Medical Oddities: When Body Fat Gets to Your Head
-
By
January 28, 2026
-
5 min
Research using whole-body MRI on nearly 26,000 UK Biobank participants reveals that the location of body fat significantly impacts brain health. It identifies six distinct fat distribution patterns, notably the pancreatic-predominant and 'skinny-fat' patterns, which correlate with decreased brain volumes, increased white matter lesions, and impaired cognitive abilities. These patterns also show a higher risk of neurologic disorders including mood issues and strokes. This suggests that the spatial distribution of fat is more critical for neurologic health than weight alone.
1. Study involved 26,000 UK Biobank participants using MRI. 2. Identified six fat distribution patterns. 3. Pancreatic-predominant and 'skinny-fat' patterns linked to brain health issues. 4. Smaller brain volumes noted in relation to fat patterns. 5. Increased prevalence of mood disorders and cognitive impairments with high-risk fat distributions.
Listen Tab content