From the Journals

Trial Tests Timing of IOPTH in RHPT Surgery

About 15% of patients with parathyroid gland enlargement from chronic kidney disease still require surgery within 10 years of starting dialysis, even with calcimimetics treatment. Surgical failure rates can reach 28%, often due to missed ectopic or supernumerary glands.

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A randomized pilot trial in Canada is assessing the feasibility of intraoperative parathyroid hormone (IOPTH) monitoring for improving surgical outcomes in patients with secondary or tertiary renal hyperparathyroidism undergoing parathyroidectomy. Researchers aim to establish whether at least 70% of eligible participants can be successfully randomized, targeting 60 patients across major endocrine surgery hospitals. Secondary goals include ensuring a 90% follow-up rate and a patient recruitment of at least 5 monthly, along with assessing surgical success and postoperative complications over 6 months.

Original Source(s)

Trial Tests Timing of IOPTH in RHPT Surgery

About 15% of patients with parathyroid gland enlargement from chronic kidney disease still require surgery within 10 years of starting dialysis, even with calcimimetics treatment. Surgical failure rates can reach 28%, often due to missed ectopic or supernumerary glands.

  • by Stanley Gajete

  • August 15, 2025

  • 3 min

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