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MDSpire News

  • August 21, 2026
Does kinematic alignment better restore gait in CPAK type 1 TKA?
  • Andrea Surnit
  • August 21, 2026
  • 5 min

Objective: To compare the effects of kinematic alignment (KA) and mechanical alignment (MA) on knee kinematics and patient-reported outcomes one year after tota

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2 min

MDSpire News

  • August 21, 2026
Prucalopride may enhance cognitive performance in remitted depression
  • Andrea Surnit
  • August 21, 2026
  • 4 min

Objective: To investigate the effects of prucalopride on cognitive performance in patients with remitted recurrent depression. Approach: Study Design: A randomi

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2 min

MDSpire News

  • August 21, 2026
IDSA updates guidance for antimicrobial-resistant gram-negative infections
  • Meg Barbor
  • August 21, 2026
  • 5 min

Objective: To provide updated guidance on treating antimicrobial-resistant gram-negative infections, incorporating newer therapies and evolving evidence. Approa

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2 min

The Pathologist

  • August 21, 2026
Why Healthcare Is Drowning in Data
  • Jessica Allerton
  • August 21, 2026
  • 5 min
  1. Healthcare systems generate vast amounts of diagnostic data, but clinicians struggle to access the right information at the point of care.
  2. Innovation often outpaces the systems needed to support it, creating a gap between potential and actual clinical practice.
  3. Fragmented diagnostic information across multiple systems complicates decision-making for clinicians, making it time-consuming.
  4. Collaboration among laboratories, clinicians, and IT teams is essential to embed actionable insights into clinical workflows.
  5. Pathologists and laboratory professionals are crucial for interpreting diagnostic information and shaping systems for data-driven care.
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The Pathologist

  • August 21, 2026
Can Portal Hypertension Testing Go Non-invasive?
  • August 21, 2026
  • 3 min

Objective: To evaluate non-invasive tests for identifying portal hypertension and determining the need for further testing. Approach: Review of Non-invasive Met

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The Ophthalmologist

  • August 21, 2026
Myopia Management with DIMS
  • Hakan Kaymak
  • Aldo Vagge
  • Stephanie Kearney
  • Cristina Álvarez Peregrina
  • Andrzej Grzybowski
  • August 21, 2026
  • 5 min
  1. Correction and control of myopia are distinct clinical acts, with axial length being central to modern myopia management.
  2. Second-generation spectacle lenses, like DIMS and H.A.L.T., aim for deliberate retinal signal design rather than just stronger optics.
  3. DIMS TED/MiYOSMART iQ shows retinal-topographic redistribution, while H.A.L.T. MAX focuses on dose-response optimization.
  4. Early clinical data indicate that MiYOSMART iQ significantly reduces axial elongation compared to single-vision spectacles.
  5. Key issues for second-generation lenses include durability, adaptation, visual performance, and the need for robust peer-reviewed data.
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The Ophthalmologist

  • August 21, 2026
Georgia Eye Partners Welcomes Glaucoma Specialist Dr. Cynthia Guerin
  • August 21, 2026
  • 2 min

Objective: To announce the addition of Dr. Cynthia M. Guerin to Georgia Eye Partners as a glaucoma specialist. Approach: Professional Background: Dr. Guerin is

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The Medicine Maker

  • August 21, 2026
What Pharma Can Learn From Military Intelligence
  • August 21, 2026
  • 6 min
  1. Tony Page transitioned from military intelligence to pharma, emphasizing the importance of structured intelligence approaches in product development.
  2. Page highlights that intelligence processes must be proactive and organized to support organizational strategy and decision-making.
  3. He stresses the need for companies to monitor their environment and anticipate potential obstacles during product development and launch.
  4. Page notes that many pharma companies fail to integrate intelligence effectively into planning, leading to reactive rather than proactive strategies.
  5. He warns that AI must be purpose-built for specific problems in pharma, rather than treated as a general productivity tool.
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Frontiers In Endocrinology

  • August 21, 2026
Transforming AI Insights into Practical Decision Support for Endocrine Disease Management
  • Tianqiang Wu
  • Wenpin Cai
  • Zhixiang Li
  • August 21, 2026

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Frontiers In Medicine

  • August 21, 2026
Managing a Ruptured Ectopic Pregnancy with Hemorrhagic Shock in an Ebola Treatment Facility in the Democratic Republic of Congo: A Case Report
  • Prince Imani-Musimwa
  • Emilie Grant
  • Daniel Mukadi-Bamuleka
  • Rigo Fraterne-Muhayangabo
  • Alfred Ombeni-Musimwa
  • Zacharie Tsongo-Kibendelwa
  • Olivier Nyakio-Ngeleza
  • Richard Kitenge-Omasumbu
  • Théophile Barhwamire-Kabesha
  • Dieudonné Sengey-Mushengezi-Amani
  • Placide Mbala-Kingebeni
  • Richard Bitwe-Mihanda
  • Juakali Sihali-Kyolov
  • Mija Ververs
  • August 21, 2026
  1. Ectopic pregnancy (EP) is a life-threatening obstetric emergency that requires prompt diagnosis and management to prevent maternal mortality.
  2. A case report describes a woman in the DRC with a ruptured ectopic pregnancy and hemorrhagic shock in an Ebola treatment facility.
  3. The patient presented with abdominal pain and was diagnosed with EP after developing acute surgical symptoms and hemoperitoneum.
  4. Due to resource limitations, the patient underwent exploratory laparotomy in an unused building, leading to successful management of her condition.
  5. This case highlights the challenges of managing obstetric emergencies in Ebola treatment units, emphasizing the need for adequate resources.
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Frontiers In Oncology

  • August 21, 2026
Initial Presentation of Primary Splenic Angiosarcoma with Multiple Bone Lesions: A Case Study and Literature Review
  • Weijun Wang
  • Xia Liu
  • August 21, 2026
  1. Primary splenic angiosarcoma (PSA) is a rare and aggressive malignant vascular neoplasm with a median survival of 5–12 months.
  2. Initial presentation of PSA with osseous metastasis is uncommon and can lead to diagnostic confusion with other malignancies.
  3. Histological differentiation in angiosarcoma does not always correlate with biological behavior, as well-differentiated tumors can be highly aggressive.
  4. Biopsy of vascular tumors like angiosarcoma carries a significant risk of hemorrhage, necessitating careful pre-procedural assessment.
  5. Accurate diagnosis of PSA requires integration of clinical, imaging, and pathological findings due to its nonspecific manifestations.
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Frontiers In Neurology

  • August 21, 2026
The Relationship Between Distress Disclosure and Health Behaviors in Stroke Patients: A Theory-Based Serial Mediation Analysis of Social Support, Self-Efficacy, and Self-Management
  • Xiaoqin Yang
  • Yan Han
  • Yuntian Liu
  • Huaqing Fan
  • Jie Wang
  • Feipeng Li
  • Yan He
  • August 21, 2026
  1. The study involved 473 stroke patients from Baotou Central Hospital, examining distress disclosure's impact on health behaviors.
  2. A positive correlation was found between distress disclosure and health behaviors, with a significant association after covariate adjustment.
  3. Social support, self-efficacy, and self-management were identified as significant mediators in the relationship between distress disclosure and health behaviors.
  4. Social support had the largest specific indirect effect on health behaviors, accounting for 35.63% of the total effect.
  5. The findings support a framework for developing communication-centered, self-management-oriented nursing interventions for stroke patients.
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Frontiers In Cardiovascular Medicine

  • August 21, 2026
Assessment of Type I Endoleak Following Endovascular Aneurysm Repair for Abdominal Aortic Aneurysm through Energy Loss Component Analysis: An Initial Feasibility Investigation
  • Ran Tao
  • Qiming Liu
  • Weihao Guo
  • Lingshang Kong
  • Wenbin Wang
  • Xudong Jiang
  • Peng Wu
  • Yeben Qian
  • August 21, 2026
  1. The study utilized hemodynamic simulations based on patient-specific AAA models to investigate energy loss associated with Type I endoleak after EVAR.
  2. Computed tomography angiography was employed to reconstruct models for patients with and without Type I endoleak, facilitating endoleak component quantification.
  3. Endoleaks were found to localize at stent-graft junctions, showing higher turbulence energy loss and mean flow energy loss compared to the no endoleak group.
  4. Turbulence energy loss values were significantly elevated in the endoleak group across main and iliac branch stents following EVAR.
  5. The study suggests that energy loss component quantification may offer a feasible method for evaluating Type I endoleak in patients post-EVAR.
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Frontiers In Immunology

  • August 21, 2026
Amendment: The Role of Lubricin in Osteoarthritis: Its Functions and Potential Therapeutic Applications
  • Haochen Li
  • Guoliang Yi
  • Dan Zhou
  • Jiayi Zhou
  • Zhi Cui
  • Haowei Zhang
  • Zhiwei Chen
  • August 21, 2026

Objective: To correct the authorship attribution regarding equal contribution in the original article. Key Findings: Author Yi Guoliang was mistakenly excluded

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1 min

Frontiers In Medicine

  • August 21, 2026
Clinical Features and Determinants of In-Hospital Mortality in Patients with Stenotrophomonas maltophilia Infections: A Retrospective Cohort Analysis from a Single Center
  • Hanli Wang
  • Min Xing
  • Haoyu Ji
  • Yusheng Cheng
  • Shuhui Hu
  • Guofeng Wang
  • Susheng Zhou
  • Yonghui Han
  • Bohan Zhang
  • Lei Zha
  • Qinghai You
  • August 21, 2026
  1. The study analyzed 458 inpatients with confirmed Stenotrophomonas maltophilia infections from June 2023 to July 2025.
  2. In-hospital mortality was 11.8%, with non-survivors exhibiting higher age, comorbidity, and severe clinical characteristics.
  3. Age and Charlson Comorbidity Index were independently associated with mortality, while mechanical ventilation's association was not statistically significant.
  4. Previous carbapenem exposure did not significantly affect mortality, suggesting it may indicate underlying disease complexity.
  5. The appropriateness of initial empirical antimicrobial therapy was not independently linked to survival after adjusting for severity factors.
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Frontiers In Medicine

  • August 21, 2026
Simulation of Error Scenarios to Enhance Nursing Students' Knowledge, Attitudes, and Confidence in Patient Safety: A Quasi-Experimental Investigation
  • Sunmi Jeon
  • Minyoung Kim
  • August 21, 2026
  1. Patient safety incidents are a significant healthcare concern, necessitating effective education for nursing students to prevent errors.
  2. The study implemented a room of errors simulation to enhance nursing students' knowledge, attitudes, and confidence in patient safety.
  3. A quasi-experimental design with 66 nursing students showed significant improvements in the experimental group's patient safety outcomes.
  4. Posttest results indicated substantial gains in knowledge, attitudes, and confidence for the experimental group compared to the control group.
  5. The findings suggest that room of errors simulations may be a feasible educational approach for reinforcing patient safety education.
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Frontiers In Endocrinology

  • August 21, 2026
Establishment of a Primary Hepatopancreatic Cell Model for Investigating Glucose Metabolism and Endocrine Regulation in Litopenaeus vannamei
  • Xiaowei Song
  • Zijie Liu
  • Jiawei Liu
  • Su Liu
  • Lin Song
  • Hu Duan
  • Yi Gao
  • August 21, 2026
  1. A primary hepatopancreatic cell model was established from Litopenaeus vannamei to study glucose metabolism and endocrine regulation.
  2. The isolated cells maintained key characteristics and viability during short-term culture for functional assays.
  3. Exogenous glucose increased glucose transport and glycolysis-related transcription while suppressing gluconeogenesis-related genes.
  4. Insulin exposure enhanced glucose accumulation and transcriptional activity, indicating preserved hormone-responsive properties.
  5. The study provides a valuable platform for investigating nutrient sensing and metabolic regulation in crustaceans.
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Frontiers In Cardiovascular Medicine

  • August 21, 2026
Factors Influencing Graft Patency Following Coronary Artery Bypass Grafting
  • Hao-Hui Ti
  • Sheng-Bo Gao
  • Yu-Ting Wu
  • Sheng-Jun Dong
  • August 21, 2026

Get a structured, in-depth report that distills clinical articles into clear insights, data, and analysis for deeper learning.

Read Full Report