Sex-related disparities in antimicrobial dosing for sepsis can lead to treatment failures and increased drug toxicity, as highlighted in a study by Dr. Helena Barrasa and colleagues. They identified that current antibiotic dosing protocols frequently disregard important sex- and gender-based pharmacokinetic differences. Women, for instance, are more prone to adverse drug reactions due to physiological variations, which can lead to overexposure. Conversely, younger men tend to have subtherapeutic concentrations due to increased renal clearance. Addressing these disparities is crucial for improving sepsis outcomes.
1. Sex- and gender disparities exist in antimicrobial dosing for sepsis.2. Women often have physiological differences affecting drug metabolism.3. Higher body fat increases risk of drug toxicity in women.4. Men may experience subtherapeutic levels of renally excreted antibiotics.5. The Cockcroft-Gault equation underestimates renal function in women.6. Early broad-spectrum antibiotics are often underprescribed for women.7. Recognizing sex differences is vital for effective sepsis management.
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