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The Ophthalmologist

  • September 8, 2026
Contact Lenses as Optical Interventions for Myopia Management
  • Sotiris Plainis
  • Beata Tapaszto
  • Andrzej Grzybowski
  • September 8, 2026
  • 8 min

Objective: To explore the role of contact lenses in managing myopia by influencing ocular growth rather than merely correcting refractive error. Approach: Optic

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2 min

The Ophthalmologist

  • September 8, 2026
Earlier Intervention for Neurotrophic Keratitis?
  • September 8, 2026
  • 2 min

Objective: To evaluate the effectiveness of decellularized basement membrane (DBM) grafts as an earlier intervention for neurotrophic keratitis (NK). Approach:

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2 min

The Ophthalmologist

  • September 8, 2026
Rising Stars of Retina
  • September 8, 2026
  • 1 min

Objective: To celebrate 10 ophthalmologists who are significantly impacting the future of the retina specialty. Approach: Selection Process: Honorees were selec

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1 min

The Medicine Maker

  • September 8, 2026
CD19 CAR T Therapy Tested in Refractory Rheumatoid Arthritis
  • September 8, 2026
  • 3 min

Objective: To evaluate the safety and preliminary efficacy of CD19 CAR T cell therapy in patients with severe, treatment-refractory rheumatoid arthritis. Approa

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2 min

The Medicine Maker

  • September 8, 2026
Musings from The Power List: Miguel Forte
  • Miguel Forte
  • September 8, 2026
  • 5 min

Objective: To discuss the current state and future of the cell and gene therapy field, highlighting challenges and progress. Approach: Leadership Role: Miguel F

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Frontiers In Oncology

  • September 8, 2026
Magnetic Resonance Imaging Characteristics of Uterine Adenomatoid Tumors: A Study of Clinical and Histopathological Correlations
  • Changhuan Chen
  • Yudian Huang
  • Ping Chen
  • Caixia Zheng
  • Chengsheng Wang
  • Mingsi Yang
  • September 8, 2026
  1. Uterine adenomatoid tumors (ATs) are uncommon benign neoplasms arising from mesothelial tissue, often discovered incidentally during histopathological examination.
  2. The study analyzed 16 surgically resected uterine ATs, revealing a median patient age of 51 years and coexistence with uterine fibroids in 8 cases.
  3. MRI characteristics showed that ATs typically appear as solid masses with well-defined margins, lacking a discernible capsule, and may exhibit cystic degeneration.
  4. On T1-weighted imaging, solid components of ATs are isointense, while T2-weighted imaging predominantly shows them as hypointense with possible 'target sign' features.
  5. Histopathologically, uterine ATs consist of gland-like spaces among smooth muscle and fibrous tissue, correlating closely with their MRI findings.
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Frontiers In Medicine

  • September 8, 2026
Case Study: Potentially Spatially-Separated De Novo Invasive Cervical Carcinoma Following Isolated Persistent HPV16 After Histological Clearance of CIN3 via ALA-PDT
  • Huihui Cai
  • Yanci Che
  • Yutong Liu
  • Jing Wang
  • Tingting Ma
  • Rui Yao
  • September 8, 2026

Objective: To document a case of invasive cervical carcinoma arising after histological remission of CIN3 in a patient with persistent HPV16 infection. Approach

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Frontiers In Oncology

  • September 8, 2026
Accelerated Recurrence of Intracranial Solitary Fibrous Tumor After TERT-Wild-Type Primary Tumor: A Case Study
  • Longfei Shao
  • Chao Yang
  • Xukun Teng
  • Jianmin Yang
  • Jinyang Li
  • Yinghao Gu
  • Shuo Sun
  • September 8, 2026
  1. Intracranial solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm, constituting approximately 0.09% of intracranial tumors.
  2. The case study details a 70-year-old male with recurrent SFT after a TERT-wild-type primary tumor, showing rapid clinical deterioration.
  3. The recurrent tumor exhibited a Ki-67 index of 70%, indicating significant proliferative activity compared to the primary tumor's 15%.
  4. Differential diagnosis between dura-based SFTs and meningiomas is critical due to overlapping imaging characteristics and differing management.
  5. The original histology slides from the primary tumor were unavailable, limiting independent verification of its WHO grade and characteristics.
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Frontiers In Oncology

  • September 8, 2026
Activation of Host TLR4 by Tenascin-C Correlates with MMP14-Driven Invasion in Gliomas
  • Hannah Haneke
  • Ibrahim E. Efe
  • Omar Dzaye
  • Helmut Kettenmann
  • Fatih Yalcin
  • September 8, 2026
  1. Glioblastoma is characterized by diffuse invasion and remodeling of the tumor microenvironment, primarily influenced by tumor-associated myeloid cells.
  2. Tenascin-C (TNC) is upregulated in glioblastoma and acts as an endogenous ligand for Toll-like receptor 4 (TLR4) in host myeloid cells.
  3. Activation of TLR4 by TNC correlates with increased expression of matrix metalloproteinase 14 (MMP14), promoting glioma invasion.
  4. High expression levels of TNC and MMP14 in glioma are associated with shorter overall survival in patients.
  5. Loss of TLR4 in organotypic brain slices reduces glioma expansion and infiltrative behavior, indicating its role in tumor invasion.
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Frontiers In Cardiovascular Medicine

  • September 8, 2026
Real-World Analysis of Dapagliflozin Initiation in Patients with Heart Failure and Reduced Ejection Fraction in the UK
  • Steven Coombs
  • Angela Tithecott
  • Cristina Thiebaud
  • Parminder Chaggar
  • Diane Barker
  • Prithwish Banerjee
  • Henry Oluwasefunmi Savage
  • Alastair Gray
  • Geraint Jenkins
  • Mohammad Albarjas
  • Liz Hennessy
  • Joanna De Courcy
  • Hannah Wallis
  • Thom Dewar
  • Reece Manuell
  • Sophie Barlow
  • Samuel Adamsson Eryd
  • Jil Billy Mamza
  • Tamsin Morris
  • September 8, 2026
  1. The study followed 237 UK adults with heart failure and reduced ejection fraction who initiated dapagliflozin.
  2. Dapagliflozin discontinuation occurred at a rate of 11.7/100 patient-years, primarily due to adverse drug reactions.
  3. Mean KCCQ-23 scores improved from 67.6 to 71.6, indicating a positive change in quality of life over 12 months.
  4. High treatment adherence was observed, with MARS-5 scores averaging at least 23.1 throughout the study.
  5. Overall work impairment decreased from 31.2% to 16.3%, while activity impairment slightly reduced from 40.5% to 36.8%.
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Frontiers In Surgery

  • September 8, 2026
Management of a Patient with Acute Appendicitis and Anaphylactic Shock Triggered by Esomeprazole: A Case Study
  • Jiangfeng Pu
  • Li Xin
  • Yikuan Chen
  • Xuemei Jiang
  • September 8, 2026
  1. A 53-year-old man with acute appendicitis developed anaphylactic shock and cardiac arrest after esomeprazole infusion.
  2. Core nursing interventions included rapid response activation, CPR, defibrillation, intubation, and VA-ECMO initiation.
  3. The patient required 48 days of intensive therapy and nursing care, ultimately leading to good recovery and stabilization.
  4. Effective management relied on prompt drug-allergy recognition, multidisciplinary collaboration, and precise nursing interventions.
  5. This case highlights the rarity of esomeprazole-induced anaphylactic shock and the critical nature of nursing care in such emergencies.
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Frontiers In Reproductive Health

  • September 8, 2026
Expert Insights on the Ethical Considerations of Fertility Preservation
  • Silviya Aleksandrova-Yankulovska
  • Marcin Orzechowski
  • Katharina Hancke
  • Karin Bundschu
  • Florian Steger
  • September 8, 2026
  1. Fertility preservation involves saving reproductive material for future use, with ethical challenges including access and financing.
  2. Experts identified four main themes: decision-making autonomy, benefits and risks, access, and funding related to fertility preservation.
  3. Informed consent is crucial, especially for pediatric patients, who should be involved in decisions according to their maturity.
  4. Health insurance coverage for fertility preservation is debated, with unanimous support only for medical indications.
  5. Fertility preservation technologies present both benefits and risks, including potential false hope regarding success rates.
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Frontiers In Medicine

  • September 8, 2026
Integration of AI-Enhanced Virtual Standardized Patients with Scenario-Based Simulation in Anesthesiology Education: A Randomized Pilot Investigation
  • Xiaohua Wang
  • Aming Sang
  • Jing Zhang
  • Hexiao Tang
  • Yujia Liu
  • Zirui Zhao
  • Jinping Liu
  • Ming Xu
  • Xinyi Li
  • September 8, 2026
  1. AI-driven virtual standardized patients (AI-VSPs) were integrated into anesthesiology education to enhance crisis management training.
  2. The study involved 60 anesthesiology master's students, divided into three groups for different instructional methods.
  3. Group C, which included AI-VSP training, showed significantly higher performance in simulated clinical tasks compared to groups A and B.
  4. Teaching satisfaction was measured but not considered an indicator of effectiveness in this pilot study.
  5. The results suggest potential advantages of AI-VSPs in crisis resource management, but further research is needed for comprehensive evaluation.
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Frontiers In Oncology

  • September 8, 2026
Management Strategies for Hydrocephalus in Pediatric Medulloblastoma: A Retrospective Cohort Analysis
  • Yunwei Ou
  • Yiqiao Xu
  • Jingzhe Yuan
  • Haoqi Zeng
  • Chunde Li
  • Jian Gong
  • September 8, 2026
  1. The study analyzed 420 pediatric patients with medulloblastoma and preoperative hydrocephalus at Beijing Tiantan Hospital from 2014 to 2018.
  2. Three management pathways were compared: VP shunting, upfront tumor resection, and preoperative endoscopic third ventriculostomy (ETV).
  3. ETV showed a lower infection frequency than VP shunting, but the difference was not statistically significant.
  4. Postoperative infection rates were 24.2% for VP shunts, 22.1% for upfront resection, and 9.4% for ETV.
  5. The study concluded that larger, multi-institutional investigations are needed for more definitive results on hydrocephalus management.
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Frontiers In Oncology

  • September 8, 2026
The Role of PPIB in Prostate Cancer: Links to Transcriptomic Changes and Splicing Variations
  • Shuangyu Ma
  • Aikeshanjiang Ailiyaer
  • Huixiang Chen
  • Yishen Mao
  • Mulati Rexaiti
  • Abdureheman Zebibula
  • September 8, 2026
  1. PPIB mRNA expression is significantly elevated in prostate cancer tissues compared to non-tumor areas, as shown in TCGA-PRAD analysis.
  2. PPIB knockdown in PC-3 cells resulted in suppressed proliferation, migration, invasion, and tumor growth in xenograft models.
  3. Transcriptomic profiling revealed 570 differentially expressed genes and 873 alternative splicing events associated with PPIB depletion.
  4. Joint analysis identified 22 shared genes between differentially expressed genes and splicing events, including metabolic regulators PHGDH and SHMT2.
  5. Re-expression of shRNA-resistant PPIB restored migration and invasion capabilities reduced by PPIB knockdown in prostate cancer cells.
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Frontiers In Neurology

  • September 8, 2026
Assessment of Intracranial Hemorrhage Size and Location in Acute Stroke Cases: Its Relationship with Initial NIHSS Scores and Implications for Direct-to-Angiography Protocols
  • Anh Nguyen
  • Mira Katan
  • Raphael Guzman
  • Jehuda Soleman
  • Christian Nickel
  • Marios-Nikos Psychogios
  • Alex Brehm
  • September 8, 2026
  1. Intraparenchymal hemorrhage accounted for 89% of cases in the study, with median volume measured at 18 mL.
  2. Volume of intracranial hemorrhage significantly correlated with NIHSS scores, indicating a relationship between size and stroke severity.
  3. Patients with NIHSS scores ≥7 had larger hemorrhages compared to those with scores <7, with median volumes of 38 mL and 6 mL, respectively.
  4. Lobar hemorrhages exhibited the greatest volumes, while infratentorial hemorrhages, particularly in the brainstem, caused severe deficits despite smaller volumes.
  5. The study highlights the challenges in detecting small-volume infratentorial hemorrhages on FDCT, emphasizing the need for improved imaging quality.
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Frontiers In Immunology

  • September 8, 2026
A signature associated with endoplasmic reticulum stress and Golgi apparatus dysfunction indicates immune microenvironment alterations and MUC16-mediated PI3K/AKT pathway activation in lung adenocarcinoma
  • Weihao Zhang
  • Lei Liu
  • Jianwei Liu
  • September 8, 2026

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Frontiers In Immunology

  • September 8, 2026
Investigating the Cytotoxic Effects and Tumor-Promoting Potential of Acetyl Tributyl Citrate in Prostate Cancer via Network Toxicology and Immune Microenvironment Analysis
  • Shangyan Xie
  • Mingsong Qing
  • Zihong Zhang
  • Hang Zhang
  • Yunxiao Zhang
  • Zhenyu Yang
  • Zhiwei Chen
  • Zhuozhi Liang
  • Garu A
  • September 8, 2026
  1. Acetyl tributyl citrate (ATBC) is a plasticizer that may contribute to prostate cancer (PCa) progression through its cytotoxic effects.
  2. Machine learning algorithms identified EZH2, DNMT1, and PRMT5 as key targets influencing immune infiltration in PCa related to ATBC exposure.
  3. The study utilized various online databases and molecular docking analysis to explore the interaction between ATBC and identified key genes.
  4. Virtual knockdown of DNMT1, EZH2, and PRMT5 showed their importance in maintaining prostatic stromal homeostasis and ECM integrity.
  5. The findings suggest a potential link between ATBC exposure and PCa, highlighting the need for further investigation into its toxicological pathways.
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