From the Journals

Positive Urine Cytology Reveals Melanoma

Rare case links prior melanoma in situ to ureter and porta hepatis metastases

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A 77-year-old woman developed metastatic melanoma four years after excision of a lesion previously diagnosed as melanoma in situ. Presenting with symptoms like hematuria and abdominal pain, imaging revealed extensive metastases primarily affecting the right ureter and porta hepatis. Histopathological evaluations confirmed metastatic disease, distinguishing it from primary urothelial carcinoma. The case highlights the rarity of such occurrences and emphasizes the critical need for thorough assessment and immunohistochemical analysis in atypical genitourinary tumors, ensuring accurate diagnosis and prompt treatment with systemic immunotherapy.

Original Source(s)

Positive Urine Cytology Reveals Melanoma

Rare case links prior melanoma in situ to ureter and porta hepatis metastases

  • by Jess Allerton

  • February 16, 2026

  • 3 min

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