Patterns of failure following stereotactic radiosurgery salvage for recurrent high-grade glioma
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By
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March 14, 2026
Objective:
To analyze patterns of failure and outcomes of salvage stereotactic radiosurgery (SRS) for recurrent high-grade gliomas (HGG), focusing on progression-free survival, overall survival, and local failure-free survival, while identifying factors predicting benefit from SRS.
Key Findings:
- SRS demonstrated potential benefits in local control for recurrent HGG, suggesting a need for tailored treatment approaches.
- Patterns of failure included local, marginal, and distant failures, with varying rates based on treatment characteristics, indicating the complexity of disease management.
- Demographic and clinical factors such as age and tumor characteristics influenced outcomes, highlighting the importance of personalized treatment strategies.
Interpretation:
The study suggests that salvage SRS can be an effective treatment option for recurrent HGG, with specific patient characteristics potentially predicting better outcomes.
Limitations:
- Single-institution study may limit generalizability; further multi-center studies are needed to validate findings.
- Small sample size and retrospective nature may introduce bias, necessitating caution in interpreting results.
Conclusion:
Salvage SRS for recurrent HGG shows promise, particularly in select patient populations, warranting further investigation to refine treatment strategies and identify optimal patient profiles.
