From the Journals

Distinct Monocyte State Linked to Fatigue and Pulmonary Impairment in Long COVID

Single-cell profiling reveals persistent immune alterations associated with fatigue severity and impaired lung function.

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A recent study has identified a specific immune cell state linked to chronic fatigue and respiratory issues in long COVID patients. Researchers discovered a CD14-positive monocyte transcriptional state, termed LC-Mo, associated with systemic immune dysfunction and ongoing inflammation lasting up to nine months post SARS-CoV-2 infection. Patients exhibiting higher LC-Mo levels showed greater fatigue and poorer respiratory outcomes, suggesting a potential link between immune alterations and lung remodeling. While these associations are evident, further research is needed to confirm causality and explore therapeutic options.

Original Source(s)

Distinct Monocyte State Linked to Fatigue and Pulmonary Impairment in Long COVID

Single-cell profiling reveals persistent immune alterations associated with fatigue severity and impaired lung function.

  • by Olivia Anderson

  • February 4, 2026

  • 3 min

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