The 5-Hour Sepsis Test: No Cultures Required
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By
February 4, 2026
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8 min
A clinical study presented by Antoine Dewitte at the Sepsis Update Congress 2025 highlights a culture-free blood test that significantly improves the detection of bloodstream infections in suspected sepsis patients. The assay, which delivers results in approximately five hours, outperforms traditional blood cultures, detecting nearly three times as many infections. Its innovative method enriches intact bacterial cells for rapid genomic identification, reducing reliance on culture growth while facilitating early clinical decision-making and potential shifts in sepsis management practices.
1. Culture-free blood test shows nearly 3x detection compared to blood cultures. 2. Median turnaround time is 5 hours, significantly faster than traditional methods. 3. Assay improves identification of bacteria in low-load bloodstream infections. 4. The test's methodology reduces reliance on bacterial growth. 5. High sensitivity (95%) and negative predictive value (98%) reported. 6. Useful in real-world ICU scenarios with patients on antibiotics. 7. Potential to reduce unnecessary broad-spectrum antibiotic usage. 8. Future studies needed for wider implementation and validation.
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