Clinical Guidelines

The 60 Percent Diagnostic Gap in M/E

What earlier mNGS testing could mean for labs and clinicians

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Meningitis and encephalitis (M/E) diagnostics often lead to undetermined causes despite extensive testing. Steve Miller from Delve Bio discusses a study that explores earlier use of metagenomic next-generation sequencing (mNGS) to enhance M/E diagnostics. Traditional hypothesis-driven methods can leave over 60% of cases undiagnosed due to limited testing, while mNGS can reduce the need for microbiologic tests and shorten diagnosis time significantly. This could ultimately affect treatment decisions and hospital stays.

Original Source(s)

The 60 Percent Diagnostic Gap in M/E

What earlier mNGS testing could mean for labs and clinicians

  • by Jessica Allerton

  • March 12, 2026

  • 6 min

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