From the Journals

PPIs Linked to Worse Breast Cancer Outcomes

Pooled analysis of nearly 23,000 patients shows medication commonly used for acid reflux may interfere with cancer treatment effectiveness.

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A recent pooled analysis involving 23,211 breast cancer patients revealed that the use of proton pump inhibitors (PPIs) is linked to poorer survival rates and increased adverse events in cancer treatments. This study, which analyzed data from 19 clinical trials, suggested that PPIs may negatively affect cancer outcomes by disrupting gut microbiota and altering the effectiveness of anti-cancer therapies. Lead author Natansh D. Modi from Flinders University emphasizes the importance of monitoring concomitant medications in breast cancer management.

Original Source(s)

PPIs Linked to Worse Breast Cancer Outcomes

Pooled analysis of nearly 23,000 patients shows medication commonly used for acid reflux may interfere with cancer treatment effectiveness.

  • by Mouj Hijazi

  • November 18, 2025

  • 3 min

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