What Cats Can Tell Us About Cancer
Large-scale feline sequencing study highlights diagnostic and therapeutic targets shared with human cancers
Research on nearly 500 domestic cats with cancer has identified genetic mutations resembling those in human tumors, making feline cancer a promising model for developing diagnostics and therapies. The study, published in Science, analyzed 493 tumor–normal pairs from 13 cancer types, uncovering 31 key driver genes and prevalent mutations like TP53 and FBXW7, which also appear in human malignancies. The findings suggest conserved cancer pathways between species and the potential for feline clinical trials to inform human cancer treatment, as noted by lead researcher Geoffrey Wood from the Ontario Veterinary College.
1. Study analyzed 493 tumor-normal pairs from domestic cats with cancer.2. Identified 31 likely driver genes linked to cancer.3. TP53 was the most frequently mutated gene.4. FBXW7 alterations show overlap with human breast cancer.5. Research opens potential for genotype-guided therapy in cats.6. Establishes a genomic reference dataset for feline cancers.7. Highlights shared environmental exposures between pets and humans.