The interplay of maturity-onset diabetes of the young, obesity, uncontrolled hypertension, and cannabinoid hyperemesis in the progression to end-stage renal disease: a case report
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By
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May 1, 2026
Objective:
To document the rapid progression to end-stage renal disease (ESRD) in a young patient with maturity-onset diabetes of the young (MODY), obesity, uncontrolled hypertension, and cannabinoid hyperemesis, emphasizing the role of cannabis use in renal decline.
Key Findings:
- Serum creatinine increased from 0.9 to 10.8 mg/dL.
- eGFR decreased from 115.98 to 4.69 mL/min/1.73 m².
- HbA1c levels remained inadequately managed (mean 9.79%).
- Urinary microalbumin rose significantly from 1.2 to 138 mg/g.
- BMI increased from 22.4 to 37.9 kg/m².
Interpretation:
The case highlights the interplay of MODY, obesity, uncontrolled hypertension, and cannabis use in accelerating renal decline, underscoring the need for early identification and management strategies tailored to high-risk patients.
Limitations:
- Single case study limits generalizability and may not represent broader populations.
- Lack of long-term follow-up data post-ESRD diagnosis limits understanding of long-term outcomes.
Conclusion:
This case illustrates an unusually rapid progression to ESRD in a young adult with multiple risk factors, emphasizing the importance of cohesive management strategies in high-risk patients and the need for further research in this area.