Low-power ultrasound biomodulation presents a promising noninvasive strategy for lowering intraocular pressure (IOP) in glaucoma patients, a leading cause of ir
Wearable and implantable devices are transforming intraocular pressure (IOP) monitoring in glaucoma management, addressing limitations of traditional tonometry
In March, prominent ophthalmic research centers in Philadelphia convened for the inaugural All Philadelphia Glaucoma Research Retreat, aimed at enhancing collab
Surgical decisions in pregnant women with glaucoma require careful risk assessment and multidisciplinary coordination. When medication and laser therapy fail to
Recent advancements in glaucoma surgery focus on improving the function of Schlemm’s canal through novel implantable bioscaffolds and dilation techniques. Tradi
In the interventional era of glaucoma treatment, the effectiveness of patient counseling is crucial. Glaucoma often goes unnoticed until significant damage occu
The Via360 surgical system by New World Medical integrates adjustable canaloplasty and trabeculotomy, featuring on-demand viscodilation for enhanced control dur
Objective: To assess the efficacy and safety of rimegepant in the treatment of migraines, including its role in both acute management and prevention. Key Findin
Objective: To propose a framework for understanding microbiome-immune interactions in acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) and their im
Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) significantly contributes to short-term mortality and requires further investigation into its biological mechanisms.
The distal lung microbiome is not sterile; it harbors microorganisms that may interact with host immune responses in the context of AE-IPF.
Pulmonary dysbiosis and microbial stimulation can enhance immune signaling, modify macrophage behavior, and provoke harmful neutrophil responses.
Increased microbial load in IPF correlates with worse clinical outcomes, although specific causative pathogens remain to be definitively identified.
The proposed amplification model highlights the interplay between microbial activation and immune responses, suggesting a self-perpetuating cycle in AE-IPF.
Objective: To assess the impact of extended reality (XR) simulations on various training outcomes in ophthalmology, including technical proficiency and complica
Objective: To assess the clinical significance of sophisticated Monte Carlo (MC)-based dose-calculation methods for linear accelerators (LINACs) and their advan
Monte Carlo (MC) simulation offers superior dose calculation accuracy in radiotherapy compared to traditional algorithms, especially in complex scenarios.
Recent advancements in GPU acceleration have significantly reduced MC computation times, achieving speed enhancements of 50 to 2500 times.
Artificial intelligence (AI) is utilized in MC methods to minimize noise and further decrease computational duration in dose calculations.
Elekta's Monaco system features a validated rapid MC engine, while Varian systems typically use MC for independent quality verification.
Despite improvements in MC methodologies, direct evidence linking enhanced dosimetry to better clinical outcomes remains limited.
Objective: To review the impact of bone marrow hemodilution on measurable residual disease (MRD) assessment in multiple myeloma, highlighting its clinical signi
Objective: To explore changes in diuretic and renal outcomes following initiation of combined ARNI and SGLT2 inhibitors therapy in patients with acute heart fai
Objective: To identify and characterize a novel pathogenic subset of CD14+ monocytes in Myasthenia Gravis (MG) using multi-omics and machine learning approaches
Objective: To compare the effects of immediate high-energy nutritional support versus gradual energy increase in patients with acute pancreatitis, focusing on p
Objective: To document the rapid progression to end-stage renal disease (ESRD) in a young patient with maturity-onset diabetes of the young (MODY), obesity, unc
A 24-year-old male with suspected MODY, obesity, and uncontrolled hypertension advanced to end-stage renal disease within five years of diagnosis.
The patient's renal function deteriorated significantly, with serum creatinine rising from 0.9 to 10.8 mg/dL and eGFR declining from 115.98 to 4.69 mL/min/1.73 m².
Despite treatment with insulin and metformin, the patient's glycemic control remained poor, with a mean HbA1c of 9.79% over the study period.
Chronic cannabis use contributed to recurrent acute kidney injury and exacerbated the patient's renal decline, leading to prerenal azotemia.
This case highlights the urgent need for early identification and comprehensive management of patients at high risk for rapid renal deterioration.
Objective: To review the potential effects of gluten on Hashimoto’s thyroiditis (HT) and its relationship with celiac disease (CD), and to evaluate the implicat
