Lung Cancer's Paradox: Never-Smokers Outlive Smokers?
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By
January 15, 2025
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3 min
A retrospective cohort study compared the clinical characteristics, survival rates, and histopathology findings of never-smokers and smokers with non–small cell lung cancer, revealing that never-smokers were more likely to present with stage IV disease but demonstrated significantly better long-term survival rates, living an average of 2.7 years longer. The study emphasized potential implications for screening protocols and targeted management strategies based on the differences observed between the two groups.
1. Never-smokers with non–small cell lung cancer demonstrated better long-term survival rates, living an average of 2.7 years longer than smokers. 2. Clinical characteristics showed that smokers were older and more often male. 3. Subsolid and ground-glass nodules were exclusively adenocarcinoma. 4. Never-smokers were more frequently diagnosed with stage IV disease, positive nodal disease, and metastatic disease. 5. The study highlighted potential implications for screening protocols and targeted management strategies.
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