From the Journals

CYP2D6 Testing and Postoperative Opioids

Investigators evaluate whether genotype-guided prescribing improves postoperative pain management.

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A recent randomized clinical trial explored the impact of genotype-guided opioid prescribing on postoperative pain management. Conducted across eight US health systems, the trial involved 1,602 patients and found that while genotype-guided prescribing improved the alignment of opioid selection with metabolic phenotype, it did not result in significant differences in postoperative pain intensity or overall opioid usage. Patients receiving genotype guidance had higher concordance in opioid prescribing, yet their pain outcomes were comparable to those under usual care. The findings suggest limited benefits of this approach in the context of multimodal pain management, as reported by Larisa H. Cavallari, PharmD, and colleagues.

Original Source(s)

CYP2D6 Testing and Postoperative Opioids

Investigators evaluate whether genotype-guided prescribing improves postoperative pain management.

  • by Kathryn Wighton

  • March 9, 2026

  • 5 min

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