Patient Insights on HRQOL in Chronic GVHD
January 7, 2025
-
3 min
Researchers conducted a study to analyze the health-related quality of life (HRQOL) impacts of cutaneous chronic graft-vs-host disease (GVHD). The study identified five HRQOL domains based on patient perspectives, revealing significant skin-related symptoms, social, psychological, and physical impairments. It emphasized the need for disease-specific tools to assess treatment efficacy and improve clinical care.
1. 65% of patients with cutaneous graft-vs-host disease reported dry skin, 61% reported tightness, and nearly half struggled with itchiness. 2. The study identified five HRQOL domains: skin changes and symptoms, social functioning, psychological and emotional functioning, physical functioning, and general health perceptions. 3. Significant gaps in patient-reported outcome measures for cutaneous chronic GVHD were identified, emphasizing the need for disease-specific tools. 4. Disease duration varied significantly between the epidermal and sclerotic subtypes. 5. The study cohort included 31 adults with active cutaneous chronic GVHD from the University of Pennsylvania. 6. Most participants had severe disease, with sclerotic and combination subtypes more frequently classified as severe compared with epidermal cases. 7. Thematic analysis revealed prevalent social impairments, psychological effects, and physical limitations.
Listen Tab content
