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How Metal Imbalance Rewires Metabolism 

Integrated metallomics and metabolomics map metabolic responses to metal imbalance

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  • February 25, 2026

  • 2 min

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A study utilizing metallomics and metabolomics in Caenorhabditis elegans reveals how fluctuations in metal homeostasis alter metabolic pathways. Researchers assessed the effects of acute and chronic exposure to iron, manganese, and zinc on cellular metabolism. The findings indicate that zinc serves as a key regulator within this balance, while iron and manganese negatively affect zinc levels. Notably, chronic iron exposure disrupts carbon metabolism, potentially linking metal imbalance to neurodegenerative diseases, particularly in energy-demanding neurons. The findings advocate for extended research on metal-speciation analysis across different models.

Original Source(s)

How Metal Imbalance Rewires Metabolism 

Integrated metallomics and metabolomics map metabolic responses to metal imbalance

  • February 25, 2026

  • 2 min

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