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MDSpire is an innovative platform aiming to create a smarter, faster, and more connected medical community.

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February 16, 2026

Omadacycline for Pediatric CAP

Doug Brunk
February 16, 2026
4 min

A 4-year-old girl with community-acquired pneumonia and multiple antibiotic hypersensitivities successfully improved after a 7-day intravenous treatment with om

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4-year-old girl with pneumonia and antibiotic hypersensitivities treated with omadacycline.
Symptoms included fever and productive cough.
Initial culture identified resistant Streptococcus pneumoniae and Mycoplasma pneumoniae.
Treatment included 7 days of intravenous omadacycline followed by oral doxycycline.
No hypersensitivity reactions during omadacycline therapy.
Follow-up showed regression of lung consolidation.
Call for prospective studies to evaluate omadacycline's efficacy in pediatrics.

February 16, 2026

Lutein in Children: What Changed?

Jess Allerton
February 16, 2026
2 min

A randomized controlled trial published in Translational Vision Science & Technology found that lutein ester supplementation preserved subfoveal choroidal thick

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Study on the effect of lutein ester supplementation on choroidal thickness.
180 children aged 8-12 participated in a randomized trial.
Significant preservation of subfoveal choroidal thickness after 6 months.
No significant changes in axial elongation or refractive outcomes.
Optical coherence tomography was used for measurements.
Results indicated the need for long-term studies on myopia progression.
No adverse events reported during the trial.

February 16, 2026

Positive Urine Cytology Reveals Melanoma

Jess Allerton
February 16, 2026
3 min

A 77-year-old woman developed metastatic melanoma four years after excision of a lesion previously diagnosed as melanoma in situ. Presenting with symptoms like

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Metastatic melanoma can occur years after melanoma in situ excision.
Atypical genitourinary lesions should include metastatic melanoma in differential diagnosis.
Immunohistochemical evaluation is critical for accurate diagnosis.
Ureteral involvement in melanoma is rare (0.2% to 1%).
Patient was treated with pembrolizumab after diagnosis of metastatic melanoma.

The Medicine Maker

February 16, 2026

New Novartis Biomedical Research Facility Planned for San Diego

February 16, 2026
3 min

Novartis is constructing a new 466,000-square-foot Biomedical Research center in San Diego, expected to be operational in 2029. This facility will house around

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Novartis is building a new research center in San Diego by
The facility will span 466,000 square feet.
Around 1,000 employees will work at the new center.
Focus areas include neuroscience and oncology.
The center will utilize advanced technologies like gene therapies.
It forms part of a larger USD 23 billion investment in the US.
The center will enhance global research collaborations.

February 16, 2026

Metformin and AMD: Signal or Noise?

Conexiant News Staff
February 16, 2026
4 min

A study linked metformin use to a 37% lower incidence of intermediate age-related macular degeneration (AMD) over five years in type 2 diabetes patients. Conduc

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- Metformin linked to a 37% lower incidence of intermediate AMD. - Study conducted in Liverpool under ISDR program. - Used systematic retinal image grading for accuracy. - No significant reduction in early AMD or late progression. - Findings emphasize potential benefits for metformin beyond glycemic control. - Observational study, causality not established. - Calls for further clinical trials on metformin for AMD reduction.

The Pathologist

February 16, 2026

Breaking the Biomarker Bottlenecks: Part 2

February 16, 2026
9 min

As precision medicine evolves, artificial intelligence (AI) is crucial for personalizing cancer treatment. AI enhances diagnostic accuracy, improves patient sel

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AI enhances diagnostic reproducibility.
It provides accurate quantitative results crucial for therapy decisions.
AI captures more complex biological data than human pathologists.
Multimodal biomarkers are vital for personalized therapies.
Collaboration is necessary for effective patient selection strategies.
Regulatory clarity is essential for technology adoption.
Incremental steps can improve diagnostic methods.
Focus on patient-centered care is imperative.

February 16, 2026

Intermittent Fasting Shows No Edge Over Standard Diets

Kerri Miller
February 16, 2026
3 min

A Cochrane systematic review analyzed 22 randomized controlled trials with 1995 participants, examining the efficacy of intermittent fasting compared to traditi

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22 trials with 1995 participants.
Intermittent fasting vs regular dietary advice yields −0.33% weight change.
Evidence certainty low due to bias.
Little difference in quality of life outcomes.
Adverse events slightly higher in modified fasting regimens.
High-income country studies report more adverse effects.
Challenges in participant satisfaction and comorbidity data present gaps.
No dedicated funding reported among studies.

The Pathologist

February 16, 2026

Improving How We Read the Microbiome

February 16, 2026
2 min

A novel computational method, Microbiome Elastic Feature Extraction (MEFE), has been developed to enhance the identification of disease-related patterns in micr

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MEFE enhances disease-related pattern identification in microbiome data.
Traditional analysis methods often miss signals in complex datasets.
MEFE incorporates relationships among microbes for better accuracy.
Tested on datasets related to autism and type 2 diabetes.
The method reduces false positives and negatives effectively.
Potential to advance microbiome-based diagnostics and biomarker development.

The Analytical Scientist

February 16, 2026

The Molecular Secret to Spider Silk’s Strength

February 16, 2026
3 min

Research from King's College London and San Diego State University has clarified the molecular mechanisms behind the transformation of soluble spider silk prote

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Spider dragline silk is structurally unique with high tensile strength.
Arginine and tyrosine amino acids facilitate fiber formation.
Cation-π interactions act as molecular stickers during phase separation.
NMR and molecular dynamics were used for investigation.
Phosphate ions influence liquid–liquid phase separation.
Findings suggest applications in medical and protective materials.

The Analytical Scientist

February 16, 2026

How Methodological Flaws Distorted a Decade of Serum SERS Studies

James Strachan
February 16, 2026
10 min

Roberto Gobbato and colleagues from the University of Trieste's Raman Spectroscopy Lab have unveiled significant methodological flaws in the interpretation of s

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SERS analysis of serum can provide rapid disease diagnosis.
Uric acid and hypoxanthine are dominant in serum SERS spectra.
Methodological flaws in spectral interpretation have led to widespread misinterpretations.
Importance of rigorous validation in SERS research.
Pressure to publish affects analytical science integrity.

The Medicine Maker

February 16, 2026

Why AI, Cloud & Sustainability Strategies May Collide

Martyn Williams
February 16, 2026
5 min

Digital transformation in UK pharmaceutical manufacturing is being challenged by simultaneous but conflicting initiatives, such as AI adoption, cloud migration,

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UK pharma faces challenges in digital transformation by
Conflicting digital initiatives can create operational friction.
Over-customization impedes successful project scalability.
Hidden costs of AI usage may clash with sustainability goals.
Rethinking data management is crucial for efficiency.
The investment context for life sciences remains cautious.
Manufacturers should standardize rather than over-customize.

The Ophthalmologist

February 16, 2026

Dry Eye After Cataract Surgery

February 16, 2026
3 min

Dry eye disease (DED) significantly impacts patient satisfaction after cataract surgery, often underestimated despite its prevalence. A prospective study from J

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Dry eye disease is common post-cataract surgery.
MSICS may worsen tear film stability compared to phacoemulsification.
Both techniques show acute deterioration of ocular surface health.
Symptoms remained significantly worse at Day 60 post-surgery.
OSDI and Schirmer tests are effective for monitoring DED during recovery.

The Ophthalmologist

February 16, 2026

ISS 2026 to Convene Global Imaging Experts in Singapore

February 16, 2026
2 min

The 22nd International Scientific Symposium (ISS) on Ophthalmic Imaging, taking place on September 18-19, 2026, in Singapore, continues a legacy of scientific e

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ISS 2026 on September 18-19, 2026, in Singapore.
Formerly the International SPECTRALIS Symposium.
Theme: 'Imaging that Inspires'.
Discussions on multimodal imaging, AI in ophthalmology.
Jointly directed by Professors Lim and Schmetterer.
Venue: Shangri-La Rasa Sentosa, Singapore.
Focus on translating imaging data into clinical insights.

The Ophthalmologist

February 16, 2026

Decision Making in the Modern OR: Designing for Efficiency and Predictability

February 16, 2026
6 min

Dr. Reena Garg, a glaucoma surgeon at Visionary Eye Doctors in Washington, DC, discusses the evolving landscape of ophthalmic surgery and the importance of deci

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Dr. Garg emphasizes efficiency as standardization and predictability.
The VIA360 Surgical System aids procedural goals.
Decision-making simplified with safety and reliability as key criteria.
Importance of adaptability in surgical techniques.
Less complex, implant-free approaches can streamline workflows.

Roswell Park Comprehensive Cancer Center

February 13, 2026

Roswell Park Achieves National Accreditation for Rectal Cancer Care

February 13, 2026

The Roswell Park Comprehensive Cancer Center has achieved accreditation from the National Accreditation Program for Rectal Cancer (NAPRC), recognizing its high

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Roswell Park accredited by NAPRC for rectal cancer care.
Accreditation demonstrates adherence to high surgical standards.
Over 90% of colorectal surgeries utilize robotic assistance.
Emphasis on multidisciplinary care for improved outcomes.
NAPRC accreditation involves rigorous on-site evaluation.
Collaboration among oncology teams is crucial for patient care.

The Pathologist

February 13, 2026

Breaking the Biomarker Bottlenecks: Part 1

February 13, 2026
12 min

The collaboration between pharmaceutical and diagnostics companies is essential for advancing precision medicine through companion diagnostics, which accurately

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Companion diagnostics enhance therapy effectiveness.
AI integration in diagnostics improves accessibility.
Infrastructure and regulatory challenges hinder widespread use.
Collaboration is essential for patient-centric therapy decisions.
The focus must shift from monetization to solving patient challenges.
AI can democratize healthcare access, especially in underserved areas.

February 13, 2026

Does Air Pollution Affect Skin Health?

Julie Greenbaum
February 13, 2026
5 min

A systematic review evaluated the connection between ambient air pollution and various skin diseases, including atopic dermatitis, psoriasis, and melanoma. Desp

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Reviewed associations between air pollution and skin diseases.
Focused on atopic dermatitis, psoriasis, urticaria, acne, melanoma.
77 studies selected with varying quality of evidence.
Immediate effects from short-term exposure noted.
High risk of bias due to confounding factors.
Need for more longitudinal studies emphasized.
Lack of data from low- and middle-income countries acknowledged.

February 13, 2026

Conjugative CRISPR System Cuts Resistance

Julie Greenbaum
February 13, 2026
4 min

A proof-of-principle study published in npj Antimicrobials and Resistance explored a gene drive-like system using a 65-kilobase plasmid, pPro-MobV, to effective

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Engineered pPro-MobV plasmid targets antibiotic resistance.
Horizontal gene transfer demonstrated with a frequency of ~40%.
RecA-deficient strains showed enhanced effects.
Insertional inactivation more effective than plasmid elimination.
Study highlights implications for microbiome engineering and ecological health.

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