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Compendium

  • August 13, 2026
Dentulu, Guide GLP Partnership Highlights Medical-Dental Integration in Sleep, Metabolic, and Preventive Care
  • News Staff
  • August 13, 2026
  • 6 min
  1. Dentulu Health partnered with Guide GLP to integrate dental and medical services in metabolic health, sleep health, and preventive care.
  2. The collaboration focuses on obstructive sleep apnea, connecting patients with screening, testing, and treatment through a coordinated care model.
  3. The partnership highlights the link between diabetes and periodontal disease, emphasizing the need for communication between dental and medical professionals.
  4. Dentulu provides a referral pathway for dental practices to access medical resources without establishing their own medical practice.
  5. The collaboration aims to improve patient care by addressing systemic health issues encountered during dental visits.
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MDSpire News

  • August 13, 2026
Medical Oddities: Not a feces sign, a wine cork
  • Teraya Smith
  • August 13, 2026
  • 4 min
  1. A 25-year-old man with chronic psychosis presented with acute small bowel obstruction and was found to have wine cork fragments in his ileum and stomach.
  2. Initial CT imaging misidentified the intraluminal mass as a classic 'small bowel feces sign' due to its gas-mottled appearance.
  3. Differentiating between a feces sign and a discrete mass is crucial for diagnosis and treatment in cases of bowel obstruction.
  4. Surgical exploration confirmed the presence of wine-bottle cork fragments without underlying strictures or bowel ischemia.
  5. This case highlights the unexpected nature of surgical findings and the importance of accurate imaging interpretation.
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The Pathologist

  • August 13, 2026
How to Take the Pain out of Pathology
  • Helen Bristow
  • August 13, 2026
  • 5 min
  1. Lab leaders face challenges including communication breakdowns, succession planning, and unfavorable contracts, as highlighted in the PNPL survey.
  2. Karim E. Sirgi identifies strategic issues like digital pathology and AI adoption as current pain points in pathology practices.
  3. Common pain points among pathology labs include workload distribution, staff retention, and physician recruitment, with succession planning being a significant concern.
  4. Factors contributing to pain points include a shrinking pipeline of pathologists, tighter contract terms, and increased billing complexity.
  5. Sirgi's consulting approach involves detailed surveys and retreats to address governance, communication, and decision-making issues in pathology groups.
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The Pathologist

  • August 13, 2026
Cyclospora Alert Spurs US Testing Focus
  • August 13, 2026
  • 2 min

Objective: To address the multistate outbreak of Cyclospora infections linked to recalled iceberg lettuce. Approach: Investigation Overview: The CDC is investig

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The Ophthalmologist

  • August 13, 2026
Migraine and Glaucoma: Causal Link or Clinical Coincidence?
  • August 13, 2026
  • 4 min
  1. A genetic analysis found no causal relationship between migraine and glaucoma using bidirectional Mendelian randomization.
  2. Previous studies reported mixed results, with some indicating a higher risk of glaucoma in migraine sufferers.
  3. The study utilized substantial sample sizes, including 184,654 individuals for migraine and 218,792 for glaucoma.
  4. Sensitivity testing confirmed the null results, indicating no causal effect of glaucoma on migraine or vice versa.
  5. The authors suggest that shared biological mechanisms exist, but these do not imply that one condition causes the other.
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The Ophthalmologist

  • August 13, 2026
OCT: Beyond Red and Green
  • August 13, 2026
  • 3 min
  1. Optical coherence tomography (OCT) is essential in glaucoma care, using color-coded reports to indicate retinal nerve fiber layer (RNFL) thickness.
  2. A study from the POAAGG suggests the Cirrus HD-OCT database may misclassify eyes of African ancestry as more abnormal than an ancestry-specific reference.
  3. The analysis included 787 eyes with primary open-angle glaucoma, revealing that the ancestry-specific model produced fewer abnormal classifications.
  4. Reclassification varied by retinal quadrant, with the temporal quadrant showing the greatest shift in OCT color codes.
  5. The study emphasizes the need for more representative normative datasets to improve the accuracy of OCT findings in diverse populations.
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The Analytical Scientist

  • August 13, 2026
A Matter of Mosquito Taste
  • August 13, 2026
  • 3 min

Objective: To investigate the attraction patterns of three mosquito species to different human volunteers and identify the chemical and microbial signatures ass

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The Analytical Scientist

  • August 13, 2026
Microplastics Reach the Deep Sea Floor
  • August 13, 2026
  • 3 min

Objective: To investigate the presence of microplastics in deep-sea animals from hydrothermal vents and understand their connection to surface-derived plastic p

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The Medicine Maker

  • August 13, 2026
Why Cell Therapy Needs a Digital Backbone
  • August 13, 2026
  • 8 min
  1. Alexander Seyf emphasizes the need for digital platforms to scale cell and gene therapy production beyond individual patient treatment.
  2. The UK has lost momentum in cell and gene therapy compared to Europe and Asia, partly due to Brexit and reduced government focus.
  3. Collaboration and information sharing are critical bottlenecks in the cell and gene therapy ecosystem, hindering progress.
  4. California's California Institute for Regenerative Medicine exemplifies effective collaboration, supporting biotech growth.
  5. Digitalization is viewed as essential for overcoming inefficiencies and enhancing scalability in cell therapy manufacturing.
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Frontiers In Cardiovascular Medicine

  • August 13, 2026
Editorial: Navigating the Spectrum from Athletic Heart Adaptations to Cardiovascular Issues: Strategies and Challenges in Sports Medicine Risk Management
  • Clotilde Castaldo
  • Franca Di Meglio
  • Daria Nurzynska
  • August 13, 2026
  1. The article discusses risk management challenges in cardiovascular sports medicine, focusing on athlete's heart and cardiopathy.
  2. Athlete's heart involves structural and functional adaptations from regular training, complicating the differentiation from cardiac disorders.
  3. Cardiac remodeling varies by sport type, with anaerobic training leading to concentric hypertrophy and aerobic training resulting in eccentric hypertrophy.
  4. Endurance sports present diagnostic challenges due to physiological stress causing changes that may mimic cardiovascular disease.
  5. Recent findings support individualized strategies for athletes with hypertrophic cardiomyopathy, emphasizing multidisciplinary assessments.
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Frontiers In Endocrinology

  • August 13, 2026
Regulation of Bone and Marrow Microenvironment by Adipoq-Lineage Cells: Characteristics, Roles, and Mechanisms
  • Chunyan Zhang
  • Xiaohui Gu
  • Yuyan Xiang
  • Chanchan Zheng
  • Lei Yang
  • Jianquan Chen
  • August 13, 2026
  1. Bone marrow Adipoq-lineage cells include all cells that have expressed Adipoq and their descendants, playing critical roles in various physiological processes.
  2. Adipoq-lineage cells exhibit considerable heterogeneity, including true adipogenic precursors (MALPs) and bipotent adipo-osteoprogenitors (Adipoq+Osx+ cells).
  3. MALPs primarily function as lineage-restricted adipo-progenitors, contributing to marrow adipogenesis but showing minimal potential for osteoblast differentiation.
  4. Adipoq+Osx+ cells are located in the endosteal niche and significantly participate in the formation of both osteoblasts and adipocytes.
  5. The review emphasizes the need for further research to explore the regulatory mechanisms and functional characteristics of Adipoq-lineage cells.
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Npj Digital Medicine

  • August 13, 2026
Correction Notice: A Comprehensive Embedding Framework for Representing Sepsis Data
  • Tuo Liu
  • Yonglin Li
  • Hongyi Chen
  • Naiqing Li
  • Yan Zhang
  • Xuanqi Huang
  • Jin Wang
  • Rui Chen
  • Yuping Zeng
  • Yuntao Liu
  • Danwen Zheng
  • Darong Wu
  • Changdong Wang
  • Tao Yu
  • Xiaotu Xi
  • Zhongde Zhang
  • August 13, 2026

Objective: To address errors in the initial publication regarding the arrangement of variables and inaccuracies in unit labels and variable names. Key Findings:

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Frontiers In Surgery

  • August 13, 2026
Case Report of a Giant Cervical Internal Carotid Artery Aneurysm Accompanied by Multiple Intra- and Extracranial Aneurysms
  • Xavier Wong-Achi
  • Ambar Riley-Moguel
  • José Guillermo Flores-Vázquez
  • Alejandro Becerril-Mejía
  • Dora Yvette Lugo-Hilario
  • Edgar Nathal
  • August 13, 2026
  1. A case of a 29-year-old male with a giant, partially thrombosed cervical internal carotid artery aneurysm and multiple aneurysms is reported.
  2. The patient presented with ischemic stroke symptoms, including aphasia and right hemiplegia, due to significant hemodynamic compromise.
  3. Imaging revealed a giant cervical ICA aneurysm, multiple intracranial aneurysms, and a thoracic aortic dissection classified as DeBakey IIIa.
  4. Surgical management involved aneurysm trapping and aneurysmectomy without cerebral revascularization, yielding favorable short-term results.
  5. The case highlights the importance of thorough vascular evaluation and personalized decision-making in managing complex aneurysmal diseases.
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Frontiers In Cardiovascular Medicine

  • August 13, 2026
The role of the systemic inflammation response index (SIRI) as a mediator between the ApoB/ApoA1 ratio and atrial fibrillation, with combined biomarkers demonstrating superior discriminative power compared to individual markers
  • Chenyang Zheng
  • Meixue Jia
  • Bin Ning
  • August 13, 2026
  1. The study examined the systemic inflammation response index (SIRI) as a mediator between the ApoB/ApoA1 ratio and atrial fibrillation (AF).
  2. A total of 638 individuals were analyzed, including 212 with persistent AF, 212 with paroxysmal AF, and 214 controls without AF.
  3. SIRI was found to be a partial mediator in the inverse relationship between the ApoB/ApoA1 ratio and AF.
  4. The combined model of ApoB/ApoA1 and SIRI demonstrated superior discriminative power for detecting AF compared to individual markers.
  5. The findings indicate a significant link between elevated SIRI, decreased ApoB/ApoA1 levels, and higher odds of AF.
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Frontiers In Medicine

  • August 13, 2026
Editorial: Merging Behavioral Neuroscience with Educational Psychology in Healthcare Education
  • Sarmishtha Ghosh
  • Shereen El Tarhouny
  • Elena Nixon
  • Tayseer Mansour
  • August 13, 2026

Objective: To discuss the integration of behavioral neuroscience and educational psychology in healthcare training. Approach: Neurocognitive foundations and lea

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Frontiers In Immunology

  • August 13, 2026
Theoretical Framework for Immunologically Guided Skin Regeneration: Connecting Extracellular Matrix, Immune Response, and Skin Allografts
  • Marcelo Fonseca
  • August 13, 2026
  1. Fibrosis characterizes adult skin healing, contrasting with regenerative capabilities seen in fetal wound healing and other biological systems.
  2. Immunoguided Cutaneous Regeneration (ICR) proposes that regeneration depends on the interaction between a preserved extracellular matrix and a regulated immune response.
  3. The ICR framework outlines four phases of regeneration: biological barrier, immune activation, selective epidermal elimination, and regenerative remodeling.
  4. The graft acts as a temporary microenvironment, facilitating recipient cell recruitment and tissue reorganization during the regeneration process.
  5. The ICR model synthesizes historical and experimental data, offering a structured platform for future research on skin allotransplantation and regeneration.
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Frontiers In Pediatrics

  • August 13, 2026
Recent Developments in Diagnosing and Treating Abdominoscrotal Hydrocele: A Comprehensive Review
  • Fangyuan Li
  • Lina Zhang
  • Yalong Ma
  • Jinsong Sun
  • Baohua Yu
  • August 13, 2026
  1. Abdominoscrotal hydrocele (ASH) is a rare variant characterized by fluid collections in the scrotum and abdomen communicating via the inguinal canal.
  2. Diagnosis of ASH requires ultrasonography to confirm continuity between scrotal hydrocele and abdominal fluid collection, with MRI for complex cases.
  3. Proposed mechanisms for ASH formation include pressure-driven extension of a scrotal hydrocele and persistent patency of the processus vaginalis.
  4. Management options for ASH include observation, surgical intervention, and sclerotherapy, with no single surgical method proven superior.
  5. Multicenter studies with standardized criteria are necessary for improving diagnosis and management strategies for pediatric ASH.
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Frontiers In Oncology

  • August 13, 2026
Correction: Outcomes and Surgical Interventions for Patients with Intestinal Metastases from Advanced Epithelial Ovarian Cancer
  • Hongxia Wang
  • Yijie Li
  • Zhifen Yang
  • Jinxiu Wang
  • Kaiyun Qin
  • Yu Yu
  • Na Wang
  • Jingde Jia
  • Wenhong Zhao
  • Fenghua Zhang
  • Mario M. Leitao
  • Ran Meng
  • Yueping Liu
  • Yan Ding
  • Zhengmao Zhang
  • August 13, 2026

Objective: To correct inaccuracies in the published article regarding surgical treatment and prognosis in patients with intestinal metastases from advanced epit

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