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From the Journals

Low-Dose PFAS Exposure Alters Cellular Metabolism 

Cell culture model reveals lipid remodeling and oxidative stress following prolonged PFAS exposure 

  • March 24, 2026

  • 2 min

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A study utilizing a long-term cell culture model combined with targeted mass spectrometry and transcriptomics indicates that low-dose exposure to per- and polyfluoroalkyl substances (PFAS) can significantly alter cellular metabolism, despite minimal intracellular accumulation. Researchers exposed hTERT RPE-1 human epithelial cells to PFOA and PFOS over 24 weeks, observing limited accumulation but notable changes in oxidative stress pathways and lipid metabolism. The results suggest that PFAS toxicity may result from cellular membrane interactions rather than sustained accumulation. However, the findings cannot fully represent the complexities of in vivo PFAS effects.

Original Source(s)

Low-Dose PFAS Exposure Alters Cellular Metabolism 

  • March 24, 2026

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