Long-term data from the 10-year follow-up of the APPAC trial indicates that antibiotic therapy remains an effective treatment for uncomplicated acute appendicitis in adults. Over 50% of patients initially treated with antibiotics avoided surgery, with a recurrence rate of 38% and a surgical intervention rate of 44% within the decade. Most recurrences occurred within the first two years, and the long-term complication rates favored the antibiotic group. Quality of life was comparable between both treatments, and patient satisfaction was notably high among those who avoided appendectomy. The study underscores the importance of patient selection for this treatment approach, ensuring imaging confirms uncomplicated appendicitis.
1. Antibiotic therapy can effectively treat uncomplicated acute appendicitis. 2. Over 50% of patients avoided surgery after antibiotic treatment. 3. Recurrence rate after 10 years was 38%. 4. Complication rates were lower for antibiotic therapy compared to surgery. 5. Patient satisfaction was high, especially among those avoiding surgery. 6. Careful selection of patients is critical. 7. MRI was used to assess appendiceal tumors after 10 years. 8. Quality of life was similar for both treatment groups.
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