Objective: To announce the FDA approval of additional iohexol injection products by Amneal Pharmaceuticals. Approach: Product Details: The approval includes ioh
Objective: To evaluate the effectiveness of regenerative therapies for hair loss and hair transplantation, focusing on platelet-rich plasma (PRP) and other emer
Objective: To evaluate the impact of a consultative general internal medicine program on diagnoses and treatment plans in patients with complex medical conditio
Objective: To advocate for the routine implementation of enhanced radiation protection devices in fluoroscopy laboratories. Approach: Panel Composition: Led by
Objective: To assess the prevalence, patterns, acquisition, administration routes, and health consequences of ADHD stimulant medication misuse among US adults.
Objective: To enhance the surgical evaluation and treatment process for patients with drug-resistant epilepsy through advanced technologies. Approach: Robotic s
Objective: To develop a ferroptosis-related prognostic model for esophageal squamous cell carcinoma (ESCC) using single-cell RNA sequencing and bulk transcripto
Objective: To describe the association between CCI-defined comorbidity burden and long-term all-cause mortality in elderly patients with acute myocardial infarc
Objective: To examine trends and disparities in the prevalence of selected cancers among U.S. adults from 2019 to 2023. Approach: Study Design: Cross-sectional
Objective: To determine the performance of a deep learning-based super-resolution (SR) dynamic contrast-enhanced (DCE) radiomic model in predicting nonspecific
Objective: To investigate the cross-cultural associations between emotional/behavioural and cognitive/adaptive differences in autistic children and parental wel
Objective: To assess the feasibility of a PNI-focused assessment battery in combination with community-based chiropractic care in adults with obesity and explor
Objective: To explore the discharge challenges faced by patients experiencing homelessness, particularly those with Alternate Level of Care (ALC) designations.
Objective: To understand the drivers of racial separation of care and their impact on hospital admissions among Black and minority populations. Approach: Study
Objective: To evaluate the association between payments from device manufacturers and the volume of procedures performed with their corresponding devices by ind
The Physician Payments Sunshine Act mandates disclosure of payments from manufacturers to physicians through the Open Payments Program.
Between 2013 and 2022, over $12 billion in industry payments were made to physicians, with more than half of US physicians receiving at least one payment.
Research indicates that pharmaceutical payments influence prescribing patterns, but the impact of medical device payments on clinical practice is less understood.
This study linked the Open Payments dataset with Medicare claims to evaluate the relationship between device manufacturer payments and procedure volumes.
The analysis focused on specific devices and procedures across various specialties, examining the association between payment amounts and procedure utilization.
Objective: To analyze trends in short-acting hormonal contraceptive use among premenopausal US females and assess differences by age, race and ethnicity, and sp
Objective: To investigate the prognostic value of postoperative radiotherapy (RT) for overall survival (OS) in patients with de novo metastatic hormone receptor
The study analyzed 2,266 patients with de novo metastatic HR-positive breast cancer from the SEER database to evaluate postoperative radiotherapy's impact on overall survival.
Kaplan–Meier analysis showed significantly better overall survival in the postoperative radiotherapy group compared to the non-radiotherapy group.
Logistic regression emerged as the most effective machine learning model for predicting 3-year overall survival, achieving an AUC of 0.721.
Postoperative radiotherapy was confirmed as an independent protective factor for overall survival in both the training and external validation cohorts.
The study emphasizes the need for accurate prognostic risk stratification in patients with metastatic HR-positive breast cancer under current treatment strategies.
Objective: To evaluate the feasibility and clinical impact of international outsourcing of molecular diagnostics for CNS tumors in a limited-resource setting. A
Molecular profiling is essential for CNS tumor diagnosis and treatment, as emphasized by the 2021 WHO Classification.
A retrospective review at KHCC involved 105 patients who underwent outsourced molecular testing to SickKids in Canada.
Outsourced testing yielded a 92% conclusive result rate, with the highest in medulloblastoma and the lowest in ependymoma.
The median turnaround time for molecular testing was 26 days, with a total expenditure of 153,506 US Dollars.
Outsourcing molecular diagnostics is feasible and impactful in limited-resource settings, aiding in accurate diagnoses and identifying actionable targets.