Metformin and AMD: Signal or Noise?
Five-year population study details 37% lower incidence of intermediate AMD in type 2 diabetic patients prescribed metformin
A study linked metformin use to a 37% lower incidence of intermediate age-related macular degeneration (AMD) over five years in type 2 diabetes patients. Conducted under the ISDR program in Liverpool, UK, this population-based research utilized systematic retinal image grading instead of administrative data, enhancing its reliability. Although baseline data showed varying AMD stages, metformin did not affect early AMD progression. Findings suggest metformin's potential benefits beyond glycemic control, warranting further clinical trials, despite observational limitations.
- Metformin linked to a 37% lower incidence of intermediate AMD.- Study conducted in Liverpool under ISDR program.- Used systematic retinal image grading for accuracy.- No significant reduction in early AMD or late progression.- Findings emphasize potential benefits for metformin beyond glycemic control.- Observational study, causality not established.- Calls for further clinical trials on metformin for AMD reduction.