From the Journals

Proton Pump Inhibitors and Cancer Risk

Investigators evaluate cancer risk tied to extended acid suppression therapy.

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A multinational case-control study across five Nordic countries found no significant correlation between long-term proton pump inhibitor (PPI) use and the risk of gastric non-cardia adenocarcinoma. The research included over 17,000 patients and matched controls, analyzing prescription histories extending back at least five years. Adjustments for various health factors, including obesity and medication use, showed that any observed risk vanished after accounting for confounders. Despite thorough measures against bias, some limitations remain, as highlighted by lead author Onyinyechi Duru from Karolinska Institutet.

Original Source(s)

Proton Pump Inhibitors and Cancer Risk

Investigators evaluate cancer risk tied to extended acid suppression therapy.

  • by Kathryn Wighton

  • February 19, 2026

  • 3 min

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