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A Roadmap for Organoid Toxicology

How digital pathology and AI are helping validate complex in vitro models for preclinical safety testing

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Luisa Bell, a Neuropathology scientist at Roche, presented groundbreaking advancements in complex in vitro models (CIVMs) at DP&AI: Europe 2025, highlighting their potential to enhance drug development by providing high-fidelity simulations of human tissues and the blood-brain barrier for preclinical toxicity testing. Through a multidisciplinary approach, the team has developed AI algorithms to streamline the assessment of organoids, bridging gaps in traditional histology and offering improved methods for characterizing drug responses. This potentially paves the way for a more effective shift from bench to bedside in clinical practices.

Original Source(s)

A Roadmap for Organoid Toxicology

How digital pathology and AI are helping validate complex in vitro models for preclinical safety testing

  • by Jessica Allerton

  • February 17, 2026

  • 7 min

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