Towards a Unified Picture of Chromatin Biology
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By
January 14, 2026
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5 min
A team from CABIMER, led by Román González Prieto, has developed PLAMseq, a groundbreaking method that combines proximity labeling with mass spectrometry and DNA sequencing. This technique captures protein environments and genomic locations without requiring specific antibodies, thus sidestepping significant cost and ethical issues. The research addresses challenges in studying SUMOylation and chromatin-associated proteins, improving the understanding of epigenetic regulation and potentially transforming future research methodologies.
1. PLAMseq combines proximity labeling, mass spectrometry, and DNA sequencing.2. The method bypasses the need for specific antibodies, making it cost-effective and ethical.3. It allows for direct studies of chromatin-associated proteins.4. PLAMseq addresses challenges in studying SUMOylation.5. Future research aims to characterize histone SUMOylation and protein interactions.
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