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June 1, 2026

CAA Use Tied to Higher Arthroplasty Risk

Andrea Surnit
June 1, 2026
6 min

Summary
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Objective: To evaluate the association between the initiation of centrally acting analgesics (CAAs) and the risk of knee or hip replacement in patients with ost

Centrally acting analgesics are linked to an 81% higher hazard of knee or hip replacement compared to selective serotonin reuptake inhibitors.
The study involved 11,734 patients initiating centrally acting analgesics and 11,734 initiating SSRIs, with a median follow-up of 9.5 years.
Deaths occurred more frequently among SSRI initiators (11.0%) than centrally acting analgesic initiators (7.1%) in the matched cohort.
Tricyclic antidepressants and gabapentinoids also showed increased hazards for knee or hip replacement compared to SSRIs.
The researchers cautioned that the study could not establish causality and residual confounding by indication may exist.

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June 1, 2026

Cognition Associated With Future Depression Risk

Kathryn Wighton
June 1, 2026
4 min

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Objective: To investigate the relationship between cognitive performance and future depression risk in individuals with remitted depression compared to matched

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June 1, 2026

Troponin Testing and Early MI Discharge

Kathryn Wighton
June 1, 2026
4 min

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Objective: To evaluate the performance of sixth-generation high-sensitivity cardiac troponin T in patients with suspected non-ST-segment elevation myocardial in

The sixth-generation high-sensitivity cardiac troponin T assay identified 61% of patients with concentrations below 13 ng/L at presentation.
The sixth-generation assay demonstrated a negative predictive value of 99.9% and sensitivity of 99.4% for type 1, 4b, or 4c MI.
Using the sixth-generation assay, 41% of patients were classified as low risk at presentation, compared to 17% with the fifth-generation assay.
The study highlighted the need for more diverse cohorts and prospective studies to confirm the benefits of the sixth-generation assay.
The sixth-generation assay showed higher cardiac troponin T concentrations than the fifth-generation, indicating they are not interchangeable.

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The Pathologist

June 1, 2026

Enhancing Your Professional Membership

Stephanie Whitehead
June 1, 2026
4 min

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Objective: To ensure every ASCP member feels supported and equipped to grow through their membership. Key Findings: The Commission on Membership is committed to

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The Pathologist

June 1, 2026

Mapping Cancer Through Cell Surface Sugars

June 1, 2026
2 min

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Objective: To develop a microscopy-based method that maps the organization of glycans on cell surfaces and links these patterns to cellular behavior and disease

Researchers developed a microscopy-based method called 'glycan atlassing' to map glycans on cell surfaces at nanometer-scale resolution.
The glycocalyx plays a crucial role in immune signaling, cell adhesion, inflammation, and cancer biology.
The method combines DNA-tagged lectins, metabolic glycan labeling, and super-resolution microscopy to analyze glycan distribution.
Glycan patterns differed between normal and transformed breast epithelial cells and changed during epithelial-to-mesenchymal transition.
The technique revealed distinct glycan signatures in activated immune cells compared to resting cells, indicating dynamic changes.

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June 1, 2026

Can Proteomics Refine Lung Screening?

Kathryn Wighton
June 1, 2026
5 min

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Objective: To evaluate the effectiveness of the INTEGRAL-Risk model in classifying patients at risk for lung cancer within one year, specifically comparing it t

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The Analytical Scientist

June 1, 2026

Federal Funding Uncertainty Leaves US Research in Limbo

Henry Thomas
June 1, 2026
7 min

Summary
Takeaways
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Objective: To highlight the ongoing uncertainty and challenges faced by US research institutions due to changes in federal funding policies, emphasizing the urg

Uncertainty in federal science funding has disrupted US research, affecting budgets, hiring, and priorities across universities.
The NIH's budget for fiscal year 2026 is approved, but grant activity has slowed significantly due to delayed apportionments.
Universities report a 30% drop in research proposals and awards, impacting faculty and student research opportunities.
Funding cuts have led to housing and food insecurity among students, affecting their ability to pursue scientific careers.
Shifts in federal funding priorities emphasize societal impact and collaboration, raising concerns about censorship in research.

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June 1, 2026

Celiac Tied to Higher Transplant Rate

Kathryn Wighton
June 1, 2026
6 min

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Objective: To evaluate the association between biopsy-confirmed celiac disease and the rate of solid organ transplantation in a nationwide cohort. Key Findings:

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The Medicine Maker

June 1, 2026

This Week’s CGT News: Base Editing Takes Aim at Cholesterol

June 1, 2026
5 min

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Objective: To report on recent advancements in genetic therapies targeting cholesterol and related conditions, including specific therapies and their mechanisms

VERVE-102 is a one-time base editing therapy that inactivates PCSK9, showing significant cholesterol reduction in a phase 1 study.
The therapy produced up to 88% reduction in PCSK9 and 62% reduction in LDL-C, with effects lasting over a year in some participants.
Eli Lilly acquired Engage Bio to enhance its genetic medicines portfolio with non-viral DNA delivery technologies.
Korecyte Bio is developing a tumour-activated CAR-T therapy platform aimed at improving treatment for solid cancers.
Scribe Therapeutics has received clearance for a first-in-human study of STX-1150, a CRISPR-based therapy targeting PCSK9.

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The Medicine Maker

June 1, 2026

The New Reality of Peptide Analysis

James Strachan
June 1, 2026
9 min

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Objective: To explore the analytical challenges and misconceptions in peptide therapeutics, particularly in the context of GLP-1 drugs. Key Findings: Peptide th

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The Ophthalmologist

June 1, 2026

Nomogram Advances Retinopathy Screening

June 1, 2026
3 min

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A new nomogram-based tool predicts retinopathy risk using clinical data from a multi-ethnic cohort of 2,447 adults without retinopathy at baseline.
Over a mean follow-up of just over three years, 5.9% of participants developed retinopathy, indicating risk extends beyond traditional diabetic populations.
The combination model achieved better discrimination (AUC 0.75) compared to the baseline model (AUC 0.64), improving sensitivity and specificity.
Key predictors of retinopathy included body mass index, waist-to-hip ratio, triglyceride levels, blood pressure, and hypertension history.
The study highlights ethnic variations in retinopathy incidence, suggesting the need for tailored screening approaches in diverse populations.

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The Ophthalmologist

June 1, 2026

Expanding Imaging Capabilities

June 1, 2026
3 min

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Objective: To address the significant challenge ophthalmologists face in identifying, localizing, and assessing peripheral retinal lesions within a single imagi

Optos launched the Silverstone RGB system in October 2025 to enhance retinal imaging capabilities for ophthalmologists.
The Silverstone RGB system integrates nine imaging modalities, enabling comprehensive retinal assessments within a single platform.
This system retains ultra-widefield imaging and adds swept-source OCT for improved color fidelity and deeper tissue penetration.
Clinician feedback was crucial in developing the system, focusing on accessibility, intuitive modality switching, and efficient image capture.
The Silverstone RGB aims to improve clinical decision-making, monitoring, and patient outcomes in retinal pathology assessment.

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Gut

June 1, 2026

Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome

Giulia Milardi
Barbara Franceschini
Chiara Camisaschi
Simone Puccio
Guido Costa
Cristiana Soldani
Paolo Uva
Davide Cangelosi
Roberta Carriero
Luca Lambroia
Antonella Cammarota
Giulio Lodetti-Zangrandi
Ines Malenica
Marco Erreni
Ilaria Montali
Tiziano Lottini
Chiara Raggi
Paolo Kunderfranco
Michela Anna Polidoro
Alessio Aghemo
Rita Balsano
Tiziana Pressiani
Salvatore Piscuoglio
Luca Di Tommaso
Guido Torzilli
Lorenza Rimassa
Enrico Lugli
Barbara Cassani
Ana Lleo
June 1, 2026

Summary
Takeaways
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Poll

Objective: To investigate the role of B lymphocytes in intrahepatic cholangiocarcinoma (iCCA) and their implications for immunotherapy response, particularly in

Intrahepatic cholangiocarcinoma (iCCA) has a poor prognosis and is characterized by a chronically inflamed and immunosuppressive tumor microenvironment.
High densities of B cells in peritumoral areas are linked to improved disease-free survival, indicating a potential protective role.
Tumor-infiltrating B cells in iCCA are primarily immature and functionally suppressed due to influences from primary tumor cells and cancer-associated fibroblasts.
BAFFR+ B cells in peripheral blood can predict responses to chemoimmunotherapy, suggesting their role as biomarkers.
Targeting B-cell interactions within the tumor microenvironment may provide new therapeutic strategies to enhance immunotherapy efficacy in iCCA.

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Frontiers In Endocrinology

June 1, 2026

Nonlinear association between serum insulin, visceral fat area, and kidney function in female with type 2 diabetes: a retrospective study

Yuqin Gan
Mengjie Chen
Zhitao Xiao
Bo Li
Yu Gao
Kaili Dai
June 1, 2026

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Objective: To investigate the nonlinear associations between fasting insulin (FIns), visceral fat area (VFA), and estimated glomerular filtration rate (eGFR) in

This study analyzed nonlinear relationships between fasting insulin levels, visceral fat area, and renal function in women with type 2 diabetes.
A total of 595 female patients with type 2 diabetes were included after excluding those with incomplete data.
Fasting insulin levels above 70.28 pmol/L negatively correlated with estimated glomerular filtration rate, indicating renal function impairment.
Visceral fat area above 73.6 cm² was negatively correlated with renal function, while lower values showed a positive correlation.
The findings suggest critical thresholds for fasting insulin and visceral fat area that may aid in risk stratification for renal function in diabetic women.

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Frontiers In Medicine

June 1, 2026

Evidence-based summary of optimal home self-management for elderly ostomy patients

Jiayi Feng
Fang Lu
Bo Zhou
Ji Li
Jian Shen
Lulu Tang
Yangyang Chen
Liping Kang
Guanghui Li
Zhaobei Wang
Huiqin Lin
Yuehua Gao
June 1, 2026

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Objective: To summarize the best evidence supporting home self-management for elderly ostomy patients. Key Findings: A total of 36 pieces of evidence were summa

Elderly ostomy patients face significant home self-management challenges due to insufficient care capacity and lack of integrated evidence.
A systematic literature search identified 15 high-quality studies focusing on home stoma self-management for elderly ostomy patients.
The studies encompassed six core domains: self-management goals, stoma assessment, psychological adjustment, dietary management, behavioral management, and medication management.
A total of 36 pieces of evidence were summarized, addressing the specific needs of elderly ostomy patients for home self-management.
Future research should aim to develop targeted, evidence-based interventions to enhance home stoma self-management for elderly patients.

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Frontiers In Cardiovascular Medicine

June 1, 2026

Unraveling the cardiovascular burden of long COVID: symptom profiles, underlying mechanisms, and clinical management insights

Jie Sheng
Yuchen Song
Aiping Zhang
Minhua Wang
Tao Li
Jianjian Ji
June 1, 2026

Takeaways
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Long COVID is characterized by multisystem symptoms that begin within 3 months of COVID-19 infection and persist for at least 2 months.
Cardiovascular complications of Long COVID include myocardial dysfunction, arrhythmias, endothelial injury, and impaired exercise tolerance.
Current management strategies for cardiovascular Long COVID are primarily symptom-based, focusing on risk assessment and multidisciplinary follow-up.
Vaccination reduces the incidence and duration of Long COVID symptoms but does not eliminate the overall risk of developing the syndrome.
Proposed mechanisms for Long COVID symptoms include immune dysregulation, endothelial dysfunction, and persistent viral reservoirs.

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Frontiers In Oncology

June 1, 2026

Spectral CT quantitative parameters for predicting complete ablation after radiofrequency ablation in liver tumors: a retrospective study

Bin Zhang
Xiaoli Ge
June 1, 2026

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This study evaluated the correlation between spectral CT quantitative parameters and complete ablation after radiofrequency ablation for liver tumors.
109 patients who underwent RFA were analyzed, with 81 achieving complete ablation and 28 experiencing incomplete ablation based on postoperative MRI.
Significantly lower arterial phase NIC, λ-HU, and Z-eff values were found in the complete ablation group compared to the incomplete ablation group.
Logistic regression identified maximum tumor diameter, preoperative AFP levels, and vessel adjacency as independent predictive factors for complete ablation.
A combined predictive model using these factors achieved an AUC of 0.933, indicating superior predictive performance for complete ablation.

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Frontiers In Cardiovascular Medicine

June 1, 2026

Research and development of novel embolization materials and study on their feasibility of preventing T2EL after EVAR abdominal aortic aneurysm

E. Erdemutu
Boru Huang
Liqiang Hu
Shaohong Yin
Ying Lan
Chongbin Zhou
Xiangchen Dai
June 1, 2026

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Objective: Emphasize the clinical significance of preventing T2EL. Key Findings: Include the significance of findings in relation to existing treatments. Interp

The study developed a novel embolization material, Thrombin-Coated Controllable Coil (TCC), to prevent Type II Endoleak after Endovascular Aneurysm Repair.
TCC demonstrated superior coagulation efficiency, significantly shortening coagulation time compared to interlocking detachable coils and control groups.
In vitro, TCC promoted apoptosis in vascular smooth muscle cells while minimally affecting vascular endothelial cells.
In vivo tests showed TCC effectively prevented Type II Endoleak and achieved complete thrombosis without complications in a minipig model.
Transcriptomic analysis revealed significant gene expression changes associated with TCC treatment, indicating its potential biological mechanisms.

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