From the Journals

Weight Regain Rapidly Follows GLP-1 Cessation

Systematic review finds most lost weight returns within two years of stopping weight management medication

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A systematic review published in The BMJ found that patients rapidly regained weight after discontinuing weight management medications like semaglutide and liraglutide, with a projected return to baseline weight within 1.7 years. Researchers analyzed data from 37 weight loss studies involving over 9,300 participants, indicating an average weight loss of 8.3 kg during treatment, followed by a regain of 0.4 kg per month post-cessation. The study emphasizes the need for continued treatment for effective long-term obesity management, highlighting rising concerns over treatment cost-effectiveness and discontinuation rates among patients.

Original Source(s)

Weight Regain Rapidly Follows GLP-1 Cessation

Systematic review finds most lost weight returns within two years of stopping weight management medication

  • by Conexiant News Staff

  • February 18, 2026

  • 4 min

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