Maternal and neonatal vitamin D metabolite profiling and its long-term impact on childhood growth: findings from the KLOTHO birth cohort
-
By
-
March 25, 2026
Objective:
To investigate the associations between maternal vitamin D metabolite profiles at birth and childhood anthropometry.
Key Findings:
- Trends of association were observed primarily for D3-related metabolites and linear growth indices.
- Selected adiposity-related measures also showed exploratory associations.
- No associations reached statistical significance after correction for multiple testing.
Interpretation:
The findings suggest potential links between D3-related metabolites at birth and later childhood growth, but they are not statistically confirmed and should be viewed as hypothesis-generating.
Limitations:
- Small sample size of 98 mother-child pairs limits the generalizability of findings.
- Exploratory nature of the analysis means results require further validation in larger studies.
Conclusion:
The study highlights the need for larger longitudinal studies to clarify the role of early-life vitamin D metabolism in childhood growth.
