Optimal treatment for Bowen's disease involves balancing lesion clearance, treatment burden, and patient preferences. A recent analysis in Dermatology assessed the effectiveness of topical 5-fluorouracil (5-FU) as a first-line treatment in a multicenter trial with 250 patients. While surgical excision provided the best sustained clearance after 12 months, topical 5-FU was noninferior in effectiveness and offered lower treatment intensity, particularly appealing for older patients or those prioritizing convenience. The study underscores the potential of 5-FU in routine dermatology practice, especially when managing recurrence is feasible.
1. Bowen's disease treatment requires balancing clearance, burden, and patient preferences. 2. A study in Dermatology assessed topical 5-FU for 250 patients. 3. Surgical excision showed the highest sustained clearance at 12 months. 4. Topical 5-FU is effective with a reduced treatment burden. 5. Lower intensity and convenience make 5-FU suitable for older patients. 6. Recurrences after 5-FU are manageable. 7. Treatment decisions should consider patient-centered care.
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