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MDSpire is an innovative platform aiming to create a smarter, faster, and more connected medical community.

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February 5, 2026

Surgical Sequencing in Esophageal Cancer

Margery Weinstein
February 5, 2026
4 min

A phase 3 clinical trial from Sichuan Cancer Hospital investigated treatment outcomes for locally advanced esophageal squamous cell carcinoma. Patients underwen

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The study compared neoadjuvant chemoradiotherapy and surgery with adjuvant therapy.
No significant overall survival difference was found.
Complete pathologic response greatly improved outcomes.
Similar adverse effect rates were observed between groups.
Tumor resection with negative margins was achieved in over 95% of patients.
Study limitations include single-center design and modest sample size.
Tailored treatment strategies are essential for optimal patient outcomes.

February 5, 2026

Oral TYK2 Inhibition in Atopic Dermatitis

Kathryn Wighton
February 5, 2026
4 min

In a phase 2 randomized clinical trial, oral ICP-332 effectively reduced atopic dermatitis severity and pruritus in 75 adults over four weeks, demonstrating a f

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ICP-332 reduced atopic dermatitis severity in adults.
75 participants aged 18-75 were involved.
The trial showed 64% of ICP-332 patients achieved a 75% improvement.
Treatment duration was 4 weeks.
No serious adverse events were reported.
Adverse events mainly mild to moderate.
The study underscores the need for phase 3 trials.

February 5, 2026

Smell Screening With a Mobile Test

Kathryn Wighton
February 5, 2026
3 min

A novel mobile application-based olfactory screening test shows promise for rapid olfactory dysfunction diagnosis. Conducted at a US tertiary medical center, th

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Novel mobile olfactory screening test developed.
Study with 484 participants showed diagnostic accuracy.
Test sensitivity: 74%, specificity: 86%.
Age and olfactory dysfunction related to test scores.
Rapid, scalable tool with cloud-based data storage.
Limitations include single-center design and test performance variability.
Lead author: Dr. Benjamin J. Bernard.

February 5, 2026

Vegan Diets and Infant Growth: Any Clues?

Kerri Miller
February 5, 2026
6 min

A nationwide retrospective cohort study led by Kerem Avital, MPH, examined growth patterns in infants from vegan, vegetarian, and omnivorous households using da

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Study analyzed growth in infants from various dietary households.
99% were from omnivorous households.
Early underweight risk was higher in vegan infants.
Stunting prevalence similar across all diets by 24 months.
Well-planned vegan diets can support healthy growth.
Nutritional counseling is vital for vegan families.
Data based on records from Family Child Centers.
Study had limitations regarding data collection and dietary assessments.

The Pathologist

February 5, 2026

From Classroom Curiosity to Global Movement

Jessica Allerton
February 5, 2026
1 min

Blessing Oyeleye, the Founder and Executive Director of the Pathology Awareness Foundation in Nigeria, emphasizes the importance of enhancing pathology educatio

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Blessing Oyeleye advocates for global pathology education.
Importance of a strong diagnostic workforce highlighted.
Recognized in The Pathologist Power List: Leading Voices
Founder and Executive Director of the Pathology Awareness Foundation, Nigeria.
Conversation with Deputy Editor Jessica Allerton underscores educational initiatives.

The Pathologist

February 5, 2026

Laboratory Testing Brings Clarity to Brucellosis

February 5, 2026
3 min

A multicenter study in Cameroon has established Brucella abortus as the sole circulating Brucella species in livestock across three regions, revealing an 8.3% p

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B. abortus is the only Brucella species found in Cameroon livestock.
Study conducted on 4,612 animals including cattle, goats, sheep, and pigs.
Prevalence: 8.3% in cattle, 7.3% in goats.
Cultural positivity rate was low at 0.8%.
Serologic tests can't differentiate between Brucella species.
Importance of combining serological & molecular methods emphasized.
Genomic analysis indicates long-term circulation of B. abortus in sub-Saharan Africa.
Samples collected at slaughterhouses due to lack of livestock traceability.

The Analytical Scientist

February 5, 2026

Out of the Basement and Into the Light

James Strachan
February 5, 2026
12 min

Prominent analytical chemists Coral Barbas, Georgios Theodoridis, and Michael Witting highlight the urgency of elevating analytical science's status as fundamen

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Importance of valuing measurement quality in analytical science.
Recognition of analytical chemists' vital role in society.
Need for increased visibility and respect for the field.
Importance of funding substantial core facilities.
Necessity for complete and rigorous journal methods sections.
Advocacy for broader education on analytical science's contributions.
Call for collaboration among scientists to improve analytical methods understanding.

February 5, 2026

Dental Nitrous Oxide Use Has Measurable Climate Impact, Study Finds

Olivia Anderson
February 5, 2026
3 min

A national quality improvement project in the UK revealed the environmental impact of nitrous oxide used in dental inhalation sedation. Researchers analyzed dat

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Nitrous oxide has a measurable environmental impact.
Mean carbon footprint per sedation appointment: 28.62 kg CO2 equivalent.
84% use cylinder supply, 16% use piped systems.
Average nitrous oxide delivery duration: 28 minutes.
National success rate for nitrous oxide sedation: 92%.
Monitoring nitrous oxide use is essential for sustainability.
Emphasis on reducing flow rates without compromising clinical efficacy.

The Ophthalmologist

February 5, 2026

Driving Progress in Dry Eye Care

February 5, 2026
3 min

The World Council of Optometry (WCO) and Alcon have renewed their educational partnership to enhance understanding and management of dry eye disease, acknowledg

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WCO and Alcon renew partnership for dry eye education.
Initiative focuses on mitigation, measurement, and management methods.
Affects 1.6 billion people, tied to screen use and aging.
Educational platform offers WCO-Alcon Dry Eye Wheel.
Interactive tool provides clinical decision-making resources.
Collaboration aims to support global optometrist education.
Importance of proper management to prevent complications highlighted.

The Ophthalmologist

February 5, 2026

Uveitis and Inflammation: A Two-Way Risk

February 5, 2026
2 min

Uveitis, a potentially sight-threatening condition, is linked to systemic immune-mediated inflammatory diseases (IMIDs) in a significant manner. A study utilizi

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Uveitis can indicate systemic autoimmune diseases.
Study utilized EHR data from over 120 million patients.
Strong associations with IMIDs like ankylosing spondylitis.
Uveitis patients have higher odds of prior IMID diagnoses.
Need for interdisciplinary collaboration among ophthalmologists and rheumatologists.
Increased risk of new IMID development post-uveitis diagnosis.

February 5, 2026

Putting a POC Troponin to the Test

Julie Greenbaum
February 5, 2026
3 min

A multicenter study confirmed the reliability of the QuidelOrtho TriageTrue high-sensitivity troponin I (hs-TnI) assay, demonstrating acceptable precision and m

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The study verified the hs-TnI assay's precision and analytical performance.
Intra-assay CVs ranged from 2.8% to 15.9%.
Hemolysis interference was minimal up to 10 g/L.
Correlation coefficients with other assays were as high as 0.
The assay performs adequately for diagnosing myocardial infarction in various settings.
Limitations included logistical constraints in sample collection.
Recommendations support integration into emergency care pathways.

February 5, 2026

How AI Is Shaping Thyroid Disease Care

Julia Cipriano, MS, CMPP
February 5, 2026
4 min

Artificial intelligence (AI) has significantly evolved in thyroid disease research, expanding from diagnosis to comprehensive management strategies over the pas

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AI's role in thyroid disease management has broadened over 3 decades.
Systematic review evaluated AI applications in diagnostics and treatments.
Major advances in imaging and pathology analysis reported.
Challenges include the black-box nature of AI and workflow integration.
Future research priorities highlighted for improving AI use in clinics.

The Medicine Maker

February 5, 2026

Beckman Coulter and Automata in Agentic AI Partnership

February 5, 2026
2 min

Beckman Coulter Life Sciences and Automata have established a strategic partnership aiming to enhance research capabilities through improved workflow and data i

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Beckman Coulter partners with Automata for lab automation.
Focus on improving workflow reliability and data integrity.
Integration of liquid handling and genomic analysis technologies.
Aim for scalable, AI-ready research environments.
LINQ ecosystem enables standardized experimental processes.

The Medicine Maker

February 5, 2026

Five Ways AI Will Reshape Life Sciences in 2026

Chris Moore
February 5, 2026
6 min

The life sciences industry is transitioning to a new phase of AI adoption, moving away from hype-driven initiatives towards strategic applications that enhance

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AI adoption in life sciences is transitioning to high-value applications.
Industry-specific AI will enhance commercial coordination.
Data agility is essential for timely therapy launches.
AI lab assistants will improve lab efficiency.
Enhanced clinical trial data flow will streamline recruitment and patient participation.

February 4, 2026

FDA Expands HPV Primary Screening Options

Kathryn Wighton
February 4, 2026
2 min

The FDA has approved an expanded indication for Hologic's Aptima HPV assay, allowing for primary human papillomavirus screening. This new approval introduces an

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FDA expands approval for the Aptima HPV assay for primary screening.
The assay targets messenger RNA to identify high-risk infections.
Approximately 13,490 new cervical cancer cases expected in
Study involved over 650,000 women, demonstrating comparable sensitivity.
Hologic offers three recommended cervical cancer screening strategies.
Co-testing detects up to 95% of cervical cancers.
Providers show high confidence in screening for women aged 30-65.

February 4, 2026

Plasma pTau217 Cutoffs for Clinical Use

Kathryn Wighton
February 4, 2026
4 min

A recent study indicates that kidney dysfunction and anemia lead to elevated plasma phosphorylated tau 217 (p-tau217) levels, complicating diagnostic classifica

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Elevated p-tau217 levels due to kidney dysfunction/anemia complicate Alzheimer’s diagnostics.
Study utilized multicenter cohort analysis.
Subgroup-specific cutoffs improved diagnostic accuracy for chronic kidney disease.
The double-cutoff strategy shows higher accuracy but yields many intermediate results.
Inversely associated with glomerular filtration rate and hemoglobin.
Tailored approaches are necessary for precise diagnosis.
Future research should expand to diverse populations.

KFF Health News

February 4, 2026

Who Decides When a Doctor Steps Back?

Paula Span
February 4, 2026
7 min

A surgical oncologist's troubling behavior in the operating room raised concerns about his cognitive abilities, leading to evaluations under a late-career progr

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Surgical oncologist exhibited concerning behavior in OR.
Evaluation revealed mild cognitive impairment.
Late-career programs are critical due to aging physician workforce.
Screening can help retain experienced practitioners in adjusted roles.
Legal challenges have hindered implementation of mandated cognitive testing.
Physicians often resist regulation and self-assessment.
Effective screening is essential for patient safety and healthcare integrity.

Baptist Health South Florida

February 4, 2026

Despite Progress, Heart Disease Still Nation's Leading Killer

February 4, 2026
7 min

Recent statistical data indicates a decline in deaths from cardiovascular diseases, attributed to advances in healthcare technologies such as minimally invasive

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Deaths from heart disease and stroke have decreased.
Heart disease remains the leading cause of death in the U.S.
Significant risk factors include hypertension, diabetes, and obesity.
Advances in technology aid in prevention and treatment.
80% of cardiovascular events are preventable through lifestyle changes.
The American Heart Association promotes 'Life’s Essential 8' for heart health.
Ongoing vigilance is necessary to combat cardiovascular diseases.
A heart scan can identify hidden risks associated with heart disease.

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