Objective: Assess DNA and other biological material recovered from Shroud of Turin samples and determine whether the findings could establish the artifact’s age
DNA analysis of 12 Shroud of Turin specimens found that most genetic material reflected modern handling and environmental exposure.
More than 98% of the short DNA fragments lacked molecular damage patterns generally associated with ancient DNA, and testing detected modern contamination.
The predominant mitochondrial lineage matched that of 1978 sample collector Pierluigi Baima Bollone, while mixed DNA prevented attribution to an original individual.
The samples contained skin-associated microbes and diverse plant and animal DNA, including crops introduced to Europe during or after the Middle Ages.
Metagenomic testing could not determine whether the Shroud was medieval or approximately 2,000 years old; dated casket threads corresponded to documented repairs.
Objective: The article examines the objective, findings, and clinical context described in Are Labs Ready for HPV Self-sampling?. Approach: Screening pathway: E
NHS England introduced HPV self-sampling to increase cervical screening uptake, prompting laboratories to plan for changes in sample volumes and types.
Experts said clinician-taken samples remain the gold standard because trained professionals collect samples directly from the cervix.
A BMJ Open study estimated that AI-assisted digital cytology could reduce slide-review time by 69%, with productivity gains of 76% in primary screening and 64% in consultant review.
AI-assisted review can identify cells for closer assessment, while biomedical scientists and cytopathologists retain decision-making and focus on complex cases, quality assurance, and training.
Safe implementation at scale requires digital infrastructure, secure image sharing, system integration, training, validation, quality assurance, and governance.
Objective: To describe pregnancy and early maternal and infant outcomes after CAR T-cell therapy for autoimmune disease. Approach: Study population: Georg Schet
The report described 14 pregnancies in 13 patients who had received CAR T-cell therapy for autoimmune disease.
No autoimmune disease flares occurred during pregnancy, and all but one patient remained drug-free or used only prophylactic hydroxychloroquine.
Eight healthy babies had been born, five pregnancies were ongoing, and one pregnancy was electively terminated for reasons unrelated to autoimmune disease.
Newborns had no detectable CAR T cells, and reported CD19-positive B-cell counts, immunoglobulin G levels, and early development were normal.
The researchers called for pregnancy registries and further studies of fertility after lymphodepletion and CAR T-cell treatment.
Objective: To identify and characterize a previously unknown tick-borne virus in patients with fever and tick exposure in China. Approach: Patient testing: Rese
Researchers identified Asian longhorned tick nairovirus (ALTNV), a previously unknown orthonairovirus, in patients with fever and tick exposure in China.
Among 3,163 patients with fever and recent tick exposure, 10.4% had ALTNV RNA or immunoglobulin M antibodies; 15.1% of those testing negative for Dabie bandavirus had evidence of ALTNV infection.
Among 56 patients infected only with ALTNV, fatigue occurred in 84%, gastrointestinal symptoms in 80%, thrombocytopenia in 38%, and elevated aminotransferase levels in 36%; all recovered without repor
Among 38 patients coinfected with ALTNV and Dabie bandavirus, respiratory symptoms and kidney impairment were more frequent than in patients with Dabie bandavirus alone, and 7 coinfected patients died
ALTNV RNA was detected in 1.29% of 47,428 ticks, and laboratory experiments showed that Haemaphysalis longicornis could transmit the virus to mice.
Objective: The article examines the objective, findings, and clinical context described in A Glimpse into the Future of Analytical Instrument Design?. Approach:
SCANIMUS continuously records video while scanning slides at 10 to 20 mm per second, unlike conventional scanners that stop to capture each image.
An AI image-to-image model reconstructs sharp micrographs from motion-blurred scans, using much slower, high-quality scans as training references.
The portable system was designed to make slide digitization more accessible in routine pathology settings, where the developer says more than 90% of biopsies are not digitized.
SCANIMUS also offers a slower stop-and-stare mode, although its modest hardware does not match the throughput of high-end commercial scanners in that mode.
The article recommends validating reconstructed images against reference measurements, testing unseen specimens and conditions, quantifying error and uncertainty, and preserving raw data and provenanc
Objective: Demonstrate why spectral counts alone do not indicate the chemical coverage of a mass spectrometry database. Approach: Repository: Researchers create
GinorMass is a public repository containing 23,971,300 tandem mass spectra, all acquired from the single molecule arginine.
The repository demonstrates that a high spectrum count does not necessarily indicate broad chemical coverage.
Researchers acquired the spectra from an arginine reference standard using a quadrupole time-of-flight mass spectrometer under fixed conditions.
Repeated spectra can capture variation across instruments, laboratories, and acquisition conditions, but measurements under fixed conditions may become redundant.
The authors recommended reporting spectral counts alongside chemical diversity, acquisition conditions, annotation confidence, and data provenance.
Objective: The video interview discusses John Tomtishen’s career, changes across the cell therapy field, and his perspectives on product characterization, CMC,
The video interview features John Tomtishen, Catalent’s Global Head of Cell Therapy Field Application Scientists and Strategic Alliances.
Tomtishen discusses his career and changes he has witnessed across the cell therapy field.
He explains why developers should prioritize product characterization early in development.
Tomtishen also emphasizes the importance of addressing chemistry, manufacturing, and controls early in development.
He discusses technologies and manufacturing strategies that could improve scalability and the industry’s efforts to bring future cell therapies to more patients.
Objective: Precure, LLC aims to identify biological changes that occur before disease symptoms emerge by linking molecular data with longitudinal clinical infor
Mayo Clinic and Thermo Fisher Scientific launched Precure, LLC, to study biological changes that occur before disease symptoms emerge.
Precure plans to generate molecular data from 1 million biospecimens and link it with clinical information collected over several years.
The initiative will combine proteomic, genomic, and longitudinal clinical data and use artificial intelligence and analytics to identify biological patterns.
Thermo Fisher will contribute proteomics expertise and technologies, including the Olink Explore HT platform and Thermo Scientific Orbitrap Mass Spectrometry.
Mayo Clinic will hold a majority stake, and financial returns will be reinvested in its nonprofit missions of patient care, research, and education.
Objective: To compare the effects of nonnutritive sweetened (NNS) beverages and water on body weight reduction over 104 weeks in adults participating in a behav
The SWITCH trial randomly assigned 493 adults to consume either water or nonnutritive sweetened beverages for weight management.
After 104 weeks, body weight decreased by 3.7 kg in the water group and 4.8 kg in the NNS beverage group, with no significant between-group difference.
Both groups experienced reductions in waist and hip circumference, but no statistically significant differences were observed between them.
The water group showed greater reductions in glycated hemoglobin and diastolic blood pressure, while total cholesterol increased in the NNS group.
The study faced limitations, including participant attrition and lack of race and ethnicity data, which may affect generalizability.
Objective: To compare the accuracy of an AI model and experienced radiologists in estimating pleural effusion volume on chest radiography. Approach: Study Desig
Objective: To discuss the circumstances under which vascular surgeons innovate to treat complex cases. Approach: Established Guidelines: Examples include abdomi
Objective: To explain the benefits of the totally thoracoscopic (TT) maze surgery for treating longstanding persistent atrial fibrillation (AFib). Approach: Sur
Objective: To evaluate the potential of vibroarthrography combined with machine learning as a noninvasive method for identifying osteoarthritis-related cartilag
Objective: To discuss the development and validation challenges of nucleic acid aptamers for use in molecular diagnostics. Approach: Aptamer Development: Aptame
Katelynn Perrault Uptmor established a research group at William & Mary in 2023, focusing on undergraduate involvement in research.
Her laboratory employs comprehensive two-dimensional gas chromatography (GC×GC) to address forensic challenges and fundamental separation science questions.
Perrault emphasizes the importance of better instrumentation and intuitive software for advancing GC×GC toward routine use.
She believes that early student involvement in research can have a lasting impact on their skills and development.
Perrault draws parallels between scientific research and endurance sports, highlighting the significance of small incremental gains.