From the Journals

How Does Trisomy 21 Affect Fetal Hematopoiesis?

Fetal hematopoietic stem cells in Down syndrome are 'primed' for differentiation, as revealed by single-cell multi-omics of over 1.1 million cells, potentially explaining early hematological abnormalities.

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A recent study illustrated that hematopoietic stem cells in fetuses with Down syndrome exhibit signs suggesting their priming for differentiation, indicative of prenatal changes in blood cell development. This dysregulation of hematopoiesis was linked to alterations in gene expression, chromatin accessibility, and the regulatory landscape, potentially impacting the risk of leukemia. Notably, trisomy led to enhanced accessibility and gene upregulation in Down syndrome hematopoietic stem cells, along with increased mitochondrial mass and oxidative stress levels.

Original Source(s)

How Does Trisomy 21 Affect Fetal Hematopoiesis?

Fetal hematopoietic stem cells in Down syndrome are 'primed' for differentiation, as revealed by single-cell multi-omics of over 1.1 million cells, potentially explaining early hematological abnormalities.

  • by Kathryn Wighton

  • October 4, 2024

  • 3 min

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