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MDSpire News

  • August 4, 2026
Distribution Barriers May Reduce Biologic Drug Survival
  • Andrea Surnit
  • August 4, 2026
  • 3 min
  1. Distribution barriers may reduce biologic drug survival among patients with moderate-to-severe psoriasis.
  2. Patients reporting medication distribution problems were more likely to discontinue biologic therapy.
  3. Adalimumab was the most frequently prescribed biologic, followed by secukinumab and ustekinumab.
  4. Approximately one-third of patients reported their biologic medication was out of stock during therapy.
  5. The study acknowledged limitations due to its retrospective design and small sample size.
...more

MDSpire News

  • August 4, 2026
Uncovering Persistent Pain Pattern in Gout
  • Andrea Surnit
  • August 4, 2026
  • 4 min
  1. About one-third of gout patients report a constant pain pattern instead of the typical intermittent flares.
  2. The study analyzed data from 90 adult patients with physician-diagnosed gout who experienced at least two flares in the previous six months.
  3. Younger age at gout onset, greater activity limitation, and current anxiety or depression were independently associated with constant pain.
  4. Patients with greater activity limitation had nearly six times the odds of reporting constant pain compared to those with intermittent pain.
  5. The study's cross-sectional design limits causal inference, and findings may not generalize to all gout patients.
...more

MDSpire News

  • August 4, 2026
Uncovering Persistent Pain Pattern in Gout
  • Andrea Surnit
  • August 4, 2026
  • 4 min

Objective: To analyze the prevalence and factors associated with constant pain patterns in patients with gout. Approach: Study Design: Prospective observational

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MDSpire News

  • August 4, 2026
Uncovering Persistent Pain Pattern in Gout
  • Andrea Surnit
  • August 4, 2026
  • 4 min
  1. About one-third of gout patients report a constant pain pattern, differing from the traditional intermittent flare model.
  2. The study analyzed data from 90 adult patients with physician-diagnosed gout who experienced at least two flares in the previous six months.
  3. Independent factors associated with constant pain included younger age at gout onset, greater activity limitation, and current anxiety or depression.
  4. Patients with greater activity limitation had nearly six times the odds of reporting constant pain compared to those with intermittent pain.
  5. The study's cross-sectional design limits causal inference, and findings may not generalize to all gout patients due to recruitment criteria.
...more

Inside Dentistry

  • August 4, 2026
Three DEXIS Solutions Earn Digital Dentistry Society Certification
  • Inside Dentistry Staff
  • August 4, 2026
  • 2 min
  1. DEXIS announced that three of its digital dentistry solutions received certification from the Digital Dentistry Society.
  2. The certified solutions include DEXIS™ Imprevo™, ORTHOPANTOMOGRAPH™ OP 3D™ LX, and DTX Studio™ Clinic.
  3. Certification criteria focused on safety, usability, and clinical relevance as evaluated by the Digital Dentistry Society.
  4. The certified products are designed to function as part of a unified digital workflow for imaging and diagnostics.
  5. DEXIS is part of the Envista family and offers dental imaging technologies integrated within a connected digital workflow.
...more

MDSpire News

  • August 4, 2026
An Overlooked Cause of Pediatric Anaphylaxis
  • Teraya Smith
  • August 4, 2026
  • 3 min
  1. Spice allergy is a potential cause of pediatric anaphylaxis, particularly during cooking rather than after eating.
  2. The first reported case of cumin-induced anaphylaxis from inhalation involved a 17-year-old girl with a history of allergic conditions.
  3. Spices accounted for 4% of anaphylaxis cases in children in a 2016 European registry and 0.7% in a 2023 analysis.
  4. The study highlighted the need for better skin testing standardization to reduce false-positive results in spice allergy diagnosis.
  5. Clinical history is crucial for diagnosing spice allergies, which may be overlooked without thorough investigation.
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The Ophthalmologist

  • August 4, 2026
GA Treatment Preferences
  • August 4, 2026
  • 4 min

Objective: To quantitatively assess retina specialists' preferences for geographic atrophy (GA) treatment options. Approach: Study Design: A best-best discrete

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The Ophthalmologist

  • August 4, 2026
Eye Drop Cataract Study Enrolls First Patient
  • August 4, 2026
  • 3 min

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The Medicine Maker

  • August 4, 2026
Do Pharma Supply Chains Have a Visibility Problem?
  • Adriana Stalteri
  • August 4, 2026
  • 6 min
  1. The global pharmaceutical supply chain involves billions of dollars in medications moving from manufacturers to healthcare providers.
  2. Recent incidents highlight the need for improved visibility and control in managing pharmaceutical inventory across healthcare organizations.
  3. Fragmented systems and manual workflows contribute to significant inventory losses, especially during temperature excursions.
  4. RFID-enabled visibility can enhance inventory management by providing real-time awareness of medication location and conditions.
  5. Interoperable standards like GS1 are essential for improving traceability and operational responsiveness in the pharmaceutical supply chain.
...more

The Ophthalmologist

  • August 4, 2026
The Emotional Side of Cataracts
  • August 4, 2026
  • 3 min

Objective: To explore the relationship between emotional wellbeing and care dependence in older adults with cataracts. Approach: Study Design: Cross-sectional s

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The Pathologist

  • August 4, 2026
Peer-to-Peer: Ivan Damjanov in Conversation with Raimundo Geronimo Junior
  • Ivan Damjanov
  • August 4, 2026
  • 10 min
  1. Dr. Raimundo Geronimo Junior is the President of the Brazilian Society of Pathology and advocates for medical education in pathology.
  2. Pathology has evolved to become central to clinical decision-making, particularly in oncology and precision medicine.
  3. The SBP prioritizes continuing education in digital pathology, AI, and molecular diagnostics to prepare Brazilian pathologists for future challenges.
  4. Brazil faces regional disparities in access to advanced diagnostic technologies and a need for workforce renewal in pathology.
  5. The SBP has engaged over 350 medical students for its national congress, indicating a growing interest in pathology as a career.
...more

The Pathologist

  • August 4, 2026
ADLM 2026: Machine Learning Tumor Test Accuracy
  • August 4, 2026
  • 3 min
  1. Machine learning improved diagnostic accuracy of plasma metanephrine testing for adrenal tumors in a large study.
  2. The study evaluated over 20,500 adults who underwent plasma-free metanephrine testing at Samsung Medical Center.
  3. Combining laboratory results with structured clinical information enhanced diagnostic interpretation significantly.
  4. The best-performing model increased the area under the curve from 0.81 to 0.91 with added clinical data.
  5. Robust validation and transparency are essential for effective machine learning implementation in laboratory diagnostics.
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The Analytical Scientist

  • August 4, 2026
Spectroscopy Roundup: From Attoseconds to Aging Collections
  • August 4, 2026
  • 8 min
  1. Metasurface-enhanced Raman spectroscopy tracks conformational changes in individual proteins without chemical modification or immobilization.
  2. The technique achieved a 10 million times increase in Raman signal by using a metasurface of gold nanoparticles.
  3. Time-resolved reflectance spectroscopy captured a hidden state in a metal-organic framework within 30 femtoseconds.
  4. Table-top transient absorption resolved electronic coherences in xenon cycling in just over three femtoseconds using attosecond XUV pulses.
  5. A new physics-paired framework enhances signal-to-noise in Raman spectroscopy while maintaining quantitative contrast and 3D structure.
...more

The Analytical Scientist

  • August 4, 2026
A Molecular Map of Fabry Disease
  • August 4, 2026
  • 3 min
  1. A multimodal imaging workflow has mapped lipid accumulation in cardiac tissue related to Fabry disease.
  2. Fabry disease is characterized by insufficient breakdown of globotriaosylceramides (Gb3), leading to lipid accumulation.
  3. Raman microscopy and AP-MALDI mass spectrometry imaging were combined to identify and localize Gb3 lipoforms in cardiac tissue.
  4. Gb3 accumulation in heart tissue from mouse models showed localized hotspots and distinct spatial patterns of different variants.
  5. The research team plans to extend their imaging workflow to human tissue samples to better understand lipid distribution.
...more

The Medicine Maker

  • August 4, 2026
The 10 Biggest Bottlenecks Slowing Drug Development
  • August 4, 2026
  • 8 min
  1. Patient recruitment for clinical trials is a significant bottleneck, necessitating a balance between scientific rigor and practical considerations.
  2. The complexity of clinical trials has increased, making patient recruitment more challenging due to evolving regulatory requirements and specific inclusion criteria.
  3. Boards and executives must adapt to the intensified competition in drug development, as outdated strategies hinder funding opportunities.
  4. Accurate measurement of target engagement in tissues is crucial, as current reliance on plasma-based assays limits the ability to address underlying challenges.
  5. Translational predictability remains a major bottleneck, especially for neurodegenerative diseases, due to reliance on inadequate model systems.
...more

MDSpire News

  • August 3, 2026
FDA Approves Pluvicto for Hormone-Sensitive Prostate Cancer
  • Kathryn Wighton
  • August 3, 2026
  • 3 min
  1. The FDA approved Pluvicto for adults with PSMA-positive metastatic hormone-sensitive prostate cancer.
  2. The approval is based on the phase 3 PSMAddition trial, showing Pluvicto reduced disease progression risk by 28%.
  3. An updated analysis indicated a 33% reduction in disease progression or death risk with Pluvicto plus standard care.
  4. Grade 3 or higher adverse events occurred in 51% of patients receiving Pluvicto, compared to 43% with standard care.
  5. Pluvicto is an intravenous radioligand therapy that targets prostate cancer cells expressing PSMA using lutetium-177.
...more

Inside Dentistry

  • August 3, 2026
Henry Schein Announces Leadership Restructuring and Executive Transitions
  • Inside Dentistry Staff
  • August 3, 2026
  • 5 min

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MDSpire News

  • August 3, 2026
Can Peroxisome Preservation Slow Aging?
  • Andrea Surnit
  • August 3, 2026
  • 2 min

Objective: To investigate the effects of inhibiting the peroxisomal protein PRX-11 on aging and mitochondrial health in Caenorhabditis elegans. Approach: Experi

...more