The interaction between immune molecules IL-31 and IL-33 is pivotal in driving the intense itching associated with atopic dermatitis, a chronic inflammatory skin condition characterized by a compromised barrier and recurrent eczema-like lesions. This cytokine axis creates a feedback loop linking immune activation to nerve signaling, exacerbating itching when the skin barrier is compromised. Elevated levels of IL-31 and IL-33 correlate with disease severity, providing insights into potential targets for new treatments and helping clinicians monitor therapeutic responses.
1. IL-31 and IL-33 are cytokines linked to itch in atopic dermatitis.2. Atopic dermatitis is characterized by dry skin and itchy lesions. 3. IL-33 acts as an alarmin released during skin injury.4. IL-31 directly stimulates itch-sensing nerve fibers.5. Increased IL-31 and IL-33 correlate with disease severity, aiding treatment monitoring.
Listen Tab content
