UVB and Psoriasis: More Than Immunosuppression - Summary - MDSpire
Commentary & Perspectives

UVB and Psoriasis: More Than Immunosuppression

UVB's benefits may run deeper than inflammation suppression—cholesterol metabolism could be a key link.

Share

Recent insights into psoriasis indicate that psoriatic skin may have increased cholesterol synthesis, influencing the disease's inflammatory pathways. Andrzej T. Slominski from the University of Alabama at Birmingham and collaborators propose a hypothesis explaining how UVB phototherapy could be effective. They suggest that UVB light disrupts cholesterol metabolism, thus lowering substrates for cholesterol production and activating metabolites that inhibit inflammatory signaling pathways. This perspective opens new avenues for treating psoriasis by integrating metabolic insights with established therapies.

Original Source(s)

UVB and Psoriasis: More Than Immunosuppression

  • by Kerri Miller

  • April 6, 2026

Related Content

Skin Fluorescent Imaging Shows High Sensitivity, Specificity for Discriminating Melanoma Lesions

Skin fluorescent imaging demonstrated high sensitivity and specificity for the discrimination of low- and high-risk lesions, showing an alternative, noninvasive approach to melanoma biopsies, accordin...

Pathology Machine-Learning Models and Diagnosis of Nonmelanoma Skin Cancers in Resource-Limited Settings

Artificial intelligence (AI) models, which were pretrained on vast data sets, outperformed a standard baseline model in identifying nonmelanoma skin cancers from digital images of tissue samples, base...

Tanning Bed Exposure and Melanoma Risks

Research has elucidated how radiation from tanning beds increases the mutation burden across a broad area of melanocytes, thereby significantly raising the risk of developing melanoma. Findings publis...