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April 1, 2026

FDA Approves Lilly’s Foundayo Oral GLP-1 Pill

Kathryn Wighton
April 1, 2026
2 min

Orforglipron (Foundayo), a once-daily oral GLP-1 receptor agonist developed by Eli Lilly and Company, has been approved by the FDA for chronic weight management

...more

Orforglipron is FDA approved for chronic weight management.
It is taken once daily as an oral GLP-1 receptor agonist.
Significant mean weight loss observed: 27.3 lbs with high dose.
Reduces cardiometabolic risk markers.
Safety warning for thyroid tumors; not for certain patient histories.
Available via LillyDirect starting April 6,
Pricing options available for patients, including a savings program.

April 1, 2026

FDA Broadens CFTR Therapy Eligibility

Kathryn Wighton
April 1, 2026
3 min

The FDA has expanded the eligibility of cystic fibrosis modulators vanzacaftor/tezacaftor/ivacaftor (ALYFTREK) and elexacaftor/tezacaftor/ivacaftor (TRIKAFTA) t

...more

FDA approved expanded indications for CFTR modulators.
Approximately 95% of cystic fibrosis patients are now eligible.
Vanzacaftor/tezacaftor/ivacaftor for ages 6+.
Elexacaftor/tezacaftor/ivacaftor for ages 2+.
800 additional patients eligible after expansion.
Monitor liver function regularly for patients on these treatments.
Common side effects include cough and upper respiratory infections.

April 1, 2026

Problem-Solving

Markus B. Blatz
April 1, 2026
3 min

Halitosis, commonly known as bad breath, is a significant yet often mismanaged oral health issue affecting patient well-being due to its social stigma. A struct

...more

Halitosis is a major oral health issue impacting patient psychology.
The new classification system helps distinguish between various sources of halitosis.
Accurate diagnosis of halitosis facilitates effective treatment planning.
Penicillin allergy's implications in dentistry are crucial for patient safety.
The issue highlights innovative dental rehabilitation techniques.

April 1, 2026

Achieving Predictable Facial Bone Reconstruction at Immediate Implant Placement Utilizing the Facial Allograft Shield Technique

Naushad Edibam
Samantha Eyen
David Salomon
Gregori M. Kurtzman, DDS
April 1, 2026
20 min

Resorption following tooth loss poses challenges for dental implant treatments, especially in the esthetic zone. Traditional bone augmentation methods, such as

...more

Tooth loss leads to predictable alveolar resorption affecting esthetics.
The FAST technique uses allogeneic bone membranes for immediate implant placement.
Reduces the need for donor site surgeries and associated complications.
Fast healing with high predictability and stability for patients.
Ideal for type II socket defects where facial plates are compromised.

April 1, 2026

The Power of Interdisciplinary Collaboration: Bringing Dental Specialists Together Through Professional Community

Alan Farber
April 1, 2026
5 min

The future of dentistry relies on effective interdisciplinary collaboration among clinicians to tackle increasingly complex patient cases. This requires special

...more

Interdisciplinary collaboration centralizes complex patient care in dentistry.
iADS fosters communication among various dental specialties.
The iADS Forum promotes collaborative learning experiences.
Scheduled for May 14-16, 2026, in Chantilly, Virginia.
Specialists bring diverse perspectives to treatment planning.
Importance of evolving dental practices with emerging technologies.
Knowledge sharing enhances clinical outcomes and patient care quality.

April 1, 2026

EBITDA Meets AI: The New Economics of Running a Dental Practice

Stephen Fong
April 1, 2026
7 min

Dental support organizations (DSOs) face significant challenges such as staffing shortages and rising costs. AI is emerging as a pivotal tool for CFOs, helping

...more

DSOs are under pressure from staffing shortages and rising costs.
AI can enhance revenue cycle performance by automating claims and eligibility checks.
It improves labor efficiency by removing repetitive tasks.
AI aids in scheduling to maximize patient capacity and reduce no-shows.
Modern CFOs require fluency in data and technology to drive financial performance.
AI enables better financial oversight and quicker decision-making.
Integration of AI can protect and potentially grow EBITDA.

April 1, 2026

Open Access Has a Dirty Secret, Surgical Editors Say

Kerri Miller
April 1, 2026
3 min

The Surgery Journal Editors Group, including Dr. Sherry M. Wren, Dr. Elliott R. Haut, and Dr. Fausto Catena, highlight a significant equity paradox in open acce

...more

Open access publishing may impose financial burdens on authors.
The disparity in APC costs limits participation from low- and middle-income countries.
Recommendation to waive fees for specific authors from LMICs.
Transformative agreements offer a solution but have caps.
Current system risks creating a two-tier knowledge economy.

April 1, 2026

Mirtazapine Cuts Meth Use in Phase 3 Trial

Andrea Surnit
April 1, 2026
2 min

In a phase 3 clinical trial involving 339 patients with moderate to severe methamphetamine use disorder, mirtazapine was shown to reduce methamphetamine usage d

...more

Mirtazapine reduces methamphetamine use in a phase 3 trial.
339 patients participated over 12 weeks.
Mirtazapine group saw a 7-day reduction in use days.
Adverse effects included drowsiness (47%) and weight gain (10%).
No significant changes in depression or quality of life metrics.

April 1, 2026

BMI Patterns in ILD Outcomes Examined

Kathryn Wighton
April 1, 2026
3 min

A systematic review of 25 articles and 29 studies involving 23,741 patients has revealed that a higher body mass index (BMI) correlates with reduced mortality a

...more

Higher BMI correlates with lower mortality in ILD patients.
The systematic review analyzed 25 articles and 29 studies.
Obesity is linked to slower decline in lung function.
Most studies had moderate risk of bias.
Limitations include heterogeneity in ILD subtypes.
90% of participants had idiopathic pulmonary fibrosis.
BMI should reflect overall health, not a therapeutic target.

The ASCO Post

April 1, 2026

Early Results From a Trial of Active Surveillance for Low-Risk DCIS are ‘Reassuring,’ Say Researchers

The ASCO Post Staff
April 1, 2026
4 min

The LORD trial, presented at the 15th European Breast Cancer Conference, evaluates the safety of active surveillance for low-risk ductal carcinoma in situ (DCIS

...more

LORD trial evaluates active surveillance vs immediate surgery for DCIS.
Presented at EBCC15 by Dr. Jelle Wesseling.
Involved 1,423 patients; monitored for two years.
6% of active surveillance patients developed invasive cancer.
9% in immediate surgery group developed invasive cancer.
Active surveillance does not mean withholding treatment.
Longer follow-up needed for conclusive results.
Study contributes to reducing overtreatment in breast cancer.

The Medicine Maker

April 1, 2026

Could Mass Spec Overcome the CAR T Solid Tumor Barrier?

April 1, 2026
8 min

CAR T cell therapy has transformed treatment for blood cancers, yet its application to solid tumors faces significant challenges, including elusive targets and

...more

CAR T therapy shows promise for blood cancers, limited in solid tumors due to target challenges.
Analytical science is key for understanding CAR T functions.
Mass spectrometry plays a critical role in identifying targets.
Development of CAR therapies for solid tumors is underway with significant potential.
Research at NRC focuses on data-driven CAR T therapy advancements.
Novel analytics may guide improved therapy design and outcomes.
Future CAR T products could be universal and off-the-shelf.

The Analytical Scientist

April 1, 2026

PFAS Exposure Linked to Faster Epigenetic Aging

April 1, 2026
2 min

Recent research has established a link between lesser-studied PFAS compounds, specifically PFNA and perfluorooctane sulfonamide, and accelerated epigenetic agin

...more

Study focused on lesser-studied PFAS: PFNA and PFSA.
Strongest aging associations found in men aged 50-
95% of participants had detectable PFNA/PFSA levels.
Analyzed data from NHANES 1999-
Used 12 epigenetic aging algorithms.
Smoking may compound risks from PFAS.
Results encourage evaluation beyond legacy PFAS.
Research ongoing into PFAS and other pollutants' cumulative health effects.

The Medicine Maker

April 1, 2026

From One Stem Cell to Millions of Cancer Killers

April 1, 2026
1 min

Researchers from China have pioneered a novel method for mass-producing cancer-fighting immune cells by transforming a single stem cell into millions of natural

...more

New method developed for NK cell mass production from stem cells.
Process includes expansion of CD34+ stem cells and differentiation via organoid systems.
Yields of ~14 million NK cells per stem cell achieved.
Dramatic reduction in viral vector needs (up to 600,000-fold).
Effective at suppressing tumor growth in leukemia models.
Potential for cost-effective 'off-the-shelf' immunotherapies.
CAR-NK cells retain potency post-cryopreservation.

The ASCO Post

April 1, 2026

AI-Driven Multiagent System for Guiding First-Line Immunotherapy for NSCLC

Lisa Astor
April 1, 2026
5 min

An AI multiagent system has shown capability in determining immunotherapy options for patients with non-small cell lung cancer (NSCLC) in a first-line setting.

...more

AI multiagent system aids immunotherapy for NSCLC.
58 patients studied for treatment outcomes.
Correct treatment recommendations achieved 72% of the time.
System evaluated by specialized oncologists.
Enhancements in AI decision-making confirmed as necessary.
Dr. Corso presented findings at ESMO Congress.
Agentic AI shows potential in complex clinical tasks.
Future validation with larger cohorts planned.

April 1, 2026

Prednisolone Linked to Metabolic Benefits

Henry Thomas
April 1, 2026
2 min

A randomized crossover trial indicates that low-dose prednisolone taken once daily may provide some cardiometabolic benefits compared to thrice-daily hydrocorti

...more

Low-dose prednisolone may have cardiometabolic benefits over hydrocortisone.
Study involved 46 patients with adrenal insufficiency.
Prednisolone dosage ranged from 2 to 5 mg.
Slower bone turnover observed with prednisolone.
Improvements noted in weight and diabetes markers.
Subjective health outcomes were similar between treatments.
No adrenal crises reported.
Longer-term studies are required for clinical significance.

Baptist Health South Florida

April 1, 2026

Baptist Health Brain & Spine Care Takes Center Stage at Neuroscience Nursing Conference

April 1, 2026
2 min

At the AANN annual conference, Baptist Health Brain & Spine Care showcased innovative stroke care practices, led by Nurse Practitioner Ashley Bolling. The team

...more

AANN conference showcased Baptist Health's stroke care initiatives.
Importance of FAST and BEFAST acronyms for stroke recognition.
High-performing stroke nurses respond to alerts and conduct follow-ups.
Community education plays a crucial role in awareness.
ICH alert protocol enhances timely care in stroke management.
Innovative practices improve interdisciplinary collaboration.
Presentations addressed both education and care delivery advancements.

The Pathologist

April 1, 2026

Strengthening Pathways for Military Laboratory Professionals

Sean Chickery
April 1, 2026
3 min

Military laboratory professionals are crucial in supporting healthcare for service members and their families, adapting to high-pressure environments with preci

...more

Military laboratory professionals play a vital role in healthcare.
ASCP offers initiatives for professional growth.
Many military personnel possess strong teamwork skills.
'Bridge and Broaden' promotes long-term engagement for veterans.
Transitioning to civilian roles presents unique challenges.
Understanding gaps in veteran engagement is crucial.
Future initiatives will spotlight military contributions.

The Pathologist

April 1, 2026

Your Biological Age? It's in the Blood

April 1, 2026
2 min

The European MARK-AGE study reveals that a panel of 10 blood-based biomarkers can more accurately estimate biological age than chronological age, potentially ai

...more

MARK-AGE study identifies 10 biomarkers for biological age.
Analyzed over 3,300 individuals aged 35 to
Developed sex-specific algorithms for age estimation.
HDL cholesterol and vitamin D correlate with younger biological profiles.
Highlights importance of multi-marker panels versus single-analyte testing.
Higher biological age indicates increased disease risk.
Study indicates potential for personalized preventive care strategies.

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