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March 25, 2026

Postmortem Blood Cultures May Aid Autopsy Analysis

Jess Allerton
March 25, 2026
3 min

A study analyzing 100 medico-legal autopsies examined postmortem blood cultures to assess their role in determining the cause of death. Findings revealed that 6

...more

Study of 100 autopsies assessed postmortem blood cultures.
66% cases showed bacterial growth; Klebsiella pneumoniae was most common.
93.8% positive cultures in disease-related deaths.
Postmortem interval and hospital stay duration had no significant influence.
Culture results must correlate with autopsy findings and clinical history.
Limitations included a small sample size and no molecular confirmation.

March 25, 2026

Study Tests Two Achilles Pain Therapies

Doug Brunk
March 25, 2026
3 min

A randomized clinical trial published in Cureus found that ultrasound-guided percutaneous electrolysis significantly outperforms dry needling in treating Achill

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Ultrasound-guided percutaneous electrolysis was superior to dry needling in managing Achilles tendinopathy.
60 patients participated, receiving either treatment with similar stretching protocols.
Significant improvements were noted in pain levels and functional assessments.
The electrolysis group had greater gains post-treatment from week two onwards.
Limitations included a modest sample size and short follow-up time.
Both methods targeted different anatomical structures.

March 25, 2026

Emerging Strategies for Septic Shock Management

Kerri Miller
March 25, 2026
4 min

Emerging critical care strategies for managing septic shock involve early multimodal vasopressor therapy, individualized fluid resuscitation, and AI-supported m

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Early multimodal vasopressor therapy recommended for septic shock management.
Norepinephrine is the first-line agent for vasopressor therapy.
Individualized fluid resuscitation strategies are essential.
Balanced crystalloids preferred over saline.
Combining vasopressors may enhance effectiveness.
AI and biomarkers have potential in personalizing treatment.
Evidence for current practices remains weak to moderate.
Further research needed to optimize septic shock management.

March 25, 2026

ADA adds mental health, GLP-1 questions to health history forms

Mary Beth Versaci
March 25, 2026
3 min

The American Dental Association (ADA) has updated its patient health history forms to include a new screening question related to mental health and the inclusio

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ADA updates health history forms with mental health questions.
Inclusion of GLP-1 receptor agonists in medication questions.
Recommended updates every two years.
Emphasis on connection between oral and overall health.
Support resources for dentists addressing mental health.
Webinar on connecting patients to mental healthcare available on demand.
Opportunity for dentists to refer patients for mental health support.

March 25, 2026

H-1B Sponsorship of Surgeons Rises

Jess Allerton
March 25, 2026
3 min

Over the past decade, the number of surgeons sponsored for H-1B visas in the U.S. has risen, particularly in rural and high-poverty areas. Researchers analyzed

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H-1B visa surgeons increased by an average of 33 annually.
662 surgeons sponsored in fiscal year
Sponsored surgeons <1% of total U.S. surgical workforce.
Concentration in rural, high-poverty communities.
Rising application fees raised workforce shortage concerns.
Important for maintaining surgical access in underserved areas.
Study uses application data, not confirmed employment.
International medical graduates comprise 20% of active general surgeons.

March 25, 2026

New ADA executive director emphasizes clarity, trust, and growth

Noah Levine
March 25, 2026
9 min

Nader A. Nadershahi, D.D.S., M.B.A., Ed.D., has been appointed as the American Dental Association's executive director, bringing significant experience in organ

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Nader A. Nadershahi appointed ADA executive director on March 10,
Emphasizes service and collaboration in leadership.
Prior roles included dean at the Arthur A. Dugoni School of Dentistry.
Leadership style focuses on listening and shared purpose.
Aims to address challenges in dental education and workforce.
Encourages community engagement in shaping the profession's future.
Values clarity, trust, and growth within the organization.

The Pathologist

March 25, 2026

Value-based Healthcare: How Do We Get There?

Helen Bristow
March 25, 2026
12 min

Part Two of the round table with Project Santa Fe's experts explores the practicalities of Clinical Lab 2.0, advocating for pathologists' proactive engagement i

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Clinical Lab 2.0 emphasizes the shift towards value-based healthcare.
Pathologists must understand healthcare systems to contribute meaningfully.
Predictive data plays a critical role in patient care.
Engaging with patients enhances their understanding and management of diseases.
Laboratories need to demonstrate their impact on clinical outcomes.
Familiarity with policy and reimbursement practices is essential.
Advancing technology can optimize diagnostic processes.

The Pathologist

March 25, 2026

Tau Biomarker Expands Beyond Alzheimer’s

March 25, 2026
3 min

Recent research has highlighted elevated levels of phosphorylated tau (p-tau181) in patients with AL and ATTR amyloidosis, suggesting its potential as a blood-b

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Elevated phosphorylated tau levels noted in AL and ATTR amyloidosis patients.
Study involved 280 individuals across multiple European countries.
p-tau181 shows moderate diagnostic discrimination for systemic amyloidosis.
Neuropathy associated with elevated p-tau181 levels in amyloidosis patients.
Further studies needed to incorporate biomarkers in routine diagnostic workflows.
p-tau217 also shows similar elevation pattern in amyloidosis patients.
Elevated tau may reflect cellular responses to amyloid deposition.

The Analytical Scientist

March 25, 2026

Vibe Coding Comes to Omics

James Strachan
March 25, 2026
16 min

Jesse Meyer, an Assistant Professor of Computational Biomedicine at Cedars Sinai, utilizes 'vibe coding'—a new method that allows non-programmers to create soft

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Vibe coding enables software creation via natural language.
Jesse Meyer built Rescoop.xyz and PeerAI.app as prototypes.
The approach allows rapid prototyping of scientific applications.
Success depends on clear input specifications and verification.
The efficiency of creating functional software has transformed research workflows.
Caution is necessary to ensure validation of outputs.
Future developments may enhance research productivity significantly.

The Analytical Scientist

March 25, 2026

A Closer Look at Vascular Cell States in Marfan Syndrome

March 25, 2026
2 min

A study has uncovered distinct vascular cell states in Marfan syndrome using a label-free single-cell proteomics approach. Researchers analyzed nearly 5,000 cel

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Single-cell proteomics reveals vascular cell states in Marfan syndrome.
Nearly 5,000 cells analyzed from aortic roots of mouse models.
Key cell types include endothelial cells and smooth muscle cells.
Identified 16 cell groups with distinct smooth muscle subtypes.
Disease-enriched populations associated with LRP1 and PRSS
Proteomics provides insights alongside RNA data.
New smooth muscle populations may impact aneurysm progression understanding.

KFF Health News

March 25, 2026

CDC Cuts: Fallout Hits Workforce

March 25, 2026
5 min

Sarah Boim, a former CDC employee, reflects on her termination amid significant layoffs affecting over 3,000 staff, which severely undermines public health effo

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Sarah Boim was terminated from the CDC amid mass layoffs.
Over 3,000 CDC employees were impacted.
Protests arose in response to the layoffs.
The economic impact on local businesses was noted.
The cuts hinder public health capabilities.
The interim CDC director is Jay Bhattacharya.
Current CDC employees express distress regarding their safety.
Mutual aid groups have provided support to former employees.

The Medicine Maker

March 25, 2026

What I Learned Bringing Slalom Chromatography Back from the Dead

March 25, 2026
9 min

A new approach to slalom chromatography (SC) has emerged to address the challenges in separating large DNA and RNA macromolecules critical for cell and gene the

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Slalom chromatography (SC) helps separate large DNA/RNA molecules.
Initiated by Edward Bouvier's idea over a decade ago.
The research team explored theoretical and experimental aspects of SC.
Key findings about DNA migration and shear forces led to column development.
Waters commercialized the first SC column, enhancing biopharmaceutical processes.
Emphasis on interdisciplinary approach for scientific innovation.
Importance of broad scientific education for researchers.

The Ophthalmologist

March 25, 2026

Layer-Specific Corneal Changes in TED

March 25, 2026
3 min

A study published in Translational Vision Science & Technology investigates the association of thyroid eye disease (TED) with diffuse corneal stromal thinning,

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Study links thyroid eye disease (TED) to corneal stromal thinning.
Spectral-domain OCT used for corneal assessment.
Central corneal thickness significantly lower in TED eyes.
Anterior corneal shape remains preserved in inactive TED.
Epithelial thickness showed no significant difference between groups.
Potential mechanism includes autoimmune-mediated remodeling.
Importance of layer-specific corneal assessments highlighted.

The Ophthalmologist

March 25, 2026

Next-Generation Spectacle Lens Aims to Strengthen Myopia Control in Children

March 25, 2026
5 min

The introduction of Essilor Stellest 2.0 represents a significant advancement in pediatric myopia management, aiming to slow axial elongation through innovative

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Essilor Stellest 2.0 aims to slow axial elongation.
Incorporates H.A.L.T. MAX technology for enhanced optical performance.
Clinical trials show 1.88x slower eye growth compared to original Stellest.
Features 12 concentric rings of lenslets for improved design.
Targets younger kids for better myopia management.
Myopia prevalence globally is rising, demanding effective interventions.
Offers a non-invasive spectacle solution complementing other treatments.

The Medicine Maker

March 25, 2026

Japan Clears First iPSC Therapies for Clinical Use

March 25, 2026
2 min

Japan’s Ministry of Health, Labour and Welfare has made a groundbreaking decision by granting conditional approval to two induced pluripotent stem cell (iPSC)-d

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Japan's MHLW granted conditional approval to two stem cell therapies.
ReHeart is for severe ischemic heart failure.
Amchepry targets Parkinson's disease.
Both were derived from induced pluripotent stem cells.
Early trials showed safety but require larger studies.
Approval allows continued monitoring of patient outcomes.
Japan’s initiative pushes for faster regenerative medicine development.

The Medicine Maker

March 25, 2026

CAR-Engineered Astrocytes in Alzheimer’s Models

March 25, 2026
2 min

Research has developed CAR-expressing astrocytes which can clear amyloid-β associated with Alzheimer's disease. In vitro tests and mouse models show that these

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- Development of CAR-expressing astrocytes for Alzheimer's. - Targeting and clearing amyloid-β in vitro and in mouse models. - Non-invasive delivery via adeno-associated viral vectors. - Self-sustaining system reduces safety risks associated with monoclonal antibodies. - Variation in CAR designs yields different biological impacts. - Need for further studies to ensure safety and human applicability.

Frontiers In Endocrinology

March 25, 2026

Maternal and neonatal vitamin D metabolite profiling and its long-term impact on childhood growth: findings from the KLOTHO birth cohort

Spyridon N. Karras
Maria Kypraiou
Vikentia Harizopoulou
Antonios Vlastos
Marios Anemoulis
Maria Dalamaga
Neoklis Georgopoulos
Evanthia Kassi
Georgios Mastorakos
Kali Makedou
Dimitrios Skoutas
Melpomeni Peppa
Dimitrios G. Goulis
March 25, 2026

Objective: To investigate the associations between maternal vitamin D metabolite profiles at birth and childhood anthropometry. Key Findings: Trends of associat

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Vitamin D plays a crucial role in growth, metabolism, and body composition during early life, impacting long-term health outcomes.
The KLOTHO cohort study analyzed eight vitamin D metabolites in cord blood to explore their associations with childhood growth.
Preliminary trends indicated that D3-related metabolites may correlate with linear growth and adiposity measures in children.
None of the associations reached statistical significance after multiple testing corrections, highlighting the exploratory nature of the findings.
The study emphasizes the need for larger longitudinal studies to better understand the role of vitamin D metabolism in childhood growth.

Frontiers In Endocrinology

March 25, 2026

Helicobacter pylori infection is independently associated with triglyceride levels: a propensity score–matched cross-sectional study

Yu Zhou
Jie Xu
Yating Shi
Ge Yu
Hui Duan
Zhaoyi Chen
Daoxing He
March 25, 2026

Objective: To investigate the association between H. pylori infection and serum lipid levels, specifically triglycerides. Key Findings: H. pylori-positive parti

...more

Helicobacter pylori infection affects over 50% of the global population and is linked to various upper gastrointestinal diseases.
The study enrolled 678 participants to examine the relationship between H. pylori infection and serum lipid levels.
H. pylori-positive participants exhibited significantly higher triglyceride levels compared to H. pylori-negative participants.
Total cholesterol, LDL-C, and HDL-C levels did not significantly differ between the H. pylori-positive and negative groups.
The findings suggest H. pylori infection may play a role in metabolic risk assessment, warranting further research.

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