A recent study by scientists at the Instituto Latinoamericano de Salud Cerebral reveals that molecules in donated blood may influence the progression of Alzheimer’s-like pathology. The research utilized Tg2576 transgenic mice to assess the impact of whole blood infusions from young and old wild-type donors over a 30-week duration. Results indicated that mice receiving blood from older donors exhibited significantly impaired cognitive performance and increased amyloid-β deposition. The study's proteomic analysis uncovered molecular changes related to synaptic signaling, suggesting peripheral blood factors could modulate neurodegeneration.
1. Study by BrainLat assessed blood's influence on Alzheimer's-like pathology. 2. Tg2576 mice infused with blood from older donors showed cognitive decline. 3. Older mice had increased amyloid-β deposition. 4. Proteomic analysis revealed changes related to synaptic signaling. 5. Increased levels of α2δ2 subunit of calcium channels were noted. 6. Findings suggest that blood factors could modulate neurodegeneration. 7. Further research is needed to identify specific circulating factors.
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