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Conexiant

July 14, 2026

FDA Expands Test for Gastric and Esophageal Cancers

Kathryn Wighton
July 14, 2026
2 min

Summary
Takeaways
Insight Report
Poll

Objective: To identify patients whose tumors express programmed death ligand 1 (PD-L1) for potential treatment eligibility with nivolumab or nivolumab and hyalu

...more

The FDA approved Agilent Technologies' companion diagnostic for identifying tumors expressing PD-L1 in gastric and esophageal cancers.
The approval is for patients with esophageal squamous cell carcinoma, gastric tumors, gastroesophageal junction tumors, and esophageal adenocarcinoma.
The PD-L1 IHC 28-8 pharmDx assay is a diagnostic aid for detecting PD-L1 expression with a Combined Positive Score of 1 or greater.
Esophageal cancer is the 11th most common cancer globally, with over 510,000 new cases and 445,000 deaths annually.
Gastric cancer ranks fifth in global incidence, with approximately 968,000 new cases and 660,000 deaths each year.

...more

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Conexiant

July 14, 2026

Autism Spectrum Disorder Linked to Distinct Urine Metabolite Pattern

Kathryn Wighton
July 14, 2026
5 min

Summary
Takeaways
Insight Report
Poll

Objective: To evaluate urinary concentrations of microbially derived metabolites in children with autism spectrum disorder (ASD) compared to typically developin

...more

Children with autism spectrum disorder (ASD) exhibited higher urinary concentrations of microbially derived metabolites compared to typically developing controls.
The study achieved 90% sensitivity and 100% specificity in classifying children with ASD based on elevated metabolite levels.
Researchers identified over 600 metabolites differing between groups, with 23 of 24 selected metabolites significantly elevated in children with ASD.
The MDM System developed in the study assigned scores based on elevated metabolites, with children with ASD averaging a score of 3.3.
The study was a pilot and highlighted the need for replication in an independent cohort due to its limitations and exclusions.

...more

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Conexiant

July 14, 2026

Are GLP-1s Linked to Optic Neuropathy?

Andrea Surnit
July 14, 2026
3 min

Summary
Insight Report
Poll
Clinical Scorecard

Objective: To investigate the association between glucagon-like peptide-1 receptor agonists (GLP-1s) and the risk of anterior ischemic optic neuropathy compared

...more

2 min

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Conexiant

July 14, 2026

CGM Linked to More Time in Range

Andrea Surnit
July 14, 2026
4 min

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To evaluate the impact of real-time continuous glucose monitoring (CGM) on glycemic control in patients with insulin-treated type 2 diabetes receivin

...more

2 min

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Conexiant

July 14, 2026

Stroke Audit Finds Long CT-to-CTA Times

Andrea Surnit
July 14, 2026
5 min

Summary
Insight Report
Poll

Objective: To evaluate the intervals between computed tomography (CT) and computed tomography angiography (CTA) in patients with large-vessel occlusion stroke r

...more

1 min

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The Pathologist

July 14, 2026

Pathology Pain Points

July 14, 2026
1 min

Summary
Insight Report
Quiz

Objective: To identify and rank the most pressing concerns for laboratory leaders based on the 2026 Pain Points Survey conducted by the Panel of National Pathol

...more

1 min

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The Pathologist

July 14, 2026

Bias Study Raises Concerns Over Medical Education

July 14, 2026
2 min

Summary
Quiz
Clinical Scorecard

Objective: To investigate the influence of patient demographic information on diagnostic decision-making among medical students and residents. Approach: Study D

...more

2 min

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The Ophthalmologist

July 14, 2026

Cataract Goggles Put Football Skills to the Test

July 14, 2026
3 min

Summary
Insight Report
Quiz

Objective: To demonstrate the functional impact of cataracts through a football-themed event. Approach: Event Description: Teams from SpaMedica and Freedom Visi

...more

1 min

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The Ophthalmologist

July 14, 2026

UNITY Cataract System Debuts in Canada

July 14, 2026
2 min

Summary
Quiz
Poll
Clinical Scorecard

Objective: To announce the launch of the UNITY Cataract System (CS) in Canada during the COS Annual Meeting and Exhibition and highlight its features. Approach:

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2 min

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The Ophthalmologist

July 14, 2026

The Future of Personalized PALs

Griffith Altmann
July 14, 2026
6 min

Summary
Insight Report
Quiz

Objective: To explore advancements in presbyopia management through personalized progressive addition lenses (PALs) that cater to individual visual needs. Appro

...more

2 min

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The Medicine Maker

July 14, 2026

Inside VIVEbiotech’s Work with Zelluna on TCR-NK Cell Therapy

July 14, 2026
4 min

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To detail the collaboration between VIVEbiotech and Zelluna focused on GMP lentiviral vector manufacturing for TCR-NK cell therapy. Approach: Collabo

...more

2 min

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Frontiers In Oncology

July 14, 2026

Prediction of anastomotic leakage after esophagectomy for esophageal cancer: a nomogram study integrating systemic inflammation indices and clinical factors

Ruonan Tan
Lili Guo
Saitian Li
Weiran Huang
Hang Zhang
Tongtong Gu
Qian Ba
July 14, 2026

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To develop and validate a predictive model for assessing the risk of anastomotic leakage (AL) in esophageal cancer patients undergoing esophagectomy.

...more

3 min

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Frontiers In Immunology

July 14, 2026

Anti-inflammatory CAR-microglia targeting Aβ for Alzheimer’s disease therapy

Xizhong Ding
Xukai Hu
Wanqiang Xue
Yingrui An
Wei Cheng
Shaolong Zhang
Anhua Lei
Jin Zhang
July 14, 2026

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To develop a novel anti-inflammatory CAR-Microglia (CAR-Mic) targeting amyloid-β (Aβ) for enhanced clearance and reduced neuroinflammation in Alzheim

...more

3 min

Alzheimer's disease is marked by amyloid-β plaque accumulation and chronic neuroinflammation, leading to neuronal loss and cognitive decline.
Monoclonal antibodies targeting amyloid-β have shown limited efficacy due to insufficient clearance and treatment-associated neuroinflammation.
A novel anti-inflammatory CAR-Microglia was developed, utilizing TAM receptors to enhance Aβ clearance while reducing proinflammatory cytokine release.
AXL-CAR-iMGLs demonstrated improved Aβ clearance in an AD mouse model without severe adverse effects, indicating potential for cell therapy.
The study establishes TAM receptor-based CAR-iMGLs as a promising approach for treating Alzheimer's disease and other neurodegenerative disorders.

...more

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Frontiers In Immunology

July 14, 2026

Programmed cell death mechanisms of traditional plant medicine in prostate cancer therapy

Yuchen Zhang
Sheng Qin
Yingping Wang
Yajuan Xu
Yanzhu Zhu
July 14, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To explore the mechanisms of programmed cell death (PCD) induced by traditional plant medicine (TPM) in the treatment of prostate cancer (PCa). Appro

...more

3 min

Prostate cancer (PCa) is a common malignancy in men, with significant mortality and treatment challenges due to resistance and recurrence.
Traditional plant medicines (TPM) have shown potential in inducing programmed cell death (PCD) and exhibiting anticancer activity against PCa.
The review identifies 42 drugs from TPM that regulate various forms of PCD, including apoptosis, ferroptosis, and necroptosis in PCa.
Key signaling pathways involved in TPM's anticancer effects include PI3K/AKT/mTOR and AMPK/mTOR, among others.
Further research is needed to clarify the effects of TPM on autophagy and pyroptosis in the context of PCa treatment.

...more

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Frontiers In Neurology

July 14, 2026

Predictive value of water swallow test score, serum albumin, and systemic immune-inflammation index for stroke-associated pneumonia in patients with acute isolated pontine infarction

Jingjing Ding
Haifeng Jin
Xiaomei Ren
Jieli Geng
July 14, 2026

Summary
Insight Report
Quiz

Objective: To identify independent predictors of stroke-associated pneumonia (SAP) in patients with acute isolated pontine infarction (AIPI) and to investigate

...more

3 min

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Frontiers In Pediatrics

July 14, 2026

Underutilisation of rehabilitation for children with cancer in Gaza: the experience of the non-governmental organisation Children Not Numbers

Abu Sidhanee
Ibtisam Abo Jabal
Ilham Lubbad
Soha Nassar
Mahmoud Jamal
Jehad Alawna
Safiyyah Abbas
Trish Scanlan
Ala Shatali
July 14, 2026

Summary
Takeaways
Insight Report
Quiz

Objective: To explore the underutilisation of rehabilitation services for children with cancer in Gaza, particularly in the context of ongoing conflict. Approac

...more

3 min

The conflict in Gaza has severely impacted healthcare, particularly rehabilitation services for children with cancer.
Each year, 210 children are diagnosed with cancer in Gaza, but many face significant barriers to accessing care.
The NGO Children Not Numbers registered 67 children with cancer, yet none were referred for rehabilitation despite evident needs.
Factors contributing to the underutilization of rehabilitation include inadequate analgesia, undernutrition, and psychological challenges.
Protecting health infrastructure and ensuring the evacuation of children with cancer are urgent priorities under international humanitarian law.

...more

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Jama Network Open

July 14, 2026

Buprenorphine-Naloxone vs Extended-Release Naltrexone Following Opioid Withdrawal Treatment

Heather E. Hsu
Sara Lodi
Shapei Yan
Benjamin J. Bovell-Ammon
Paul J. Christine
Alyssa S. Tilhou
Dana Bernson
Patricia Novo
Joshua D. Lee
John Rotrosen
Jane M. Liebschutz
Alexander Y. Walley
Marc R. Larochelle
July 14, 2026

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To compare the effectiveness of initiating buprenorphine-naloxone versus extended-release naltrexone specifically after opioid withdrawal management.

...more

4 min

Buprenorphine-naloxone and extended-release naltrexone are FDA-approved medications for opioid use disorder.
Prior studies suggest buprenorphine-naloxone may reduce fatal and nonfatal opioid overdose compared to XR naltrexone.
The X:BOT trial compared buprenorphine-naloxone and XR naltrexone but did not statistically analyze mortality differences.
This study utilized a target trial emulation framework to compare the effectiveness of buprenorphine-naloxone and XR naltrexone.
Outcomes measured included all-cause mortality and nonfatal opioid overdose within 24 weeks of medically managed opioid withdrawal.

...more

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Frontiers In Neurology

July 14, 2026

Synergistic effects of early sequential enhanced external counterpulsation and electric tilt table training on functional recovery in ischemic stroke: study protocol of a randomized controlled trial

Liu Shi
Jiagui Ma
Xilian Hu
Zhaohui Jin
Zhenying Zhang
Zishuang Liu
Yanyan Yin
Xiaojing Sun
Cheng Yang
Weitao Wang
Yanjun Liu
Tiejun Liu
July 14, 2026

Summary
Takeaways
Insight Report
Poll
Clinical Scorecard

Objective: To determine whether early sequential application of Enhanced External Counterpulsation (EECP) followed by Electric Tilt Table (ETT) training improve

...more

3 min

Ischemic stroke is a leading cause of disability, and early rehabilitation is essential for functional recovery.
Electric tilt table (ETT) training improves motor and balance function but is limited by orthostatic hypotension (OH).
Enhanced external counterpulsation (EECP) may improve tolerance to verticalization and reduce symptomatic OH during rehabilitation.
This study will assess the sequential application of EECP followed by ETT training on neurological and functional recovery in stroke patients.
The trial will enroll 104 participants and evaluate outcomes using various scales, with safety monitored throughout the study.

...more

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