Clinical Guidelines
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Ivosidenib: IDH1 Inhibitor for the Treatment of Acute Myeloid Leukemia

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  • July 22, 2019

  • 13 min

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Acute myeloid leukemia (AML) is a hematologic cancer characterized by the uncontrolled growth of immature blood cells. Prognosis depends on patient factors like age and genetic markers. While younger patients may achieve remission with standard therapies like daunorubicin and cytarabine, older patients often struggle. Treatment options include hematopoietic stem cell transplant for eligible patients and new targeted therapies such as ivosidenib, an IDH1 inhibitor. This agent shows promise for relapsed/refractory AML cases, with clinical trials ongoing to evaluate its efficacy and safety.

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