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Compendium

  • September 10, 2026
Planmeca Introduces New Cuspidor Design and DVGW 2.0 Water Management for Planmeca Pro50™ Dental Unit
  • News Staff
  • September 10, 2026
  • 2 min
  1. The Planmeca Pro50™ dental unit now features two cuspidor configurations, including a new enclosed water treatment system.
  2. The new uniform cuspidor frame enhances aesthetics and supports flexible water treatment solutions.
  3. Clinics can choose between a bottled water system or the DVGW 2.0 water management system for improved workflows.
  4. DVGW 2.0 automatically doses hydrogen peroxide disinfectant into treatment water, ensuring consistent hygiene.
  5. The integrated disinfectant system reduces maintenance effort and enhances safety for clinical staff and patients.
...more

Frontiers In Neurology

  • September 10, 2026
Clinical Trial Protocol for Evaluating Acupuncture's Effects on Chronic Tinnitus Using Auditory Brainstem Response Measurements
  • Shiyu Zhang
  • Minghui Zhao
  • Kaili Chen
  • Shenglu Xu
  • Keqin Ye
  • Lianqiang Fang
  • Hong Gao
  • September 10, 2026

Objective: To compare ABR parameters in patients with chronic tinnitus and healthy controls and examine whether clinical changes after acupuncture intervention

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3 min

Frontiers In Neurology

  • September 10, 2026
Transcranial Doppler Detection of Microembolic Signals and Their Prognostic Impact on Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis
  • Jun Qiao
  • Zhikun Zhang
  • Yujin Feng
  • Yi Wang
  • September 10, 2026
  1. Transcranial Doppler ultrasonography can detect microembolic signals (MES), which indicate ongoing cerebral embolization in acute ischemic stroke patients.
  2. A meta-analysis of 13 cohort studies with 1,777 patients found that MES presence significantly correlates with poor functional outcomes after acute ischemic stroke.
  3. The odds ratio for poor functional outcomes associated with MES was 2.85, indicating a strong association without significant heterogeneity among studies.
  4. Subgroup analyses showed consistent results across different study designs and patient characteristics, with no significant modifiers of the association.
  5. Further research is needed to confirm the independent prognostic value of MES beyond established clinical and imaging predictors in acute ischemic stroke.
...more

Frontiers In Neurology

  • September 10, 2026
Investigating the Genetic Factors of Charcot-Marie-Tooth Disease in Consanguineous Families from Pakistan
  • Zafar Ali
  • Muhammad Jameel
  • Joakim Klar
  • Muhammad Suleman
  • Uswah Batool
  • Hammad Yousaf
  • Farhan Ali
  • Ambrin Fatima
  • Shahid Mahmood Baig
  • Niklas Dahl
  • Mathais Toft
  • Uzma Abdullah
  • Zafar Iqbal
  • September 10, 2026
  1. Charcot-Marie-Tooth (CMT) disease is a prevalent inherited neuromuscular disorder characterized by muscle weakness and atrophy.
  2. The study involved five consanguineous Pakistani families with 14 affected individuals exhibiting severe CMT symptoms.
  3. Whole exome sequencing identified four homozygous missense variants in GDAP1 and one in SBF2 across the studied families.
  4. Molecular modeling indicated that the identified variants destabilize the GDAP1 and SBF2 protein structures.
  5. The findings expand the genetic spectrum of CMT and highlight the utility of whole exome sequencing for diagnosis.
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Frontiers In Neurology

  • September 10, 2026
A Comprehensive Framework for Managing Variability in Adrenal Insufficiency Treatment in Duchenne Muscular Dystrophy: The 2025 PJ Nicholoff Steroid Guidelines
  • Anne Marie Sbrocchi
  • Alexandra Ahmet
  • Kathi Kinnett
  • Maria-Elena Lautatzis
  • Hugh J. McMillan
  • Susan Apkon
  • Meilan M. Rutter
  • Leanne M. Ward
  • Sasigarn A. Bowden
  • Anne M. Connolly
  • Garey Noritz
  • Rachel Schrader
  • Kathryn Selby
  • Aravindhan Veerapandiyan
  • Sze Choong Wong
  • David R. Weber
  • September 10, 2026
  1. Chronic glucocorticoid therapy in Duchenne muscular dystrophy can lead to adrenal suppression and increase the risk of adrenal crisis.
  2. The 2025 PJ Nicholoff Steroid Protocol provides a structured framework for managing adrenal suppression in individuals with DMD.
  3. Variability in glucocorticoid treatment regimens for DMD exists globally due to differences in drug availability and clinician preferences.
  4. Vamorolone, a newer treatment, selectively modulates glucocorticoid receptor activity, potentially reducing adverse effects associated with classic glucocorticoids.
  5. Effective management of adrenal suppression requires anticipatory education, stress-steroid plans, and careful transitions between glucocorticoid agents.
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MDSpire News

  • September 9, 2026
FDA expands sevabertinib approval in NSCLC
  • Kathryn Wighton
  • September 9, 2026
  • 2 min
  1. The FDA granted accelerated approval to sevabertinib for adult patients with advanced nonsquamous non-small cell lung cancer with HER2 mutations.
  2. Sevabertinib was previously approved for patients who had received prior systemic therapy for the same condition.
  3. Efficacy was evaluated in the SOHO-01 trial, showing a 75% objective response rate among patients without prior systemic therapy.
  4. The recommended dosage of sevabertinib is 20 mg orally twice daily until disease progression or unacceptable toxicity.
  5. The FDA's review was part of Project Orbis, collaborating with the UK's Medicines and Healthcare products Regulatory Agency.
...more

The Pathologist

  • September 9, 2026
Can Technology Make Pathology More Human? Part 3
  • Helen Bristow
  • September 9, 2026
  • 20 min

Objective: To discuss the ethics of integrating AI into pathology and the management of AI validation data. Approach: Expert Debate: Experts debate the balance

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3 min

MDSpire News

  • September 9, 2026
Inflammatory signatures may distinguish dental caries
  • Andrea Surnit
  • September 9, 2026
  • 3 min

Objective: To assess the ability of salivary cytokine signatures to distinguish carious lesions from healthy oral states and gingival inflammation. Approach: St

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MDSpire News

  • September 9, 2026
HOTV may improve vision screening before age 8
  • Andrea Surnit
  • September 9, 2026
  • 4 min

Objective: To compare the effectiveness of HOTV letter-matching testing versus tumbling E testing for vision screening in children under 8 years old. Approach:

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MDSpire News

  • September 9, 2026
Where AI is already paying off in drug development
  • Doug Brunk
  • September 9, 2026
  • 5 min
  1. AI is reshaping pharmaceutical development by improving efficiency in manufacturing and drug candidate design.
  2. Generative AI can make mistakes and cannot replace essential scientific expertise and clinical judgment.
  3. AI tools have been used to create digital twins that accelerate the drying of active pharmaceutical ingredients.
  4. Machine learning helped Pfizer analyze antibody viscosity, speeding up design and avoiding lengthy testing cycles.
  5. Pharmaceutical companies will likely use a mix of in-house and external AI tools, requiring internal expertise for evaluation.
...more

Baptist Health South Florida

  • September 9, 2026
Taylor Wingo, M.D., Joins Baptist Health Orthopedic Care as Orthopedic Foot and Ankle Surgeon
  • September 9, 2026
  • 3 min
  1. Taylor Wingo, M.D., has joined Baptist Health Orthopedic Care as an orthopedic foot and ankle surgeon.
  2. Dr. Wingo specializes in minimally invasive surgery and treatment of various foot and ankle conditions.
  3. She completed her orthopedic foot and ankle surgery fellowship at Baptist Health Orthopedic Care in Miami.
  4. Dr. Wingo has authored peer-reviewed publications and presented research on minimally invasive techniques.
  5. She will see patients at Baptist Health Orthopedics locations in West Kendall and Coral Gables, FL.
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MDSpire News

  • September 9, 2026
Seminal fibrils may facilitate mpox infection
  • Andrea Surnit
  • September 9, 2026
  • 4 min

Objective: To investigate the role of human seminal fluid and its fibrils in enhancing mpox virus infection in primary human cells. Approach: Experimental Desig

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2 min

Inside Dentistry

  • September 9, 2026
ADHA President Jessica August Looks to the Future
  • Fred W. Michmershuizen
  • September 9, 2026
  • 16 min

Objective: To discuss the vision and goals of Jessica August as the 100th president of the American Dental Hygienists’ Association (ADHA). Approach: Professiona

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3 min

MDSpire News

  • September 9, 2026
Tricuspid regurgitation thresholds reassessed
  • Kathryn Wighton
  • September 9, 2026
  • 4 min

Objective: To assess disease-specific echocardiographic thresholds for tricuspid regurgitation in patients with transthyretin amyloid cardiomyopathy and compare

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MDSpire News

  • September 9, 2026
Top 10 evidence-based essentials in pediatrics
  • MDSpire News Staff
  • September 9, 2026
  • 4 min

Objective: To outline widely used resources that inform pediatric care. Approach: Bright Futures/AAP Recommendations: Guidelines for preventive health supervisi

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2 min

The Pathologist

  • September 9, 2026
Fallowed Fields Tied to Valley Fever
  • September 9, 2026
  • 3 min

Objective: To investigate the association between natural landscapes, agricultural uses, and fallowed farmland with coccidioidomycosis incidence in California.

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2 min

MDSpire News

  • September 9, 2026
4CMenB tied to modest gonorrhea protection in real-world study
  • Julia Cipriano, MS, CMPP
  • September 9, 2026
  • 4 min

Objective: To assess the impact of the four-component meningococcal serogroup B vaccine (4CMenB) on gonorrhea and oropharyngeal meningococcal carriage among ado

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2 min

The Ophthalmologist

  • September 9, 2026
The Posterior Outflow Puzzle
  • September 9, 2026
  • 3 min

Objective: To report evidence of a previously unrecognized posterior ocular lymphatic outflow (POLO) pathway and its implications for ocular fluid homeostasis.

...more