Objective: To provide expert insights into CPS scoring in challenging cases across different indication types. Key Findings: Indication-specific staining charac
Objective: To review the application of Raman spectroscopy and its enhanced variants in detecting pandemic-prone viruses, emphasizing its significance in pandem
Objective: To report a rare case of metachronous multicentric giant cell tumor of bone (MGCTB) with pulmonary metastases and analyze the long-term management ou
Objective: To compare the efficacy and safety of sequential versus concurrent neoadjuvant immunochemotherapy in patients with locally advanced esophageal squamo
The study involved 70 patients with resectable locally advanced esophageal squamous cell carcinoma (ESCC) from July 2019 to June 2023.
The primary endpoint was pathological complete remission (pCR), with an overall rate of 22.2% and no significant difference between sequential and concurrent groups.
The concurrent group experienced significantly higher rates of nausea and diarrhea, with 14.2% of participants reporting grade 3–5 treatment-related adverse events.
Six treatment-related fatalities occurred, with five in the concurrent group and one in the sequential group, indicating higher risks associated with concurrent therapy.
No significant differences in overall survival or disease-free survival were found between the sequential and concurrent immunochemotherapy approaches.
Objective: To investigate a novel intronic variant in the COL4A5 gene and assess its pathogenic implications in a Chinese family affected by X-linked Alport syn
Objective: Emphasize the significance of AI in improving outcomes for ovarian cancer. Key Findings: Include specific metrics or examples to enhance credibility.
Objective: To evaluate the therapeutic impacts of various brands of botulinum toxin A on Meige syndrome, particularly focusing on the accompanying anxiety sympt
Objective: To explore the overlap between neurosyphilis and autoimmune limbic encephalitis, emphasizing diagnostic and treatment strategies and their clinical s
Neurosyphilis presents with diverse neurologic symptoms, often mimicking autoimmune limbic encephalitis, complicating diagnosis and treatment.
Patients with neurosyphilis may exhibit psychiatric disturbances, cognitive impairment, seizures, and inflammatory cerebrospinal fluid characteristics.
Limited observations suggest modest improvement with antimicrobial treatment, while immunomodulation may lead to more significant recovery in some patients.
A dual diagnostic approach is recommended to ensure antimicrobial coverage for neurosyphilis while facilitating prompt autoimmune phenotyping.
The overlap of neurosyphilis and autoimmune limbic encephalitis challenges traditional diagnostic paradigms and necessitates careful clinical evaluation.
Objective: To identify trends and key research areas in PCOS and pregnancy outcomes and synthesize effective treatment strategies for PCOS-related infertility.
Objective: To investigate the safety and therapeutic effectiveness of TACE combined with DynaCT-guided MWA for liver tumors ≤5 cm located in high-risk areas, de
The study evaluated the safety and effectiveness of combining TACE with DynaCT-guided MWA for liver tumors ≤5 cm in high-risk locations.
Fifty-five patients with newly diagnosed liver cancer underwent the combination treatment, achieving a 96.4% objective response rate after one month.
Adverse events were mostly mild, classified as grade 1 or 2, requiring minimal intervention, indicating a favorable safety profile.
The mean overall survival was 41.0 months, and the mean progression-free survival was 31.2 months in the high-risk location group.
The combination treatment demonstrated promising cumulative survival rates of 98.1%, 94.5%, 85.4%, and 74.5% at 6, 12, 24, and 36 months, respectively.
Objective: To develop a predictive framework for early postoperative outcomes in patients with breast cancer-related lymphedema undergoing combined suction-assi
Objective: To report the long-term outcomes of a pediatric patient with recurrent Wilms tumor treated with BRAF/MEK inhibition, focusing on the implications of
Objective: Emphasize the rarity of the case more strongly. Key Findings: Provide more context regarding the significance of the findings. Interpretation: Elabor
Objective: To examine the association between simulation-integrated clinical learning and academic performance, satisfaction, self-confidence, and anxiety among
Objective: To assess the feasibility, safety, and effectiveness of BKV-specific T cells in pediatric patients with refractory BKV infections post-allogeneic ste
BK virus reactivation is common after allogeneic stem cell transplantation and can lead to serious complications like nephropathy and hemorrhagic cystitis.
Current treatments for BKV infections are mainly supportive, with cidofovir lacking definitive evidence of effectiveness, highlighting the need for new therapies.
Adoptive transfer of BKV-specific T cells showed feasibility and safety in four pediatric patients with refractory BKV infections, with three showing decreased viral load.
The treatment was well tolerated, with no infusion-related adverse effects or severe graft-versus-host disease reported among the patients.
Further research is necessary to confirm the effectiveness of BKV-specific T cells as a therapeutic option for refractory BKV viremia in pediatric patients.
Objective: To report a rare case of poroid hidradenoma (PH) located on the eyelid, emphasizing its rarity, and discuss its clinical presentation, diagnosis, and
Poroid hidradenoma (PH) is a rare, benign neoplasm from eccrine sweat glands, typically appearing in older adults.
The case study presents an 88-year-old woman with a non-tender, enlarging eyelid mass diagnosed as PH after excisional biopsy.
Histopathological analysis revealed solid and cystic formations with a pseudocapsule, confirming the diagnosis of PH.
Surgical excision is the standard treatment for PH, with low recurrence rates, as demonstrated in the 3-month follow-up.
This case highlights the diagnostic challenges of PH in atypical locations like the eyelids, emphasizing the need for awareness among ophthalmic professionals.
Objective: To document a case of diffuse subretinal fibrosis and uveitis syndrome occurring alongside vitreoretinal traction syndrome in an older female patient