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The Ophthalmologist

  • August 25, 2026
Calculating the Myopic Nerve
  • August 25, 2026
  • 3 min

Objective: To estimate the probability of high myopia-associated glaucomatous or glaucoma-like optic neuropathy (GLON) and non-glaucomatous optic neuropathy (NG

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MDSpire News

  • August 24, 2026
FDA clears pTau217 blood test for Alzheimer's disease
  • Kathryn Wighton
  • August 24, 2026
  • 2 min
  1. The FDA has cleared the Elecsys Phospho-Tau (217P) Plasma blood test for identifying amyloid pathology in Alzheimer's disease.
  2. The test is intended for patients aged 55 and older with cognitive decline symptoms and provides classifications of positive, intermediate, or negative.
  3. Elecsys pTau217 was developed in collaboration with Eli Lilly and Company and shows high concordance with amyloid PET imaging results.
  4. The assay can be integrated into existing laboratory workflows on Roche cobas instruments without additional equipment.
  5. The test results should be used alongside other clinical information and are not established for predicting future dementia or tracking treatment responses.
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MDSpire News

  • August 24, 2026
Survey identifies specialty-based differences in CDI management
  • Julia Cipriano
  • August 24, 2026
  • 4 min
  1. A national survey found differences in CDI management practices among gastroenterologists, infectious diseases specialists, and primary care physicians.
  2. Gastroenterologists and infectious diseases specialists reported higher adherence to clinical practice guidelines compared to primary care physicians.
  3. Primary care physicians were less likely to use recommended multistep algorithms for CDI testing than specialists, with significant differences in prescribing practices.
  4. Fewer than 10% of physicians felt very knowledgeable about donor-derived microbiome therapies, highlighting a need for more education and data.
  5. The study suggests a need for standardized diagnostic and treatment algorithms to improve consistency in CDI management across specialties.
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MDSpire News

  • August 24, 2026
Risk models may improve lung cancer screening
  • Olivia Anderson
  • August 24, 2026
  • 3 min

Objective: To evaluate the effectiveness of risk-based lung cancer screening strategies compared to current USPSTF eligibility criteria. Approach: Study Design:

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2 min

Kff Health News

  • August 24, 2026
Violence against healthcare workers and staffing shortages fuel hospital strikes
  • Lynn Arditi
  • August 24, 2026
  • 8 min
  1. Nurses at Henry Ford Genesys Hospital have been on strike since September 1, 2025, due to workplace violence and staffing shortages.
  2. Hospital workers are seven times more likely to be injured on the job from violent acts compared to the general workforce.
  3. Research indicates that understaffing and lack of training increase the risk of violence against healthcare workers.
  4. The American Hospital Association advocates for making assaults on healthcare workers a federal crime, but evidence shows laws have not reduced violence.
  5. Striking healthcare workers demand safe staffing levels rather than harsher punishments for violent patients to improve workplace safety.
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MDSpire News

  • August 24, 2026
Heartbeat-powered pacemaker may pave way for self-sustaining devices
  • Andrea Surnit
  • August 24, 2026
  • 4 min

Objective: To develop a self-sustaining leadless intracardiac pacemaker powered by energy harvested from cardiac motion. Approach: Device Development: Researche

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2 min

Baptist Health South Florida

  • August 24, 2026
Harel Deutsch, M.D., Joins Baptist Health Miami Neuroscience Institute as Director of Spine Surgery
  • August 24, 2026
  • 3 min
  1. Harel Deutsch, M.D., has joined Baptist Health Miami Neuroscience Institute as the director of spine surgery.
  2. Dr. Deutsch specializes in minimally invasive spine surgery and has nearly 30 years of experience in the field.
  3. He previously served as a professor and co-director at the Rush Spine Center in Chicago.
  4. Dr. Deutsch has authored over 100 peer-reviewed publications and has led numerous FDA clinical trials.
  5. He emphasizes a patient-centered approach, focusing on conservative treatment and minimally invasive surgery.
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MDSpire News

  • August 24, 2026
DOOR framework shows similar outcomes in skin infection trials
  • Matthew Solan
  • August 24, 2026
  • 7 min

Objective: To evaluate the overall outcomes of omadacycline and linezolid in treating acute bacterial skin and skin structure infections using the DOOR framewor

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The Medicine Maker

  • August 24, 2026
This Week’s CGT News: Antifreeze Sugars Protect CAR T Cells
  • August 24, 2026
  • 6 min
  1. The FDA has granted accelerated approval to GENGLYCOS, the first gene therapy for glycogen storage disease type Ia.
  2. Ultragenyx's AAV8-based gene therapy delivers a functional copy of G6PC, crucial for glucose release during fasting.
  3. MIT's sugar-based freezing method for CAR T cells improves cell survival and could broaden access to therapies.
  4. USC researchers used focused ultrasound to enhance CAR T cell targeting of solid tumors, achieving significant tumor shrinkage.
  5. A lipid nanoparticle developed by Nagoya University enhances mRNA delivery, showing potential for various therapeutic applications.
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The Medicine Maker

  • August 24, 2026
The Biggest Bottlenecks Holding Back Cell and Gene Therapy
  • August 24, 2026
  • 10 min
  1. Limited patient access due to manufacturing capacity, clinical delivery, and reimbursement constraints hampers cell and gene therapy growth.
  2. Delivery challenges, including slow and complex manufacturing processes, hinder the scalability of cell and gene therapies.
  3. Fragmentation across biology, manufacturing, and regulatory pathways creates inefficiencies that slow down therapy development.
  4. Access to capital is a significant bottleneck, as investor confidence has waned following previous overexuberant investments.
  5. The industry needs to adopt industrial-scale manufacturing practices to improve efficiency and patient access to therapies.
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The Pathologist

  • August 24, 2026
Could Omics Improve Fabry Disease Diagnosis?
  • August 24, 2026
  • 3 min

Objective: To explore how multi-omics research can identify potential biomarkers for improved detection and monitoring of Fabry disease. Approach: Review of Mul

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The Pathologist

  • August 24, 2026
The Cancer Diagnosis That Didn't Fit
  • August 24, 2026
  • 4 min
  1. A cancer misdiagnosis can delay treatment and worsen outcomes, highlighting the need for accurate diagnostic tools.
  2. AI-assisted molecular profiling can enhance diagnostic accuracy by integrating large volumes of molecular data.
  3. In a case study, a benign breast biopsy and extensive lymphadenopathy led to the use of AI to identify a hematologic malignancy.
  4. AI tools are validated algorithms that help pathologists incorporate molecular data into their clinical judgments.
  5. AI has the potential to improve efficiency in pathology, allowing professionals to focus on complex diagnostic tasks.
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The Analytical Scientist

  • August 24, 2026
GCxGC Detective Stories: Follow Your Nose
  • August 24, 2026
  • 5 min
  1. The research project aimed to develop analytical tools to understand aroma perception during food consumption.
  2. A simplified simulated mouth system was created to generate reproducible aroma-release profiles while minimizing variability.
  3. Four analytical platforms were evaluated, revealing consistent aroma release behaviors across different food matrices.
  4. The project resulted in a decision-framework for selecting analytical tools based on specific research questions.
  5. The study emphasized the importance of timing in aroma release, highlighting its impact on flavor perception.
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The Ophthalmologist

  • August 24, 2026
Post-COVID Eye Syndrome?
  • August 24, 2026
  • 3 min

Objective: To investigate persistent ocular symptoms in individuals who had mild COVID-19 and to identify potential neuroimmune signatures associated with these

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The Ophthalmologist

  • August 24, 2026
Investigating Long-COVID Eye Symptoms
  • August 24, 2026
  • 7 min

Objective: To investigate long-term ocular symptoms in non-hospitalized patients who contracted mild COVID-19. Approach: Study Design: A cohort study was conduc

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Frontiers In Immunology

  • August 24, 2026
Case Study: Challenges in Diagnosis and Biomarker-Driven Treatment of CD20-Negative Epstein–Barr Virus-Positive Diffuse Large B-Cell Lymphoma
  • Jingjing Wen
  • Chenxing Zhao
  • Shaozhen Chen
  • Xiurong Chen
  • Qinghu Lv
  • Wei Liu
  • Jiesong Wang
  • Daoguang Chen
  • August 24, 2026
  1. CD20-negative EBV+ DLBCL, NOS is a rare subtype of diffuse large B-cell lymphoma complicating diagnosis and treatment options.
  2. The absence of CD20 restricts the use of anti-CD20 antibodies and expands the differential diagnosis for lymphomas.
  3. Integrated immunophenotypic and molecular analyses were crucial for accurate diagnosis of the patient's lymphoma subtype.
  4. The patient received biomarker-guided treatment, including CD30-targeted therapy and PD-1 blockade, resulting in a complete metabolic response.
  5. This case emphasizes the need for prospective evaluation of CD20-independent treatment strategies in high-risk lymphoma patients.
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Frontiers In Immunology

  • August 24, 2026
Stimulating Antitumor Immunity in Patients with Multiple Chronic Conditions: A Proposal Integrating Cryoablation-Induced Immunogenic Cell Death and Multi-Target Traditional Chinese Medicine
  • Lihui Liu
  • Honglin Chen
  • Jingxiao Wang
  • Jingjing Yang
  • Yong Zhou
  • Baoping Luo
  • Yana Zhou
  • Kaiwen Hu
  • August 24, 2026
  1. Cancer primarily affects older adults with multiple chronic conditions, leading to an immunosuppressive inflammatory environment.
  2. Cryoablation induces immunogenic cell death, promoting dendritic-cell maturation and CD8+ T-cell priming.
  3. Multi-target Traditional Chinese Medicine (TCM) reduces inflammatory signaling and remodulates the tumor microenvironment.
  4. The proposed Tumour Green Therapy framework integrates cryoablation and TCM to enhance antitumor immunity and reduce treatment burden.
  5. The hypothesis requires prospective validation and aims to transform 'cold' tumors into 'hot' tumors while maintaining quality of life.
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Frontiers In Cardiovascular Medicine

  • August 24, 2026
Effects of Drug-Coated Balloons on Stenosis of the Left Anterior Descending Artery Near Myocardial Bridges
  • Yuqing Jia
  • Yangfeng Xie
  • Ying Li
  • Huaipeng Zhang
  • Yanfen Li
  • Weiming Li
  • Chuang Li
  • Yixing Yang
  • Wenhao Jia
  • Wenbo Han
  • August 24, 2026
  1. This study investigates drug-coated balloons (DCBs) for treating left anterior descending artery stenosis near myocardial bridges.
  2. A total of 30 patients received DCB treatment, while 105 patients were treated with drug-eluting stents (DES) in this retrospective cohort.
  3. No significant difference in major adverse cardiac events (MACEs) was observed between DCB and DES groups during a median follow-up of 507 days.
  4. Kaplan–Meier analysis showed MACE-free survival rates of 73.96% for DCB and 82.49% for DES, with no statistically significant difference.
  5. The study concludes that DCB does not demonstrate a significant benefit over DES for LAD stenosis proximal to myocardial bridges.
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