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Conexiant

July 2, 2026

FDA Expands Gene Therapy for Younger Patients

Kathryn Wighton
July 2, 2026
3 min

Summary
Quiz
Clinical Scorecard

Objective: To report the FDA's approval of exagamglogene autotemcel (CASGEVY) for younger patients with sickle cell disease and transfusion-dependent beta thala

...more

2 min

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Conexiant

July 2, 2026

Low Vitamin D Persists Year-Round in Northern Britain

Andrea Surnit
July 2, 2026
3 min

Summary
Insight Report
Quiz

Objective: To assess the prevalence of vitamin D insufficiency and deficiency among older and ethnic patients in northern Britain. Approach: Study Design: Scree

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1 min

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The Pathologist

July 2, 2026

Are E-Notebooks Delivering on Their Promise?

Jessica Allerton
July 2, 2026
6 min

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To explore the current sentiment among laboratory professionals regarding electronic lab notebooks (ELNs) and AI tools, and to identify the technolog

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2 min

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The Pathologist

July 2, 2026

Tracking JAK2 Before Disease Strikes

July 2, 2026
2 min

Summary
Insight Report
Quiz

Objective: To investigate the behavior of JAK2 V617F-mutated blood cell clones before the development of overt myeloproliferative neoplasms (MPNs). Approach: St

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1 min

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The Ophthalmologist

July 2, 2026

Smartphones Spot Ocular Malignancies

July 2, 2026
3 min

Summary
Takeaways
Insight Report
Quiz
Poll

Objective: To evaluate a smartphone-based AI platform for the early detection of ocular surface malignancies. Approach: Development of CaptureTumor (CaT): An AI

...more

A smartphone-based AI platform named CaptureTumor (CaT) aims to improve early detection of ocular surface malignancies.
The system utilizes smartphone photography and automated image analysis to classify lesions as benign or malignant.
In a clinical trial, the app achieved an AUC of 0.977, with sensitivity of 89.3% and specificity of 95.9% in real-world screening.
The platform identified 20 confirmed malignancies, with 19 cases being previously undiagnosed, suggesting earlier detection.
The study demonstrates the potential of consumer technologies in enhancing public health and access to specialist eye care.

...more

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The Ophthalmologist

July 2, 2026

UK College of Optometrists Elects New President

July 2, 2026
1 min

Summary
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To announce the election of Professor Irene Ctori as the new President of the UK College of Optometrists. Approach: Event: The election took place du

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1 min

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The Analytical Scientist

July 2, 2026

Business-in-Brief: June 2026

July 2, 2026
5 min

Summary
Quiz
Poll
Clinical Scorecard

Objective: To summarize recent deals, acquisitions, collaborations, and product releases in the life sciences and diagnostics sectors. Approach: Deals and Acqui

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2 min

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Conexiant

July 2, 2026

Immediate Repair Successful After Urethral Injury

Mouj Hijazi
July 2, 2026
3 min

Summary
Insight Report
Quiz

Objective: To report on the outcomes of immediate urethral reconstruction following a urethral injury during rectal cancer surgery. Approach: Case Report: Descr

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2 min

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The Medicine Maker

July 2, 2026

A Singular Approach to Combatting Infectious Disease

LaToya Montgomery
Anis Larbi
July 2, 2026
5 min

Summary
Quiz
Clinical Scorecard

Objective: To explore the role of single-cell analysis in enhancing vaccine development and understanding immune responses. Approach: Single-Cell Analysis Techn

...more

2 min

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Frontiers In Immunology

July 2, 2026

The plasmacytoid dendritic cell paradox in cancer: impaired type I interferon responses in a nucleic acid–rich tumor microenvironment

Aliki Vasilakou
Séverine Loizon
Maxime Dubois
Paôline Laurent
Vanja Sisirak
Dorothée Duluc
July 2, 2026

Summary
Takeaways
Insight Report
Quiz
Poll

Objective: To examine the mechanisms constraining IFN-I responses by plasmacytoid dendritic cells (pDCs) in the tumor microenvironment (TME) and explore their i

...more

3 min

Plasmacytoid dendritic cells (pDCs) produce type I interferons (IFN-I) but often exhibit impaired production in tumor environments.
Tumor-infiltrating pDCs can adopt immunosuppressive properties, indicating a paradox between nucleic acid availability and pDC function.
The tumor microenvironment (TME) may drive pDC dysfunction through factors like cytokines and chemokines that impair their activation.
Impaired IFN-I production by pDCs correlates with poor prognosis in various cancers, suggesting their functional state is crucial.
Understanding the mechanisms that constrain pDC IFN-I responses in tumors is essential for exploring their therapeutic potential.

...more

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Frontiers In Immunology

July 2, 2026

Durable stable disease and immune activation in metastatic uveal melanoma treated with tebentafusp: case report

Parham Habibzadeh
Anushri Kulkarni
Drew Hurd
Amy Rose
Danielle Bednarz
Yana G. Najjar
John M. Kirkwood
Arivarasan Karunamurthy
Diwakar Davar
July 2, 2026

Summary
Takeaways
Insight Report
Poll
Clinical Scorecard

Objective: To describe the case of a patient with metastatic uveal melanoma treated with tebentafusp, highlighting the immune response and disease stability obs

...more

3 min

Tebentafusp is an ImmTAC targeting gp100 in HLA-A*0201+ patients, showing overall survival benefits in metastatic uveal melanoma.
A patient treated with tebentafusp for over two years achieved durable stable disease but died from sudden cardiac death.
Autopsy revealed extensive tumor necrosis and immune cell infiltration in liver lesions, indicating robust immune activation.
The case highlights the discordance between radiographic assessments and actual tumor response, emphasizing the need for integrated evaluations.
Cardiovascular events in tebentafusp patients, especially those with pre-existing conditions, require careful monitoring and interpretation.

...more

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Frontiers In Medicine

July 2, 2026

Comparative efficacy of traditional and modern mind-body exercises in middle-aged and older adults with knee osteoarthritis: a network meta-analysis of randomized controlled trials

Rui Pan
Ao Mi
Hui Cheng
July 2, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To compare the relative efficacy of traditional and contemporary Mind-body exercise methods on KOA-related pain, function, stiffness, and psychologic

...more

3 min

This network meta-analysis compared the efficacy of traditional and contemporary mind-body exercises for knee osteoarthritis in older adults.
A total of 29 randomized controlled trials involving 2,095 participants were included in the analysis.
Tai Chi and Wuqinxi significantly reduced WOMAC pain scores compared to no exercise intervention.
Pilates, Baduanjin, and Tai Chi significantly improved WOMAC physical function scores.
The study highlights the need for further high-quality, long-term RCTs to strengthen the evidence on exercise interventions for KOA.

...more

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Frontiers In Medicine

July 2, 2026

Adjunctive regenerative therapies in hair transplantation: a comprehensive review of platelet-rich plasma, exosomes, and emerging methods

Abdulaziz Balwi
Tamer Koldas
July 2, 2026

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To provide a structured, evidence-based narrative review of platelet-rich plasma (PRP), extracellular vesicles/exosomes, and emerging adjunctive ther

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3 min

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Frontiers In Oncology

July 2, 2026

Adverse effects of systemic therapy in a patient with urothelial bladder cancer and chronic kidney disease – a case report

Martyna Najmrocka
Aleksandra Semeniuk
Rafał Stec
July 2, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To report a case of a patient with urothelial bladder cancer and chronic kidney disease who experienced immune-related adverse events during nivoluma

...more

2 min

Immune checkpoint inhibitors (ICIs) are a therapeutic alternative for urothelial bladder cancer patients ineligible for cisplatin-based chemotherapy.
A 72-year-old man with CKD developed severe immune-related adverse events after three cycles of nivolumab treatment.
Clinical symptoms included diffuse myalgia, limb weakness, and elevated troponin and ALT levels, necessitating glucocorticosteroid treatment.
Multidisciplinary evaluation revealed chronic steroid toxicity and secondary testosterone deficiency during treatment.
The case highlights the diagnostic challenges in distinguishing irAEs from CKD progression, emphasizing the need for coordinated care.

...more

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Frontiers In Endocrinology

July 2, 2026

Risk factors associated with aggressive tumor phenotypes in papillary thyroid microcarcinoma: a systematic review and meta-analysis

Máté Orgoványi
Anett Rancz
Anca Dolhascu
Gergely Agócs
Boglárka Lilla Szentes
Emese Sipter
Péter Hegyi
Gábor László Kovács
July 2, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To investigate how baseline clinical and molecular risk factors influence aggressive phenotypes in papillary thyroid microcarcinoma (PTMC). Approach:

...more

3 min

The study investigates clinical and molecular risk factors influencing aggressive phenotypes in papillary thyroid microcarcinoma (PTMC).
Key risk factors for central lymph node metastasis include male sex, age under 55, tumor size over 5 mm, multifocality, bilaterality, and BRAFV600E mutation.
Lateral lymph node metastasis is associated with similar risk factors, particularly male sex, younger age, larger tumor size, multifocality, and bilaterality.
Extrathyroidal extension risk factors include tumor size greater than 5 mm, multifocality, bilaterality, and the presence of BRAFV600E mutation.
The systematic review and meta-analysis adhered to PRISMA 2020 guidelines and was registered in PROSPERO under identifier CRD42024603662.

...more

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Int. Journal Of Computer Assisted Radiology And Surgery

July 2, 2026

Nail It! A learning framework for autonomous surgical suturing and teleoperation on the dVRK

Luigi Muratore
Matteo Pescio
Federica Barontini
Francesco Marzola
Pietro Leoncini
Carlo Alberto Ammirati
Alberto Arezzo
Giulio Dagnino
Giuseppe Averta
July 2, 2026

Summary
Insight Report
Poll
Clinical Scorecard

Objective: To address the challenges of autonomous surgical suturing by developing a high-fidelity simulation framework that integrates learning-based methods w

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3 min

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Updates In Surgery

July 2, 2026

Application of three-dimensional visualization technology on one-step PTCSL for complex hepatolithiasis

Yawen Cao
Qing Wu
Li-Yun Huang
Shunqian Wen
Zhi-Hao Lai
Shuai-Mei Luo
Zhao-Wei Ding
Cheng Li
Yong-Qing Ye
July 2, 2026

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To investigate the benefits of integrating 3D visualization technology into one-step percutaneous transhepatic cholangioscopic lithotripsy (PTCSL) fo

...more

3 min

Complex primary hepatolithiasis involves extensive stone distribution and is associated with high recurrence rates after surgery.
Percutaneous transhepatic cholangioscopic lithotripsy (PTCSL) is a minimally invasive alternative to hepatectomy for treating hepatolithiasis.
Traditional PTCSL requires multiple surgeries and a long treatment cycle due to limitations in imaging and surgical planning.
3D visualization technology enhances surgical precision by clearly displaying liver anatomy and the spatial relationship of structures.
The study investigates the benefits of integrating 3D visualization into one-step PTCSL for improved clinical outcomes in complex hepatolithiasis.

...more

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Frontiers In Cardiovascular Medicine

July 2, 2026

Association of intraluminal thrombus in thoracoabdominal aortic aneurysms with a blood stasis model

Guangqiang Zhao
Nan Hu
Peng Wu
Zijian Dong
Kang Han
Xiaoqiang Li
Ran Tao
Xudong Jiang
July 2, 2026

Summary
Takeaways
Insight Report
Quiz

Objective: To perform patient-specific hemodynamic simulations of thoracoabdominal aortic aneurysm (TAAA) models and evaluate the potential for intraluminal thr

...more

3 min

The study aimed to evaluate intraluminal thrombus formation in thoracoabdominal aortic aneurysms using patient-specific hemodynamic simulations.
Computed Tomography Angiography data from 12 TAAA patients were used to create models grouped by the presence or absence of intraluminal thrombus.
The ILT group showed significantly higher old blood volume fraction and convergence time compared to the non-ILT group, indicating pronounced blood stasis.
Blood stasis is identified as a critical determinant of intra-aneurysmal thrombosis, differing from conventional hemodynamic parameters.
The blood stasis model provides insights for diagnosing and treating intraluminal thrombus in TAAA, aiding operative planning and evaluation.

...more

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