From the Journals

Rethinking Acetaminophen in the NICU

Prophylactic treatment closed the ductus arteriosus faster but did not reduce mortality or severe morbidity in extremely premature infants

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A phase 3 randomized clinical trial, the TREOCAPA trial, assessed the efficacy of prophylactic intravenous acetaminophen in extremely preterm infants, focusing on its impact on ductus arteriosus closure and long-term survival without severe morbidity. Conducted across 43 neonatal intensive care units in 14 European countries, the study involved 778 infants and found that while acetaminophen accelerated ductus closure, it did not improve survival rates or reduce severe morbidity. Notably, cholestasis was more frequent in the acetaminophen group, raising safety concerns.

Original Source(s)

Rethinking Acetaminophen in the NICU

Prophylactic treatment closed the ductus arteriosus faster but did not reduce mortality or severe morbidity in extremely premature infants

  • by Kerri Miller

  • February 17, 2026

  • 4 min

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