ATM IHC Identifies POLE-Mutant Endometrial Cancer - Summary - MDSpire
From the Journals

ATM IHC Identifies POLE-Mutant Endometrial Cancer

Loss staining patterns help flag tumors for sequencing when molecular testing is limited.

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Research led by Xinyi Huang from the Department of Pathology at Xijing Hospital identifies immunohistochemistry patterns of ataxia telangiectasia-mutated (ATM) protein in endometrial carcinomas, yielding a notable 97% specificity and 80% accuracy for detecting polymerase-epsilon variants in tumors absent of mismatch repair deficiency and p53 abnormalities. A study involving 378 patients found that those with POLE variants predominantly exhibited nondiffuse-positive ATM staining. Despite limitations including a single-center approach and small sample size, the study proposes that ATM IHC may serve as a cost-effective screening tool for patients warranting further molecular testing.

Original Source(s)

ATM IHC Identifies POLE-Mutant Endometrial Cancer

  • by Andrea Surnit

  • April 2, 2026

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