A large-scale postmortem study has unveiled hundreds of genes and biological pathways linked to Alzheimer's disease (AD) using brain tissue from 207 African American donors. This extensive research, published in 'Alzheimer’s & Dementia,' identifies 482 genes with significant expression differences between individuals with AD and healthy controls. Notably, the gene ADAMTS2 exhibited heightened expression in those with AD, connecting genetic risk to gene activity changes. This study underscores the importance of diverse cohorts in understanding disease mechanisms and highlights energy metabolism's role in neurodegeneration.
1. Study analyzed RNA sequencing from 207 African American brains. 2. Found 482 differentially expressed genes in AD. 3. ADAMTS2 showed 1.5-fold higher expression in AD. 4. Genes linked to cellular energy metabolism were affected. 5. Identified coordinated gene expression changes. 6. Genetic variants influence nearby gene expression. 7. Highlights importance of diverse cohorts in AD research.
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