Folate: A Shield Against Lead's Impact?
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By
October 16, 2024
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2 min
A study from Canada revealed an association between gestational blood lead levels and autistic-like behaviors in preschool-age children, particularly pronounced in cases with lower maternal folate levels. The research, conducted with 601 mother-child pairs, highlighted that third-trimester blood lead levels were linked to increased SRS-2 scores among participants with low plasma total folate concentrations. Moreover, the study indicated potential benefits of folic acid supplementation in mitigating the effects of lead exposure during pregnancy.
1. Association between gestational blood lead levels and autistic-like behaviors in preschool-age children\n2. Stronger association observed with lower maternal folate levels\n3. Potential benefits of folic acid supplementation in mitigating lead exposure effects\n4. The study involved 601 mother-child pairs from the MIREC study\n5. Assessment of autistic-like behaviors conducted using the Social Responsiveness Scale-2 (SRS-2)\n6. Mention of potential influence of MTHFR genotype on the associations\n7. Study limitations include participant demographics and residual confounding
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