Objective: Assess the 52-week safety and clinical outcomes of motugivatrep 0.3% ophthalmic suspension, used alone or with existing dry eye therapies, in adults
In this 52-week, open-label, single-arm phase 3 study, 162 adults with dry eye disease received motugivatrep 0.3% 4 times daily alone or with existing therapies.
Treatment-emergent adverse events occurred in 45% of patients, and treatment-related adverse events occurred in 15%; most treatment-related events were mild.
No severe or serious treatment-related adverse events or deaths were reported, and 3 serious adverse events were considered unrelated to treatment.
Patient-reported symptoms and corneal staining improved during treatment, while tear break-up time increased; tear secretion decreased from baseline.
The uncontrolled, unmasked design and enrollment of mostly Japanese patients with relatively mild corneal staining limit attribution of improvements and generalizability.
Objective: The article reports the FDA approval of pimicotinib for adults with symptomatic TGCT when surgery may worsen functional limitations or cause severe m
The medical examiner classified Floyd’s death as a homicide caused by cardiopulmonary arrest complicating law enforcement subdual, restraint, and neck compression.
The autopsy found no life-threatening injuries or distinctive traumatic evidence of airway or neck damage, but those absences do not exclude functional breathing impairment.
Floyd’s hospital-admission blood contained fentanyl at 11 ng/mL and methamphetamine at 19 ng/mL, alongside substantial cardiovascular disease.
Toxicology and cardiac findings were plausible contributors to cardiopulmonary arrest, but they do not establish that drugs and disease fully explain the death.
Floyd’s ability to speak indicates that his airway was not completely obstructed while he spoke, but does not establish adequate breathing or oxygenation.
Objective: To assess the diagnostic performance of metagenomic and targeted next-generation sequencing (NGS) of bronchoalveolar lavage fluid in patients with su
In a retrospective study of 941 patients with suspected lower respiratory tract infections, both metagenomic and targeted NGS had greater diagnostic yield than conventional microbiological testing.
Metagenomic NGS sensitivity was 90.6%, compared with 73.4% for targeted NGS, but the methods were evaluated in separate patient groups.
Targeted NGS identified 54 cases of Mycobacterium tuberculosis, including 42 missed by conventional testing, and detected Pneumocystis jirovecii when silver staining was negative.
After targeted NGS results, 22.6% of patients required antimicrobial treatment escalation, and 66.2% showed clinical improvement, similar to 66.7% with initially appropriate treatment.
Both sequencing approaches had low specificity, and the retrospective, single-center study could not establish that sequencing-guided treatment caused improved outcomes.
Objective: Assess whether legalization of online sports betting was associated with changes in behavioral health care use among adults with employer-sponsored i
A quasi-experimental analysis of commercial insurance claims included 61,951,305 enrollee-years among adults aged 18 to 64 years in 35 states.
Online sports betting legalization was associated with increased antidepressant and antianxiety medication use and outpatient depression and anxiety care.
Associations were generally larger or more robust among men, although estimated increases in several outcomes were numerically larger among women.
Mental health care associations generally grew over time after legalization, while emergency department visits and hospitalizations did not change significantly.
The study was limited to employer-insured adults, and claims data could not identify betting participation or distinguish worsening mental health from improved access to care.
A physics-based framework classifies MSI extraction as thermodynamic desorption, kinematic extraction, or a mixture of both.
The dimensionless parameter Πσ compares impact-generated stress with the cohesive forces binding molecules to the sample; kinematic extraction can begin at Πσ ≥ 1.
The model indicates that active extraction requires electric acceleration to exceed the combined effects of aerodynamic drag and inertia.
The framework places atmospheric-pressure DESI, nano-DESI, and liquid microjunction sampling mainly in the thermodynamic regime, and vacuum-based droplet-impact and cluster-ion methods mainly in the k
Higher Πσ values are associated with greater fragmentation likelihood, but Πσ does not directly predict ionization softness.
Objective: To assess the association between first-trimester doxycycline exposure and pregnancy loss compared with alternative antibiotics. Approach: Design and
This retrospective cohort study analyzed 218,234 pregnancies with respiratory tract infections and 6,636 pregnancies with acne in US claims databases.
For respiratory tract infections, first-trimester doxycycline exposure was associated with higher adjusted relative risks of pregnancy loss than amoxicillin or macrolides in both databases.
For acne, doxycycline was associated with higher pregnancy loss risk than topical clindamycin in MarketScan, but not in Medicaid.
Sensitivity analyses generally supported the respiratory tract infection findings, while stillbirth-specific results were inconclusive because of few events.
The observational study could not establish causality and was limited by possible exposure misclassification, missed early losses, and residual confounding.
Objective: The article examines the objective, findings, and clinical context described in FDA flags vision loss risk with GLP-1 drugs. Approach: Safety action:
Objective: The article examines the objective, findings, and clinical context described in FDA approves first factor XIa stroke drug. Approach: Approval: The FD
The FDA approved asundexian (Sunharbo), the first factor XIa inhibitor, to reduce stroke risk after recent noncardioembolic ischemic stroke or high-risk TIA.
The 50-mg tablet is taken once daily with antiplatelet therapy in eligible patients; the indication does not include stroke prevention in atrial fibrillation.
In the phase 3 OCEANIC-STROKE trial of 12,327 adults, ischemic stroke occurred in 6.2% of asundexian recipients and 8.4% of placebo recipients.
Major bleeding rates were similar overall, but were higher with asundexian among patients older than 75 years and during the first 90 days of treatment.
The prescribing information advises against use with combined P-glycoprotein and strong CYP3A4 inducers or in moderate or severe hepatic impairment, and recommends withholding treatment around procedu
Objective: To develop and evaluate a CAR T-cell platform that senses the central nervous system (CNS) before activating tumor-targeting activity against diffuse
UCSF researchers developed B-SYNC, a preclinical CAR T-cell platform that uses brain-associated brevican to trigger tumor-targeting CAR expression.
After sensing brevican, B-SYNC cells target either EphA2 or IL-13Rα2, antigens associated with diffuse midline glioma.
In mouse models, intravenous B-SYNC treatment produced complete tumor regression in 7 of 14 and 4 of 11 animals across two models.
Ventricular administration eliminated tumors in all 19 treated mice across two models, and surviving animals resisted tumor rechallenge.
A B7-H3-targeting circuit caused fatal neurotoxicity in mice, while a modified circuit cleared tumors without detectable neurotoxicity; dosing and safety need further study.
Objective: Explore whether AI can generate discoveries for new medicines and examine its role in drug development, regulation, and biomedical research. Approach
Objective: To compare public trust, confidence, comfort, and privacy concerns regarding dermatologists and AI for facial skin evaluation and skincare management
Objective: Assess what higher perceived empathy ratings for LLM-generated health care responses establish—and what they leave unresolved about communication qua
Across 10 studies, AI-generated responses received higher empathy ratings than physician responses (standardized mean difference, 1.02; 95% CI, 0.44-1.60; odds ratio, 5.5).
The review found substantial heterogeneity (I²=73%) and no randomized trials, longitudinal data, or direct measurement of trust; empathy did not differ in the sole disease-specific study.
Written-response ratings do not capture empathy in clinical dialogue, including how clinicians address ambiguity, respond to emotion, and adapt to changing patient information.
In one study, reviewers identified potentially harmful AI responses that patients rated highly and could not distinguish, showing that convincing language can accompany inaccuracy.
The authors call for risk-proportionate evaluation, including local validation, longitudinal auditing, readability and subgroup assessments, and workflow monitoring before deployment.
Objective: Correct the author list of the article published in Pediatric Cardiology. Approach: Correction: Pedrom Farid was inadvertently omitted as the article
Objective: Correct an error in the article’s description of Ucp1. Approach: Correction: In the section “ILC2s and metabolic homeostasis,” “transcription factor