene Delivery Extends Lifespan in Aged Mice
  • October 19, 2026
  • 3 min

Objective: Identify a gene that can make aged cells show younger molecular features while preserving their specialized identity, and test its effects in aged mi

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2 min

Jama Network Open

  • October 19, 2026
Nativity and Length of US Residence in Relation to Nonadherence to Colorectal Cancer Screening
  • Sebastian O. Ekenze
  • Areesh Mevawalla
  • Aayan E. Kibria
  • Kizuki Yuza
  • Abdulaziz Elemosho
  • Timothy M. Pawlik
  • October 19, 2026

Objective: Assess whether nativity and duration of US residence were associated with nonadherence to colorectal cancer screening guidelines among US adults aged

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2 min

Jama Network Open

  • October 19, 2026
Implementing Drug Allocation Policies Amid a Severe Chemotherapy Shortage
  • Eric C. Blackstone
  • Yating Wang
  • Eno-Abasi Inyang
  • Andrew G. Shuman
  • Michael Casey
  • Gregory A. Abel
  • Andrew Hantel
  • October 19, 2026

Objective: To evaluate implementation of the Dana-Farber Cancer Institute (DFCI) carboplatin allocation plan and assess whether clinical or demographic factors

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1 min

Clinical Research In Cardiology

  • October 19, 2026
Takotsubo Syndrome Revisited: Findings From a Multicenter Cohort Study
  • Hugo Lanz
  • Endrit Cekaj
  • Lucas Bacmeister
  • Christian Jung
  • Samuel Muli
  • Sabine Hoffmann
  • Matthias Schmid
  • Marcelo Galdos-Bejar
  • Daniel Hoyer
  • Lisa Crusius
  • Norman Mangner
  • Lisa Reinhardt
  • Loubna Yahsaly
  • Lars Michel
  • Victoria Pfeiffer
  • Mostafa Salem
  • Rafael Henrique Rangel
  • Johannes Terporten
  • Fabian Heindl
  • Marcus Brugger
  • Sebastian Zimmer
  • Tienush Rassaf
  • David Leistner
  • Dirk Westermann
  • Benjamin Meder
  • Malte Kelm
  • Stephan Baldus
  • Christian Schulze
  • Georg Nickenig
  • Franz Haertel
  • Enzo Lüsebrink
  • October 19, 2026
  1. This retrospective multicenter cohort included adults with Takotsubo syndrome treated at 13 German tertiary care centers from 2013 through 2024.
  2. Patients were classified by acute neurologic, other physical, emotional, or unidentified triggers.
  3. The study examined whether acute brain pathology was associated with cardiac dysfunction severity differently from other physical stressors.
  4. Investigators assessed short-term cardiac recovery and factors associated with a critical in-hospital course.
  5. The composite in-hospital cardiac complication endpoint included atrial fibrillation, ventricular tachycardia or fibrillation, pulmonary edema, cardiogenic shock, and death.
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Jama Network Open

  • October 19, 2026
At-Home Transcranial Direct Current Stimulation Combined With Gamified Cognitive Control Training for Depression: A Study
  • Esther Dechantsreiter
  • Frank Padberg
  • Yuval Benjamini
  • Stephan Goerigk
  • Linda Rubene-Kesele
  • Liene Konosonoka
  • Ulrike Vogelmann
  • Tamar Cohen
  • Naamah Lerner
  • Gerrit Burkhardt
  • Aldo Soldini
  • Fabienne Windel
  • Marios Fanourakis
  • Zeno Menestrina
  • Arthur Nguyen
  • Angela Pasqualotto
  • Takuya Morishita
  • Amir Dotan
  • Shira Ahissar
  • Alon Morash
  • Jonas Björklund
  • Lucia Bulubas
  • Daniel Keeser
  • Netta Assa
  • Rémy Gardier
  • Roser Viñals
  • Jean-Philippe Thiran
  • Ronen Segman
  • Omer Bonne
  • Amit Lotan
  • Friedhelm C. Hummel
  • Elmars Rancans
  • Daphne Bavelier
  • Mor Nahum
  • October 19, 2026

Objective: To assess the feasibility, safety, and efficacy of home-based transcranial direct current stimulation (tDCS) combined with gamified cognitive control

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1 min

Intensive Care Medicine

  • October 19, 2026
Recent Updates in Point-of-Care Lung Ultrasound: Interpreting the New Recommendations
  • Giovanni Volpicelli
  • Luna Gargani
  • Laurent Zieleskiewicz
  • October 19, 2026

Objective: The commentary identifies what is new in two recent evidence-based publications on lung ultrasound and explains the purpose and limits of their forma

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1 min

United States Department Of Health And Human Services

  • October 19, 2026
Trump Signs Executive Order to Expand Women’s Health Research, With First Lady Melania Trump’s Support
  • Assistant Secretary for Public Affairs (ASPA)
  • October 19, 2026

Objective: The article examines the objective, findings, and clinical context described in Trump Signs Executive Order to Expand Women’s Health Research, With F

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2 min

Jama Network Open

  • October 19, 2026
Mortality Risk in Individuals With Attention-Deficit/Hyperactivity Disorder: Systematic Review and Meta-Analysis
  • Lucy Corrigan
  • Lauren Heywood
  • Gavin R. Stewart
  • Elizabeth O’Nions
  • Henry Shelford
  • Joshua Stott
  • Amber John
  • October 19, 2026

Objective: To synthesize evidence on whether ADHD is associated with higher all-cause and cause-specific mortality than no ADHD, and whether ADHD medication use

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4 min

Infection

  • October 19, 2026
Comparing Short- and Long-Duration Antibiotic Therapy for Bone Infections: A Meta-Analysis of Randomized Controlled Trials
  • Yang Sun
  • Yu Sun
  • Zhaolun Feng
  • Bo Hakert
  • Jiantong Ma
  • Jillian Cornish
  • October 19, 2026

Objective: To compare short- and long-course antibiotic therapy for bacterial bone infections, assessing treatment failure and antibiotic-related adverse events

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3 min

Clinical Research In Cardiology

  • October 19, 2026
Time-Dependent Cytokine Patterns During Microaxial Flow Pump Support Reveal a High-Risk Inflammatory Profile in Cardiogenic Shock
  • Julian Kreutz
  • Joshua Amoah
  • Klevis Mihali
  • Lukas Harbaum
  • Georgios Chatzis
  • Nikolaos Patsalis
  • Styliani Syntila
  • Bernhard Schieffer
  • Birgit Markus
  • October 19, 2026
  1. This retrospective, single-center cohort study examined cytokine trajectories in adults with SCAI stage C or higher cardiogenic shock receiving Impella support from 2021 to 2023.
  2. Researchers measured serum IL-1β, IL-6, IL-8, and TNF-α at device implantation and at 24, 72, 120, and 168 hours when samples were available.
  3. The study assessed cytokine patterns alongside CRP, procalcitonin, leukocyte count, vasoactive-inotropic score, SOFA score, and blood culture results.
  4. Patients receiving support for less than 24 hours, concomitant VA-ECMO, Impella 5.5, or lacking serial cytokine measurements were excluded.
  5. Later cytokine measurements were less frequent, and the 168-hour time point was considered exploratory; infection adjudication and distinction from culture contamination were not consistently availabl
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