MDSpire - MDSpire Home
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

The Pathologist

  • August 20, 2026
Measles Outbreaks Are a Lab Wake-Up Call
  • Jessica Allerton
  • August 20, 2026
  • 8 min

Objective: To highlight the challenges and necessary improvements in laboratory response to measles outbreaks in the US, particularly in the context of declinin

...more

The Pathologist

  • August 20, 2026
A Closer Look at the Complete Genome
  • August 20, 2026
  • 3 min
  1. Researchers developed a nearly complete diploid genome benchmark to improve genomic analysis methods.
  2. The study focused on HG002, a reference sample from the Genome in a Bottle Consortium, covering 99.4% of the diploid genome.
  3. The new T2T-HG002 benchmark added 701.4 Mb of high-confidence sequence, including both sex chromosomes.
  4. Genome Quality Checker software was created to evaluate sequencing methods against the diploid benchmark.
  5. The benchmark aids in assessing genomic assays in challenging regions, though it is not error-free and lacks standardized metrics.
...more

The Ophthalmologist

  • August 20, 2026
WaveFront Dynamics Expands Scleral Lens Options With Two New Integrations
  • August 20, 2026
  • 2 min

Objective: To provide eye care professionals with greater flexibility in premium scleral lens selection and patient care through new integrations. Approach: Col

...more

The Ophthalmologist

  • August 20, 2026
Early Warning in Young Eyes
  • August 20, 2026
  • 3 min
  1. Retinal neurodegeneration may be detectable in youth with type 1 diabetes before clinically apparent diabetic retinal disease emerges.
  2. The study analyzed 294 young participants with type 1 diabetes, focusing on retinal layer thickness and glycemic outcomes.
  3. Higher HbA1C levels were associated with thinner ganglion cell and outer retinal layers in participants.
  4. The presence or severity of diabetic retinal disease was not significantly associated with total retinal thickness.
  5. The findings suggest that OCT may help identify young patients with subclinical retinal changes before visible disease appears.
...more

The Analytical Scientist

  • August 20, 2026
Can Blood Filtration Reduce PFAS?
  • August 20, 2026
  • 3 min

Objective: To investigate whether therapeutic apheresis can reduce circulating PFAS and microplastic-related signals in patients. Approach: Study Design: The st

...more

The Medicine Maker

  • August 20, 2026
Musings from The Power List: Daniel Vitt
  • Daniel Vitt
  • August 20, 2026
  • 7 min
  1. Immunic closed a $400 million private placement financing to support Phase 3 trials in multiple sclerosis and transition to a commercial neurology company.
  2. Small molecules remain crucial in targeting intracellular pathways, particularly in conditions like multiple sclerosis, due to their practical advantages.
  3. Early small-molecule discovery is accelerating through AI and advanced screening technologies, enhancing the efficiency of candidate identification.
  4. Drug development faces complexity from stringent clinical trial requirements and evolving regulations, necessitating smarter trial designs and better data use.
  5. Expanding biomarker-based trial endpoints could streamline drug approvals, reduce costs, and enhance competition in pharmaceutical research and development.
...more

Food Safety And Risk

  • August 20, 2026
Evaluation of Raw Milk Quality and Water Contamination in the Dairy Value Chain of West Hararghe Zone, Eastern Ethiopia
  • Nuredin Seid Ali
  • Teressa Fekata Jebessa
  • Workneh Ensermu Bayisa
  • August 20, 2026
  1. Ethiopia produces approximately 3.32 billion liters of cow milk annually, accounting for 91% of the country's total milk production.
  2. Milk quality is threatened by natural deterioration and deliberate adulteration, with water addition being the most common method.
  3. Adulterated milk poses public health risks due to potential contamination from pathogenic microorganisms and chemical substances.
  4. About 95% of marketed milk in Ethiopia flows through informal value chains, facing challenges like inadequate regulatory enforcement and quality control.
  5. The study aimed to assess raw milk's chemical composition and the prevalence of water adulteration in the West Hararghe Zone of Eastern Ethiopia.
...more

Frontiers In Medicine

  • August 20, 2026
Investigating the Connection Between C. psittaci Infection and Respiratory Failure Through Pulmonary Microbiota Analysis: A Retrospective Cohort Investigation
  • Lulu Chen
  • Ling Ye
  • Xianming Li
  • Haiting Zhou
  • August 20, 2026
  1. The study enrolled 20 patients with psittacosis pneumonia, categorizing them based on the presence of respiratory failure at admission.
  2. Patients with respiratory failure showed a significant increase in C. psittaci sequences compared to those without respiratory failure.
  3. A significant negative correlation was found between C. psittaci sequences and CD4+ T-lymphocyte counts, indicating potential immune response impairment.
  4. A negative correlation between C. psittaci and Pseudomonas suggests a competitive relationship, while Veillonella showed a positive correlation with C. psittaci.
  5. The findings provide preliminary insights into the relationship between lung microbiota composition and the severity of psittacosis pneumonia.
...more

Frontiers In Endocrinology

  • August 20, 2026
Weak Photon Emission in Biological Systems: Exploring Links Between Oxidative Metabolism and DNA Communication Through Biochemical, Biophysical, and Quantum Biological Lenses
  • Jozsef Bodis
  • Jozsef Berke
  • Bernadett Nagy
  • Istvan Gulyas
  • Péter Hersics
  • Akos Varnagy
  • Kalman Kovács
  • August 20, 2026
  1. Ultra-weak photon emission (UPE) in living organisms is linked to oxidative processes and may represent cellular organization.
  2. UPE measurement techniques include CMOS systems, CCD cameras, and photomultiplier tubes, used to study mouse embryos.
  3. Cellular states influence UPE, with mitochondria and DNA potentially acting as emitters and resonators of photon emissions.
  4. Current hypotheses suggest UPE may reflect biological organization and could serve as a non-invasive biomarker in reproductive biology.
  5. Research indicates UPE correlates with oxidative stress and may serve as an indicator of cellular physiological states.
...more

Frontiers In Surgery

  • August 20, 2026
Case Report on the Diagnosis and Management of Incarcerated Inguinal Hernia with Successful "Complete Reduction
  • Haron Or Rashid Palash
  • Lide Tao
  • Muhammad Asad Iqbal
  • Anlai Ji
  • August 20, 2026
  1. Reduction en masse (REM) in incarcerated inguinal hernias can lead to closed-loop obstruction, posing a risk for bowel strangulation.
  2. A 70-year-old male experienced small-bowel obstruction after forceful self-reduction of a right inguinal hernia, with symptoms worsening over time.
  3. Contrast-enhanced CT revealed the 'preperitoneal hernia-sac sign,' indicating an obstructed jejunal loop adjacent to the inferior epigastric vessels.
  4. Laparoscopic exploration confirmed REM, allowing for bowel viability assessment and definitive repair, minimizing postoperative morbidity.
  5. Increased awareness of REM and timely imaging are crucial for preventing diagnostic delays and severe complications in similar cases.
...more

Frontiers In Psychiatry

  • August 20, 2026
Effective Treatment of Trichotillomania in a Patient Experiencing Hypersomnia Due to SSRI: A Case Study
  • Deemah Ateeq Alateeq
  • August 20, 2026
  1. Trichotillomania management often involves serotonergic pharmacotherapy, but options are limited for patients intolerant to first-line medications.
  2. A 25-year-old female with severe trichotillomania experienced debilitating hypersomnia from SSRIs, leading to academic decline.
  3. After failing two SSRIs, the patient was treated with bupropion and mindfulness-based behavioral therapy, resulting in significant improvement.
  4. The patient's improvement was maintained for 24 months after stopping bupropion, while she continued mindfulness practice.
  5. This case highlights the potential of bupropion as a treatment for trichotillomania in patients with SSRI intolerance.
...more

Frontiers In Surgery

  • August 20, 2026
Evaluating a Multidisciplinary Approach to Preoperative Management and Workflow Enhancement in Lung Cancer Care Over Seven Years
  • Adriana Nocera
  • Leonardo Petracca-Ciavarella
  • Maria Letizia Vita
  • Maria Teresa Congedo
  • Chiara Scognamiglio
  • Claudia Leoni
  • Claudia Bellettati
  • Alessia Senatore
  • Antonio Giulio Napolitano
  • Dania Nachira
  • Filippo Lococo
  • Elisa Meacci
  • Stefano Margaritora
  • August 20, 2026
  1. A retrospective analysis of 2,691 patients treated under a structured Lung Cancer Pathway (LCP) was conducted from 2018 to 2024.
  2. The median length of the LCP significantly decreased from 9 days in 2018 to 1 day by 2024 (p < 0.001).
  3. The median interval between LCP closure and surgery increased from 29 days in 2018 to 35 days in 2024 (p = 0.013).
  4. 16.6% of patients evaluated did not undergo surgery due to advanced disease, comorbidities, or individual preference.
  5. The study indicates that a structured LCP enhances diagnostic efficiency and decision-making in lung cancer care over seven years.
...more

Frontiers In Medicine

  • August 20, 2026
Development of a Predictive Model for Postpartum Hemorrhage in Preterm Deliveries: A Retrospective Matched Case-Control Analysis
  • Qiuping Liao
  • Baomei Xu
  • Lin Lin
  • Lianghui Zheng
  • Jinying Luo
  • Qian Yu
  • Jianying Yan
  • August 20, 2026
  1. A predictive model for postpartum hemorrhage (PPH) in preterm deliveries was developed using clinical data from 728 singleton pregnant women.
  2. Logistic regression analysis identified significant risk factors for PPH, including induced abortions, gestational diabetes, anemia, and polyhydramnios.
  3. The nomogram prediction model achieved a receiver operating characteristic (ROC) curve area under the curve (AUC) of 0.770.
  4. Placenta accreta and increta were highlighted as the most significant risk factors for PPH in preterm deliveries, according to the BP neural network analysis.
  5. The study's findings indicate that the predictive model has moderate capability for identifying women at high risk for PPH during preterm delivery.
...more

Frontiers In Psychiatry

  • August 20, 2026
Impact of Earthquakes on Children with Autism: Insights from Teachers' Observations and Experiences Post-Disaster
  • Mehmet Akif Kay
  • Osman Tayyar Çelik
  • Muhammed Abdulbaki Karaca
  • Özlem Aslan-Bağcı
  • August 20, 2026
  1. The study investigates behavioral, emotional, and academic changes in children with autism after the February 2023 Kahramanmaraş earthquakes.
  2. Twenty-two special education teachers from severely impacted provinces reported increased problematic behaviors and emotional fatigue in children with ASD.
  3. Teachers noted declines in academic abilities and learning challenges, linked to displacement and disrupted educational access post-earthquake.
  4. Inadequate educational settings and environmental factors were identified as barriers to recovery for children with ASD following the disaster.
  5. The findings highlight the need for trauma-informed, holistic support services for children with ASD to aid in their recovery and educational continuity.
...more

Frontiers In Medicine

  • August 20, 2026
Impact of a Clinically Guided "Sandwich" Teaching Approach on Professional Development, Learning Involvement, and Essential Skills in Cardiac Surgery ICU Nursing Staff
  • Liqin Mo
  • Yunyun Zeng
  • Yunxiao Liang
  • Changfeng Huang
  • August 20, 2026
  1. The study evaluated the impact of a clinically led 'sandwich' teaching approach on CSICU nurses' knowledge and skills.
  2. Sixty nurses participated, with one group receiving traditional teaching and the other the combined teaching intervention.
  3. Significant improvements were noted in theoretical knowledge, critical care nursing skills, and core competencies in the intervention group.
  4. The control group showed only a significant enhancement in critical care nursing skills, with no significant changes in other areas.
  5. The findings suggest that the 'sandwich' teaching model may enhance training for CSICU nursing, though its impact on learning engagement remains unclear.
...more

Pediatric Cardiology

  • August 20, 2026
Use of Extracorporeal Life Support in Interventions for Pediatric Pulmonary Vein Stenosis
  • Stephanie M. Tsoi
  • Roberta L. Keller
  • Loren D. Sacks
  • Vinod Sebastian
  • Sanjeev A. Datar
  • Michael A. Smith
  • Jason Boehme
  • Jeffrey R. Fineman
  • Elena K. Amin
  • August 20, 2026
  1. Pediatric pulmonary vein stenosis (PVS) has a mortality rate of 40% for 1–2 vessel disease and 80% for ≥ 3 vessel disease within 4 years of diagnosis.
  2. Advancements in pediatric PVS management include serial cardiac catheterizations with balloon angioplasty and stent placement, despite high risks.
  3. Catheterization for multivessel disease has a 12% rate of catastrophic adverse events, with stroke being the most common.
  4. Veno-arterial extracorporeal life support (VA-ECLS) was utilized in three pediatric patients during interventions, leading to favorable outcomes.
  5. All patients supported by VA-ECLS showed improvements in venous obstruction and no adverse cerebrovascular events during their procedures.
...more

Frontiers In Neurology

  • August 20, 2026
Hypertensive Crisis with Vasogenic Cerebral Edema Induced by Droxidopa in a Patient with Pure Autonomic Failure
  • Min-Ku Kim
  • Sung-Sik Kim
  • Jong-Gyu Baek
  • August 20, 2026
  1. A 60-year-old female with advanced pure autonomic failure experienced a hypertensive crisis after starting low-dose droxidopa.
  2. Droxidopa, commonly used for neurogenic orthostatic hypotension, can cause severe hypertensive complications even at low doses.
  3. The patient exhibited significant blood pressure lability and supine hypertension prior to droxidopa treatment.
  4. Emergency evaluation revealed elevated blood pressure and cerebral edema, confirmed by brain MRI showing multifocal lesions.
  5. This case highlights the need for careful monitoring and dose titration of droxidopa in patients with advanced autonomic dysfunction.
...more

Frontiers In Oncology

  • August 20, 2026
Retrospective Analysis of a Rare Collision Tumor: Mantle Cell Lymphoma Coexisting with Rectal Adenocarcinoma and Molecular Profiling of Multiple Specimens
  • Qing Zhang
  • Yingjie Xiu
  • Junhong Li
  • Xin Cao
  • August 20, 2026
  1. Collision tumors of colorectal adenocarcinoma and mantle cell lymphoma are rare, with limited molecular characterization of their components.
  2. A 65-year-old woman developed mantle cell lymphoma after initial treatment for rectal adenocarcinoma, highlighting diagnostic challenges.
  3. Molecular profiling revealed shared TP53 alterations in both adenocarcinoma and lymphoma components, indicating partial overlap.
  4. The mantle cell lymphoma was initially undetected in the rectal resection specimen, only identified after systemic disease emerged.
  5. The patient received treatment with bendamustine and rituximab, followed by zanubrutinib, and remained in remission at follow-up.
...more