Digging for Antibiotics in Ancient Microbes
October 2, 2025
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2 min
Research from the Perelman School of Medicine at the University of Pennsylvania has unveiled potential new antibiotics, termed archaeasins, derived from archaea, microorganisms found in extreme conditions. Advanced AI techniques identified 12,623 candidates, leading to the synthesis of 80 compounds with a remarkable 93% showing efficacy against resistant bacteria. Notable among them, Archaeasin-73 demonstrated significant effectiveness in mouse models. This innovative approach highlights the potential of AI in accelerating antibiotic discovery, particularly for treating complex infections like those caused by carbapenem-resistant Acinetobacter baumannii.
1. New antibiotics called archaeasins derived from archaea found. 2. Advanced AI identified 12,623 candidates, synthesizing 80. 3. 93% of synthesized archaeasins showed activity against resistant bacteria. 4. Archaeasin-73 was particularly effective in mouse models. 5. Focus on complicated skin infections, especially concerning Acinetobacter baumannii. 6. Highlights potential for AI in accelerating antibiotic discovery. 7. Researchers also consider novel delivery methods for these compounds.
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