From the Journals

Frailty Linked to Higher Mortality Risk in Men Than Women After Heart Attack

National study of more than 900,000 patients finds frailty more prevalent in women but more strongly associated with death in men, highlighting a “sex-frailty paradox” in outcomes.

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A national study analyzed 931,133 patients hospitalized with acute myocardial infarction (AMI) from 2005 to 2019 and revealed that while frailty is more common in women, it correlates with higher mortality rates in men. The research, led by Hasan Mohiaddin from Keele University, used the Secondary Care Administrative Records Frailty (SCARF) index to classify frailty levels. Findings indicated that severe frailty was linked to a 26% greater increase in 1-year mortality for males compared to females, suggesting a critical “sex-frailty paradox” in AMI outcomes.

Original Source(s)

Frailty Linked to Higher Mortality Risk in Men Than Women After Heart Attack

National study of more than 900,000 patients finds frailty more prevalent in women but more strongly associated with death in men, highlighting a “sex-frailty paradox” in outcomes.

  • by Olivia Anderson

  • March 2, 2026

  • 3 min

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