MDSpire Home

Blood Cancer Journal

August 22, 2026

Influence of Lymphocyte Dynamics and Immune Profile on Outcomes of Bispecific Antibody Treatment in Relapsed/Refractory Multiple Myeloma

Mansi R. Shah
Aishee Bag
Asis Shrestha
Yetunde Ogunsesan
Anup Trikannad
Sruthi Vellanki
Sanjay Muttineni
Hira Cheema
Syed Naqvi
Sasya Dronavalli
Samer Al Hadidi
Sharmilan Thanendrarjan
Maurizio Zangari
Frits van Rhee
Aniko Szabo
Rajshekar Chakraborty
Meera Mohan
Carolina Schinke
August 22, 2026

Bispecific antibodies targeting BCMA or GPRC5D show overall response rates of 70% in relapsed/refractory multiple myeloma.
Baseline absolute lymphocyte count (ALC) and lymphocyte subset composition may reflect immune competence affecting bsAb treatment response.
Patients with high-risk cytogenetic abnormalities had lower response rates, while prior autologous stem cell transplant status influenced outcomes.
Lymphocyte kinetics showed a significant initial drop in ALC after bsAb initiation, with responders demonstrating faster recovery.
Exploratory analyses indicated that Day 30 lymphocyte subset measures could predict progression-free survival and overall survival.

...more

European Radiology

August 22, 2026

Dynamic contrast-enhanced MRI for early evaluation of therapeutic response in pancreatic ductal adenocarcinoma

Martin D. Holland
Ezinwanne E. Onuoha
Darryl Outlaw
Mehmet Akce
Midhun Malla
Salila Hashmi
Sushanth Reddy
J. Bart Rose
Desiree E. Morgan
Grant R. Williams
Moh’d Khushman
Dana B. Cardin
Katherine Frederick-Dyer
Xiaoyu Jiang
Zarine K. Shah
Bassel El-Rayes
Junzhong Xu
Harrison Kim
August 22, 2026

Pancreatic ductal adenocarcinoma (PDAC) has a low five-year survival rate of approximately 10% due to late diagnosis and limited treatment options.
Dynamic contrast-enhanced MRI (DCE-MRI) may provide early evaluation of PDAC response to chemotherapy by quantifying tissue perfusion.
A portable perfusion phantom (P4) was developed to correct inter- and intra-scanner variability in DCE-MRI measurements.
In a preliminary study, P4-corrected DCE-MRI measurements differentiated responders from non-responders better than RECIST.
The study aimed to validate the clinical utility of quantitative DCE-MRI for predicting early treatment response in PDAC at two institutions.

...more

World Journal Of Urology

August 22, 2026

Clinical Features, Treatment Approaches, and Survival Rates in Ductal Adenocarcinoma of the Prostate: A Retrospective Multicenter Study

A. Handke
P. Paffenholz
K. Schlack
K. E. Seifert
J. Linxweiler
J. Mink
F. Flockerzi
T. Nestler
M. Wenzel
C. Siech
C. Darr
V. Grünwald
F. Roghmann
K. H. Tully
August 22, 2026

Prostatic ductal adenocarcinoma (PDA) is an aggressive subtype of prostate cancer with poorer prognosis compared to acinar adenocarcinoma.
PDA is often diagnosed at advanced stages, correlating with higher ISUP grades, extraprostatic extension, and positive surgical margins.
Lower serum PSA concentrations in PDA may contribute to underdiagnosis, despite its aggressive nature and high disease-specific mortality.
The study enrolled 82 patients with histologically confirmed PDA from seven urological centers in Germany, focusing on oncologic outcomes.
Overall survival for metastatic PDA is 72% at 5 years, with median survival reaching 77 months, highlighting its serious nature.

...more

Digital Health

August 22, 2026

Creation, refinement, and future methodological investigation of a patient experience scale for endoscopy in China along with a decision support tool

Chengcheng Gao
Xicheng Chen
Yan Wang
Weijia Dou
Qiongjie Shao
Rui Zhang
Ying Liang
Nan Li
Fang Hu
Yang Zhao
Zhenxiong Liu
Lei Shang
August 22, 2026

A total of 40 million gastrointestinal endoscopic procedures were performed in China in 2023, highlighting the need for improved patient experience measures.
The Endoscopy Patient Experience Scale (EPES) was developed to assess patient experiences during gastrointestinal endoscopy in the Chinese context.
The study introduced the Simplified Endoscopy Patient Experience Scale (S-EPES) using a multi-objective black-winged kite algorithm for scale simplification.
The Endoscopy Patient Experience Decision Support System (EPE-DSS) was created to assist clinical decision-making based on patient experience data.
The study's methodology included cross-sectional design and psychometric evaluation, with ethical approval obtained from the relevant medical ethics committee.

...more

Archives Of Orthopaedic And Trauma Surgery

August 22, 2026

Impact of Scheduling Elective Arthroplasty on "High-Risk" Dates: Analysis of 43,000 Procedures Reveals No Adverse Outcomes

Nike Walter
David W. Lowenberg
Christian Heiss
Edmund C. Lau
Markus Rupp
August 22, 2026

The study analyzed 43,000 elective arthroplasties to assess the impact of performing surgeries on Friday the 13th.
Data were sourced from Medicare records covering procedures from January 1, 2009, to December 31, 2019.
No significant differences were found in complication rates or mortality between surgeries on Friday the 13th and other Fridays.
A total of 945 arthroplasties were performed on Fridays that fell on the 13th, with similar outcomes to other Fridays.
Statistical analyses showed adjusted hazard ratios for revisions and mortality were not significantly different for Friday the 13th surgeries.

...more

Archives Of Orthopaedic And Trauma Surgery

August 22, 2026

Long-term Outcomes of Hip Resurfacing Arthroplasty: Higher Revision Rates in Female Patients with Dysplasia and Smaller Components After 14 Years

Yu-Chih Lin
Chih-Hsiang Chang
Pang-Hsin Hsieh
Yu-Yi Huang
Dave W. Chen
Ngi-Chiong Lau
August 22, 2026

Hip resurfacing arthroplasty (HRA) is a bone-conserving alternative to total hip arthroplasty (THA) for young, active individuals with advanced hip disease.
Survivorship rates after Birmingham Hip Resurfacing are 96.5% for men and 87.0% for women at 20 years, decreasing to 89.5% and 66.9% by 25 years.
Female sex, smaller component size, and developmental dysplasia of the hip (DDH) are identified as risk factors for HRA failure.
The study categorized hips by etiology as Primary OA, DDH, or Non-OA, with avascular necrosis (AVN) evaluated separately.
Long-term outcomes of HRA require comprehensive evaluation, including serum metal-ion measurements and MARS-MRI.

...more

Digital Health

August 22, 2026

Exploring Motion Sickness Induced by Head-Mounted Displays in Individuals with Aphasia

Muhammed Intiaz
Rajath Shenoy
Apoorva Pauranik
Girish Menon
Shivani Tiwari
Aparna Pai
Gopee Krishnan
August 22, 2026

Aphasia affects one-third of individuals with stroke or brain damage, impairing language and communication.
Extended Realities (XR) technologies, including VR, AR, and MR, create engaging therapeutic environments for rehabilitation.
VR interventions for aphasia focus on enhancing linguistic outcomes and functional communication through simulated environments.
Simulation sickness is a common adverse effect of head-mounted displays, causing symptoms like nausea and dizziness.
Factors influencing simulation sickness include visual-vestibular conflict, display properties, and user-specific characteristics.

...more

Acta Paediatrica

August 22, 2026

Co-Occurrence of Neurodevelopmental Disorders and Early-Onset Type 1 Diabetes in Families

Shengxin Liu
Gisele Magarotto Machado
Irzam Hardiansyah
Xinyue Gu
Jonas F. Ludvigsson
Paul Lichtenstein
Soffia Gudbjörnsdottir
Ebba Du Rietz
Brian D'Onofrio
Henrik Larsson
Mark J. Taylor
Ralf Kuja-Halkola
Agnieszka Butwicka
August 22, 2026

Type 1 diabetes (T1D) is a prevalent chronic disorder that often begins in childhood and is associated with neurodevelopmental conditions (NDCs).
Neurodevelopmental conditions include ADHD, autism, and intellectual disability, affecting approximately 235 million individuals worldwide.
The study investigates the familial co-occurrence of childhood-onset T1D and NDCs, focusing on shared genetic and environmental factors.
Data for the study was sourced from several Swedish national registers, including the National Patient Register and the Total Population Register.
The cohort comprised over 4 million individuals born in Sweden, with analyses examining the relationship between T1D and NDCs among relatives.

...more

Pharmacoepidemiology And Drug Safety

August 22, 2026

Patterns of Medication Discontinuation and Their Impact on Accessibility in Brazil (2014–2024)

Raphaella Oliveira Martins de Lima
Esther Ramos Silva
Isabel C. M. Emmerick
Danielle Maria de Souza Serio dos Santos
Isabella Piassi Dias Godói
Ana Cristina Viana Campos
Luisa Arueira Chaves
August 22, 2026

Objective: To examine the national drug discontinuation panel in Brazil to characterize the extent and patterns of medicine discontinuation, determine the princ

...more

Archives Of Orthopaedic And Trauma Surgery

August 22, 2026

Assessment of an Innovative Strap Fixation Technique for Biomechanical Analysis of Sheep Achilles Tendons

Onur Basci
Selahaddin Aydemir
Resit Bugra Husemoglu
Mustafa Çeltik
August 22, 2026

Biomechanical investigations of tendons are crucial for understanding soft-tissue behavior and improving surgical techniques.
Tendons are prone to slippage during tensile tests, leading to inaccurate measurements and limited reproducibility.
Various fixation techniques exist, but many can cause tendon deformation or slippage, compromising measurement reliability.
This study compares four fixation techniques for sheep Achilles tendons to identify a practical, low-cost method.
Forty sheep Achilles tendon specimens were tested under standardized conditions to assess biomechanical strength.

...more

Archives Of Orthopaedic And Trauma Surgery

August 22, 2026

Systematic Review of Postoperative Periprosthetic Fractures Linked to Compressive Osseointegration with the Zimmer Biomet Compress® Device

Kazuhiko Hashimoto
Shunji Nishimura
Koji Goto
August 22, 2026

The Zimmer Biomet Compress® device utilizes compressive osseointegration to improve implant fixation and reduce stress shielding.
Periprosthetic fractures associated with the CPS device were documented at a low incidence of 2.7% in a multicenter cohort study.
Fractures primarily occurred within the first two postoperative years, contrasting with traditional cemented stems that fail over time.
Methodological quality of the included studies was moderate, with common weaknesses including retrospective designs and limited control groups.
The systematic review aimed to assess postoperative periprosthetic fractures related to the CPS device compared to conventional cemented stems.

...more

Int. Journal Of Computer Assisted Radiology And Surgery

August 22, 2026

Predicting Clinical Outcomes of Contour Neurovascular System Therapy Using Pre-Treatment Geometric and Hemodynamic Factors

Fina Gießler
Anna Bernovskis
Franziska Gaidzik
Jana Korte
Philipp Berg
Sönke Peters
Naomi Larsen
Sylvia Saalfeld
August 22, 2026

Intracranial aneurysms pose a significant rupture risk, leading to morbidity or death, necessitating effective management strategies.
The Contour Neurovascular System (CNS) has shown an 84% adequate occlusion rate in early clinical investigations for treating wide-necked bifurcation aneurysms.
Incomplete occlusion and device deformation have been documented post-treatment, potentially requiring additional interventions.
The study analyzes pre-treatment geometric and hemodynamic factors to predict clinical outcomes and shape modifications of the CNS.
A cohort of 39 aneurysms was evaluated, with outcomes classified as positive or negative based on clinical deterioration during follow-up.

...more

Clinical Rheumatology

August 22, 2026

Correction: Electroacupuncture Slows the Advancement of Juvenile Collagen-Induced Arthritis Through Modulation of the NLRP3/NF-κB Signaling Pathway and Its Effects on Pyroptosis and Autophagy

Fater A. Khadour
Younes A. Khadour
Tao Xu
August 22, 2026

Objective: To correct specific figures in the original article regarding the effects of electroacupuncture on juvenile collagen-induced arthritis. Approach: Fig

...more

1 min

Bmc Cancer

August 22, 2026

Retraction Notice: Improved Antitumor Activity in Colon Cancer Utilizing EGF-Modified PLGA Nanoparticles Loaded with 5-Fluorouracil and Perfluorocarbon

Pingping Wu
Qing Zhou
Huayun Zhu
Yan Zhuang
Jun Bao
August 22, 2026

The article titled 'Improved Antitumor Activity in Colon Cancer Utilizing EGF-Modified PLGA Nanoparticles Loaded with 5-Fluorouracil and Perfluorocarbon' has been retracted.
The retraction was prompted by post-publication concerns regarding the integrity of the article's images.
Similarities were noted between the fourth and sixth panels in the second row of Fig. 5A.
The authors did not respond to the concerns raised by the Editors regarding the article.
Due to the lack of response, the Editors lost confidence in the article's data and conclusions.

...more

Digital Health

August 22, 2026

Governance of AI Ethics in Digital Health for Indigenous Communities: A Narrative Review and Conceptual Framework

Amal Khan
Alyson S. N. Bear
Mairyn Rackow
Cassandra Opikokew Wajuntah
Kenneth Lai
Veronica McKinney
John Costa
Ivar Mendez
August 22, 2026

AI is increasingly integrated into digital health care, potentially enhancing health outcomes and addressing systemic healthcare inequities.
Ethical issues in AI integration include equitable system design, culturally grounded implementation, and privacy protection, particularly for Indigenous populations.
A unified ethical governance framework for AI in digital health specific to Indigenous populations is currently lacking and is essential for ethical implementation.
The narrative review synthesizes literature on ethical considerations in AI for Indigenous health, aiming to inform policymakers and developers.
The multidisciplinary author group emphasizes Indigenous self-determination and the importance of including Indigenous perspectives in AI development.

...more

Digital Health

August 22, 2026

A Comprehensive Review of Artificial Intelligence Applications in Classifying Oral Cancer and Potentially Malignant Oral Disorders Using Visible-Light Imaging

Charles Goodmaker
Rishi Bhandari
Anwar Tappuni
Tuan D. Pham
August 22, 2026

Oral cancer is the 16th most prevalent cancer globally, with 389,846 cases reported, highlighting significant morbidity and mortality.
Oral potentially malignant disorders (OPMDs) include conditions like oral leukoplakia, which can progress to oral squamous cell carcinoma.
Histopathological biopsy is the gold standard for diagnosing oral lesions, yet it only samples a limited anatomical region.
Artificial intelligence (AI) shows promise in classifying oral lesions, with machine learning and deep learning techniques being explored.
This review focuses on visible-light intraoral clinical photography for AI applications in oral cancer detection and classification.

...more

Digital Health

August 22, 2026

Analyzing Patient Perspectives on Digital Doctor Review Platforms: Varied Topics, Emotions, and Service Requirements Based on Disease Risk Levels

Jingwen Ma
Ruojia Wang
Keming Fan
Rui Lian
August 22, 2026

Online healthcare platforms (OHPs) have significantly expanded the accessibility of medical services in China.
Patient satisfaction and service quality concerns are increasingly important in the context of online medical services.
Patients at different disease risk levels have distinct expectations and needs regarding online medical services.
The study proposes an integrated analytical framework to assess patient satisfaction and service needs across disease-risk groups.
Research on online doctor reviews (ODRs) in China provides empirical evidence from a non-Western healthcare context.

...more

Drugs - Real World Outcomes

August 22, 2026

Evaluation of Pain Management Efficacy Using Injectable Etoricoxib: Findings from the RAPID Study

Shiva Shankar Jha
Anoop Dhamangaonkar
Rajkumar Iyengar
Gautam Chakraverty
Kotini Saskar Rao
Abhijeet Mukherji
Sameer Muchhala
Vidhya Natarajan
August 22, 2026

The RAPID study evaluated the efficacy of intramuscular etoricoxib 90 mg for acute pain management across 68 sites in India.
Patients receiving intramuscular etoricoxib experienced significant pain reduction within 60 minutes, lasting up to 24 hours.
Intramuscular etoricoxib was generally well tolerated, with few reported side effects, indicating its potential for acute pain management.
The study aimed to assess pain intensity changes using the Numeric Pain Rating Scale and evaluate tolerability through adverse events.
Etoricoxib's injectable formulation addresses the need for effective pain relief when oral medications are impractical or contraindicated.

...more