From the Journals

Collagenase Effective for Recurrent Dupuytren

Collagenase treatment improves contracture recurrence in patients after prior surgery

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Injection therapy using collagenase clostridium histolyticum (CCH) is shown to be a viable non-surgical alternative for treating recurrence of Dupuytren contracture in patients previously operated on. Conducted at ten clinical centers, a study analyzing 101 patients revealed a significant improvement in joint extension after CCH therapy. Patients experienced a median recurrence of symptoms 36 months post-surgery, with a mean baseline contracture of 52°. At follow-up, clinical success was achieved for 65% of joints treated, suggesting that CCH therapy may effectively mitigate complications associated with repeat surgical procedures.

Original Source(s)

Collagenase Effective for Recurrent Dupuytren

Collagenase treatment improves contracture recurrence in patients after prior surgery

  • by Alun Evans

  • March 11, 2026

  • 3 min

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