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European Radiology

  • September 26, 2026
Multicenter Assessment of AI-Based Risk Stratification for Identifying Clinically Relevant Prostate Cancer via Biparametric MRI
  • Karsten Guenzel
  • Maarten G. Poirot
  • Almar van Loon
  • Emanuele Messina
  • Martina Pecoraro
  • Valeria Panebianco
  • Robert Princenthal
  • Francesco Giganti
  • September 26, 2026

Objective: To compare artificial intelligence–based risk classification with radiologist-assigned PI-RADS for detecting clinically significant prostate cancer (

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5 min

Food Safety And Risk

  • September 26, 2026
Safety Assessment of Microbiological and Chemical Properties in Artisanal Dark and White Chocolate from Small-Scale Producers in West Java, Indonesia
  • Gisubizo Fabien
  • Uswatun Hasanah
  • Harsi Dewantari Kusumaningrum
  • Hanifah Nuryani Lioe
  • September 26, 2026
  1. Chocolate is a highly consumed product, with global sales exceeding USD 130 billion in 2023 and projected to reach USD 182 billion by 2032.
  2. Indonesia is the third-largest cocoa producer globally, with West Java being a key region for artisanal chocolate production.
  3. Microbiological contamination and chemical hazards are significant concerns in chocolate manufacturing, particularly for small-scale producers.
  4. Lead and cadmium are the primary heavy metal safety concerns in cacao, with their accumulation influenced by environmental factors and processing practices.
  5. Regulatory limits for heavy metals in chocolate vary by jurisdiction, complicating compliance for artisanal producers targeting export markets.
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World Journal Of Urology

  • September 26, 2026
Correspondence on the Study of 3D-Presumed Circular Area Ratio in MRI Evaluation of Benign Prostatic Hyperplasia
  • Ajay Guru
  • September 26, 2026

Objective: To discuss the findings of the study on 3D-presumed circular area ratio (3D-PCAR) in MRI assessment of benign prostatic hyperplasia (BPH). Approach:

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1 min

Blood Cancer Journal

  • September 26, 2026
Maintenance Therapy with Daratumumab ± Pomalidomide Following Salvage Autologous Stem Cell Transplantation in Relapsed Multiple Myeloma: Results from a Phase 2 Trial
  • Oren Pasvolsky
  • Bruno Almeida Costa
  • Yosra M. Aljawai
  • Krina K. Patel
  • Qaiser Bashir
  • Dawen Sui
  • Samer A. Srour
  • Mark R. Tanner
  • Uday R. Popat
  • Neeraj Y. Saini
  • Chitra Hosing
  • Jeremy L. Ramdial
  • Hans C. Lee
  • Gregory P. Kaufman
  • Sheeba K. Thomas
  • Donna M. Weber
  • Melody Becnel
  • Guilin Tang
  • Robert Z. Orlowski
  • Richard E. Champlin
  • Yago Nieto
  • Elizabeth J. Shpall
  • Muzaffar H. Qazilbash
  • September 26, 2026
  1. A phase 2 trial evaluated daratumumab with or without pomalidomide as maintenance therapy after salvage autologous stem cell transplantation in relapsed multiple myeloma.
  2. The study included 13 patients, with a median age of 64 years and a median of 2 prior therapy lines before salvage ASCT.
  3. At 4 years post-salvage ASCT, progression-free survival was 62%, while overall survival reached 100%.
  4. Response rates improved during maintenance, with 85% of patients achieving complete response or better by the final assessment.
  5. Neutropenia was the most common grade ≥3 adverse event, affecting 62% of patients during the study.
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Obesity Surgery

  • September 26, 2026
Link Between Cholecystectomy and Inflammatory Changes in the Gastroesophageal Region Following Sleeve Gastrectomy: An Endoscopic and Metabolic Assessment
  • Gabriel Guerra Cordeiro
  • Vinícius Vasconcelos do Amaral
  • Luiz Alberto Reis Mattos Júnior
  • Flávio Kreimer
  • José Guido Correia de Araújo Júnior
  • Álvaro Antônio Bandeira Ferraz
  • September 26, 2026
  1. Obesity prevalence has tripled since 1975, leading to increased interest in bariatric surgery as an effective treatment for severe obesity.
  2. Sleeve gastrectomy is the most frequently performed bariatric operation, associated with low incidences of immediate and late postoperative complications.
  3. Cholecystectomy is indicated for approximately 35% of patients after sleeve gastrectomy due to increased incidence of cholelithiasis.
  4. The study analyzed long-term esophageal and gastric mucosal changes in patients undergoing cholecystectomy after sleeve gastrectomy.
  5. Among 133 patients, the median BMI decreased significantly from 39.96 kg/m² before sleeve gastrectomy to 27.84 kg/m² before cholecystectomy.
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Diagnostic Pathology

  • September 26, 2026
Assessment of Androgen Receptor Expression in Endometrial Carcinoma via Immunohistochemistry and Its Clinical Implications
  • Alaa saad Abd elhamid Mohamed
  • Heba Ashraf Hosni
  • Maram Salaheldeen Mahmoud
  • Alzahraa Abdelmoktader Mohammed
  • September 26, 2026
  1. Endometrial carcinoma (EC) is the most commonly diagnosed gynecological malignancy in developed countries, with rising incidence and mortality rates.
  2. Current EC classification includes four molecular groups: POLEmut, MMRd, p53abn, and NSMP, enhancing tumor behavior prediction and clinical management.
  3. Androgen receptor (AR) activation may inhibit EC proliferation and migration, particularly in postmenopausal women through bioactive androgen production.
  4. The study evaluates AR expression in EC tissue samples to assess its correlation with tumor differentiation, FIGO stage, and tumor grade.
  5. Immunohistochemistry (IHC) was used to assess AR expression, with distinct nuclear staining indicating AR positivity in neoplastic glandular epithelial cells.
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Blood Cancer Journal

  • September 26, 2026
Transformation to Hodgkin Lymphoma in Chemotherapy-Naïve Patients with Chronic Lymphocytic Leukemia
  • Paul J. Hampel
  • Ying Huang
  • John N. Allan
  • Seema A. Bhat
  • David Bond
  • Danielle M. Brander
  • John C. Byrd
  • Julio C. Chavez
  • Elise Chong
  • Alexey Danilov
  • Matthew S. Davids
  • Kaitlyn Dvorak-Kornaus
  • Hannah Freedman
  • Nikita Malakhov
  • Matthew Matasar
  • Cecelia Miller
  • Sarah Miller
  • Zulfa Omer
  • Sameer A. Parikh
  • Erin M. Parry
  • Kari G. Rabe
  • Phil Raess
  • Manoj Rai
  • Joanna M. Rhodes
  • Kerry A. Rogers
  • Aditi Saha
  • Jake Schade
  • Geoffrey Shouse
  • Stephen Spurgeon
  • Deborah Stephens
  • Yucai Wang
  • Jennifer A. Woyach
  • Max Yano
  • Adam S. Kittai
  • September 26, 2026
  1. Hodgkin lymphoma transformation occurs in 1 of every 200 patients with chronic lymphocytic leukemia within 10 years after diagnosis.
  2. Patients with Hodgkin lymphoma transformation have longer survival compared to those with diffuse large B-cell lymphoma transformation.
  3. The study identified 43 patients with Hodgkin lymphoma transformation, with 23 having no prior CLL treatment and 20 having prior treatment.
  4. The overall response rate to first-line Hodgkin lymphoma treatment was 79%, with a 67% complete response rate among assessed patients.
  5. The 24-month overall survival rate was 80%, with 86% for patients with no prior CLL treatment and 70% for those with prior treatment.
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The Pathologist

  • September 25, 2026
Is AI Adoption Outpacing Infrastructure? Part 2
  • Helen Bristow
  • September 25, 2026
  • 10 min
  1. AI-only biomarker tests are emerging, increasing the urgency for digitally enabled pathology labs.
  2. Data quality is a significant bottleneck for successful AI deployment in pathology.
  3. Variations in laboratory processes can lead to incorrect treatment decisions, highlighting the need for data consistency.
  4. Integrated pilots are essential for testing AI solutions in real-world environments and identifying potential issues.
  5. Sustainability of AI in pathology requires understanding its clinical value and ensuring reimbursement mechanisms.
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The Pathologist

  • September 25, 2026
Bloodstream Infection Results in Hours
  • September 25, 2026
  • 3 min

Objective: To identify bloodstream pathogens and measure their antimicrobial susceptibility within hours using a single-cell analysis platform. Approach: Workfl

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2 min

MDSpire News

  • September 25, 2026
FDA monthly preview: Key October decisions to watch
  • Kathryn Wighton
  • September 25, 2026
  • 5 min
  1. The FDA is set to make key regulatory decisions in October 2026 regarding multiple therapies for various cancers and other conditions.
  2. Atezolizumab's application for colon cancer treatment received Priority Review, based on the phase 3 ATOMIC trial results.
  3. Ifinatamab deruxtecan's application for small cell lung cancer also received Priority Review, supported by phase 2 trial results.
  4. Satralizumab's application for thyroid eye disease is under Priority Review, with significant efficacy demonstrated in phase 3 trials.
  5. Bepirovirsen's application for chronic hepatitis B has been granted Priority Review, showing higher cure rates in phase 3 trials.
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Hemasphere

  • September 25, 2026
Unraveling mutations in ribosomal proteins linked to cancer: Advancements in the understanding of cancer and ribosome function
  • Mirsada Čaušević
  • Robbie Loewith
  • Siniša Volarević
  • September 25, 2026

Objective: To explore the role of ribosomal protein (RP) mutations in cancer susceptibility and their impact on ribosome function. Approach: Ribosome Functional

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Hemasphere

  • September 25, 2026
Analysis of Gene Expression Following Treatment with BTK and PI3Kδ Inhibitors in Chronic Lymphocytic Leukemia Reveals CXCR4 as a Potential Target for Combination Therapy
  • Gabriela Mladonicka Pavlasova
  • Veronika Sandova
  • Laura Ondrisova
  • Vaclav Seda
  • Petra Pavelkova
  • Daniel Filip
  • Krystof Hlavac
  • Josef Vecera
  • Sarka Pospisilova
  • Anna Panovska
  • Stacey M. Fernandes
  • Michael Doubek
  • Jennifer R. Brown
  • Marek Mraz
  • September 25, 2026
  1. BTK and PI3Kδ inhibitors are effective in chronic lymphocytic leukemia (CLL), with BTK inhibitors preferred due to lower toxicity.
  2. Treatment with ibrutinib and idelalisib significantly altered gene expression, affecting 225 and 340 mRNAs respectively.
  3. Both inhibitors suppressed CD20 expression, complicating the use of anti-CD20 antibodies in combination therapies.
  4. CXCR4, IL2RA, and ROR1 were upregulated after treatment, indicating potential targets for monoclonal antibody therapies.
  5. The study highlights CXCR4 as a promising target for combination therapy in CLL, given its role in cell migration and poor prognosis.
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Bmj Paediatrics Open

  • September 25, 2026
Assessing the Effectiveness of Artificial Intelligence in Educating Pediatric Patients: A Comparative Cross-Sectional Analysis
  • Ellaha Haidar
  • Alice Ruan
  • September 25, 2026
  1. AI chatbots ChatGPT-3.5 and DeepSeek were compared to NHS leaflets for pediatric ophthalmological conditions.
  2. NHS materials had significantly lower reading levels and higher readability scores than AI-generated content.
  3. Quality assessment revealed NHS leaflets outperformed AI in information quality, with significant differences in EQIP scores.
  4. AI-generated materials lacked citations and visual aids, compromising evidence-based practice and patient safety.
  5. The study highlights AI's current limitations in readability and quality for pediatric patient education compared to human-authored resources.
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Bmc Cardiovascular Disorders

  • September 25, 2026
Inequities in the Treatment of Cardiogenic Shock Associated with Acute Myocardial Infarction: Findings from a Survey in Beijing
  • Yidan Ren
  • Yuwei Liu
  • Yaxin Xie
  • Chenxu Zhao
  • Xiaqiu Tian
  • Liangshan Wang
  • Zhongtao Du
  • Xing Hao
  • Chenglong Li
  • Xiaotong Hou
  • Hong Wang
  • September 25, 2026
  1. Cardiogenic shock (CS) primarily results from acute myocardial infarction and has a mortality rate of 40%-50%.
  2. The 2025 ACC expert consensus emphasizes standardized treatment pathways and regional care networks for CS management.
  3. This study evaluated AMI-CS treatment practices across 89 hospitals in Beijing to assess inter-hospital differences.
  4. Hospitals were classified into three levels based on their capacity to manage CS, with Level 1 hospitals providing comprehensive care.
  5. The survey aimed to establish benchmarks for AMI-CS management in China, addressing gaps in resource distribution and quality control.
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Bmc Cardiovascular Disorders

  • September 25, 2026
Three-Dimensional Totally Endoscopic Mitral Valve Repair Utilizing Left Atrial Appendage Orientation in a Case of Situs Inversus Totalis with Mirror-Image Dextrocardia
  • Qiuji Wang
  • Dagang Li
  • Gengliang Qin
  • Yalin Liao
  • Ping Zhao
  • Xu Chen
  • Ruiguo Qiao
  • Biru Zeng
  • Yueer Chen
  • Gangbing Ding
  • Xiaohua Liu
  • Hanwei Li
  • Bobo Shi
  • Xiaoxuan Lin
  • Daiqiang Huang
  • Zhaoxu Gai
  • Miao Xu
  • Qijun Zheng
  • Chunying Meng
  • September 25, 2026
  1. Situs inversus totalis with mirror-image dextrocardia presents unique challenges during cardiac surgery due to reversed anatomy.
  2. Minimally invasive mitral valve surgery requires careful preoperative imaging and planning to navigate altered anatomical relationships.
  3. A three-dimensional totally endoscopic approach was utilized for mitral valve repair in a patient with severe degenerative mitral regurgitation.
  4. The surgical team employed a left-sided approach, adjusting retractor angles to accommodate the mirror-image anatomy during the procedure.
  5. Standard right-handed instruments were used effectively, demonstrating that dedicated left-handed tools were unnecessary in this case.
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Journal Of Medical Internet Research

  • September 25, 2026
Exploring the Current Landscape and Influencing Factors of Technophobia Regarding Digital Health Technologies in Older Stroke Patients: A Mixed Methods Approach
  • Yingjie Yang
  • Yongye Wu
  • Zhuoyun Wu
  • Yang Wu
  • Zilu Zhang
  • Yuxia Li
  • September 25, 2026

Objective: To investigate the factors influencing technophobia in older stroke patients regarding digital health technologies. Approach: Study Design: A mixed m

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Bmj Open Gastroenterology

  • September 25, 2026
Pancreatic Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia: A Comprehensive Review of Existing Cases
  • Isabel de Jager
  • Ebba Asplund
  • Nikolaos Kartalis
  • Poya Ghorbani
  • Nina Bloch
  • Johannes Matthias Löhr
  • Miroslav Vujasinovic
  • September 25, 2026
  1. This systematic review identified 19 patients with pancreatic arteriovenous malformations (AVMs) associated with hereditary hemorrhagic telangiectasia (HHT).
  2. Females represented 58% of the patients, with a mean age of 52 years; 50% were asymptomatic and 73% showed no laboratory abnormalities.
  3. CT was the primary diagnostic method used in 56% of cases, and the mean size of pancreatic AVMs was reported as 7.1 mm.
  4. Conservative management was the predominant treatment approach, utilized in 69% of the cases reviewed.
  5. The study concluded that pancreatic AVMs in HHT are generally smaller and less symptomatic compared to those in the general population.
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Bmj Paediatrics Open

  • September 25, 2026
Influences of Structure and Interagency Collaboration on Health Assessments for Children in Out-of-Home Care in Sweden: A Qualitative Analysis of Child Protection Services Practitioners
  • Godfried Van Agthoven
  • Gabriel Otterman
  • Rajna Knez
  • Kathi Makoroff
  • Laura Korhonen
  • September 25, 2026
  1. Children in out-of-home care in Sweden face significantly worse health outcomes compared to their peers.
  2. Less than half of eligible children in out-of-home care receive mandated health assessments, indicating low implementation rates.
  3. CPS caseworkers reported fragmented interagency structures and unclear responsibilities as barriers to effective health assessment implementation.
  4. The study identified four key themes affecting health assessment processes: initiation, scheduling, conduct, and reporting.
  5. Strengthening collaboration and clarifying roles between CPS and healthcare may enhance the effectiveness of health assessments.
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