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MDSpire News

  • October 22, 2026
FDA clears integrated kidney replacement system
  • Mouj Hijazi
  • October 22, 2026
  • 3 min

Get a concise, at-a-glance scorecard that distills clinical guidelines into key recommendations, patient insights, and treatment considerations.

View Scorecard

MDSpire News

  • October 22, 2026
FDA approves ravulizumab for IgA nephropathy
  • Mouj Hijazi
  • October 22, 2026
  • 3 min
  1. The FDA granted accelerated approval to ravulizumab-cwvz to reduce proteinuria in adults with primary IgA nephropathy at risk for disease progression.
  2. Approval was based on the phase 3 I CAN trial, in which ravulizumab reduced proteinuria by 46.6% at week 34, compared with 5.6% with placebo.
  3. Whether ravulizumab slows kidney function decline has not been established; the ongoing I CAN trial will assess eGFR change at week 106.
  4. The most frequently reported adverse events with ravulizumab were upper respiratory tract infection, nasopharyngitis, and infusion-related reactions.
  5. Ravulizumab carries a boxed warning for serious meningococcal infections, and the FDA advises vaccination before treatment unless delaying therapy poses greater risks.
...more

MDSpire News

  • October 22, 2026
Biomaterial approach may help cartilage retain shape
  • Andrea Surnit
  • October 22, 2026
  • 4 min

Objective: To develop and evaluate a programmable 4D bio-Kirigami system for shaping cell-laden hydrogel constructs and assessing whether cartilage-like matrix

...more
2 min

MDSpire News

  • October 22, 2026
Medical Oddities: When puberty arrives at 4 months old
  • Teraya Smith
  • October 22, 2026
  • 6 min
  1. A girl with estrogen-related changes beginning at 4 months had recurrent vaginal bleeding, advanced bone age, severe anemia, and endometrial abnormalities by age 6 years and 7 months.
  2. Whole-exome sequencing identified a likely pathogenic ESR1 p.Tyr537Ser variant, while suppressed luteinizing hormone argued against central precocious puberty; causation remains unconfirmed.
  3. Tamoxifen temporarily reduced the cervicovaginal mass and improved symptoms, but recurrence was documented by February 2025, prompting combined letrozole–tamoxifen therapy.
  4. The case report authors noted that the long-term malignancy risk is unknown, and the unusually early puberty’s relationship to excessive estrogen receptor activity remains uncertain.
  5. The report described atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia in a child, an extraordinarily unusual finding in childhood.
...more

MDSpire News

  • October 22, 2026
CPAP changes may precede choroidal detachment
  • Andrea Surnit
  • October 22, 2026
  • 4 min

Objective: To describe a case of choroidal detachment occurring after changes to continuous positive airway pressure (CPAP) therapy and discuss a possible relat

...more
2 min

MDSpire News

  • October 22, 2026
STAT6 may aid diagnosis of giant pulmonary SFT
  • Andrea Surnit
  • October 22, 2026
  • 4 min

Objective: To describe the diagnosis and clinical course of a giant intrapulmonary solitary fibrous tumor (SFT) in a 57-year-old woman. Approach: Diagnostic eva

...more
2 min

The Analytical Scientist

  • October 22, 2026
Food Analysis Enters the Data Age
  • Henry Thomas
  • October 22, 2026
  • 6 min

Objective: The interview with food chemist Francesco Cacciola discusses recent developments in food analysis, his group’s research, current analytical challenge

...more
3 min

The Medicine Maker

  • October 22, 2026
Can Clinical Trials Collect Less Data Without Compromising Safety?
  • Mouj Hijazi
  • October 22, 2026
  • 8 min

Objective: The article describes FDA–TransCelerate tabletop exercises on pragmatic clinical trials and selective safety data collection (SSDC), and discusses th

...more
3 min

The Pathologist

  • October 22, 2026
The Gross Room’s Digital Makeover
  • Jessica Allerton
  • October 22, 2026
  • 8 min
  1. Gross specimens vary in size, shape, orientation, texture, and clinical context, making them harder to digitize than standardized glass slides.
  2. Digital grossing trends include intake technologies for documenting specimens, integration tools that connect information, and computational intelligence.
  3. An integrated digital system could link specimen images, measurements, annotations, and sampling details throughout the pathology workflow.
  4. Digital tools could improve measurement, structured documentation, and consistency while automating repetitive tasks such as calculations.
  5. Technology should support, not replace, professional judgment; laboratory professionals must be able to understand, question, and override it.
...more

The Pathologist

  • October 22, 2026
Genetic Link Explains Inherited Blindness
  • October 22, 2026
  • 2 min

Objective: To investigate the genetic and biochemical basis of retinitis pigmentosa in individuals with variants affecting both copies of IDUA. Approach: Partic

...more
2 min

The Pathologist

  • October 22, 2026
Genetic Link Explains Inherited Blindness
  • October 22, 2026
  • 2 min

Objective: To investigate the genetic and biochemical basis of retinitis pigmentosa in individuals with variants affecting both copies of IDUA. Approach: Partic

...more
2 min

The Analytical Scientist

  • October 22, 2026
A Billion-Scale Dataset for Proteomics AI
  • October 22, 2026
  • 3 min

Objective: To create a standardized, large-scale mass spectrometry dataset for developing and evaluating artificial intelligence models in proteomics. Approach:

...more
2 min

Critical Care

  • October 22, 2026
Authors’ response to comments on MAPSE in critical illness: translating prognostic associations into clinical practice
  • Oscar Cavefors
  • Jonatan Oras
  • October 22, 2026

Objective: The article examines the objective, findings, and clinical context described in Authors’ response to comments on MAPSE in critical illness: translati

...more
2 min

Intensive Care Medicine

  • October 22, 2026
Recent Advances in Critical Care for Multisystem Trauma
  • Tobias Gauss
  • Martin W. Dünser
  • October 22, 2026

Get a concise, at-a-glance scorecard that distills clinical guidelines into key recommendations, patient insights, and treatment considerations.

View Scorecard

Kaiser Family Foundation

  • October 22, 2026
Health Insurance Premiums and Employee Contributions in Employer-Sponsored Plans, 1999–2026
  • kffmichaelp
  • October 22, 2026
  1. The Employer Health Benefits Survey has tracked employer-sponsored health insurance trends since 1999 among private and nonfederal public employers with at least 10 employees.
  2. The survey reports premiums, defined as the full per-person cost of coverage, and worker contributions, defined as the portion paid by workers.
  3. Premium and worker contribution estimates are weighted by the number of workers receiving health benefits and adjusted for industry and firm size.
  4. Standard errors quantify estimate uncertainty, which generally increases for smaller groups; differences between estimates may not be statistically significant.
  5. Family coverage represents coverage for a four-person family, and firms offering multiple plan types are classified by their largest plan type.
...more

Kaiser Family Foundation

  • October 22, 2026
Workers’ Average Annual Contribution to Employer-Sponsored Family Health Coverage Reaches $7,471, Up 9% From 2025, Survey Finds
  • kffrainl
  • October 22, 2026

Objective: The article reports findings from KFF’s 2026 Employer Health Benefits Survey, including worker contributions to family premiums, total premiums, empl

...more
2 min

Kaiser Family Foundation

  • October 22, 2026
What Growth Is Projected for U.S. Health Spending?
  • Shameek Rakshit
  • Imani Telesford
  • Aubrey Winger
  • Lynne Cotter
  • Juliette Cubanski
  • Matt McGough
  • October 22, 2026

Objective: The article examines the objective, findings, and clinical context described in What Growth Is Projected for U.S. Health Spending?. Approach: Project

...more
1 min

Critical Care

  • October 22, 2026
A substantial share of excess deaths among immunocompromised patients with viral severe acute respiratory infection occurs after ICU discharge
  • Leyi Xu
  • Ting Ye
  • October 22, 2026
  1. Among ICU survivors, 10.0% of immunocompromised patients died before hospital discharge, compared with 4.0% of immunocompetent patients.
  2. Post-ICU deaths accounted for approximately one-half of the absolute difference in in-hospital mortality between immunocompromised and immunocompetent patients.
  3. The authors note that treatment limitations, late secondary infection, or progression of underlying disease could contribute to excess mortality after ICU discharge.
  4. The SARI case definition and exclusion of patients with unknown immune status may have affected cohort composition, particularly for COVID-19 admissions.
  5. Approximately three-quarters of the 11.0-point shortfall in 30-day discharge reflected excess hospital mortality rather than a greater proportion remaining hospitalized.
...more