FDA & Government News

Exercise in a Pill Is Now in Human Trials

Atrogi's ATR-258 just dosed its first subjects — and the muscle data it's hunting could reframe how we treat weight loss.

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The University of Copenhagen has initiated human trials for ATR-258, an innovative oral compound developed by Atrogi to mimic the positive metabolic effects of exercise, focusing on fat loss while preserving muscle. This GRK2-biased β2-agonist aims to enhance muscle-building signaling without the cardiovascular risks associated with traditional β2-agonists. An initial Phase 1 trial confirmed its safety, and this new study targets muscle physiology data in overweight males, aiming to address muscle-wasting issues during weight loss and aging.

Original Source(s)

Exercise in a Pill Is Now in Human Trials

  • by Kerri Miller

  • March 18, 2026

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