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Acta Neuropathologica (Springer)

March 22, 2026

Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan

Jesse R. Pascual
Isabel Rivera
Halyma Nguyen
Phong T. Ngo
Alan Hoang
Elizabeth J. Andrews
Jeremy Rouanet
Sierra T. Wright
Lorena Sordo
Julia Kofler
Milos D. Ikonomovic
Florence Lai
Mark Mapstone
Bradley T. Christian
Benjamin L. Handen
Ira T. Lott
Eric Doran
Christy L. Hom
Jordan Harp
Frederick Schmitt
Dana L. Tudorascu
Beau M. Ances
Michael Phelan
Lei Liu
Lisi Flores-Aguilar
Elizabeth Head
March 22, 2026

Objective: To quantify the neuropathology burdens of pThr181, pThr231, and pThr217 in the frontal cortex of individuals with Down syndrome (DS) and late-onset A

...more

World Journal Of Urology (Springer)

March 22, 2026

Experience of 5 years adjustable continence therapy (ProACT): the surgical learning curve and patient outcomes

Lisa M. de Zeeuw
Coen H. H. Christiaans
Sebastiaan Remmers
Bertil F. M. Blok
Alexander B. Stillebroer
March 22, 2026

Objective: To map the learning curve of a single surgeon performing ProACT and assess post-surgery outcomes, including incontinence and complications, over five

...more

Drug Safety (Springer)

March 22, 2026

Disseminated Intravascular Coagulation Following Idarucizumab and Andexanet Alfa: Assessment of a Signal of Disproportionate Reporting From the Food and Drugs Administration Adverse Event Reporting System (FAERS) Database

Giuseppe Roberto
Lorenzo Parmeggiani
Alessandra Flaccavento
Alfredo Vannacci
Guido Mannaioni
Rosa Gini
Gianni Virgili
Marco Tuccori
March 22, 2026

Objective: To analyze the FDA Adverse Event Reporting System (FAERS) database for potential safety signals related to disseminated intravascular coagulation (DI

...more

European Radiology (Springer)

March 21, 2026

Convolutional neural networks in paediatric fracture detection: pooled evidence from a systematic review and meta-analysis

Alina Pervez
S. Umar Hasan
Alan R. Norrish
March 21, 2026

Objective: To synthesize the diagnostic accuracy of specific AI algorithms for paediatric appendicular fracture detection and assess limitations related to exte

...more

Fractures are common in children, with significant morbidity, making accurate and timely diagnosis essential to prevent complications.
AI, particularly convolutional neural networks, shows promise in improving diagnostic accuracy for paediatric fractures on X-rays.
Current research on AI for paediatric fracture detection is limited, with concerns about heterogeneity and generalizability of findings.
The systematic review aimed to evaluate the diagnostic accuracy of AI models for detecting paediatric appendicular fractures.
The study followed PRISMA-DTA guidelines and focused on sensitivity, specificity, and other accuracy metrics per radiograph.

Drug Safety (Springer)

March 21, 2026

International Medicinal Product Information Documents: A Quantitative Content Analysis of Instructions for Preventing, Mitigating, and Monitoring Adverse Drug Reactions

Daniele Sartori
Michele Fusaroli
Jeffrey K. Aronson
G. Niklas Norén
Igho J. Onakpoya
March 21, 2026

Objective: To quantify and compare the completeness of instructions in product information documents (PIDs) for monitoring, preventing, and mitigating adverse d

...more

The study analyzed 627 signals of adverse drug reactions, focusing on the completeness of instructions in product information documents.
Instructions for prevention and mitigation were complete in only 30% of documents, while monitoring instructions were complete in 22%.
Product information documents from the European Union and Canada provided the most comprehensive information on adverse drug reactions.
Disagreement analysis revealed international differences in documenting adverse reactions, suggesting a need for global collaboration.
The research highlights the inadequacy of current guidelines and the necessity for updated international studies on product information documents.

Hernia (Springer)

March 21, 2026

Trunk muscle strength assessment as a predictor of complications in patients undergoing incisional hernia repair

P. Bravo-Ratón
J. C. Santos-Sánchez
J. L. Gil-Delgado
A. Sánchez-Arteaga
J. Tinoco-González
B. Sañudo Corrales
L. Tallón-Aguilar
March 21, 2026

Objective: To evaluate the association between preoperative trunk muscle strength and early postoperative complications in patients undergoing incisional hernia

...more

Incisional hernia occurs in approximately 12.8% of patients after midline laparotomy, with recurrence rates ranging from 25-50%.
Preoperative trunk muscle strength may predict postoperative complications in patients undergoing incisional hernia repair.
Strain gauge systems offer a low-cost alternative for assessing abdominal muscle strength compared to traditional isokinetic dynamometry.
The study included 75 adults undergoing elective incisional hernia repair, focusing on the relationship between muscle strength and complications.
Postoperative complications were assessed within 30 days using the Clavien-Dindo classification, with 100% follow-up achieved.

Clinical Rheumatology (Springer)

March 21, 2026

Effectiveness of physical exercise on foot pain and function in adults with rheumatoid arthritis: systematic review and meta-analysis

Alejandro Cruz-López
Ana María Rayo-Pérez
Natalia Tovaruela-Carrión
Priscila Távara-Vidalón
Pedro V. Munuera-Martínez
March 21, 2026

Objective: To synthesize available evidence on the effects of physical exercise on foot pain and function in adults with rheumatoid arthritis (RA), and to compa

...more

Hernia (Springer)

March 21, 2026

Smoking cessation and weight loss before ventral hernia repair – can we really justify this? A single center cohort study

Line Marker
Anna Fisker
Frederik Helgstrand
March 21, 2026

Objective: To evaluate the feasibility and potential impact of a smoking cessation and weight loss program prior to elective ventral hernia repair (VHR) within

...more

Journal Of Gastroenterology (Springer)

March 21, 2026

Reply to “Checking the shape of hepatocellular carcinoma: How irregular is irregular?”

Feng Zhang
Yong-Shuai Wang
Lian-Xin Liu
Ji-Zhou Wang
March 21, 2026

Objective: To address comments on the study establishing the alpha-fetoprotein (AFP) and tumor shape irregularity (ATSI) score for survival prediction in advanc

...more

The ATSI score combines alpha-fetoprotein levels and tumor shape irregularity for survival prediction in advanced hepatocellular carcinoma patients.
Tumor shape irregularity was defined using four CT/MRI criteria, validated by three senior radiologists to minimize interobserver bias.
AI-based radiomics analysis revealed that 3D shape irregularity correlates significantly with poor prognosis in hepatocellular carcinoma.
The total tumor volume is a more accurate measure of tumor burden than diameter or number-based parameters in HCC prognostic models.
The ATSI score supports personalized treatment decisions, but its clinical utility needs confirmation through large-scale prospective studies.

World Journal Of Urology (Springer)

March 21, 2026

Ejaculation-preserving holmium laser enucleation of the prostate: a systematic review of techniques, functional outcomes, and safety

Mehmet Hamza Gultekin
Kadir Can Sahin
Admir Ozturk
Feyyaz Irmak
Bulent Onal
March 21, 2026

Objective: To systematically review ejaculation-preserving modifications of HoLEP and compare preservation of antegrade ejaculation (AE) between EP-HoLEP and st

...more

Holmium laser enucleation of the prostate (HoLEP) is a guideline-endorsed surgical standard for benign prostatic hyperplasia (BPH) with low retreatment rates.
Conventional HoLEP is associated with high rates of retrograde ejaculation, prompting the need for techniques that preserve antegrade ejaculation.
Anatomical studies suggest that preserving peri-verumontanum and bladder-neck structures is crucial for maintaining ejaculatory function post-surgery.
Various ejaculation-preserving modifications of HoLEP have been proposed, each differing in tissue preservation and potential impact on ejaculatory function.
A systematic review of ejaculation-preserving HoLEP techniques aims to compare outcomes related to antegrade ejaculation and urinary function.

Obesity Surgery (Springer)

March 21, 2026

Analysis of the Supportive Care Needs after Metabolic Bariatric Surgery in Germany Using an Adjusted Supportive Care Needs Survey- Short Form (SCNS-SF34)

Jonas Wagner
Madita Roll
Tobias Kantowski
Sara Notz
Gabriel Plitzko
Jakob Izbicki
Oliver Mann
Thilo Hackert
Anna Duprée
Freya Brodersen
Angelika Weigel
March 21, 2026

Objective: Consider adding context about the importance of addressing supportive care needs in MBS. Key Findings: Quantify the levels of reported needs for psyc

...more

Drug Safety (Springer)

March 21, 2026

Strengthening Pharmacovigilance in Latin America: Multidisciplinary Insights from Two ISoP Latin American Chapter Symposia

Jessica Liliana Vargas-Neri
Angela Caro-Rojas
Gilberto Castañeda-Hernández
Christian Camilo Cuello-Meza
Betty Duarte
Daniela Fontana
Cinthya Galicia-Quintanar
Victoria Hall-Ramírez
Diego Salas
Maribel Salas
Julia Jeanett Segura-Uribe
Mónica Tarapues
Heyde Patricia Zuluaga-Arias
Carlos Aceves-González
Josué Bautista-Arteaga
William Carreño-Quintero
Daniela Daza-Paz
Diana María González-Achury
Rosana Angélica Ramírez-Pedreros
Diego Armando Galvis-Sánchez
Luz Dary Terán-Mercado
March 21, 2026

Objective: To strengthen pharmacovigilance in Latin America through regional collaboration and multidisciplinary discussions, addressing specific regional chall

...more

ISoP LATAM organized symposia to enhance pharmacovigilance by uniting regulators, academia, and industry across Latin America.
Key priorities identified include regulatory convergence, real-world evidence integration, and prevention of medication errors.
Expanding pharmacovigilance education and promoting patient engagement are essential for improving drug safety in the region.
The symposia facilitated discussions on common challenges and proposed strategies for strengthening pharmacovigilance capacity.
Regional collaboration is crucial to address the diverse regulatory frameworks and resource limitations in Latin American countries.

The ASCO Post

March 20, 2026

FDA Approves Chemoimmunotherapy Regimen for Hodgkin Lymphoma

The ASCO Post Staff
March 20, 2026
3 min

On March 20, the FDA approved nivolumab (Opdivo) in combination with doxorubicin, vinblastine, and dacarbazine (AVD) for adults and adolescents (12+) with untre

...more

Nivolumab approved with AVD for untreated Hodgkin lymphoma (12+).
Study CA209-8UT had 994 participants, showing improved progression-free survival.
Nivolumab dosing: 240 mg or 3 mg/kg every 28 days for 6 cycles.
Serious adverse reactions in 39% of nivolumab patients.
Collaborative review under Project Orbis involving multiple international agencies.

Baptist Health South Florida

March 20, 2026

Lawrence Blacher, M.D., Memorial Lecture: Advancing the Fight Against Cardiac Amyloidosis: A 2026 Update

March 20, 2026
1 min

On April 16, 2026, Baptist Hospital will host a live, hybrid conference focusing on cardiac amyloidosis, a significant cause of heart failure and cardiomyopathy

...more

Conference on cardiac amyloidosis on April 16,
Features Dr. Omar F. Abou-Ezzeddine.
Discusses diagnosis and management.
Highlights advances in imaging and biomarkers.
Focus on emerging therapies.
Importance of early recognition emphasized.
Participants will learn supportive management strategies.

March 20, 2026

Obesity Care Lags Behind Advances in Treatment

Kerri Miller
March 20, 2026
3 min

Eighty-eight percent of individuals with obesity face stigma affecting their care experience. A new perspective by Miras et al. in Obesity Science & Practice id

...more

88% of individuals with obesity face stigma affecting care.
Dependence on BMI hinders effective obesity diagnosis.
9 major challenges in current obesity care identified.
Individualized treatment targets recommended.
Economic impacts of obesity on productivity noted.
Advanced treatment options are underused.
Stigma persists in healthcare settings.
Need for obesity to be treated as a chronic disease emphasized.

March 20, 2026

A Case for Reframing ‘Skin of Color’

Kerri Miller
March 20, 2026
2 min

Rashmi Sarkar, MD, and Hitaishi Mehta, MD, discuss the limitations of the Fitzpatrick scale in addressing diverse skin types, particularly for darker skin tones

...more

Fitzpatrick scale limitations for darker skin types.
Evolution of the term 'skin of color' (SOC).
SOC's role in advancing healthcare equity.
Proposed distinction of SOC into four components.
Acknowledgment of underused assessment tools for SOC.
Need for clarity in clinical contexts when using SOC.
Tension between specificity and visibility in dermatology.

March 20, 2026

Open Dressings Show Early Contamination

Meg Barbor
March 20, 2026
2 min

A study published in the International Wound Journal revealed that open-but-unused wound dressings can become contaminated with microbes soon after opening, eve

...more

Open-but-unused wound dressings showed microbial contamination shortly after opening.
65% of samples tested positive for microbial growth.
Higher contamination rates observed in hospitals than primary care settings.
Coagulase-negative staphylococci were the most common contaminants.
Scissors used for cutting dressings were contaminated in 75% of cases.
Silver-containing dressings had slightly lower contamination rates.
Study highlights need for improved handling protocols to prevent contamination.

The ASCO Post

March 20, 2026

Hypofractionated Locoregional RT in Early Breast Cancer

Matthew Stenger
March 20, 2026
3 min

A French phase III trial, UNICANCER HypoG-01, has revealed that hypofractionated locoregional radiotherapy (RT) at 40 Gy over 3 weeks is noninferior to the stan

...more

Study compared hypofractionated RT (40 Gy, 3 weeks) vs standard RT (50 Gy, 5 weeks).
Noninferiority for lymphedema risk was established.
1,221 women participated post-tumor resection.
Median follow-up was 4.8 years.
Similar incidence of arm lymphedema in both groups.
Most common adverse events were pain (69%) and fatigue (65%).
The research was funded by the French National Cancer Institute.

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