From the Journals

Ivermectin vs Permethrin for Scabies

Investigators evaluate household-level cure rates in dermoscopy-confirmed cases at day 28.

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A multicenter, assessor-blinded trial showed that topical 5% permethrin cream outperformed oral ivermectin for treating classic scabies, achieving a clinical cure rate of 88.5% compared to 71.8% for ivermectin. Conducted across 28 French hospitals with 1,092 participants from 294 households, the SCRATCH trial demonstrated permethrin's statistical superiority at day 28 post-treatment. While both treatments were generally well-tolerated, compliance and ease of use were emphasized as important factors in clinical decision-making, according to lead author Franck Boralevi, a dermatologist at Hôpital des Enfants.

Original Source(s)

Ivermectin vs Permethrin for Scabies

Investigators evaluate household-level cure rates in dermoscopy-confirmed cases at day 28.

  • by Kathryn Wighton

  • March 3, 2026

  • 3 min

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