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MDSpire News

  • September 21, 2026
FDA approves combo for ESR1-mutated breast cancer
  • Kathryn Wighton
  • September 21, 2026
  • 2 min

Objective: To evaluate the efficacy of imlunestrant with abemaciclib in adults with ESR1-mutated advanced or metastatic breast cancer. Approach: Study Design: T

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MDSpire News

  • September 21, 2026
Mapping epilepsy in Down syndrome
  • Kathryn Wighton
  • September 21, 2026
  • 3 min
  1. Epilepsy prevalence among adults with Down syndrome increases with age, particularly due to symptomatic Alzheimer's disease.
  2. The study included 4,804 adults with Down syndrome from 7 clinical cohorts across Spain, Germany, Ireland, and France.
  3. Active epilepsy was identified in 15% of patients, with prevalence rising from 39 per 1,000 in ages 18-24 to 390 per 1,000 in those aged 60 and older.
  4. Cumulative incidence of late-onset myoclonic epilepsy in Down syndrome increased from 10% at Alzheimer's diagnosis to 57% nine years later.
  5. Cognitive decline accelerated significantly after seizure onset, with rates of deterioration roughly twice those seen in symptomatic Alzheimer's without epilepsy.
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The Analytical Scientist

  • September 21, 2026
The Top 40 Under 40 Power List 2026 is Live!
  • September 21, 2026
  • 1 min
  1. The Top 40 Under 40 Power List highlights rising stars in analytical science.
  2. Honorees reflect on their research interests and career-shaping decisions.
  3. The list addresses trends and challenges in analytical science, including AI's influence.
  4. This year's list features both new faces and returning honorees.
  5. The honorees include diverse individuals with various interests beyond science.
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The Pathologist

  • September 21, 2026
CRISPR Maps T Cells Gene by Gene
  • September 21, 2026
  • 3 min
  1. A genome-scale screen mapped gene regulation in primary human CD4-positive T cells using CRISPR interference and single-cell RNA sequencing.
  2. The study analyzed approximately 22 million cells from four healthy donors, linking gene activity to immune responses and autoimmune disease susceptibility.
  3. Researchers identified over 2 million gene-to-gene regulatory effects, with many dependent on cellular context and T cell activation state.
  4. The analysis revealed 1,556 gene disruptions affecting cytokine production, including established T cell receptor signaling components.
  5. Limitations included the use of cells from only four donors and the inability to capture tissue-specific environments or all T cell polarization states.
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The Pathologist

  • September 21, 2026
Lessons From ASCO 2026
  • Karan Arora
  • September 21, 2026
  • 10 min
  1. Precision oncology is shifting focus from targeted therapies to timely, actionable decisions for the right patients.
  2. Pathology is becoming a central control point in precision oncology, integrating various data types to guide treatment decisions.
  3. Clinicians face pressure to extract actionable insights from smaller tissue specimens due to advances in cancer detection.
  4. AI and digital pathology are poised to enhance diagnostic efficiency and support informed clinical decisions in oncology.
  5. Integrated workflows that connect various data types are essential for addressing the complexities of modern cancer care.
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The Ophthalmologist

  • September 21, 2026
Optogenetics Pioneers Honored
  • September 21, 2026
  • 2 min
  1. Drs. José-Alain Sahel and Botond Roska received the 2026 António Champalimaud Vision Award for their optogenetics research.
  2. Their work focuses on restoring partial vision in patients with severe retinal degeneration using optogenetics.
  3. The optogenetics approach combines gene therapy with light-stimulating technology to activate surviving retinal cells.
  4. In 2021, they reported the first clinical application of optogenetics, restoring vision in a patient with retinitis pigmentosa.
  5. The António Champalimaud Vision Award provides €1 million to support research and efforts to combat blindness.
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The Ophthalmologist

  • September 21, 2026
Can Anti-Inflammatories Slow Myopia?
  • Jody Summers
  • R. Michael Siatkowski
  • September 21, 2026
  • 3 min

Objective: To investigate the role of systemic inflammation in the development and progression of childhood myopia and the potential impact of systemic anti-inf

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2 min

The Medicine Maker

  • September 21, 2026
The Barriers Limiting Radiopharmaceutical Access
  • September 21, 2026
  • 6 min
  1. Radiopharmaceuticals combine targeted treatment with radiation delivery, enhancing precision in oncology.
  2. Access to approved radiopharmaceuticals is limited by supply chain fragility, infrastructure readiness, and workforce availability.
  3. Reimbursement complexities and regulatory oversight can hinder patient access to radiopharmaceuticals post-approval.
  4. The post-approval experiences of therapies like Pluvicto and Lutathera highlight the importance of infrastructure for real-world adoption.
  5. Early planning for access and implementation is crucial in the development of radiopharmaceuticals to ensure operational feasibility.
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The Medicine Maker

  • September 21, 2026
Long-Term Data Boost MCO-010
  • September 21, 2026
  • 2 min
  1. Nanoscope Therapeutics will present four-year follow-up data from the MCO-010 program at the Retina Society meeting in September 2026.
  2. MCO-010, branded as MOGENRY, is a one-time intravitreal gene therapy for retinal degeneration due to photoreceptor loss.
  3. Patients treated with MCO-010 have maintained gains in visual acuity four years post-treatment, according to preliminary data.
  4. MCO-010 is mutation agnostic and does not require genetic testing, differentiating it from other gene therapies.
  5. Nanoscope's Biologics License Application for MOGENRY has been accepted by the FDA, moving it closer to regulatory review.
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Journal Of Hospital Medicine

  • September 21, 2026
Staffing Models and Full-Time Equivalents in Pediatric Hospital Medicine
  • Lara Batey
  • Marie Dawlett
  • Allison Markowsky
  • September 21, 2026

Objective: To describe a practical framework for staffing in pediatric hospital medicine (PHM) that addresses physician turnover and staffing shortages, particu

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3 min

Journal Of Orthopaedic Research

  • September 21, 2026
Development of Multi-Spheroid Bone Constructs via the Combination of Large MSC Spheroids
  • Peter Zastawny
  • Stephen D. Waldman
  • September 21, 2026
  1. Bone fracture incidence reached 178 million globally in 2019, with 5%-10% of patients experiencing complications related to healing.
  2. Standard treatments for non-healing fractures include autografts and allografts, which have disadvantages like infection and donor site morbidity.
  3. Bone tissue engineering aims to create biomimetic materials that replicate the properties of bone grafts using various scaffold materials.
  4. This study developed a methodology for scaffold-free bone tissue engineering using large MSC spheroids containing 5 × 10^5 cells each.
  5. Spheroids were differentiated in chondrogenic and osteogenic media to promote mineralization and were fused to create larger bone constructs.
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Food Safety And Risk

  • September 21, 2026
Assessment of Physicochemical and Microbiological Properties of Unprocessed Cow Milk in Various Agro-Ecological Zones of Jarso District, Eastern Ethiopia
  • Takele Wolkaro
  • Kamil Hussen
  • Mitiku Eshetu
  • Michael Abdi
  • September 21, 2026
  1. Raw milk is a vital source of nutrition but is susceptible to microbial contamination due to inadequate hygiene during production and handling.
  2. Ethiopia's dairy sector faces challenges such as low productivity, poor milk quality, and inadequate infrastructure, impacting food security and livelihoods.
  3. Physicochemical properties of milk, including fat and protein content, vary based on animal management, environmental conditions, and feed availability.
  4. Microbiological quality of raw milk is crucial for food safety, with high bacterial counts indicating poor sanitation and increased foodborne illness risk.
  5. Research gaps exist regarding the combined effects of agro-ecological conditions on both physicochemical and microbiological quality of raw milk.
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Langenbecks Archives Of Surgery

  • September 21, 2026
Erratum: Outcomes After Over 12 Years of Surgical Management for Perihilar Cholangiocarcinoma Using a Modified Nagoya Technique in a Western Institution
  • İlgin Özden
  • Orhan Bilge
  • Nergiz Dağoğlu
  • Ayşen Yavru
  • Mine Güllüoğlu
  • Arzu Poyanlı
  • Yaman Tekant
  • Ahmet Kızir
  • September 21, 2026

Objective: To correct errors in the original article regarding the presentation of data in tables. Approach: Correction Details: The correction addresses errors

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1 min

National Institutes Of Health

  • September 21, 2026
NIH Launches Significant Initiatives to Enhance Human-Centric Research Infrastructure and Technologies
  • September 21, 2026

Objective: To advance biomedical research beyond animal models and enhance human-based technologies for drug development and assessment. Approach: Investment in

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2 min

Nature Medicine

  • September 21, 2026
Guidelines for Tailored Bacteriophage Therapy Based on Expert Consensus
  • Silvia Würstle
  • Simone C. Lieberknecht-Jouy
  • Anja Düchting
  • Holger Lößner
  • Pieter-Jan Ceyssens
  • Jean-Paul Pirnay
  • Mathieu de Jode
  • Shawna McCallin
  • Lorenz Leitner
  • Christian Willy
  • Sebastian Leptihn
  • Imke Korf
  • Evgeny A. Idelevich
  • Martin Witzenrath
  • Timo Faltus
  • Peter Ruth
  • Henning Blume
  • Manuel Cornely
  • Helmut Fickenscher
  • Mathias W. Pletz
  • Sylvia Hafkemeyer
  • Christine Rohde
  • Oleg Krut
  • Wolfgang Beyer
  • Oliver Hartwich
  • Ulrich Matt
  • Rebecca L. Knoll
  • Münevver Demir
  • Jens Hammerl
  • Stefanie Barbirz
  • Mirjam Stahl
  • Renate Krüger
  • Joachim Bugert
  • Melanie Kempe
  • Paul E. Turner
  • Benjamin Chan
  • Tristan Ferry
  • Maria J. G. T. Vehreschild
  • Annika Y. Classen
  • September 21, 2026
  1. The guideline provides consensus-based recommendations for personalized bacteriophage therapy to address antimicrobial resistance.
  2. An interdisciplinary expert group developed the guideline, ensuring inclusivity and relevance to clinical and societal needs.
  3. The recommendations cover phage therapy principles, preparation standards, clinical administration, and future research priorities.
  4. The guideline applies from January 5, 2026, to June 29, 2030, with annual assessments for potential updates.
  5. It targets a wide audience, including physicians, pharmacists, researchers, and policymakers involved in infectious disease management.
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Journal Of Medical Internet Research

  • September 21, 2026
Impact of Exercise-Focused Telerehabilitation on Peak Oxygen Consumption and Blood Pressure in Individuals with Cardiovascular Disease: A Systematic Review and Meta-Analysis
  • Zhicheng Zhu
  • Yong Fan
  • Zhiming Tang
  • Nangen Song
  • Youjia Mao
  • Zijian Zhu
  • September 21, 2026
  1. Cardiovascular disease (CVD) is the leading cause of mortality globally, responsible for 19.8 million deaths in 2022.
  2. By 2050, the number of individuals affected by CVD is projected to reach 1.14 billion, with deaths increasing to 35.6 million.
  3. Exercise-based cardiac rehabilitation (CR) has shown reductions in cardiovascular mortality and recurrent events.
  4. Telerehabilitation offers an alternative to conventional CR, utilizing technology for accessible and individualized exercise management.
  5. The European Association of Preventive Cardiology recognizes telerehabilitation programs as a quality indicator for center accreditation.
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Bmc Cardiovascular Disorders

  • September 21, 2026
Quality of Life, Mental Health, and Exercise Levels in Individuals with Mild to Moderate Ascending Aortic Dilation: A Cross-Sectional Case-Control Analysis
  • Fredrik Nilsson
  • Marcus Lindenberger
  • Sabina Borg
  • David Kylhammar
  • Petter Dyverfeldt
  • Filip Hammaréus
  • Lena Jonasson
  • Aleksandra Krzynska-Trzebiatowska
  • Lennart Nilsson
  • Chiara Trenti
  • Jan Engvall
  • Eva Swahn
  • September 21, 2026
  1. Ascending aortic dilation can lead to serious complications, necessitating ongoing surveillance and potential prophylactic surgery.
  2. Health-related quality of life (HRQoL) in conservatively managed patients with ascending aortic dilation is less understood compared to those who undergo surgical repair.
  3. There is a documented bidirectional association between cardiovascular disease and depression, impacting patient outcomes.
  4. Patients with aortic dilation often face restrictions on physical exercise, which may contribute to increased psychological distress.
  5. The study aims to evaluate HRQoL, psychological status, and physical activity levels in patients with mild to moderate ascending aortic dilation.
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Npj Digital Medicine

  • September 21, 2026
Correction Notice: Incorporating AI Technologies in Health Research
  • Gemma Postill
  • Jana Sedlakova
  • Stefano Tancredi
  • Frerik Smit
  • Sintieh Ekongefeyin
  • Andreas M. Baumer
  • Arnaud Chiolero
  • Jürgen Bernard
  • Laura C. Rosella
  • Viktor von Wyl
  • September 21, 2026

Objective: To correct the labeling of human involvement levels in AI automation in a previously published article. Approach: Correction Details: The correction

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1 min