Objective: The article examines the objective, findings, and clinical context described in FDA approves amivantamab for head and neck cancer. Approach: Treatmen
Objective: To assess associations between prenatal exposure to wildfire-related fine particulate matter (PM2.5) and childhood autism spectrum disorder (ASD) and
Hemimegalencephaly is rare and often causes catastrophic, drug-resistant epilepsy involving most of the affected hemisphere.
Persistent seizures despite two appropriately dosed and tolerated medications, or seizures with an abnormal MRI finding, warrant prompt evaluation at a specialized pediatric epilepsy center.
Intractable epilepsy is an independent risk factor for developmental delay and sudden unexpected death in epilepsy, supporting early imaging and referral.
Hemispherectomy remains the gold standard treatment for HME-associated epilepsy, and surgery may be considered in infancy at experienced centers.
At Phoenix Children’s, fewer than 15% of hemispherectomy patients require a shunt for postoperative hydrocephalus.
The National Sleep Foundation estimated that 145 million US adult drivers (61%) have driven while sleepy at least once, and nearly 35 million do so at least monthly.
Approximately 40% of adult drivers do not recognize basic signs of sleep-related impairment, including excessive blinking, head-nodding, and lane drifting.
The report cited AAA Foundation for Traffic Safety data indicating that drowsy driving contributes to approximately 1 in 5 fatal motor vehicle crashes.
Although 58% of adults were familiar with driver-alertness monitoring technology, 31% had used it and 62% worried that collected information could be misused.
The NSF recommends 7 to 9 hours of nightly sleep for most adults and advises sleepy drivers to stop safely, take a break, or arrange alternative transportation.
Objective: To estimate how permanent daylight-saving time (DST) would affect children’s pre-sunrise school commutes and examine the association between morning
Across 14 states, permanent DST was projected to increase annual dark-morning school commute exposure from 198 million child-days under the seasonal system to 554 million.
Permanent standard time was projected to result in approximately 97 million annual dark-morning school commute child-days across the 14 states.
A nationwide model estimated that permanent DST would add approximately 2.14 billion pre-sunrise school commutes annually, assuming an 8 AM departure time.
Among 10,305 fatal crashes on school-year weekday mornings, crashes before sunrise had 1.77 times the adjusted odds of involving a pedestrian compared with crashes after sunrise.
For pedestrians aged 5 to 18 years, fatal crashes before sunrise had 2.22 times the adjusted odds of involving a pedestrian, but the analyses could not establish causation.
The authors plan to compare a smart toilet’s hydration measurements, based on urine color and concentration, with conventional laboratory methods, including osmolality.
The device is marketed for general wellness and tracks stool patterns, hydration, urinary flow, and bathroom habits.
The article notes that frequent measurements can feel persuasive, but repetition does not establish accuracy.
Laboratory results can be wrong because of unsuitable conditions, poor methods, quality-control failures, reagent changes, matrix effects, software changes, or interferences.
As consumer devices produce measurements resembling established medical tests, clinicians and health systems will need to assess how much trust those measurements deserve.
Objective: Assess the diagnostic yield and clinical impact of whole genome sequencing (WGS) in children with cerebral palsy. Approach: Participants and testing:
Whole genome sequencing identified pathogenic or likely pathogenic variants in 11 of 86 children with cerebral palsy (12.8%) in a UK pilot study.
All 11 confirmed genetic diagnoses influenced care or genetic counselling; four led to tailored clinical management and seven to additional specialist care.
Examples of care changes included altering antiseizure medication, arranging mitochondrial assessment, and introducing cardiovascular screening.
Intellectual disability, dystonia, and abnormalities affecting multiple body systems were associated with a greater likelihood of a genetic diagnosis.
The authors support considering WGS in cerebral palsy diagnostic pathways but note that larger prospective studies are needed to assess effectiveness, cost, and patient selection.
Objective: The article examines the objective, findings, and clinical context described in Video: The Ultimate in Translational Medicine – with Harold Keer. App
Harold Keer describes industry as a way to scale individual discoveries into medicines for patients, calling it “the ultimate translational medicine.”.
Cancer treatment has expanded from cytotoxic chemotherapy to targeted therapies, monoclonal antibodies, immunotherapies, bispecific antibodies, and antibody-drug conjugates.
RAS, once considered an “undruggable” target, is now a competitive area of drug development.
Keer discusses why promising cancer programs fail and the promise and possible “irrational exuberance” surrounding emerging treatment modalities.
Keer says his unfinished business is helping Taiho’s newly acquired antibody-drug conjugate technology reach the clinic.
Objective: The article examines the objective, findings, and clinical context described in Respiratory Tract Herpesvirus Reactivation in Critically Ill Patients
Harbiye et al. linked pulmonary HSV reactivation in persistent acute respiratory failure with less favorable outcomes and a localized alveolar inflammatory response.
Elevated pulmonary HSV burden was associated with a distinct inflammatory phenotype, but its relationship to acute respiratory failure subphenotypes remains unconfirmed.
The authors call for evaluating HSV reactivation across acute respiratory failure subphenotypes and stratifying analyses by immune status, sepsis, and molecular profiles.
Upper respiratory tract HSV burden and timing of artificial airway placement warrant assessment because HSV may spread to the lower respiratory tract in ventilated patients.
The authors recommend standardizing HSV PCR results in IU/mL, investigating interactions with other airway pathogens, and testing antiviral therapy in randomized trials.
Objective: To question whether the reported cost savings for capnography account for the additional verification required when aspirate pH is unavailable or inc
Chau et al assessed capnography for detecting airway placement of nasogastric tubes in 508 patients across 21 hospitals.
The authors’ hypothetical model estimated savings of HK$210.3 per patient by excluding radiography costs for 485 patients with ETCO₂ of 5 mmHg or less.
Capnography can rule out airway placement but does not confirm accurate tube position, and the cost model did not specify subsequent confirmation procedures.
At least 279 of 485 patients with negative capnography had unavailable aspirate or aspirate pH greater than 5.5, based on reported marginal counts.
The authors are asked to report joint capnography, aspirate, pH, and radiographic results and recalculate costs for a specified pathway, including required confirmation procedures.
Objective: To compare jaw function and sleep quality among people with psoriasis, including by psoriatic arthritis (PsA) status and systemic treatment, and with
In a cross-sectional study of 105 patients with psoriasis and 73 controls, overall jaw functional limitation did not differ significantly between groups.
Patients with psoriatic arthritis had higher mean jaw limitation scores than those without arthritis (0.80 vs 0.45), and PsA remained independently associated with limitation.
Psoriasis severity was independently associated with poorer sleep quality, while PsA status was not independently associated with sleep quality.
Poor sleep quality was reported by 7% of patients receiving biologics, compared with 60% receiving no systemic therapy or nonbiologic systemic therapy.
The single-center cross-sectional study relied on patient-reported measures and included a small sample, limiting causal interpretation and generalizability.
A prospective, single-center study included 74 children with SLE and 112 age-matched healthy controls.
IG percentage distinguished active SLE from remission with an area under the curve of 0.90, comparable to 0.92 for ESR.
At an IG percentage cutoff greater than 0.35%, sensitivity was 81%, specificity was 87%, and diagnostic accuracy was 84%.
IG percentage correlated moderately with SLEDAI-2K, clinical SLEDAI-2K, and physician global assessment, while complement C3 showed stronger correlations with disease activity.
The authors described WBC inflammatory parameters as complementary measures and noted that small sample size, single-center design, and lack of independent validation limited the study.
Objective: Announce Dr. Matthew J. LaVelle’s appointment to Baptist Health Orthopedic Care and summarize his specialty, training, and clinical approach. Approac
Board-certified orthopedic surgeon Matthew J. LaVelle, MD, MSE, has joined Baptist Health Orthopedic Care.
LaVelle specializes in hip and knee reconstruction, including primary and revision joint replacement and robotic-assisted procedures.
He completed an orthopedic surgery residency at the University of Miami/Jackson Memorial Hospital and an adult reconstruction fellowship at Columbia University Medical Center.
LaVelle earned a medical degree from Wayne State University and graduate and undergraduate engineering degrees from the University of Michigan.
He sees patients at Baptist Health Orthopedics | Boynton Beach East in Boynton Beach, Florida.
Objective: Reflect on how a father’s perseverance and values shaped his child’s path to practicing medicine in the United States. Approach: Father’s journey: Ra
Raised amid financial hardship in India, the author's father rode nearly 10 miles by bicycle to medical school and became a physician with his parents' support.
The author's father taught his children to be mentally strong, work hard and honestly, and respect everyone.
As an international medical graduate pursuing medicine in the United States, the author faced uncertainty and received the 2026 AMA Foundation Outstanding International Medical Graduate Award.
The author is a practicing breast and gynecologic pathologist in the United States, while the author's father pursued medical education in India.
The author describes both generations' medical journeys as grounded in perseverance, dedication, humility, and respect for others.
Objective: The review examines evidence linking CP/CPPS with pain processing, immune activity, metabolism, and gut microbiota, and discusses potential diagnosti
Chronic prostatitis/chronic pelvic pain syndrome causes persistent pelvic pain, urinary difficulties, and sexual dysfunction, but diagnosis is challenging because symptoms vary and reliable biomarkers
The review describes CP/CPPS as involving interconnected prostate inflammation, pain-processing pathways, immune activity, metabolism, and gut microorganisms.
Persistent inflammation may sensitize pelvic nerves and alter central pain processing, potentially explaining symptoms that continue after local inflammation subsides.
Candidate diagnostic approaches include inflammatory and metabolic markers, multiparametric magnetic resonance imaging, microbiome analysis, and symptom-based assessment.
The authors note that current evidence is limited and call for prospective studies and clinical trials to validate subgroups and test mechanism-guided treatment.