MDSpire - Summary
Commentary & Perspectives

Limits of Negative Infection Studies in AD

Perspective argues that study design and measurement challenges may obscure potential links between infection and disease

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The perspective by Chatila and colleagues published in 'Alzheimer's & Dementia' explores the complex relationship between herpes simplex virus-1 (HSV-1) and Alzheimer's disease. It argues that many studies dismissing a link may suffer from limitations in design and exposure measurement, like using serum antibody titers that do not reflect central nervous system conditions. The researchers suggest future studies should better account for genetic factors and the nuances of infections, particularly how they might contribute to Alzheimer's pathology, emphasizing the remaining gaps in understanding pathogenic processes.

Original Source(s)

Limits of Negative Infection Studies in AD

  • by Kerri Miller

  • March 26, 2026

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