Objective: Harold Burstein, MD, PhD, and Laura S. Dominici, MD, FACS, discuss SENOMAC trial highlights related to whether some patients with early breast cancer
Objective: Harold Burstein, MD, PhD, and Rachel Freedman, MD, MPH discuss a study on the impact of food access and poverty on patients with metastatic breast ca
Objective: The video discusses the persevERA trial and oral SERDs in metastatic breast cancer. Approach: Format: Video discussion featuring Harold Burstein, MD,
Objective: Harold Burstein, MD, PhD, and Ana C. Garrido-Castro, MD, discuss new results from the PANKU-Breast02 study of izalontamab brengitecan (iza-bren), a d
Objective: Harold Burstein, MD, PhD, and Jennifer A. Ligibel, MD, discuss research from the Breast Cancer Weight Loss (BWEL) trial and recommendations concernin
Objective: Harold Burstein, MD, PhD, and Adrienne Waks, MD, discuss the HER2CLIMB-05 trial and its relevance to treatment for HER2-positive metastatic breast ca
Objective: Harold Burstein, MD, PhD, and Adrienne Waks, MD, discuss the Neo-Healer trial in HER2-positive breast cancer. Interpretation: The supplied material i
Objective: Harold Burstein, MD, PhD, and Ana C. Garrido-Castro, MD discuss new antibody-drug conjugate treatment options for first-line triple-negative breast c
Objective: The article examines the objective, findings, and clinical context described in Medical Oddities: Alive, but convinced otherwise. Approach: Cotard’s
A man in his 40s with schizophrenia developed nihilistic delusions consistent with Cotard’s delusion after discontinuing psychiatric medication.
His belief that he was dead nearly resolved by day 6 after treatment with oral risperidone and long-acting injectable paliperidone; sustained remission was not confirmed.
A narrative review described vanillin’s antioxidant, anti-inflammatory, and antimicrobial properties and its use in experimental wound dressings, but the evidence remains largely preclinical.
In a randomized trial of 1,012 adults, COVID-19 incidence was 5.4% in both the green tea and water gargling groups over 12 weeks.
In a single-center study, thunderstorm-associated asthma was linked to younger age, more allergic rhinitis, and higher eosinophil counts than general asthma exacerbations.
In a cohort of 1,266 middle-aged adults, investigators assessed cannabis exposure over 35 years and sleep outcomes during 2020 to 2022.
Each additional cannabis-year was associated with lower sleep percentage, greater sleep fragmentation, and more wakefulness after sleep onset on actigraphy.
Recent cannabis use was associated with poorer objective sleep measures and longer sleep duration than never use; former use was not significantly associated with objective sleep.
Neither recent nor cumulative cannabis exposure was associated with self-reported sleep quality.
The observational study could not establish causation, and the authors called for longitudinal, mechanistic, and randomized studies with long-term follow-up and objective sleep assessments.
Objective: To describe a symptomatic free-floating vitreous cyst in a patient with longstanding floaters. Approach: Case: A 51-year-old woman had persistent lef
A 51-year-old woman had persistent left-eye floaters for more than 2 decades that had recently become more bothersome.
Examination and multimodal imaging showed a mobile, free-floating pigmented vitreous cyst with a translucent lumen and no attachment to the optic disc or peripheral retina.
The patient had no intraocular inflammation, and serologic testing for parasitic infection was negative.
After pars plana vitrectomy, histopathology showed a cyst wall lined by pigmented cuboidal epithelial cells, supporting an iris or ciliary body pigmented epithelium origin.
At 2 weeks after surgery, symptoms had improved and visual acuity increased from 20/60 to 20/25; the single-case report does not establish outcomes beyond this patient.
Objective: To assess whether AI analysis of intraoperative tissue samples, combined with clinical, radiographic, and molecular characteristics, can predict foca
The study evaluated whether AI-derived tumor infiltration in resection-margin samples could predict focal glioblastoma recurrence.
The retrospective development cohort included 273 margin samples from 60 patients, and a separate prospective internal cohort included 98 samples from 20 patients.
AI-derived infiltration alone had a mean area under the curve (AUC) of 0.62, while the random forest model combining infiltration with clinical, radiographic, and molecular variables had a mean AUC of
The random forest model achieved an AUC of 0.80 in the separate internal validation cohort, and a reduced model using infiltration, age, and resection cavity volume had a mean cross-validation AUC of
The validation cohort came from the development cohort’s health system, and the study’s sampling limitations included nonstandardized margin sampling and unknown performance in patients with unresecta
Objective: Assess whether fetal echocardiographic findings can predict neonatal hypoxia or the need for urgent balloon atrial septostomy (BAS) in infants with p
A prospective, multicenter study enrolled 132 mother-infant pairs with prenatally diagnosed dTGA/IVS at 23 North American institutions from 2019 to 2022.
Third-trimester fetal echocardiographic measurements did not reliably predict neonatal hypoxia or identify infants who would remain stable after birth.
Neonatal hypoxia occurred in 38% of infants; 61% of those infants and 51% of infants without hypoxia underwent BAS.
The study authors said all infants with prenatally diagnosed dTGA/IVS warrant high-risk delivery planning for possible hypoxia and urgent BAS, even when fetal echocardiograms appear reassuring.
In a separate study, bedside interventional teams reduced median time to BAS to 1.1 hours, compared with 9.3 hours after postnatal diagnosis and 4.5 hours with rapid transport.
Objective: To describe a case of mild central retinal vein occlusion (CRVO) occurring after intense exercise and assess possible contributing factors. Approach:
A 38-year-old woman developed mild, perfused central retinal vein occlusion in her left eye during a high-intensity exercise class.
Examination showed left retinal venous tortuosity and scattered intraretinal hemorrhage, with 20/20 visual acuity in both eyes and no macular edema or ischemia.
An extensive evaluation did not identify an alternative cause, and the patient received no pharmacologic treatment.
After increasing oral hydration and temporarily avoiding strenuous exercise, her retinal findings improved at 1 month and resolved by 10 months without symptom recurrence.
The authors proposed dehydration-related hyperviscosity as a possible contributor but noted that dehydration was not objectively confirmed and a single case cannot establish causation.
Objective: The article examines the objective, findings, and clinical context described in Anticoagulant recalled over life-threatening risk. Approach: Recall s
Par Health USA voluntarily recalled 22 lots of argatroban injection nationwide after detecting particulate contamination.
The particles included cellulose, polystyrene, polyethylene terephthalate, stopper material, and possibly stainless steel.
The company warned that affected injections could cause pulmonary emboli, vascular occlusion with tissue or organ damage, and venous inflammation that may lead to clot formation.
The recall covers 20 lots under NDC 42023-182-01 and 2 lots under NDC 42023-182-89, distributed to US wholesalers and hospitals from December 30, 2024, through May 5, 2026.
Wholesale distributors and hospital pharmacies should immediately stop using and distributing affected lots, and notify downstream recipients if products were redistributed.
In a prospective cohort of 1,324 mother-infant pairs, 61 infants (5%) had both colic and eczema by a median age of 6.3 months.
Each 1-point increase in maternal Mediterranean Diet Score was associated with 15% lower adjusted odds of infant colic and eczema together.
Each 1-point increase in maternal Dietary Inflammatory Index was associated with 34% higher adjusted odds of the combined outcome.
Neither dietary score was significantly associated with colic alone or eczema alone, and dairy and egg intake were not significantly associated with any outcome.
The observational study relied on maternal reports, included few infants with both conditions, and cannot establish that prenatal diet causes or prevents colic and eczema.
Objective: The article examines the objective, findings, and clinical context described in Looking Beyond Symptoms in Psychiatric Drug Development. Approach: In
Advances in human genetics, circuit biology, and translational biomarkers have expanded researchers’ ability to investigate the biology underlying psychiatric disorders.
Earlier target-engagement assessments and closer collaboration between discovery and clinical teams help evaluate mechanisms before programs advance.
EEG and brain imaging approaches, including receptor occupancy imaging and fMRI, are used or explored to assess target engagement and support dose selection.
Computational and multimodal methods may help researchers analyze heterogeneous data and identify psychiatric disease subgroups.
Fluid biomarkers, including inflammatory markers associated with an immunometabolic profile in some patients with depression, may help define subpopulations for study.