From the Journals

Apocrine Gland Changes in Early Hidradenitis Suppurativa

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A recent study published in the Journal of Investigative Dermatology has identified apocrine gland damage and the release of specific keratins, KRT18 and KRT19, as potential factors in the early pathogenesis of hidradenitis suppurativa (HS). The study analyzed skin samples from patients with HS and healthy controls, revealing significant reduction in apocrine gland size, cellular degeneration, and elevated levels of keratins in HS patients. These findings suggest a potential role for apocrine gland dysfunction and keratin release in early inflammatory processes in HS, highlighting the need for further research to validate their clinical utility as potential biomarkers for HS severity and progression. The study also indicated potential associations between serum KRT19 levels and age at disease onset, signaling the need for further investigation into its role in early disease detection.

Original Source(s)

Apocrine Gland Changes in Early Hidradenitis Suppurativa

  • by Kathryn Wighton

  • November 18, 2024

  • 2 min

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