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February 27, 2026

ACOG Parts Ways With ACIP

Kathryn Wighton
February 27, 2026
3 min

The American College of Obstetricians & Gynecologists (ACOG) has withdrawn from the CDC's Advisory Committee on Immunization Practices (ACIP) due to concerns ov

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ACOG withdrew from ACIP over scientific integrity concerns.
Dr. Steven J. Fleischman is the president of ACOG.
ACOG participated in ACIP for decades.
Importance of vaccine safety and effectiveness in pregnancy.
Recent disregard for peer-reviewed safety data by ACIP.
ACOG will continue to provide evidence-based vaccine guidance.
The committee's changes may impact public trust in vaccinations.

February 27, 2026

Children With OSA Face Higher Influenza, COVID-19 Risk

Alun Evans
February 27, 2026
4 min

A large retrospective cohort study reveals that children diagnosed with obstructive sleep apnea (OSA) have a significantly heightened risk of contracting influe

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Children with OSA have a higher risk of influenza and COVID-
OSA children have a diagnosis risk ratio of 1.80 for influenza.
COVID-19 risk ratio is 2.50 in OSA children.
Adenotonsillectomy does not reduce infection risk.
Immune dysregulation may contribute to increased viral susceptibility.
Importance of prioritizing vaccinations in children with OSA.
Large sample size strengthens the study findings.
Causality cannot be firmly established due to retrospective design.

February 27, 2026

Sequencing Therapies in Non-Hodgkin Lymphomas

F. Brianne Buchanan, PA-C
Tatjana Grgic, PharmD, BCOP, CPP
February 27, 2026
9 min

At JADPRO Live 2025, F. Brianne Buchanan, PA-C, and Tatjana Grgic, PharmD, provided insights on selecting and sequencing therapies for relapsed/refractory B-cel

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BTK inhibitors stop B-cell growth by inhibiting BTK enzyme.
Bispecific antibodies engage T-cells to kill B-cells.
CRS common after CAR T-cell therapy; first symptom is fever.
Monitoring for toxicities is crucial in advanced therapies.
Patient factors influence therapy sequencing decisions.
Palliative care improves quality of life and symptom management.
Logistical planning is vital for therapy administration.

Baptist Health South Florida

February 27, 2026

Boca Raton Regional Hospital Foundation Honors Donors at Proton Therapy Center

February 27, 2026
2 min

The Boca Raton Regional Hospital Foundation celebrated the upcoming addition of proton therapy at the Eugene M. & Christine E. Lynn Cancer Institute, scheduled

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Proton therapy to be added at Lynn Cancer Institute in Summer
Entirely funded by community donations.
Key supporters acknowledged during donor event.
Proton therapy enhances precision in cancer treatment.
Initiative emphasizes innovative cancer care.
Focus on improving patient outcomes.
Strengthens community partnership in healthcare.

February 27, 2026

Unexpected Diagnosis in Ring Finger Mass

Jess Allerton
February 27, 2026
2 min

An 18-year-old female presented with digital actinomycosis after a painless mass developed on her ring finger. This rare form of actinomycosis typically affects

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The patient was diagnosed with digital actinomycosis at 18 years old.
Actinomycosis is a chronic infection caused by Actinomyces species.
Rare involvement of fingers; lesions can be misdiagnosed.
Imaging showed poorly defined lytic lesions.
Histopathology revealed sulfur granules confirming the diagnosis.
Treatment included surgical excision and prolonged penicillin therapy.
Early diagnosis crucial to prevent misdiagnosis as malignancy.
Follow-up showed no recurrence at 4 months post-surgery.

February 27, 2026

Early Hip Fracture Surgery Safe in Patients on DOACs

Julie Greenbaum
February 27, 2026
4 min

A multicenter retrospective cohort study involving 875 patients aged 70 and older with hip fractures revealed that surgery within 24 hours for those on direct o

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Study analyzed 875 hip fracture patients aged 70+.
Early surgery (24 hours) shows similar hemoglobin decrease as delayed surgery.
Median hemoglobin decrease: early 0.6 mmol/L, delayed 0.9 mmol/L.
Early surgery linked to shorter hospital stays (6 vs 8 days).
No major differences in transfusion rates or mortality.
Limitations: missing DOAC dose info and comorbidities data.
Study supports safety of early surgery for hip fractures on DOACs.

February 27, 2026

Shared Decision-Making Is Institution-Driven

Henry Thomas
February 27, 2026
2 min

A comprehensive analysis of over 147,000 percutaneous left atrial appendage occlusion procedures reveals significant variation in the documentation of shared de

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Study analyzed 147,000+ LAAC procedures.
65% of procedures had documented SDM using DAs.
Institutional factors drove variability in SDM reporting.
Medicare coverage did not enhance SDM documentation odds.
Commentary suggests SDM may be compliance-focused rather than patient-centered.
Recommendations include improving documentation quality and institutional investment.
Higher-risk patients more likely to have documented SDM.

February 27, 2026

Digital CBT Outperforms Psychoeducation in Generalized Anxiety Disorder

Henry Thomas
February 27, 2026
3 min

A randomized clinical trial of adults with generalized anxiety disorder (GAD) evaluated a smartphone-delivered digital cognitive behavioral therapy (DCBT) progr

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Trial involved 351 adults with GAD.
DCBT led to 71.0% remission at 10 weeks.
At 24 weeks, remission increased to 77.7%.
DCBT also improved depressive symptoms and sleep quality.
Design features included independent evaluators and high retention.
Adverse events were infrequent.
Effective for accessing psychotherapy in challenging settings.
No replacement for traditional therapy, but a scalable adjunctive option.

The Analytical Scientist

February 27, 2026

How Manufacturing Changes Battery Microstructure

February 27, 2026
2 min

Researchers from the University of Oxford have developed a novel chemical staining approach to map polymer binders in lithium-ion battery anodes at the nanoscal

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New chemical staining method reveals polymer binder structures at nanoscale.
Focused on widely used CMC and SBR in battery anodes.
Silver ions and bromine vapor facilitate selective staining.
Method allows mapping with electron microscopy techniques.
Shows reduction in electronic resistivity by modifying mixing protocols.
Insights can aid quality control and optimization in battery manufacturing.
Provides previously inaccessible structural details of binders.

The Analytical Scientist

February 27, 2026

Label-Free Detection of Intracellular Microplastics

February 27, 2026
2 min

Researchers employed optical photothermal infrared (O-PTIR) spectroscopy to identify microplastics in intestinal epithelial cells, focusing on biological impact

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O-PTIR spectroscopy detects microplastics in cells.
Study focused on common household polymer microplastics.
Oxidative stress linked to exposure.
Method distinguishes polymer type and assesses biochemical effects.
Findings suggest alterations in protein structure due to microplastics.
Future research should extend beyond in vitro models.

The Pathologist

February 27, 2026

Cervical Cancer Is Preventable – So Why Do We Miss It?

February 27, 2026
6 min

Cervical cancer remains a significant health issue, being the fourth most common cancer in women worldwide. Advances in HPV vaccination and screening methods ha

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Cervical cancer is the 4th most common cancer in women.
HPV vaccination is crucial for prevention.
Regular screening is vital due to long asymptomatic periods.
HPV testing is more sensitive than cytology.
Health disparities affect access to screening.
Emerging diagnostic advances aim to personalize screening.
Symptoms like abnormal bleeding should prompt immediate evaluation.
Education on prevention and screening is key to reducing cervical cancer incidence.

The Pathologist

February 27, 2026

Earlier Detection of Organ Rejection

February 27, 2026
2 min

Donor-derived cell-free DNA (dd-cfDNA) testing is revolutionizing the monitoring of solid organ transplants by enabling earlier detection of graft injuries such

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dd-cfDNA testing enables early detection of graft injury.
Low levels of dd-cfDNA indicate stable graft health.
Two detection methods: next-gen sequencing and droplet digital PCR.
Clinical applications are strongest in kidney and heart transplants.
Rising dd-cfDNA levels may signal acute rejection.
Testing can reduce unnecessary biopsies.
Emerging applications in liver and lung transplants.
Molecular monitoring may reshape transplant diagnostics.

The Medicine Maker

February 27, 2026

Closing the Genomic Gap in Rare Disease

February 27, 2026
8 min

Ryan Taft and Stacy Musone discuss iHope's mission to ensure equitable access to genetic testing for rare diseases, emphasizing that location should not determi

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iHope Network aims for equitable access to genetic testing.
It supports over 1,000 patients annually in 14 countries.
Long-read sequencing enhances diagnostic precision.
Systemic barriers hinder access to testing globally.
Understanding genetic mutation distribution is crucial in rare diseases.
Collaboration and harmonized standards are needed in rare disease research.

The Medicine Maker

February 27, 2026

MHRA Approval for First UK-made mRNA Vaccine

February 27, 2026
2 min

Moderna's updated COVID-19 mRNA vaccine, Spikevax®, has received authorization from the UK Medicines and Healthcare products Regulatory Agency (MHRA) for indivi

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Moderna's Spikevax® vaccine targets the LP.8.1 variant.
MHRA has authorized the vaccine for ages six months and older.
Vaccines will be supplied from Harwell, Oxfordshire.
The rollout is part of the 2026 NHS COVID-19 vaccination campaign.
The vaccine demonstrates UK competence in on-shoring vaccine production.
WHO recommended updates for 2026 vaccination campaigns.
Approval gained from multiple global regulators, including FDA and EMA.

The Ophthalmologist

February 27, 2026

The Ophthalmologist’s Time Machine 38

Christopher T. Leffler
Stephen G. Schwartz
Andrzej Grzybowski
February 27, 2026
3 min

Lucien Howe, a prominent ophthalmologist from Buffalo, New York, played a pivotal role in promoting eugenics in the early 20th century, influenced by personal e

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Lucien Howe focused on hereditary glaucoma in
Angle-closure glaucoma has a heritable aspect.
Howe's family experienced glaucoma across generations.
He argued for sterilization to prevent hereditary conditions.
His wife was also his colleague.
Howe never had children, likely due to fears of passing on the condition.
The societal implications of hereditary blindness concerned him financially.

The Ophthalmologist

February 27, 2026

National Institutes of Health Builds Digital Model of RPE Cells

February 27, 2026
2 min

A team from the National Institutes of Health has pioneered a three-dimensional 'digital twin' model of retinal pigment epithelium (RPE) cells, providing valuab

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Three-dimensional digital twin of RPE cells developed by NIH researchers.
Model utilizes induced pluripotent stem cells.
AI algorithm POLARIS analyzes cellular structure.
Quantification of nuclear and organelle distribution in RPE cells.
Findings assist in understanding disruptions in AMD.
Offers insights into potential therapeutic discovery.
Combines AI and mathematical modeling for deeper cellular analysis.

February 27, 2026

Latest Clinical Evidence in Extensive-Stage Small Cell Lung Cancer Treatment

Stephanie McDonald, MSN, FNP-BC, AOCNP
Elizabeth Castronovo, MSN, AGNP-BC
February 27, 2026
8 min

Recent advancements in extensive-stage small cell lung cancer (ES-SCLC) treatment were highlighted at JADPRO Live by nurse practitioners Stephanie McDonald and

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ES-SCLC has a poor prognosis with a 5-10% 5-year survival rate.
First-line treatment includes carboplatin and etoposide + immunotherapy.
Immunotherapy agents durvalumab and atezolizumab improve survival rates.
Managing oncologic emergencies like SIADH is critical.
Tarlatamab is a preferred second-line therapy based on improved survival.
Importance of supportive care and monitoring adverse effects is emphasized.
New FDA approvals enhance options for maintenance therapy.

February 27, 2026

Novel Therapies and Multidisciplinary Strategies in Metastatic Triple-Positive Breast Cancer

Danielle Roman, PharmD, BCOP
Kaitlyn Reeder, PA-C
February 27, 2026
8 min

Metastatic triple-positive breast cancer presents a complex challenge in treatment, comprising HR+ and HER2+ characteristics that demand multimodal therapeutic

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Metastatic triple-positive breast cancer is biologically complex.
HER2+ status linked with aggressive disease and poorer prognosis.
Dual HER2 blockade is critical for effective treatment.
CDK4/6 inhibitors being considered for HER2-positive cases.
Management of treatment-related toxicities is essential for patient care.
Key clinical trials influencing current treatment standards.
Monitoring for specific adverse effects like cardiotoxicity and pulmonary issues.

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