Bundled Care Strategy May Reduce Moderate to Severe AKI - Summary - MDSpire
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Bundled Care Strategy May Reduce Moderate to Severe AKI

Multicenter trial finds KDIGO-recommended approach lowers moderate to severe acute kidney injury; measured 90-day outcomes were similar between groups

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The BigpAK-2 trial demonstrated that a preventive care strategy based on Kidney Disease: Improving Global Outcomes (KDIGO) guidelines can significantly reduce the occurrence of moderate to severe acute kidney injury (AKI) in surgical patients at high risk. Conducted across 34 hospitals in Europe with 1,180 participants, the study showed a lower incidence of AKI (14% in the intervention group vs. 22% in controls) within 72 hours post-surgery. Key interventions included hemodynamic optimization and avoidance of nephrotoxic medications, though adherence varied. This strategy emphasizes the importance of targeted supportive care to mitigate AKI risk in vulnerable surgical populations.

Original Source(s)

Bundled Care Strategy May Reduce Moderate to Severe AKI

  • by Kathryn Wighton

  • April 17, 2026

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