Objective: To synthesize evidence from systematic reviews and meta-analyses on the use of AI for diagnosing neurodevelopmental disorders in children, focusing o
Objective: To review the metabolic processes and regulatory mechanisms of vitamin D and their associations with disease pathogenesis, emphasizing the importance
Objective: To evaluate the cardiovascular effects of long-term gender-affirming hormone therapy (GAHT) initiated during adolescence on heart function and relate
Objective: To evaluate whether visualising gaze patterns during video feedback improves specific aspects of simulator performance and the overall training exper
Objective: To evaluate the prognostic performance of a previously developed multivariable risk score for predicting cardiorenal outcomes in high-risk type 2 dia
Objective: To examine the effect of metformin on GDF15 and FGF21 levels in humans and in intestinal cells in vitro. Key Findings: Metformin increased glucose ut
Objective: To explore treatment continuation and associated factors in Japanese patients with schizophrenia receiving paliperidone palmitate 3-month formulation
Paliperidone palmitate 3-month formulation (PP3M) shows high treatment continuation rates in Japanese schizophrenia patients, particularly without concomitant medications.
The 12-month treatment continuation rate for PP3M was reported at 84.7%, with higher rates for patients not using concomitant medications.
A starting dose of 175 mg of PP3M significantly increased the risk of treatment discontinuation, indicating the need for personalized dosing.
The treatment-related mortality rate was 3.94 per 1,000 person-years, with a standardized mortality ratio of 0.95 for the total population.
Stable concomitant medication use during PP3M treatment supports symptomatic stability and suggests the feasibility of monotherapy.
Objective: To systematically evaluate the efficacy and safety of honey dressing compared to conventional dressings in the treatment of diabetic foot ulcers (DFU
Objective: To investigate the effects of a 12-week 5:2 intermittent fasting diet with meal replacement on body weight, metabolic, and endocrine markers in obese
The study investigates the effects of a 12-week 5:2 intermittent fasting diet with meal replacement on obese women with PCOS.
Participants in the intervention group experienced significant reductions in body weight, waist circumference, and BMI.
Insulin resistance decreased significantly in the intervention group, along with improvements in fasting glucose levels.
Menstrual regularity improved in 80% of participants, and 50% showed enhanced ovulation frequency despite no significant changes in reproductive hormones.
The findings suggest that the 5:2 intermittent fasting diet with meal replacement is effective for improving metabolic markers in obese women with PCOS.
Objective: To examine the association between participation in therapeutic exercise and short-term changes in self-reported anxiety among psychiatric patients.
Participation in therapeutic exercise significantly reduces self-reported anxiety among psychiatric patients, with 81% showing improvement post-exercise.
Greater engagement in exercise sessions correlates with larger reductions in anxiety, indicating a dose-dependent relationship.
The study involved 179 adult psychiatric patients participating in structured exercise programs, including walking, stretching, and breathing exercises.
Anxiety reductions were consistent across various psychiatric diagnoses, suggesting broad applicability of exercise as an anxiolytic intervention.
The findings highlight the need for controlled trials to further investigate the causal effects of exercise on anxiety reduction.
Objective: To report a rare case of X-linked hypophosphatemic rickets (XLH) complicated with polyostotic fibrous dysplasia (FD) due to a PHEX gene mutation, emp
A 60-year-old male patient was diagnosed with X-linked hypophosphatemic rickets due to a PHEX gene mutation and polyostotic fibrous dysplasia.
The patient exhibited severe skeletal deformities, recurrent fractures, and persistent hypophosphatemia, with significant clinical and imaging findings.
Genetic analysis revealed a missense mutation in the PHEX gene, classified as 'Likely Pathogenic' according to ACMG guidelines.
Treatment with oral phosphate and calcitriol led to normalization of serum phosphorus levels and relief of bone pain symptoms.
This case highlights the need for comprehensive evaluation in patients with hypophosphatemia and complex skeletal abnormalities.
Objective: To evaluate serum TWEAK levels before and after therapy with adalimumab or methotrexate and correlate them with PASI and DAPSA indices to assess thei
Psoriasis affects 2-3% of the global population and can lead to psoriatic arthritis in up to 40% of patients, significantly impairing quality of life.
TWEAK, a cytokine linked to inflammation, plays a role in psoriatic disease, but its effects on treatment outcomes with adalimumab and methotrexate are not well understood.
This study evaluates serum TWEAK levels before and after treatment with adalimumab for psoriasis and methotrexate for psoriatic arthritis.
Clinical assessments included PASI for psoriasis severity and DAPSA for psoriatic arthritis activity, measured at baseline and 24 weeks.
The study design reflects real-world therapeutic standards, with a minimum of 20 participants per group to ensure sufficient statistical power.
Objective: To analyze the role of mental health professionals in facilitating psychiatric advance directives (PADs) while addressing specific ethical challenges
Objective: To analyze the association between metabolic and bariatric surgery (MBS) and outcomes in patients undergoing specific types of cardiovascular surgery
Objective: To develop and validate a machine learning model that utilizes routinely measured metabolic laboratory indices to identify advanced chronic kidney di
Objective: To highlight the critical role of altered metabolic traits and tumor microenvironment in the prognosis and management of gastrointestinal tract cance
Objective: To evaluate the validity and reliability of specific reasoning models for clinical reasoning in musculoskeletal physiotherapy for low-back pain. Key
Objective: To compare the effectiveness of colostomy and fecal management catheterization in the treatment of Fournier gangrene and to determine which method of
