Clinical Guidelines

Mass Spectrometry Takes on Amyloid 

New guidelines target false negatives, Congo red variability, and the growing role of mass spectrometry in amyloid typing

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  • February 18, 2026

  • 9 min

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The College of American Pathologists has introduced new guidelines to enhance the accuracy of amyloid diagnostics. As the detection of amyloid is critical for timely treatment, these guidelines propose standardized methods, such as optimized Congo red protocols and the adoption of mass spectrometry-based proteomics as the benchmark for fibril typing. The panel discusses the limitations of traditional methods and emphasizes the need for consistency in laboratory practices to mitigate misclassification, ensuring better patient management and outcomes in diagnosing amyloidosis.

Original Source(s)

Mass Spectrometry Takes on Amyloid 

New guidelines target false negatives, Congo red variability, and the growing role of mass spectrometry in amyloid typing

  • February 18, 2026

  • 9 min

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