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Gut

  • October 1, 2026
Global Prevalence and Impact of Pediatric Gut-Brain Interaction Disorders: Findings from the Rome Foundation's International Study
  • Samuel Nurko
  • Tiffany Taft
  • Olafur S Palsson
  • Marc Benninga
  • Carlo DiLorenzo
  • Rachel Rosen
  • Miguel Saps
  • Johann P Hreinsson
  • Xiucai Fang
  • Mizu Jiang
  • Caterina Strisciuglio
  • Erick Toro-Monjaraz
  • Ami D Sperber
  • October 1, 2026

Get a structured, in-depth report that distills clinical articles into clear insights, data, and analysis for deeper learning.

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Emergency Medicine Journal

  • October 1, 2026
Evaluating Sodium Correction Rates in Hyponatraemia: A Meta-Analysis on Clinical Outcomes
  • Ludwig Matrisch
  • Yannick Rau
  • Lars Graßhoff
  • Martin Nitschke
  • October 1, 2026

Objective: To determine whether a slower or more rapid correction of serum sodium levels in hyponatraemia is associated with lower mortality. Approach: Key Find

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5 min

Emergency Medicine Journal

  • October 1, 2026
Endovascular Resuscitation: A Comprehensive Review of Expert Practices
  • Thomas David Adams
  • Jon Barratt
  • James E Manning
  • Paul Rees
  • Ben Singer
  • Ed Benjamin Graham Barnard
  • October 1, 2026

Objective: To review endovascular resuscitation (EVR) techniques and their application in emergency medicine, particularly for patients in haemorrhagic shock or

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3 min

British Journal Of Ophthalmology

  • October 1, 2026
Comparative Efficacy of Vitamin A Ointment, Low-Dose Steroid Eye Drops, and Artificial Tears for Managing Socket Discharge and Discomfort: A Randomized Crossover Study
  • Arthur Yu Xiang Liu
  • Stijn W Van Der Meeren
  • Adriaan D Coumou
  • Rachel Kalmann
  • Dyonne T Hartong
  • October 1, 2026
  1. The study is the first systematic comparison of vitamin A ointment, low-dose steroid eye drops, and artificial tears for socket discharge.
  2. Vitamin A ointment significantly outperformed other treatments in reducing irritation and discharge in anophthalmic patients.
  3. Chronic mucopurulent discharge and discomfort are common issues faced by patients with ocular prostheses.
  4. The randomized crossover trial design allowed each participant to serve as their own control, enhancing treatment comparison reliability.
  5. Results from this study may inform personalized management approaches for ocular prosthesis complications.
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Gut

  • October 1, 2026
Impact of Pegylated Interferon Addition to Nucleos(t)ide Analogue Treatment on HBsAg Decline and Clearance: A Meta-Analysis of Individual Participant Data from Prospective Trials (PROSPER)
  • Edo J Dongelmans
  • Lesley A Patmore
  • Seng Gee Lim
  • Marc Bourliere
  • Shaowen Jiang
  • Nathalie Ganne-Carrie
  • Willem-Pieter Brouwer
  • Jordan J Feld
  • Yuxian Huang
  • Jose A Carrion
  • Teresa Broquetas
  • Qiankun Hu
  • Scott Fung
  • Fabrice Carrat
  • Fabien Zoulim
  • Bettina E Hansen
  • Qing Xie
  • Harry L A Janssen
  • Milan J Sonneveld
  • October 1, 2026
  1. This meta-analysis includes individual participant data from eight prospective studies evaluating peg-IFN added to NA therapy.
  2. The study establishes benchmark estimates for HBsAg decline and clearance through peg-IFN add-on therapy alongside NA treatment.
  3. Chronic hepatitis B affects approximately 254 million individuals globally, leading to over 1.3 million deaths annually.
  4. Achieving HBsAg loss is crucial as it can mitigate liver-related risks despite viral suppression with nucleos(t)ide analogues.
  5. The findings provide important reference points for designing future clinical trials aimed at achieving HBV cure.
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British Journal Of Ophthalmology

  • October 1, 2026
Longitudinal Analysis of Accelerated Myopic Shift in Aphakic and Pseudophakic Eyes Post-Congenital Cataract Surgery During Early Infancy Over a 13-Year Period
  • Tetsuro Oshika
  • Noriyuki Unoki
  • Mai Miyagi
  • Koji Nomura
  • Takafumi Mori
  • Naoko Matsuki
  • Takao Endo
  • Daijiro Kurosaka
  • Kazuno Negishi
  • Shigeo Yoshida
  • Toshiyuki Nagamoto
  • Sachiko Nishina
  • October 1, 2026

Get a concise, at-a-glance scorecard that distills clinical guidelines into key recommendations, patient insights, and treatment considerations.

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Emergency Medicine Journal

  • October 1, 2026
Comparison of an AI-Based Self-Triage System with Traditional Physical Triage Methods
  • Maaike Wempe
  • Frits Holleman
  • Michiel Schinkel
  • Michiel Gorzeman
  • October 1, 2026

Objective: To assess whether AI self-triage can correspond with urgency scores assigned by a conventional triage method in emergency department triage. Approach

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The Analytical Scientist

  • September 30, 2026
AI Reconstructs Molecular Structures From Simulated TERS Images
  • September 30, 2026
  • 3 min

Objective: To develop a deep learning model that reconstructs molecular geometries and identifies chemical elements from simulated tip-enhanced Raman spectrosco

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The Analytical Scientist

  • September 30, 2026
Machine Learning Alone Won’t Take Vibrational Spectroscopy Into the Clinic
  • September 30, 2026
  • 3 min

Objective: To examine the barriers to clinical adoption of machine learning-enabled vibrational spectroscopy, focusing on the complete analytical pipeline. Appr

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The Analytical Scientist

  • September 30, 2026
Vibe Coding Moves Beyond the Proteomics Prototype
  • James Strachan
  • September 30, 2026
  • 14 min
  1. Proteomics relies on software for data processing, with interdisciplinary teams developing tools for peptide identification and visualization.
  2. Mike MacCoss's lab has contributed to several widely used proteomics software tools, utilizing his expertise in mass spectrometry.
  3. Generative AI has enabled rapid exploratory software development, allowing researchers to test ideas quickly, though validation remains essential.
  4. MacCoss developed Osprey, an open-source peptide-centric DIA proteomics search tool, using vibe coding without typing code by hand.
  5. Osprey's main function is detection and scoring, allowing visual inspection of identifications in Skyline, enhancing data analysis.
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The Medicine Maker

  • September 30, 2026
FDA Approves First Gene Therapy for Sanfilippo Syndrome Type A
  • September 30, 2026
  • 3 min

Objective: To announce the FDA approval of Fayuvi, the first gene therapy for Sanfilippo syndrome type A. Approach: Treatment Description: Fayuvi (rebisufligene

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MDSpire News

  • September 29, 2026
First MCT8 deficiency therapy approved
  • Kathryn Wighton
  • September 29, 2026
  • 3 min

Objective: To announce the FDA approval of tiratricol for treating peripheral thyrotoxicosis in patients with MCT8 deficiency. Approach: FDA Approval: The FDA a

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MDSpire News

  • September 29, 2026
New dopamine agonist enters Parkinson disease care
  • Kathryn Wighton
  • September 29, 2026
  • 2 min
  1. The FDA approved tavapadon (Juvmo) for treating adults with Parkinson disease, as announced by AbbVie.
  2. The approval was based on the phase 3 TEMPO clinical trial program evaluating tavapadon in early Parkinson disease.
  3. In TEMPO-1, tavapadon improved daily living activities at week 26 compared to placebo, with significant score reductions.
  4. TEMPO-3 showed that tavapadon increased daily 'on' time without troublesome dyskinesia compared to placebo.
  5. Common mild to moderate adverse events included nausea, dizziness, and headache, with specific events varying by treatment.
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MDSpire News

  • September 29, 2026
Dietary fat type may matter after prostate cancer
  • Andrea Surnit
  • September 29, 2026
  • 4 min
  1. Replacing saturated or animal fats with monounsaturated or plant-based sources was linked to greater all-cause mortality in nonmetastatic prostate cancer patients.
  2. The study analyzed 4,884 patients diagnosed with nonmetastatic prostate cancer from 1986 to 2019, with a median follow-up of 12.8 years.
  3. Patients in the highest quintile of saturated fat intake had 24% higher all-cause mortality compared to those in the lowest quintile.
  4. Higher monounsaturated fat intake was associated with lower mortality, primarily due to reduced cardiovascular mortality.
  5. The study found no significant association between dietary fat intake and prostate cancer-specific mortality.
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MDSpire News

  • September 29, 2026
Spherical-equivalent contacts may shift binocular function
  • Andrea Surnit
  • September 29, 2026
  • 3 min

Objective: To assess changes in binocular vision measures when switching from spectacles to spherical-equivalent soft contact lenses in patients with low myopic

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2 min

MDSpire News

  • September 29, 2026
Aqueous cytology may diagnose iris metastasis without biopsy
  • Andrea Surnit
  • September 29, 2026
  • 3 min

Objective: To evaluate the effectiveness of aqueous humor cytology in diagnosing iris metastasis from lung adenocarcinoma based on a single patient case without

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MDSpire News

  • September 29, 2026
Wildfire pollution may pose cardiopulmonary risk
  • Andrea Surnit
  • September 29, 2026
  • 3 min
  1. Long-term exposure to wildfire-specific PM2.5 is linked to higher cardiopulmonary hospitalization risk compared to nonwildfire PM2.5.
  2. The study analyzed 57.3 million cardiovascular and 32.7 million pulmonary hospitalizations across 20 US states from 2006 to 2019.
  3. Each 1-µg/m³ increase in wildfire-specific PM2.5 was associated with increased hospitalization risk for various cardiopulmonary conditions.
  4. Subgroup analyses indicated higher hospitalization risks among racial and ethnic minorities and patients with obesity or diabetes.
  5. The study faced limitations including potential exposure measurement errors and lack of unique patient identifiers.
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Keck Medicine of USC

  • September 29, 2026
Meet Joni K. Doherty, MD
  • September 29, 2026
  • 4 min
  1. Joni K. Doherty, MD, is an otolaryngologist at Keck Medicine of USC with subspecialty certification in neurotology.
  2. She has advanced training in skull base surgery and focuses on hearing and balance related to the brain and nervous system.
  3. Doherty aims to see breakthroughs in gene therapy for restoring hearing and hopes for advancements in restoring auditory neurons.
  4. Her approach to patient care is characterized by attentiveness, compassion, and a calm bedside manner.
  5. Doherty values kindness and encourages medical students to choose specialties they love for a fulfilling career.
...more