The diagnostic value of immune-inflammatory markers for diabetic kidney disease in type 2 diabetic patients: a meta-analysis
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By
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March 25, 2026
Objective:
To assess the diagnostic value of immune-inflammatory biomarkers for early and established diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus, emphasizing the importance of early diagnosis.
Key Findings:
- PLR showed a sensitivity of 0.74 (95% CI: 0.65–0.81) and specificity of 0.69 (95% CI: 0.54–0.81) for early DKD.
- SII demonstrated a sensitivity of 0.68 (95% CI: 0.59–0.75) and specificity of 0.64 (95% CI: 0.54–0.72) for established DKD.
- PLR, MLR, MPV, and RDW exhibited low to moderate diagnostic accuracy for both early and established DKD (AUC range: 0.68–0.74).
Interpretation:
Common immune-inflammatory markers have diagnostic value for both early and established DKD, with PLR being moderately accurate for early DKD and SII performing better for established DKD, which could influence clinical decision-making.
Limitations:
- Heterogeneity in study results, including variations in study populations and methodologies.
- Limited number of high-quality studies, which may affect the robustness of the findings.
- Potential biases in the included studies, such as publication bias and selection bias.
Conclusion:
The findings support the diagnostic potential of immune-inflammatory biomarkers in DKD, warranting further high-quality research, particularly longitudinal studies and trials to validate these results.
