FDA Approves First Therapy for Non-cystic Fibrosis Bronchiectasis
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August 12, 2025
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2 min
The FDA has approved Brinsupri (brensocatib), the first targeted therapy for adults and adolescents with non-cystic fibrosis bronchiectasis, a condition affecting approximately 500,000 patients in the U.S. This innovative once-daily oral dipeptidyl peptidase 1 inhibitor is designed to target neutrophilic inflammation, a key factor in disease progression. Clinical trials, including Phase 3 ASPEN and Phase 2 WILLOW, demonstrated that brensocatib significantly reduces annualized exacerbation rates and improves patient outcomes.
1. Brinsupri (brensocatib) is FDA approved for non-cystic fibrosis bronchiectasis. 2. Targets neutrophilic inflammation, addressing disease pathophysiology. 3. Reduces annual exacerbation rates by more than 21%. 4. Most frequent adverse reactions include upper respiratory infections and hypertension. 5. Available through specialty pharmacies in the US, with international approvals underway.
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