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The Pathologist

June 9, 2026

Pathologist Perspectives on PD-L1 CPS Scoring in Challenging Cases.

June 9, 2026
1 min

Summary
Takeaways
Insight Report
Quiz
Clinical Scorecard

Objective: To provide expert insights into CPS scoring in challenging cases across different indication types. Key Findings: Indication-specific staining charac

Dr. Georgios Deftereos provides expert insights on CPS scoring in challenging pathology cases.
The presentation covers indication-specific staining characteristics affecting CPS evaluation.
Scoring demonstrations are included to enhance understanding of CPS evaluation.
Tips for accurate and efficient evaluation of CPS scoring will be shared.
An interactive Q&A session will allow for discussion and clarification of concepts.

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The Medicine Maker

May 6, 2026

Roving Reporter Asks: Where Do You See the Most Progress in CGT Manufacturing and Scalability?

May 6, 2026
1 min

Summary
Takeaways

A Roving Reporter series episode, produced in collaboration with IBTV, highlights key insights from the Meeting on the Mesa event. The focus is on cell and gene

- Focus on manufacturing and scalability in cell and gene therapy. - Insights shared from industry experts at Meeting on the Mesa. - Emphasizes the translation of innovation into real-world healthcare impacts. - Collaboration produced with IBTV. - Highlights challenges and opportunities in life sciences. - Video format captures real-time perspectives. - Aims to improve patient outcomes through advanced therapies.

The Medicine Maker

May 6, 2026

Roving Reporter Asks: Where Do You See the Most Progress in CGT Manufacturing and Scalability?

May 6, 2026
1 min

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To gather insights on advancements in cell and gene therapy (CGT) manufacturing and scalability from industry experts. Key Findings: Significant prog

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Kaiser Family Foundation (Kff)

May 6, 2026

KFF Health Tracking Poll: MAHA and the Midterms

Audrey Kearney
Lunna Lopes
Mardet Mulugeta
Alex Montero
Isabelle Valdes
Liz Hamel
May 6, 2026

Summary
Takeaways
Insight Report
Quiz

Objective: To assess the public's support for the MAHA movement and its impact on health-related voting priorities in the upcoming midterm elections. Key Findin

41% of U.S. adults support the MAHA movement, primarily Republicans, with broader public concerns about food safety and corporate influence.
Health care costs are a more pressing issue for voters than MAHA's focus areas, with 55% stating it will significantly impact their voting decisions.
Approval ratings for the Trump administration on vaccine and food policy are low, with Democrats trusted more on these issues than Republicans.
MAHA supporters prioritize health concerns like lowering health costs over issues like food additives and vaccine safety.
There is bipartisan agreement on the need for more regulation of food additives and pesticides, aligning with MAHA's concerns.

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Kaiser Family Foundation (Kff)

May 6, 2026

MAHA Health Concerns Resonate Broadly but Lag Behind Health Care Costs Even for MAHA Voters

kffrainl
May 6, 2026

Summary
Takeaways
Insight Report
Quiz
Poll

Objective: To examine the health priorities of MAHA supporters in relation to health care costs and other health issues. Key Findings: 42% of MAHA supporters pr

MAHA supporters prioritize lowering health care costs (42%) over other health issues like food additives (21%) and vaccine safety (10%).
A significant portion of MAHA voters (51%) state health care costs will majorly influence their voting decisions in upcoming elections.
Trust in federal health agencies and food industries is low, with only 40% of adults expressing confidence in the CDC and even lower for FDA and EPA.
About 41% of adults support the MAHA movement, with a majority identifying as Republicans or Republican-leaning.
Less than one-third of MAHA voters strongly approve of the Trump administration's handling of food and vaccine policies.

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Kaiser Family Foundation (Kff)

May 6, 2026

KFF Polling on Health Information and Trust

kffmichaelp
May 6, 2026

Summary
Takeaways
Quiz
Poll

Objective: To analyze public trust in various sources of health information, focusing on the impact of partisanship and demographic factors on this trust. Key F

Doctors are the most trusted source of health information, with significant trust disparities for government agencies like the CDC and FDA.
Partisanship influences trust levels, with Republicans more likely to trust Secretary Kennedy and President Trump compared to Democrats.
Confidence in the CDC and FDA has declined, with less than half of the public believing these agencies act independently.
Parents trust pediatricians most for vaccine information, while trust in health influencers and government officials is significantly lower.
Over half of adults use social media for health information, but trust in health content from these platforms remains low.

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Frontiers In Immunology

May 6, 2026

VEXAS Syndrome for the laboratory physician: a case report

Chaoying Chen
Miaomiao Chen
Tieqiao Chen
Yong Chen
Lingzhi Liu
Yixi Zhu
Xiaoming Yi
Shuguang He
May 6, 2026

Summary
Takeaways
Quiz
Poll

Objective: To enhance awareness and understanding of VEXAS syndrome among laboratory physicians, facilitating early diagnosis and treatment through improved dia

VEXAS syndrome is a recently identified systemic condition linked to somatic mutations in the UBA1 gene, causing autoinflammatory features.
The diagnosis of VEXAS syndrome involves recognizing clinical manifestations such as fever, rash, arthritis, and specific laboratory findings.
Current treatment strategies for VEXAS syndrome include high doses of corticosteroids and allogeneic hematopoietic stem cell transplantation.
Patients with VEXAS syndrome have a higher risk of developing malignant neoplasms compared to those with other autoinflammatory diseases.
Early identification and diagnosis of VEXAS syndrome are crucial for improving patient outcomes and require collaboration among healthcare professionals.

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Frontiers In Immunology

May 6, 2026

Editorial: Overcoming resistance to immune checkpoint inhibitors: mechanisms and strategies in cancer therapy

Margherita Piccinelli
Elio Gregory Pizzutilo
Maria Gemelli
Dhifaf Sarhan
Stefano Cavalieri
May 6, 2026

Summary
Takeaways
Insight Report
Quiz
Poll

Objective: Emphasize the clinical implications of understanding resistance mechanisms. Key Findings: ICIs show variable outcomes, with 20-40% of patients achiev

Immune checkpoint inhibitors (ICIs) enhance antitumor immunity by blocking CTLA-4 and PD-1/PD-L1 pathways exploited by tumors.
Resistance to ICIs can be primary or acquired, with 20-40% of patients achieving durable responses, leaving many without benefit.
Tumor microenvironment (TME) significantly influences immune responses, categorized as 'hot' or 'cold' based on immune infiltration.
Defects in antigen presentation and T-cell exhaustion are key mechanisms of resistance to immunotherapy, prompting combination strategies.
Cancer cachexia may alter Fcγ receptor expression, impacting ICI pharmacokinetics and contributing to poorer treatment outcomes.

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Frontiers In Immunology

May 6, 2026

Editorial: Beyond therapeutic innovation in genitourinary cancers: the unmet need for biologically driven patient selection

Brigida Anna Maiorano
Linda Cerbone
Carlo Messina
Pasquale Rescigno
Giandomenico Roviello
May 6, 2026

Summary
Takeaways
Insight Report
Quiz
Poll
Clinical Scorecard

Objective: To explore the role of specific biomarkers and biological determinants, including tissue-based and circulating biomarkers, in guiding clinical decisi

The therapeutic landscape of genitourinary cancers has transformed with new treatments, yet patient selection remains a challenge.
Biomarkers play a crucial role in predicting treatment response, but current options are heterogeneous and insufficient.
Tumor biology and microenvironment complexity significantly influence therapeutic outcomes in genitourinary malignancies.
Metabolic reprogramming and regulatory molecules like microRNAs are key factors in tumor progression and treatment sensitivity.
Future advancements depend on integrative models that combine multi-omics data and dynamic tumor characterization for better patient outcomes.

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Obesity Surgery

May 6, 2026

The Efficacy of Transversus Abdominis Plane Blocks in Roux-en-Y Gastric Bypass – a Systematic Review and Meta-Analysis of Randomised Control Trials

Caroline Drumm
Matthew G. Davey
Shane Moore
Taya Keating
Noel E. Donlon
May 6, 2026

Summary
Takeaways
Insight Report
Poll
Clinical Scorecard

Objective: To evaluate the effectiveness of TAP blocks in patients undergoing RYGB surgery, focusing on postoperative pain scores at recovery, 6, 12, and 24 hou

Roux-en-Y gastric bypass (RYGB) is an effective bariatric surgery for weight loss and metabolic condition management.
Post-operative pain management is crucial in RYGB to prevent complications like respiratory issues and delayed recovery.
Transversus abdominis plane (TAP) blocks are regional anaesthetic techniques that may reduce post-operative pain and opioid use.
This study aims to evaluate the effectiveness of TAP blocks in RYGB through a systematic review and meta-analysis of randomized controlled trials.
Primary outcomes include post-operative pain scores and opioid requirements, assessed at various recovery time points.

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Bmc Psychiatry

May 6, 2026

Neuroimaging and neurophysiologic biomarkers for diagnosis and prognosis of depressive disorders, bipolar disorder, anxiety disorders, obsessive compulsive disorder, posttraumatic stress disorder, and substance use disorder: an evidence map

Catherine Sowerby
Adrienne Landsteiner
Kristen Ullman
Maylen Anthony
Caleb Kalinowski
Michele R. Spoont
Scott Sponheim
Kelvin Lim
Jose V. Pardo
Timothy J. Wilt
Wei Duan-Porter
May 6, 2026

Summary
Quiz
Clinical Scorecard

Objective: To summarize the current evidence on the use of neuroimaging and neurophysiological biomarkers in diagnosing and treating various psychiatric disorde

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Eye

May 6, 2026

Effect of low-cost direct ophthalmoscopy training on glaucoma disc assessment by allied ophthalmic personnel students: a controlled pre-post study

Vrundaben Patel
Andreas Katsimpris
John Buchan
Kangwa Muma
Andrew Blaikie
May 6, 2026

Summary
Quiz
Poll

Objective: To evaluate the impact of a single day of focussed direct ophthalmoscopy training on the skills and knowledge of undergraduate Allied Ophthalmic Pers

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Frontiers In Immunology

May 6, 2026

Correction: First review of chronic granulomatous disease in Palestine: clinical and genetic characteristics

Fatima az-Zahra Thawabteh
Sedrah Abu Rmilah
Aya Siaj
Rawan Abu khdair
Rabee Adwan
May 6, 2026

Summary
Takeaways
Quiz
Poll

Objective: To correct the omission of author affiliation in the original review of chronic granulomatous disease in Palestine. Key Findings: The original articl

The article provides a comprehensive review of chronic granulomatous disease in Palestine.
It includes both clinical and genetic insights related to the disease.
A correction was made to include the affiliation of author Rabee Adwan.
The omitted affiliation is the Pediatrics Department at Al-Quds University in Jerusalem.
The original version of the article has been updated to reflect this correction.

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Frontiers In Immunology

May 6, 2026

Editorial: Lipid influence on lung immune-structural cell crosstalk: implications for respiratory health

Benoit Allard
May 6, 2026

Summary
Takeaways
Insight Report
Poll
Clinical Scorecard

Objective: Consider adding a statement on the significance of understanding lipid roles in respiratory health. Key Findings: Add implications for each finding t

Lipids play a crucial role in lung immune-structural cell interactions, influencing respiratory health and disease outcomes.
Pulmonary surfactant lipids regulate innate immunity and are involved in pathogen sensing and inflammation modulation.
Viral pneumonia is characterized by selective remodeling of lipid mediator networks, challenging the notion of a uniform 'lipid storm'.
Pseudomonas aeruginosa employs lipid-centered strategies for immune evasion and tissue damage, highlighting the need for lipid-targeted therapies.
Lower levels of lipoxin A4 are linked to severe COVID-19 outcomes, emphasizing the importance of resolution programs in respiratory pathology.

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May 6, 2026

Trump’s executive order on psychedelics is the right move. But is my field ready for it?

Peter S. Hendricks
May 6, 2026

Summary
Takeaways
Quiz
Poll

Objective: To evaluate the implications of President Trump's executive order on psychedelics for mental health treatment and assess the preparedness of the fiel

President Trump's executive order on psychedelics aims to accelerate research and approval processes for mental health treatments.
The order includes funding for psychedelic research and collaboration with Veterans Affairs to address veteran mental health issues.
Concerns exist regarding the politicization of science and the need for an evidence-driven approach in psychedelic therapy.
A significant workforce challenge lies ahead, requiring training for thousands of new psychedelic therapists over the next decade.
Diversity in clinical trials is crucial, as vulnerable populations must be prioritized to ensure equitable access to psychedelic therapies.

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May 6, 2026

Dr. Glaucomflecken wants to make a stink

Torie Bosch
May 6, 2026

Summary
Takeaways
Quiz
Poll

Objective: To discuss the intersection of humor and serious healthcare issues, particularly focusing on misinformation, corporate practices in medicine, and the

Will Flanary, known as Dr. Glaucomflecken, combines humor with serious healthcare issues on the 'First Opinion Podcast.'.
Flanary advocates against corporate staffing decisions in healthcare, specifically criticizing PeaceHealth's actions in Eugene, Oregon.
He highlights the negative impact of corporate interests on patient care and the importance of transparency in healthcare.
Flanary emphasizes the need for ethical doctors to engage on social media to counter misinformation and bad actors.
He believes that without ethical voices, social media will be dominated by misleading wellness influencers.

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May 6, 2026

Treatment Intensity in the Frontline Setting for Transplant-Ineligible Patients With Multiple Myeloma

Mark Davis
May 6, 2026
18 min

Summary
Insight Report
Quiz
Clinical Scorecard

Objective: To evaluate the impact of treatment intensity on outcomes for transplant-ineligible patients with multiple myeloma (MM), emphasizing its significance

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May 6, 2026

Building Bridges: The Impact of Medical Science Liaison and Advanced Practice Provider Collaborations

Katherine Albert
Kristina Byers
Chelsey Boggs
May 6, 2026
11 min

Summary
Takeaways
Insight Report
Quiz
Poll

Objective: To explore the collaboration between medical science liaisons (MSLs) and advanced practice providers (APPs) in enhancing cancer care through educatio

Collaboration between medical science liaisons (MSLs) and advanced practice providers (APPs) enhances cancer care through education and research.
MSLs provide tailored education and support clinical trials, enabling APPs to make informed decisions and improve patient outcomes.
The MSL role, established in 1967, has evolved to include clinical trial support and medical education, distinct from commercial sales.
MSLs operate in a non-promotional capacity, delivering unbiased, evidence-based information while adhering to compliance standards.
Effective MSL-APP partnerships focus on clinical research, medical education, and insight gathering, bridging scientific innovation and clinical application.

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