A systematic review and meta-analysis, conducted by Shumeng Han and colleagues from Peking Union Medical College, reveals that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) reduce serious infections by 11% compared to control groups. This analysis, covering 136 trials and 164,000 participants, found a relative risk of 0.89 for serious infections, with significant reductions noted in respiratory, skin, and musculoskeletal infections. Weight loss and HbA1c reductions correlated with lowered infection risks, highlighting the potential immunomodulatory effects of GLP-1 RAs. The findings may lead to new insights into infection risk management in diabetes treatment.
1. GLP-1 RAs reduce serious infections by 11%. 2. Meta-analysis involved 136 trials with 164,000 participants. 3. Significant reductions in respiratory, skin, and musculoskeletal infections. 4. Greater weight loss linked to lower infection risk. 5. HbA1c reduction affects infection risk. 6. Immunomodulatory effects may contribute to reduced infection incidence. 7. High certainty of evidence for serious infections, moderate for non-serious infections. 8. Study limitations include potential underreporting of infections.
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