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GLP-1 Analysis: Riding the Wave of Peptide Innovation

The remarkable commercial success of GLP-1 receptor agonists is fueling investment, accelerating science, and creating new analytical challenges. Here, we outline the hurdles these peptides present, explore methods for impurity profiling and structural characterization, and consider strategies to keep pace with this fast-moving field.

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The rise of GLP-1 receptor agonists, particularly Ozempic, marks a significant advance in peptide therapeutics. These medications, known for their efficacy in treating type 2 diabetes and obesity, are now being explored for broader applications. Innovations in drug delivery, including oral formulations and multi-agonist therapies, coupled with advancements in impurity profiling and analytical methods, highlight the need for rigorous quality control as market demand increases. Understanding the complexity of these therapies is essential for developing safer, more effective treatments.

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GLP-1 Analysis: Riding the Wave of Peptide Innovation

The remarkable commercial success of GLP-1 receptor agonists is fueling investment, accelerating science, and creating new analytical challenges. Here, we outline the hurdles these peptides present, explore methods for impurity profiling and structural characterization, and consider strategies to keep pace with this fast-moving field.

  • by Amanda M. Guiraldelli, Piotr Alvarez, Koen Sandra

  • January 26, 2026

  • 17 min

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