Commentary & Perspectives
Precision Therapies: The Last Mile
Why therapies still take years to reach the patients who need them
Despite advancements in drug development and approval, patients often face significant delays in diagnosis, sometimes extending to a decade, even for prevalent conditions. This issue stems from inadequate recognition of symptoms by primary care providers and subsequent referrals to specialists who may lack complete patient histories. The current commercial model primarily targets physicians, neglecting the early stages of the patient journey, particularly in the context of precision medicine where timely diagnosis is vital. An integrated approach that encompasses patient trajectories is necessary to bridge this gap and ensure timely treatment.
1. Drug approval does not guarantee timely diagnosis for patients. 2. Delays can be over a decade for rare diseases. 3. Primary care providers often miss critical symptoms. 4. Commercial models focus on physicians, not patient journeys. 5. Precision medicine demands timely diagnosis to be effective. 6. Machine learning can identify patterns in patient data. 7. There is a call for a systems approach to connect patients with appropriate care.