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MDSpire News

  • October 27, 2026
FDA expands talazoparib use in prostate cancer
  • Mouj Hijazi
  • October 27, 2026
  • 3 min

Objective: The article examines the objective, findings, and clinical context described in FDA expands talazoparib use in prostate cancer. Approach: Approval: T

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The Analytical Scientist

  • October 27, 2026
Inside the $10 Optical Spectrometer
  • October 27, 2026
  • 3 min

Objective: To develop and evaluate a compact, low-cost near-infrared spectrometer for identifying materials and measuring concentrations, and to explore its pot

...more
2 min

MDSpire News

  • October 26, 2026
FDA expands weekly insulin use to children
  • Mouj Hijazi
  • October 26, 2026
  • 3 min

Objective: The article examines the objective, findings, and clinical context described in FDA expands weekly insulin use to children. Approach: Approval: The F

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2 min

MDSpire News

  • October 26, 2026
Pannus may recur after sodium amide eye injury
  • Andrea Surnit
  • October 26, 2026
  • 5 min

Objective: To describe the 36-month clinical course of a patient with severe bilateral ocular injury from sodium amide. Approach: Case: Investigators followed a

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1 min

MDSpire News

  • October 26, 2026
Cryptococcal cellulitis may lead to amputation
  • Andrea Surnit
  • October 26, 2026
  • 4 min

Objective: To describe a case of rapidly progressive primary cutaneous cryptococcosis with extensive tissue destruction despite no clinically apparent systemic

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MDSpire News

  • October 26, 2026
Remote care may reduce heart failure events
  • Kerri Miller
  • October 26, 2026
  • 5 min
  1. In a 24-week, multicenter, open-label trial, 506 adults recently hospitalized for heart failure were randomly assigned to mobile health management or usual care.
  2. Mobile health management combined daily transmission of biometric data and symptom questionnaires with health care team review, alerts, and video consultations.
  3. The primary endpoint of cardiovascular mortality or worsening heart failure occurred in 17% of the mobile health group and 41% of the usual care group.
  4. Worsening heart failure occurred in 14% of patients receiving mobile health management and 39% receiving usual care; cardiovascular mortality occurred in 4% and 8%, respectively.
  5. The authors noted limitations including the open-label design, lack of systematic adverse-event data, and uncertainty about staffing and workflow requirements for broader implementation.
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The Pathologist

  • October 26, 2026
Why TB Tests Aren’t Reaching Patients
  • Jessica Allerton
  • October 26, 2026
  • 9 min
  1. A study of 327 public facilities across seven states and Delhi found the largest gaps in essential TB diagnostic access at the primary-care level.
  2. Although national policy recommends AFB smear microscopy and chest X-ray at PHCs, complete availability of both generally ranged from 0% to 10% across surveyed regions.
  3. Across tiers where tests are recommended, AFB microscopy was available in about 78% of facilities, CBNAAT and chest X-ray in about 51%, and fluorescence microscopy in 31% of district hospitals.
  4. India had 97 CDST laboratories compared with an estimated need of 283, a shortfall of 62% based on the recommended ratio to TB treatment units.
  5. The article calls for connected diagnostic networks, including expanded molecular testing, accessible chest radiography, specimen transport, and stronger culture and drug-susceptibility testing capaci
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The Pathologist

  • October 26, 2026
Long-Legged Cats Inform Genetics Studies
  • October 26, 2026
  • 2 min

Objective: Investigate the genetic basis and molecular effects of Marfan syndrome in two affected domestic cats. Approach: Clinical assessment: Researchers desc

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2 min

The Analytical Scientist

  • October 26, 2026
GCxGC Detective Stories: Another Piece of the Precision Medicine Puzzle
  • James Strachan
  • October 26, 2026
  • 12 min

Get quick, clinically relevant Q&A that turns long-form articles into clear answers for faster learning and discovery.

Take the Quiz

MDSpire News

  • October 26, 2026
Vampire bats may link Chagas cycles
  • Andrea Surnit
  • October 26, 2026
  • 4 min

Objective: Assess Trypanosoma cruzi infection and genetic diversity in common vampire bats in northern Belize, and explore possible overlap with parasite lineag

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The Medicine Maker

  • October 26, 2026
Is Stem Cell Therapy Quality Control Missing Proteotoxic Cargo?
  • October 26, 2026
  • 3 min
  1. The review argues that proteostatic fitness should be considered a critical quality attribute for stem cell and extracellular vesicle products.
  2. Conventional release tests do not routinely assess misfolded or oxidized proteins that may accumulate during cell manufacturing.
  3. Repeated ex vivo expansion can impair protein-clearance processes, while senescent cells may release inflammatory molecules and extracellular vesicles reflecting their condition.
  4. In neural stem cell models, extracellular vesicles containing oxidized SOD1 were associated with mitochondrial dysfunction and secondary senescence in recipient cells.
  5. The authors propose senescence screening, EV cargo profiling, and targeted release assays, but note that thresholds require harmonization and cargo sanitization needs further assessment.
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The Medicine Maker

  • October 26, 2026
Engineering CAR T Cells Inside Solid Tumors
  • October 26, 2026
  • 3 min

Objective: Develop and evaluate a tumor-targeted, nonviral platform for generating CAR-expressing immune cells within solid tumors. Approach: Delivery system: R

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2 min

The Medicine Maker

  • October 26, 2026
Surviving the Squeeze
  • October 26, 2026
  • 7 min
  1. Investors and partners increasingly seek clear clinical differentiation, credible execution, and a realistic path from science to patients and commercial viability.
  2. Experts warn that underinvestment in early translational research could weaken the pipeline of companies and programs.
  3. Manufacturing strategy, scalability, and cost control should be addressed early because they affect commercialization and patient access.
  4. Companies are pursuing partnerships, licensing, mergers and acquisitions, and other financing approaches to support survival and further validation.
  5. Experts emphasize focused programs that address unmet clinical needs, demonstrate efficacy, and offer practical delivery and real-world value.
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Critical Care

  • October 26, 2026
Coronary Hypoxemia During VA-ECMO: Why Peripheral Oxygenation Monitoring May Be Insufficient
  • Ignazio Condello
  • Youssef El Dsouki
  • October 26, 2026

Objective: The article examines the objective, findings, and clinical context described in Coronary Hypoxemia During VA-ECMO: Why Peripheral Oxygenation Monitor

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Nature Medicine

  • October 26, 2026
Correction: Liquid Biopsy for Early Detection of Pancreatic Ductal Adenocarcinoma
  • Caiming Xu
  • Alessandro Mannucci
  • Haiyong Han
  • Ruben M. Munoz
  • Derek Cridebring
  • Sourat Darabi
  • Yuji Toiyama
  • Yoshinaga Okugawa
  • Gagandeep Singh
  • Mustafa Raoof
  • Joon Oh Park
  • James Lin
  • Gregory Idos
  • Michael J. Demeure
  • Erkut Borazanci
  • Douglas B. Evans
  • Susan Tsai
  • Eunsung Jun
  • Carlos Becerra
  • Scott A. Celinski
  • Laleh Melstrom
  • Vincent Chung
  • Guixin Zhang
  • Dong Shang
  • David L. Bartlett
  • Mitsuro Kanda
  • Song Cheol Kim
  • Valsamo Anagnostou
  • Giulia Martina Cavestro
  • John S. Bolton
  • Ali H. Zaidi
  • Daniel Von Hoff
  • Ajay Goel
  • October 26, 2026

Objective: Report a correction to the published article’s author name. Approach: Correction: The article initially misspelled Valsamo Anagnostou’s surname as “A

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1 min

Nature Medicine

  • October 26, 2026
Correction: Phenomic profiles and disease patterns in 1.9 million Our Future Health participants
  • Vincent J. Straub
  • Stefania Benonisdottir
  • Giovanni Scotti Bentivoglio
  • Neil Wary
  • Robert Campbell
  • Augustine Kong
  • Melinda C. Mills
  • October 26, 2026

Objective: To correct an error in the data shown in the “White” section of Fig. 1d. Approach: Correction: The affected data were corrected in the HTML and PDF v

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1 min

Journal Of Medical Internet Research

  • October 26, 2026
Digital Health Engagement and Psychological Distress: Understanding Their Complex Relationship
  • Jenna Congdon
  • October 26, 2026

Objective: The article examines the objective, findings, and clinical context described in Digital Health Engagement and Psychological Distress: Understanding T

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3 min

United States Department Of Health And Human Services

  • October 26, 2026
More Than 250 Hospitals Pledge to Improve the Nutritional Quality of Hospital Food
  • Assistant Secretary for Public Affairs (ASPA)
  • October 26, 2026

Objective: The article examines the objective, findings, and clinical context described in More Than 250 Hospitals Pledge to Improve the Nutritional Quality of

...more