Objective: Report final long-term efficacy and safety results for belantamab mafodotin monotherapy versus pomalidomide-dexamethasone in relapsed or refractory m
DREAMM-3 randomized 325 patients with relapsed or refractory multiple myeloma to belantamab mafodotin monotherapy or pomalidomide-dexamethasone.
At a median follow-up of approximately 22 months, median progression-free survival was 11.2 months with belantamab mafodotin and 7.0 months with pomalidomide-dexamethasone (HR, 0.87; 95% CI, 0.64-1.18
Median overall survival was 24.0 months with belantamab mafodotin and 22.9 months with pomalidomide-dexamethasone (HR, 0.98; 95% CI, 0.73-1.30).
Median duration of response was 25.3 months with belantamab mafodotin and 9.9 months with pomalidomide-dexamethasone.
Grade 3 to 4 adverse events occurred in 71% of patients receiving belantamab mafodotin and 66% receiving pomalidomide-dexamethasone; blurred vision occurred in 48% and 7%, respectively.
Objective: To assess whether a previously described method for generating virtual dynamic contrast-enhanced (vDCE) breast MRI transfers to a scanner not used fo
This study evaluated whether virtual dynamic contrast-enhanced MRI could support BI-RADS assessment compared with multiparametric DCE-MRI.
The retrospective study included 540 women scanned at one 3-T scanner, with 76 cases in the final holdout test set.
A secondary test set included 47 examinations acquired with a matching protocol on a different 3-T scanner.
Eligible MRI protocols included T2-weighted fat-saturated imaging, diffusion-weighted imaging at multiple b-values, and a five-timepoint postcontrast T1-weighted series.
The study also assessed whether the previously described virtual DCE approach transferred to data from a scanner absent from model training.
Objective: To assess the feasibility, workflow integration, and procedural safety of robot-assisted cochlear electrode insertion using the Otoarm-Otodrive syste
Objective: To describe progressive coral reef aorta causing severe lower-extremity ischemia in a patient whose symptoms were initially attributed to lumbar disc
A 50-year-old man with lumbar disc herniation developed progressive bilateral leg ischemia, including claudication and severe rest pain.
Serial CT scans over 6 years showed progressive infrarenal aortic calcification, culminating in near-complete obstruction by protruding plaques.
The patient’s bilateral ankle-brachial index fell from 0.99 and 1.07 to 0.49, with weak femoral and barely palpable distal pulses.
Extensive circumferential calcification made endovascular treatment unsuitable, and open aortic graft replacement with inferior mesenteric artery reconstruction was performed.
At 1 year, the patient was asymptomatic with bilateral ankle-brachial indices of 1.07 and patent grafts; the single case cannot establish comparative treatment effectiveness or long-term durability.
Objective: To assess whether baseline frailty modified semaglutide’s cardiovascular effects and other outcomes in adults with established cardiovascular disease
In a SELECT trial analysis of 17,604 adults with cardiovascular disease and overweight or obesity but without diabetes, researchers assessed semaglutide outcomes by baseline frailty.
The primary cardiovascular outcome occurred less often with semaglutide than placebo across frailty groups, with no statistically significant interaction between frailty and treatment.
Semaglutide was associated with larger health-related quality-of-life improvements among patients with greater frailty, mainly in mobility, self-care, and usual activities.
Frailty status improved in 34% of semaglutide recipients and 18% of placebo recipients over 104 weeks, while it worsened in 10% and 19%, respectively.
Serious adverse events were less frequent with semaglutide, but permanent treatment discontinuation was more frequent; the exploratory findings are hypothesis-generating.
Objective: To compare hemostatic efficacy and safety of cold-stored platelets with conventional room-temperature platelets in patients undergoing complex cardia
In the phase 3 CHIPS trial, cold-stored platelets maintained noninferior hemostatic efficacy compared with room-temperature platelets in cardiac surgery patients.
Cold-stored platelets met the prespecified noninferiority criterion at every evaluated storage duration through 21 days, with posterior probabilities exceeding 99.9%.
Chest tube output at 24 hours did not differ significantly between groups, and longer cold-storage duration did not appear to affect output.
Reexploration for bleeding occurred in 4.2% of cold-stored platelet recipients and 1.8% of room-temperature platelet recipients, while cold-stored recipients received more blood products.
Exploratory safety analyses found no statistically significant between-group differences in thrombotic events, other reported adverse events, or 28-day mortality.
Objective: To assess whether daily peanut consumption affects brain insulin responsiveness and related metabolic measures in older adults. Approach: Design and
In a randomized crossover trial of 31 adults aged 60 to 75 years, participants consumed 60 g of unsalted, skin-roasted peanuts daily for 16 weeks and completed a 16-week control period.
Peanut consumption was associated with a lower insulin-induced cerebral blood flow response in one right-hemisphere cluster spanning parts of memory-related brain regions.
The regional blood flow changes were not significantly associated with previously reported improvements in verbal recognition memory.
Peanut consumption did not significantly affect global brain insulin responsiveness, liver fat, glucose homeostasis, cholesterol, or high-sensitivity C-reactive protein.
The small study used cerebral blood flow as an indirect measure of insulin-related neuronal activity and lacked an energy- and macronutrient-matched control.
Objective: To summarize the FDA approval of satralizumab-mwge for thyroid eye disease, the supporting phase 3 trial results, and relevant dosing and safety info
The FDA approved satralizumab-mwge (Enspryng) for adults with thyroid eye disease, making it the first approved at-home subcutaneous treatment for the condition.
Patients or trained caregivers can administer satralizumab-mwge, with injections at weeks 0, 2, and 4 followed by maintenance dosing every 4 weeks.
In SatraGO-2, proptosis response at week 24 occurred in 52.9% of satralizumab-treated patients and 23.4% of placebo recipients; the trial met its primary end point.
SatraGO-1 did not meet its primary end point; proptosis response occurred in 49.0% of satralizumab-treated patients and 31.2% of placebo recipients.
Prescribing information calls for screening for hepatitis B and tuberculosis and monitoring for infection, elevated liver enzymes, and reduced neutrophil counts.
Objective: To develop and evaluate a method for predicting liquid chromatography retention times across different experimental systems. Approach: Two-step predi
The 2-step method predicts compound elution order first, then converts that order into retention times for a specific laboratory method.
Its graph neural network uses molecular structure, column information, and mobile-phase pH to predict retention order.
A polynomial calibration uses confidently identified compounds as anchors; the researchers found that as few as 15 anchors could be sufficient.
Across 171 reversed-phase chromatography datasets, the condition-aware model had a retention-order error rate of 4.89%, versus 5.61% without condition information.
The method supported compound annotations in human fecal samples but is limited to reversed-phase chromatography and depends on accurate metadata and anchor identifications.
Objective: The video interview covers Nucleome Therapeutics’ use of Micro Capture-C to reconstruct DNA’s three-dimensional architecture and identify causal dise
Objective: The article examines the objective, findings, and clinical context described in What Can Skin Reveal About Dementia?. Approach: Clinical context: Tod
Overlapping symptoms and mixed pathologies can make clinical presentation alone insufficient to distinguish Alzheimer’s disease from dementia with Lewy bodies and other dementias.
Skin biopsy testing detects cutaneous phosphorylated alpha-synuclein, a protein associated with synucleinopathies, including Lewy body disease.
In the Syn-D study, cutaneous phosphorylated alpha-synuclein was detected in participants with mild cognitive impairment associated with suspected dementia with Lewy bodies.
A 6-month study of patients with dementia with Lewy bodies estimated an approximately 52% annualized increase in cutaneous phosphorylated alpha-synuclein from baseline.
Some Syn-D participants had both cutaneous phosphorylated alpha-synuclein and abnormal phosphorylated tau 217 findings, suggesting coexisting Lewy body and Alzheimer disease pathologies.
Objective: Review how the biology of cell-free fetal DNA (cffDNA) may limit noninvasive prenatal testing (NIPT) and identify research directions that could impr
Noninvasive prenatal testing screens for fetal genetic abnormalities from maternal blood from about 10 weeks’ gestation, but positive results require invasive confirmation.
The review identifies low fetal fraction, difficulty distinguishing fetal from maternal DNA, and differences between placental and fetal genotypes as key limitations.
Most circulating cell-free fetal DNA is about 143 base pairs long, but circular, ultrashort, and much longer fragments have also been identified.
The mechanisms by which cell-free fetal DNA enters and circulates in maternal blood remain unresolved, and direct evidence for release in apoptotic extracellular vesicles is lacking.
The authors call for research on DNA origin and particle association, which could inform fetal DNA enrichment methods and support more reliable diagnostic applications.
Objective: The article examines the objective, findings, and clinical context described in Musings from The Power List: Adrián de la Fuente Ballesteros. Approac
Adrián de la Fuente Ballesteros develops and validates greener, more sustainable analytical methods to detect contaminants and bioactive compounds in food and environmental samples.
He says analytical methods must be economically affordable while addressing emerging contaminants and keeping pace with new technologies.
He argues that affordable methods, open-source tools, citizen science, and open knowledge are important to making analytical science more inclusive.
He identifies delayed method validation, reference materials, and regulation, along with funding and research-to-practice transfer, as challenges for analytical science.
International collaborations, teaching, and science communication have shaped his career and his perspective on unequal access to research resources.
Objective: The article examines the objective, findings, and clinical context described in Enhancing Primary Care Through the WHO Basic Package of Rehabilitatio
Primary care is a key setting for rehabilitation, but services are often poorly integrated, particularly in low- and middle-income countries.
The WHO developed the Basic Package of Interventions for Rehabilitation to expand access where rehabilitation specialists are scarce or unavailable.
The toolkit is designed for primary care personnel without rehabilitation training and includes an intervention list, clinical resource, and implementation guide.
The Basic Package prioritizes interventions intended to be safe, evidence-based, and easy to learn, with a decision-tree format supporting clinical decisions.
The article describes a participatory, three-phase process used to develop the intervention list and clinical resource.
Objective: To describe cervical cancer screening (CCS) patterns from 2019 through 2024 across race and ethnicity, age, language, and US Census region, including
This retrospective cross-sectional study examined cervical cancer screening patterns from 2019 through 2024 using deidentified Epic Cosmos electronic medical record data.
The analytic cohort included patients assigned female at birth, aged 21 to 64 years, with an encounter in every study year and no history of cervical cancer.
Investigators described annual screening rates by race and ethnicity, age group, language, and US Census region.
The study included the COVID-19 pandemic period and addressed limited evidence on longitudinal screening patterns across multiple demographic groups.
The provided context describes the study rationale and methods but does not report screening-rate results.
Objective: To assess relationships among epigenetic aging, brain injury, socioeconomic status, and neurodevelopment in children born preterm, including whether
Preterm birth is associated with increased risks of developmental delay and cognitive, language, and motor impairments.
Epigenetic age is estimated from DNA methylation, and acceleration or deceleration describes its difference from chronological age.
Prior studies linked epigenetic aging in preterm children to neonatal morbidities and reported associations between age acceleration and higher cognitive and motor scores.
This prospective cohort recruited 195 infants born at 24 to 32 weeks’ gestational age at 2 Canadian hospitals from 2015 to 2019.
The present analysis included 102 participants with epigenetic data and examined associations among epigenetic aging, brain injury, maternal education, and neurodevelopment.
Objective: To examine whether participant characteristics, particularly preintervention social contact, were associated with changes in loneliness during a digi
This secondary analysis examined participant characteristics associated with loneliness changes during a 4-week digital social robot intervention.
The analysis included 67 community-dwelling Japanese adults aged 65 years or older who lived alone and reported loneliness.
Participants received personalized, around-the-clock voice communication through an operator-mediated humanoid robot.
Loneliness change was measured with the 20-item UCLA Loneliness Scale, with negative preintervention-to-postintervention differences indicating reduced loneliness.
Regression models assessed associations of preintervention social contact and loneliness, participant characteristics, and intervention sequence with loneliness change.
Objective: To describe homicide mortality trends among US women aged 15–44 years before, during, and after the COVID-19 surge, and assess whether post-Dobbs tre