IPF Cough: Opioid-Based Approach Tested
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January 28, 2026
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3 min
A phase 2b randomized clinical trial evaluated the efficacy of nalbuphine, an oral κ-opioid receptor agonist, in treating chronic cough in patients with idiopathic pulmonary fibrosis (IPF). Conducted across 52 sites worldwide, the study showed significant dose-dependent reductions in cough frequency after 6 weeks, with the highest dose achieving a 60% reduction compared to placebo. Improvements were also noted in cough severity and quality of life for higher dose groups. Despite mild adverse effects, findings highlight the need for further large-scale studies.
1. Nalbuphine is an oral κ-opioid receptor agonist evaluated for chronic cough in IPF.2. Phase 2b trial conducted at 52 sites across 10 countries.3. Significant reductions in cough frequency: 60% with 108 mg dose vs 17% placebo.4. Improvement in cough severity and quality of life for higher doses.5. Common mild adverse events included nausea, vomiting, dizziness.6. Key limitation: only 6 weeks of treatment duration.7. Further studies required to confirm findings in larger populations.
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